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1. 发明授权

US06747060B2 Non-natural galanin receptor ligands 失效
标题翻译：非天然甘丙肽受体配体
公开(公告)号：US06747060B2
公开(公告)日：2004-06-08
申请号：US10155376
申请日：2002-05-24
申请人： Kulliki Saar , Tamas Bartfai , Ulo Langel , Gerd Hallnemo , Sven Hellberg
发明人： Kulliki Saar , Tamas Bartfai , Ulo Langel , Gerd Hallnemo , Sven Hellberg
IPC分类号： A61K3135
CPC分类号： C07K5/06078 , A61K38/00
摘要： Compounds which are non-natural galanin receptor ligands are disclosed. The ligands are of small size, have agonist or antagonist galanin activity and may cross the blood-brain barrier to displace galanin from galanin receptors. The ligands are useful as medicaments for treatment of convulsions (e.g. in epilepsy), diseases and disorders related to endocrinology (e.g., growth hormone, insulin or prolactin release), tumors expressing galanin receptors, feeding disorders pain, allodynia, psychiatric disorders such as depression (involving e.g., noradrenaline or serotonin), cognitive disorders (e.g. Alzeimer's disease), and the like.
摘要翻译：公开了非天然甘氨酸受体配体的化合物。配体具有小尺寸，具有激动剂或拮抗剂甘丙肽活性，并且可以穿过血脑屏障以从甘丙肽受体取代甘丙肽。配体可用作治疗惊厥（例如癫痫），与内分泌学（例如生长激素，胰岛素或催乳素释放）相关的疾病和病症的药物，表达甘丙肽受体的肿瘤，进食障碍性疼痛，异常性疼痛，抑郁症等精神疾病（例如，去甲肾上腺素或5-羟色胺），认知障碍（例如Alzeimer病）等。

2. 发明授权

US6025140A Membrane-permeable constructs for transport across a lipid membrane 失效
标题翻译：用于跨膜脂质转运的膜可渗透结构
公开(公告)号：US6025140A
公开(公告)日：2000-02-15
申请号：US116294
申请日：1998-07-16
申请人： Ulo Langel , Tamas Bartfai , Margus Pooga , Andres Valkna , Kulliki Saar , Mattias Hallbrink
发明人： Ulo Langel , Tamas Bartfai , Margus Pooga , Andres Valkna , Kulliki Saar , Mattias Hallbrink
IPC分类号： A61K47/42 , A61K31/712 , A61K38/00 , A61K47/48 , A61K48/00 , C07K14/00 , C07K14/435 , C07K14/575 , C12N15/113 , C12N15/87 , C07H21/04 , C12N15/85 , C12Q1/68
CPC分类号： C12N15/113 , A61K47/48338 , C07K14/43568 , C07K14/43581 , C07K14/575 , C12N15/87 , C12N2310/3181 , C12N2310/33 , C12N2310/3513
摘要： Constructs of peptides and nucleic acid analogs conjugated together for transport across a lipid membrane and for delivery into interactive contact with intracellular polynucleotides are disclosed. Transport is effected through at least the exterior membrane of a cell, and most likely also through the walls of subcellular structures separated from the cytosol by lipid membranes, including the nucleus, mitochondria, ribosomes, etc. Peptide nucleic acid (PNA) analog sequences conjugated through a labile disulfide bond to transporting peptides, are intracellulary cleaved, and target mRNA (antigene) or dsDNA (antisense).
摘要翻译：公开了缀合在一起用于跨脂质膜传输并与细胞内多核苷酸递送成交互接触的肽和核酸类似物的构建体。运输通过至少细胞的外膜进行，并且最可能还通过脂质膜（包括细胞核，线粒体，核糖体等）从胞质溶胶分离出的亚细胞结构壁。缀合的肽核酸（PNA）类似物序列通过不稳定的二硫键转运肽，是细胞内裂解的，靶mRNA（反义）或dsDNA（反义）。

3. 发明授权

US5576296A Galanin antagonist 失效
标题翻译：格拉宁拮抗剂
公开(公告)号：US5576296A
公开(公告)日：1996-11-19
申请号：US468514
申请日：1995-06-06
申请人： Tamas Bartfai , Tomas H okfelt , Ulo Langel , Bo Ahr en , Stefan Lindskog , Silvana Consolo , Tiit Land , Zsuzsanna Wiesenfeld-Hallin
发明人： Tamas Bartfai , Tomas H okfelt , Ulo Langel , Bo Ahr en , Stefan Lindskog , Silvana Consolo , Tiit Land , Zsuzsanna Wiesenfeld-Hallin
IPC分类号： A61K38/00 , C07K7/02 , C07K7/18 , C07K7/22 , C07K14/575 , C07K14/70 , C07K5/00 , C07K7/00 , C07K17/00
CPC分类号： C07K14/575 , C07K14/70 , C07K7/02 , C07K7/18 , C07K7/22 , A61K38/00
摘要： A galanin antagonist which is a galanin receptor ligand is described. New peptides, Galanin (1-12)-Pro-Substance P(5-11), Galanin (1-12)-Pro-Bradykinin(2-9), Galanin (1-12)-Pro-Pro-Pro- (Leu.sup.5 -Enkephalin (5-1), Galanin (1-12)-Pro-Lys(.epsilon.-NH-)Pro-(Leu5-Enkephalin (5-1) and functional analogues and functional derivatives thereof are disclosed. The peptides are used in pharmaceutical preparations to treat a disorder in a mammal which depends on the physiological function of galanin at the galanin receptor.
摘要翻译：描述了作为甘丙肽受体配体的甘丙肽拮抗剂。新肽，格拉宁（1-12）-Pro-物质P（5-11），格拉宁（1-12）-Pro缓激肽（2-9），格拉宁（1-12）-Pro-Pro-Pro-（ Leu5-脑啡肽（5-1），Galanin（1-12）-Pro-Lys（ε-NH-）Pro-（Leu5-脑啡肽（5-1））及其功能类似物及其功能衍生物，在药物制剂中治疗依赖甘蓝蛋白受体的甘丙肽的生理功能的哺乳动物中的病症。

4. 发明申请

US20060177853A1 Antidepressant drug target 审中-公开
标题翻译：抗抑郁药物目标
公开(公告)号：US20060177853A1
公开(公告)日：2006-08-10
申请号：US11324770
申请日：2006-01-03
申请人： Tamas Bartfai , Bruno Conti , Xiaoying Lu
发明人： Tamas Bartfai , Bruno Conti , Xiaoying Lu
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/136 , C12Q2600/158
摘要： The galaninergic system of the dorsal raphe nucleus is employed as a target for screening drug candidates for antidepressant activity.
摘要翻译：将背根核的加兰能能系统用作筛选候选抗抑郁药活性的药物的靶标。

5. 发明授权

US5225193A Bordetella toxin peptides and vaccines 失效
标题翻译： BORDETELLA TOXIN PEPTIDES和VACCINES
公开(公告)号：US5225193A
公开(公告)日：1993-07-06
申请号：US346837
申请日：1989-05-24
申请人： Tamas Bartfai
发明人： Tamas Bartfai
IPC分类号： G01N33/53 , A61K38/00 , A61K39/00 , A61K39/10 , A61P37/00 , C07K7/08 , C07K14/235 , G01N33/569
CPC分类号： C07K14/235 , A61K39/00 , Y10S530/825
摘要： The following new polypeptides are described: (a) H-X.sup.1 -Asp-Asp-Pro-Pro-Ala-Thr-Val-Tyr-Arg-Tyr-Asp-Ser-Arg-Pro-Pro-Glu-Asp-X.sup.2 -Y, (b) H-X.sup.1 -Ser-Glu-Tyr-Leu-Ala-His-Arg-Arg-Ile-Pro-Pro-Glu-Asn-Ile-Arg-Arg-Val-Thr-Arg-Val-X.sup.2 -Y, (c) H-X.sup.1 -Ala-Phe-Val-Ser-Thr-Ser-Ser-Ser-Arg-Arg-Tyr-Thr-Glu-Val-Tyr-X.sup.2 -Y, (d) H-X.sup.1 -Gly-Ile-Thr-Gly-Glu-Thr-Thr-Thr-Thr-Glu-Tyr-Ser-Asn-Ala-Arg-Tyr-Val-X.sup.2 -Y, and (e) H-X.sup.1 -Leu-Glu-His-Arg-Met-Gln-Glu-Ala-Val-Glu-Ala-Glu-Arg-Ala-Gly-Arg-Gly-Thr-Gly-His-Phe-Ile-X.sup.2 -Y, in which X.sup.1 and X.sup.2 each represents an optional coupling-facilitating amino acid residue, and Y represents --OH or --NH.sub.2. Additionally, there is described an artificial pertussis toxin antigen, which mainly consists of at least one peptide sequence reacting with antibodies induced by the native pertussis toxin selected from the above polypeptides (a) to (e) and parts thereof. The above described artificial pertussis toxin antigen is included as a diagnostic antigen in a diagnostic immunoassay kit for the determination of antibodies induced by the native pertussis toxin in a sample of biological fluid, and as an immunizing component in a vaccine composition against whooping cough, respectively. Furthermore there is described an intradermal skin test composition comprising the above described artificial pertussis toxin antigen.

6. 发明申请

US20100090883A1 Apparatus for determining and/or monitoring the level of a medium 有权
标题翻译：用于确定和/或监测介质水平的装置
公开(公告)号：US20100090883A1
公开(公告)日：2010-04-15
申请号：US12308937
申请日：2007-06-14
申请人： Qi Chen , Tamas Bartfai , Armin Wendler
发明人： Qi Chen , Tamas Bartfai , Armin Wendler
IPC分类号： G01F23/284
CPC分类号： G01F23/284
摘要： An apparatus for ascertaining and/or monitoring fill level of a medium in a container. The apparatus includes an antenna, which transmits and receives high frequency signals in a predetermined oscillatory mode in a bounded space in a predetermined radiation direction, wherein, in front of the antenna in the radiation direction, an antenna protection element of a material transmissive for the high frequency signals is provided, and wherein a control/evaluation unit is provided, which evaluates the received high frequency signals and ascertains the fill level.
摘要翻译：一种用于确定和/或监测容器中的介质的填充水平的装置。该装置包括天线，其以预定的辐射方向在有界空间中以预定的振荡模式发送和接收高频信号，其中在辐射方向上的天线前面，透射天线的材料的天线保护元件提供高频信号，并且其中提供控制/评估单元，其评估所接收的高频信号并确定填充水平。

7. 发明授权

US5283321A Polypeptide compound which binds to glyco-conjugates and to artificial pertussis toxin antigen 失效
标题翻译：结合糖缀合物和人造百日咳毒素抗原的多肽化合物
公开(公告)号：US5283321A
公开(公告)日：1994-02-01
申请号：US375004
申请日：1989-07-18
申请人： Tamas Bartfai
发明人： Tamas Bartfai
IPC分类号： G01N33/53 , A61K39/00 , A61K39/10 , A61K49/00 , C07K7/08 , C07K14/00 , C07K14/235 , C07K14/76 , C07K19/00 , G01N33/569 , C07K7/00
CPC分类号： C07K14/235 , A61K49/00 , A61K39/00
摘要： A polypeptide of the formulaH--X.sup.1 --Gln--Thr--Art--Ala--Asn--Pro--Asn--Pro--Tyr--Thr----Ser--Arg--Arg--Ser--Val--Ala--Ser--X.sup.2 --Yin which X.sup.1 and X.sup.2 each represents an optional coupling-facilitating amino acid residue, and Y represents --OH or --NH.sub.2, and an artificial compound in free or carrier-associated form with the capability of binding to glyco-conjugates, especially immunoglobulins, which compound is chosen from the group consisting of said peptide and functional analogues and functional derivatives thereof, are disclosed. Additionally, there is described an artificial pertussis toxin antigen, which mainly consists of at least one peptide sequence reacting with antibodies induced by the native pertussis toxin selected from the above polypeptide and parts thereof. The above described artificial pertussis toxin antigen is included as a diagnostic antigen in a diagnostic immunoassay kit for the determination of antibodies induced by the native pertussis toxin in a sample of biological fluid, and as an immunizing component in a vaccine composition against whooping cough, respectively. Furthermore, there is described an intradermal skin test composition comprising the above described artificial pertussis toxin antigen.
摘要翻译： PCT No.PCT / SE87 / 00619 Sec。 371日期：1989年7月18日 102（e）日期1989年7月18日PCT 1987年12月21日PCT公布。出版物WO88 / 04665 日期：1988年6月30日。式H-X1-Gln-Thr-Art-Ala-Asn-Pro-Asn-Pro-Tyr-Thr-Ser-Arg-Arg-Ser-Val-Ala-Ser -X2-Y，其中X1和X2各自表示任选的偶合促进氨基酸残基，Y表示-OH或-NH 2，以及具有结合糖缀合物的能力的游离或载体相关形式的人造化合物，特别是免疫球蛋白，该化合物选自所述肽及其功能类似物及其功能衍生物。此外，描述了人造百日咳毒素抗原，其主要由与上述多肽及其部分的天然百日咳毒素诱导的抗体反应的至少一个肽序列组成。将上述人造百日咳毒素抗原作为诊断性抗原包括在用于测定生物流体样品中天然百日咳毒素诱导的抗体的诊断性免疫测定试剂盒中，并分别作为针对百日咳的疫苗组合物中的免疫组分。此外，描述了包含上述人造百日咳毒素抗原的皮内皮肤试验组合物。

8. 发明申请

US20130345392A1 EDN3-LIKE PEPTIDES AND USES THEREOF 审中-公开
标题翻译： EDN3样肽及其用途
公开(公告)号：US20130345392A1
公开(公告)日：2013-12-26
申请号：US14002283
申请日：2012-03-01
申请人： Tamas Bartfai , Bruno Conti , Avijit Ghosh , John Hadcock , Olivia Osborn , Manuel Sanchez-Alavez , Jean Schaefer , Iustin Tabarean
发明人： Tamas Bartfai , Bruno Conti , Avijit Ghosh , John Hadcock , Olivia Osborn , Manuel Sanchez-Alavez , Jean Schaefer , Iustin Tabarean
IPC分类号： C07K14/47
CPC分类号： C07K14/47 , A61K38/00 , C07K14/57536
摘要： This application discloses novel EDN3-like polypeptides. One such short polypeptide is EDN3 97-140, which is a 44 amino acid peptide that stimulates GLP-1 secretion in enteric cells and inhibits gluconeogenesis in hepatic cells. EDN3 97-140, as well as other EDN3-like polypeptides provided herein may be used in the study and treatment of a number of indications, including the treatment of metabolic disorders such as obesity and diabetes.
摘要翻译：该申请公开了新颖的EDN3样多肽。一种这样的短多肽是EDN3 97-140，其是刺激肠细胞中GLP-1分泌并抑制肝细胞中的糖异生的44个氨基酸的肽。 EDN3 97-140以及本文提供的其它EDN3样多肽可用于研究和治疗许多适应症，包括治疗代谢性疾病如肥胖和糖尿病。

9. 发明授权

US08040274B2 Apparatus for determining and/or monitoring the level of a medium 有权
标题翻译：用于确定和/或监测介质水平的装置
公开(公告)号：US08040274B2
公开(公告)日：2011-10-18
申请号：US12308937
申请日：2007-06-14
申请人： Armin Wendler , Qi Chen , Tamas Bartfai
发明人： Armin Wendler , Qi Chen , Tamas Bartfai
IPC分类号： G01S13/08
CPC分类号： G01F23/284
摘要： An apparatus for ascertaining and/or monitoring fill level of a medium in a container. The apparatus includes an antenna, which transmits and receives high frequency signals in a predetermined oscillatory mode in a bounded space in a predetermined radiation direction, wherein, in front of the antenna in the radiation direction, an antenna protection element of a material transmissive for the high frequency signals is provided, and wherein a control/evaluation unit is provided, which evaluates the received high frequency signals and ascertains the fill level.
摘要翻译：一种用于确定和/或监测容器中的介质的填充水平的装置。该装置包括天线，其以预定的辐射方向在有界空间中以预定的振荡模式发送和接收高频信号，其中在辐射方向上的天线前面，透射天线的材料的天线保护元件提供高频信号，并且其中提供控制/评估单元，其评估所接收的高频信号并确定填充水平。

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