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1. 发明申请

US20020146440A1 Mult-purpose skin balm including skin balm for psoriasis 失效
标题翻译：多用途皮肤膏，包括牛皮癣皮肤膏
公开(公告)号：US20020146440A1
公开(公告)日：2002-10-10
申请号：US09829272
申请日：2001-04-09
发明人： Sadie N. Smith
IPC分类号： A61K007/00 , A61K007/42 , A61K031/00 , A61K031/74 , A01N025/32 , A01N027/00 , A61K031/01 , A01N025/00
CPC分类号： A61Q17/005 , A61K8/67 , A61K8/678 , A61K9/06 , A61K45/06 , A61K2800/72 , A61Q17/02 , A61Q17/04 , A61Q19/00 , Y10S514/861 , Y10S514/863 , Y10S514/864 , Y10S514/886 , Y10S514/887
摘要： The multi-purpose skin balm series is new to the art of skin healing, maintenance, and prevention in that each balm in the series is a compound of old products. Each ingredient in the series works to function in its own way but each action is enhanced when in combination. One will discover that indeed the whole is greater than the sum of its parts. In other words, 2null2null5. These products can offer much less healing time, greater pain control, and less cosmetic disfigurement in a wide range of conditions that affect the skin In and of itself the product is excellent, but when it is combined with the gold standard for each disease entity, injury, or surgical procedure it becomes a superb product. Skin Balm For Psoriasis is the flagship of this series. It was selected as such because of the millions of people world wide who afflicted by this chronic condition. Many have had little improvement in the past.
摘要翻译：多用途护肤系列是皮肤愈合，维护和预防技术的新手段，系列中的每种香膏都是旧产品的复合物。系列中的每种成分都以自己的方式发挥作用，但是当组合时，每个动作都得到增强。人们会发现，确实，整体比它的部分总和要大。换句话说，2 + 2 = 5。这些产品可以在影响皮肤的广泛条件下提供更少的愈合时间，更好的疼痛控制和更少的化妆品损伤。本身产品本身是优秀的，但是当它与每个疾病实体的黄金标准相结合时，伤害或外科手术，成为一流的产品。皮肤膏牛皮癣是本系列的旗舰产品。这是被选中的，因为世界上数以百万计的这个慢性病患者。许多人过去几乎没有改善。

2. 发明申请

US20040131567A1 Antibacterial topical formulations 审中-公开
标题翻译：抗菌外用制剂
公开(公告)号：US20040131567A1
公开(公告)日：2004-07-08
申请号：US10615589
申请日：2003-07-08
发明人： Joe S. Wilkins JR.
IPC分类号： A61K007/06 , A61K031/01
CPC分类号： A61Q17/005 , A61K8/31 , A61Q11/00
摘要： Novel topical formulations and methods use are described herein for eradicating various disease-causing pathogens. The inventive formulations comprise effective amounts of d-limonene.
摘要翻译：本文描述了新的局部制剂和方法用于消除各种致病病原体。本发明的制剂包含有效量的d-柠檬烯。

3. 发明申请

US20040092583A1 Treatment for inhibiting neoplastic lesions 审中-公开
标题翻译：治疗抑制肿瘤病变
公开(公告)号：US20040092583A1
公开(公告)日：2004-05-13
申请号：US10250535
申请日：2004-01-02
发明人： Elizabeth Shanahan-Prendergast
IPC分类号： A61K031/343 , A61K031/335 , A61K031/01
CPC分类号： A61K45/06 , A61K31/00 , A61K31/015 , A61K31/343 , Y02A50/475
摘要： The invention discloses the use of incensole and/or furanogermacrens, derivatives metabolites and precursors thereof in the treatment of neoplasia, particularly resistant neoplasia and immunodysregulatory disorders. These compounds can be administered alone or in combination with conventional chemotherapeutic, anti-rival, anti-parasite agents, radiation and/or surgery.
摘要翻译：本发明公开了使用迷迭香和/或呋喃糖类，其衍生物代谢产物及其前体在治疗瘤形成，尤其是耐药性肿瘤和免疫调节性疾病中的用途。这些化合物可以单独施用或与常规化学治疗，抗竞争，抗寄生虫剂，放射和/或手术组合施用。

4. 发明申请

US20040009901A1 Autoimmune conditions and NADPH oxidase defects 失效
标题翻译：自身免疫病症和NADPH氧化酶缺陷
公开(公告)号：US20040009901A1
公开(公告)日：2004-01-15
申请号：US10437427
申请日：2003-05-13
发明人： Rikard Holmdahl , Peter Olofsson
IPC分类号： A61K038/17 , A61K031/739 , A61K031/496 , A61K031/202 , A61K031/685 , A61K031/01 , A61K031/045
CPC分类号： C12Q1/26 , C12Q1/32 , G01N33/564 , G01N2333/90209 , G01N2500/04
摘要： The invention relates to methods and materials involved in diagnosing and treating autoimmune conditions. In particular, the invention relates to methods and materials involved in diagnosing arthritis conditions that are accompanied by an NADPH oxidase deficiency, methods and materials involved in treating, preventing, or delaying the onset of arthritis conditions that are accompanied by an NADPH oxidase deficiency, and methods and materials involved in identifying agonists and antagonists of NADPH oxidase activity.
摘要翻译：本发明涉及诊断和治疗自身免疫病症的方法和材料。特别地，本发明涉及诊断伴随有NADPH氧化酶缺乏的关节炎状况的方法和材料，涉及治疗，预防或延迟伴有NADPH氧化酶缺乏症的关节炎病症发作的方法和材料，以及涉及鉴定NADPH氧化酶活性的激动剂和拮抗剂的方法和材料。

5. 发明申请

US20030059462A1 Carotenoid-loaded liposomes 失效
标题翻译：含有类胡萝卜素的脂质体
公开(公告)号：US20030059462A1
公开(公告)日：2003-03-27
申请号：US10073365
申请日：2002-02-13
申请人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY
发明人： Yeckezkel Barenholz , Dvorah Diminsky , Rivka Cohen
IPC分类号： A61K009/127 , A61K031/01 , A61K031/12
CPC分类号： A61K9/127 , A61K8/14 , A61K8/31 , A61K31/01 , A61K31/015 , A61K31/045 , A61K31/047 , A61K31/122 , A61K2800/522 , A61Q17/00 , A61Q17/04 , A61Q19/00
摘要： The present invention is based on a novel method for encapsulating in liposomes substantially water immiscible carotenoids. Therefore, there are provided by the present invention formulations comprising liposomes loaded with an amount of at least one water immiscible carotenoid, pharmaceutical compositions comprising such a formulation, and a method for preparing the liposomes loaded with said carotenoid.
摘要翻译：本发明基于一种用于将脂质体基本上与水不混溶的类胡萝卜素包封的新方法。因此，本发明提供了包含负载量至少一种与水不混溶的类胡萝卜素的脂质体的制剂，包含这种制剂的药物组合物和用于制备装载有所述类胡萝卜素的脂质体的方法。

6. 发明申请

US20020165130A1 Method of sensitizing microbial cells to antimicrobial compounds 审中-公开
标题翻译：使微生物细胞对抗菌化合物敏感的方法
公开(公告)号：US20020165130A1
公开(公告)日：2002-11-07
申请号：US09962379
申请日：2001-09-25
发明人： Eric A. Johnson , Byron F. Brehm-Stecher
IPC分类号： A61K038/14 , A61K031/7048 , A61K031/65 , A61K031/496 , A61K031/01
CPC分类号： A01N49/00 , A01N61/00 , A01N43/62 , A01N43/60 , A01N43/36 , A01N43/22 , A01N37/44 , A01N2300/00
摘要： A method of promoting the uptake of exogenous antimicrobial compounds by microbial cells is disclosed. In one embodiment, the method comprises the step of exposing the microbial cell to an amount of at least one sesquiterpenoid effective to enhance antimicrobial compound uptake in a microorganism and an antimicrobial compound. An antimicrobial composition comprising at least one sesquiterpenoid and an antimicrobial compound, the sesquiterpenoid being present in a concentration of between 0.1 mM and 50 mM, is also disclosed.
摘要翻译：公开了一种通过微生物细胞促进外源抗微生物化合物的吸收的方法。在一个实施方案中，该方法包括将微生物细胞暴露于至少一种倍半萜类化合物的量以有效增强微生物和抗微生物化合物中的抗微生物化合物摄取的步骤。还公开了包含至少一种倍半萜和抗微生物化合物的抗微生物组合物，倍半萜烯以0.1mM至50mM的浓度存在。

7. 发明申请

US20040127556A1 Compositions and delivery methods for the treatment of wrinkles, fine lines and hyperhidrosis 有权
标题翻译：用于治疗皱纹，细纹和多汗症的组合物和递送方法
公开(公告)号：US20040127556A1
公开(公告)日：2004-07-01
申请号：US10334887
申请日：2002-12-31
发明人： Michelle Zheng Lu , Robert E. Kalafsky , Michele C. Duggan
IPC分类号： A61K031/365 , A61K031/045 , A61K031/01
CPC分类号： A61Q19/08 , A61K8/046 , A61K8/14 , A61K8/97 , A61K31/00 , A61K31/01 , A61K31/045 , A61K31/365 , A61K45/06 , A61K2800/70 , A61K2300/00
摘要： The present invention describes compositions and methods for treating, preventing and improving the appearance of skin, particularly, treating, preventing, ameliorating, reducing and/or eliminating fine lines and/or wrinkles of skin, wherein the compositions include limonoid constituents which inhibit acetylcholine release at neuromuscular junctions of skeletal muscle so as to relax the muscles involved with wrinkling, folding and creasing of skin, e.g., facial movement and expression. The limonoids preferably include the plant alkaloids toosendanin and azadirachtin. The compositions, which also are used to treat hyperhidrosis, are preferably applied to the skin, or are delivered by directed means to a site in need thereof.
摘要翻译：本发明描述了用于治疗，预防和改善皮肤外观，特别是治疗，预防，改善，减少和/或消除皮肤细纹和/或皱纹的组合物和方法，其中组合物包括抑制乙酰胆碱释放的柠檬醛成分在骨骼肌的神经肌肉接头处，以便放松与皮肤起皱，折叠和皱纹相关的肌肉，例如面部运动和表达。柠檬醛优选包括植物生物碱toosendanin和印苦楝子素。也用于治疗多汗症的组合物优选施用于皮肤，或通过定向方式递送至有需要的部位。

8. 发明申请

US20040086477A1 Method of and kit for mitigating cradle cap 审中-公开
标题翻译：缓解摇篮帽的方法和套件
公开(公告)号：US20040086477A1
公开(公告)日：2004-05-06
申请号：US10667214
申请日：2003-09-19
发明人： Wanda Richard , Rebecca Whipple , Richard Jentis
IPC分类号： A61K007/06 , A61K007/11 , A61K031/01
CPC分类号： A61Q5/006 , A61K8/92 , A61K8/986 , A61K2800/88 , A61Q5/00 , A61Q5/02
摘要： Methods and kits for removing scales caused by cradle cap on the heads of infants are disclosed and include topically applying to the scalp an effective amount of a pre-treatment composition, a shampoo and a moisturizer for respective time periods sufficient to remove cradle cap. A scale-removing device is also used to help remove and loosen any scales.
摘要翻译：公开了用于消除由婴儿头上的摇篮盖引起的鳞屑的方法和试剂盒，并且包括在足以移除支架帽的相应时间段内局部施用有效量的预处理组合物，洗发剂和保湿剂。除垢装置也用于帮助移除和松开任何刻度。

9. 发明申请

US20030166584A1 Cytochrome P450 3A inhibitors and enhancers 有权
标题翻译：细胞色素P450 3A抑制剂和增强剂
公开(公告)号：US20030166584A1
公开(公告)日：2003-09-04
申请号：US10080043
申请日：2002-02-22
发明人： Oliver Yoa-Pu Hu , Cheng-Huei Hsiong , Benjamin Pei-Chung Kuo , Li-Heng Pao
IPC分类号： A61K031/7048 , A61K031/353 , A61K031/01 , A61K031/11
CPC分类号： A61K45/06 , A61K31/01 , A61K31/11 , A61K31/353 , A61K31/7048 , A61K2300/00
摘要： The present invention provides cytochrome P450 3A (CYP3A) inhibitors and enhancers. Examples of the CYP3A inhibitors include free bases or pharmacologically acceptable salts of at least one of the following compounds: null-naphthoflavone, null-naphthoflavone, apigenin, baicalein, null-myrcene, catechin, 3-phenylpropyl acetate, formononetin, gallic acid, hesperetin, hesperidin, isoquercitrin, lauryl alcohol, luteolin, luteolin-7-glycoside, narigin, nordihydroguaiaretic acid, quercitrin, swertiamarin, terpineol, and trans-cinnamaldehyde. Examples of the CYP3A enhancers include free bases or pharmacologically acceptable salts of at least one of the following compounds: apigenin, formononetin, and luteolin-7-glycoside. The CYP3A inhibitors can be used, alone or co-administered with a drug, to improve the drug bioavailability. The CYP3A inhibitors can also be used as chemopreventors to prevent biotransformation of procarcinogenic compounds into carcinogens via CYP3A activity or for treatment of intestinal or hepatic cancer by inhibit the CYP3A activity. The CYP3A enhancers can be used to improve the enzymatic activity of CYP3A so as to improve the biotransformation and degradation of active drugs or the sustrates of CYP3A from the body. The CYP3A inhibitors and enhancers of the present invention are natural substances extracted from herbs and non-toxic.
摘要翻译：本发明提供细胞色素P450 3A（CYP3A）抑制剂和增强剂。 CYP3A抑制剂的实例包括以下化合物中的至少一种的游离碱或药理学上可接受的盐：α-萘黄酮，β-萘醌，芹菜素，黄芩素，β-月桂烯，儿茶素，乙酸3-苯基丙酯，草铵膦，没食子酸，橙皮素，橙皮苷，异槲皮苷，月桂醇，木犀草素，木犀草素-7-糖苷，奈格林，去甲二氢愈创木酚酸，槲皮素，藜芦醇，萜品醇和反式肉桂醛。 CYP3A增强剂的实例包括至少一种以下化合物的游离碱或药理学上可接受的盐：芹菜素，角叉菜胶和木犀草素-7-糖苷。 CYP3A抑制剂可单独使用或与药物共同施用以改善药物生物利用度。 CYP3A抑制剂也可用作化学预防剂，以通过CYP3A活性或通过抑制CYP3A活性来预防致癌物质转化为致癌物质。 CYP3A增强子可用于改善CYP3A的酶活性，从而改善活体药物或体外CYP3A的生物转化和降解。本发明的CYP3A抑制剂和增强剂是从草药中提取的天然物质和无毒的。

10. 发明申请

US20030096877A1 Inhibition of exoprotein production in non-absorbent articles using isoprenoid compositions 失效
标题翻译：使用类异戊二烯组合物抑制非吸收性物品中的外生蛋白产生
公开(公告)号：US20030096877A1
公开(公告)日：2003-05-22
申请号：US09969198
申请日：2001-10-02
申请人： Kimberly-Clark Worldwide, Inc.
发明人： Rae Ellen Syverson , Richard A. Proctor
IPC分类号： A61K031/01 , A61K031/015
CPC分类号： A61L15/46 , A61L2300/22 , A61L2300/402 , A61L2300/404 , A61L2300/41 , A61L2300/45 , A61L2300/802
摘要： Non-absorbent articles are disclosed. The non-absorbent articles include an effective amount of an isoprenoid inhibitory compound such as a terpene to substantially inhibit the production of exotoxins by Gram positive bacteria.
摘要翻译：公开了非吸收性物品。非吸收性物品包括有效量的类异戊二烯抑制化合物如萜烯，以显着抑制革兰氏阳性菌产生外毒素。

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