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1. 发明授权

US06593315B2 Salicylic acid derivatives, processes for their preparation, compositions comprising them, and their use 失效
标题翻译：水杨酸衍生物，其制备方法，包含它们的组合物及其用途
公开(公告)号：US06593315B2
公开(公告)日：2003-07-15
申请号：US09896971
申请日：2001-07-02
申请人： Andreas Gypser , Thomas Grote , Joachim Rheinheimer , Ingo Rose , Oliver Cullmann , Markus Gewehr , Wassilios Grammenos , Jordi Tormo i Blasco , Bernd Müller , Hubert Sauter , Eberhard Ammermann , Siegfried Strathmann , Gisela Lorenz , Reinhard Stierl
发明人： Andreas Gypser , Thomas Grote , Joachim Rheinheimer , Ingo Rose , Oliver Cullmann , Markus Gewehr , Wassilios Grammenos , Jordi Tormo i Blasco , Bernd Müller , Hubert Sauter , Eberhard Ammermann , Siegfried Strathmann , Gisela Lorenz , Reinhard Stierl
IPC分类号： A01N3736
CPC分类号： C07C251/86 , A01N37/50
摘要： Salicylic acid derivatives of the formula I, where the index and the substituents have the following meanings: X is halogen, NO2, cyano, alkyl or alkoxy; m is 0, 1, 2 or 3, it being possible for the substituents X to be different from each other if n is greater than 1; A is OH, alkoxy, NH2, NHCH3 or N(CH3)2; R1 is phenyl, naphthyl, cycloalkyl, 5-membered or 6-membered hetaryl or 5-membered or 6-membered heterocyclyl, comprising one to three N atoms and/or one O or S atom or one or two O and/or S atoms, the ring systems being unsubstituted or substituted; R2 is hydrogen, cyano, alkyl, alkenyl, alkynyl, haloalkyl, alkoxy or alkylthio, processes for the preparation of these compounds, compositions comprising them, and their use for controlling harmful fungi.
摘要翻译：式I的水杨酸衍生物，其中指数和取代基具有以下含义：X是卤素，NO 2，氰基，烷基或烷氧基; m是0,1,2或3，取代基X可以是如果n大于1，A是不同的; A是OH，烷氧基，NH2，NHCH3或N（CH3）2; R1是苯基，萘基，环烷基，5元或6元杂芳基或5元或6- 包括一至三个N原子和/或一个O或S原子或一个或两个O和/或S原子，所述环系是未取代或取代的; R2是氢，氰基，烷基，烯基，炔基，卤代烷基，烷氧基或烷硫基，制备这些化合物的方法，包含它们的组合物及其用于控制有害真菌的用途。

2. 发明授权

US06423697B1 Intraoral topical anti-inflammatory treatment for relief of migraine, tension-type headache, post-traumatic headache, facial pain, and cervical-muscle spasm 失效
标题翻译：用于缓解偏头痛，紧张型头痛，创伤后头痛，面部疼痛和颈部肌肉痉挛的口腔内局部消炎治疗
公开(公告)号：US06423697B1
公开(公告)日：2002-07-23
申请号：US09626250
申请日：2000-07-26
申请人： Mark Friedman
发明人： Mark Friedman
IPC分类号： A01N3736
CPC分类号： A61K31/573 , A61K9/006 , A61K9/0063 , A61K31/167 , A61K31/192 , A61K31/57 , A61K31/58 , A61K31/616 , A61K2300/00
摘要： An anti-inflammatory, either a NSAID or glucocorticoid steroid in the form of an ointment, cream, lotion, gel, powder, tablet, paste, film, tape or adhesive bandage, provided with appropriate vehicle to allow specific adherence to specific gingival areas, for topical treatment of inflammation. This composition and the method of using same is used to prevent or relieve migraine, tension-type headache, post-traumatic headache, facial pain and cervical muscle spasm.
摘要翻译：抗炎剂，以软膏，乳膏，洗剂，凝胶，粉末，片剂，糊剂，胶片，胶带或粘合绷带形式的NSAID或糖皮质激素类固醇，其具有适当的载体以允许特异性粘附于特定的牙龈区域，用于局部治疗炎症。该组合物及其使用方法用于预防或缓解偏头痛，紧张型头痛，创伤后头痛，面部疼痛和颈部肌肉痉挛。

3. 发明授权

US06306842B1 Protected forms of a combination of pharmacologically active agents and uses therefor 失效
标题翻译：药理活性剂的组合的保护形式及其用途
公开(公告)号：US06306842B1
公开(公告)日：2001-10-23
申请号：US09586344
申请日：2000-06-02
申请人： Ching-San Lai , Tingmin Wang
发明人： Ching-San Lai , Tingmin Wang
IPC分类号： A01N3736
CPC分类号： C07D261/08 , A61K47/55
摘要： In accordance with the present invention, there are provided conjugates of a combination of pharmacologically active agents (e.g., NSAIDs and selective COX-2 inhibitors). Invention conjugates provide a new class of pharmacologically active agents (e.g., anti-inflammatory agents) which provide the therapeutic benefits of both NSAIDs and selective COX-2 inhibitors, while causing a much lower incidence of side-effects then are typically observed with such agents due to the protective effects imparted by modifying the pharmacologically active agents as described herein.
摘要翻译：根据本发明，提供了药理活性剂（例如NSAID和选择性COX-2抑制剂）的组合的缀合物。本发明共轭物提供了一类新的药理学活性剂（例如抗炎剂），其提供了NSAID和选择性COX-2抑制剂的治疗益处，同时引起副作用的发生率低得多，然后通常用这些药剂观察到由于通过改变本文所述的药理活性剂而赋予的保护作用。

4. 发明授权

US06689392B2 Methods and compositions for controlling plant pathogen 有权
标题翻译：用于控制植物病原体的方法和组合物
公开(公告)号：US06689392B2
公开(公告)日：2004-02-10
申请号：US10058108
申请日：2002-01-29
申请人： Ran Lifshitz
发明人： Ran Lifshitz
IPC分类号： A01N3736
CPC分类号： A01N59/26 , Y10S424/06 , A01N59/20 , A01N59/16 , A01N37/36 , A01N2300/00 , A01N59/00 , A01N61/00
摘要： A composition for controlling growth of pathological organisms on a plant, said composition comprises an effective amount of one or more of metal ion(s); one or more of chelating agent(s); and phosphorous acid, and/or salt or hydrate thereof, said composition is in an agriculturally compatible carrier or vehicle.
摘要翻译：一种用于控制植物病理生物体生长的组合物，所述组合物包含有效量的一种或多种金属离子; 一种或多种螯合剂; 和亚磷酸和/或其盐或水合物，所述组合物在农业上相容的载体或载体中。

5. 发明授权

US06436916B1 Ibuprofen-aspirin and hydroxymethylacylfulvene analogs 失效
标题翻译：布洛芬 - 阿司匹林和羟甲基酰基富烯类似物
公开(公告)号：US06436916B1
公开(公告)日：2002-08-20
申请号：US09954853
申请日：2001-09-18
申请人： Alvin Guttag
发明人： Alvin Guttag
IPC分类号： A01N3736
CPC分类号： C07C69/90 , A61K31/12 , A61K31/603 , C07C69/736 , C07C2603/94
摘要： Ibuprofen-aspirin compounds useful in treating aspirin or ibuprofen-treatable conditions and hydroxymethylacylfulvene analogs useful as antitumor drugs.
摘要翻译：可用于治疗阿斯匹林或布洛芬可治疗病症的布洛芬 - 阿司匹林化合物和可用作抗肿瘤药物的羟甲基酰基富烯类似物。

6. 发明授权

US06333317B1 Regulation of amyloid precursor protein (APP) expression by administration of an estrogenic compound 失效
标题翻译：通过施用雌激素化合物调节淀粉样蛋白前体蛋白（APP）表达
公开(公告)号：US06333317B1
公开(公告)日：2001-12-25
申请号：US09049198
申请日：1998-03-27
申请人： Robert K. K. Lee , Richard J. Wurtman
发明人： Robert K. K. Lee , Richard J. Wurtman
IPC分类号： A01N3736
CPC分类号： A61K31/566 , A61K31/00 , A61K31/565
摘要： It has been discovered that lipophilic hormones that interact with cytosolic or nuclear receptors regulate APP expression and synthesis, through modification of APP mRNA stability and/or regulation of APP gene transcription and translation activities. These studies demonstrate that the treatment of brain cells with estrone or 17&bgr;-estradiol results in a reduction in the level of APP holoprotein expression, without a concomitant change in the total level of cell protein. The reduction in the level of APP holoprotein caused by estrone or 17&bgr;-estradiol is also expected to reduce the production of neurotoxic APP fragments. In as much as estrogen deficiency in postmenopausal women is associated with a higher incidence of Alzheimer's disease, this discovery opens the possibility that estrogen therapy may prevent some of the neurodegenerative and cognitive changes associated with Alzheimer's disease, aging and other disease conditions associated with such neurodegenerative and cognitive decline.
摘要翻译：已经发现，通过修饰APP mRNA稳定性和/或调节APP基因转录和翻译活性，与胞质或核受体相互作用的亲脂性激素调节APP表达和合成。这些研究表明，使用雌酮或17β-雌二醇治疗脑细胞导致APP蛋白表达水平的降低，而细胞蛋白总水平没有伴随的变化。由雌酮或17β-雌二醇引起的APP蛋白水平的降低也有望降低神经毒性APP片段的产生。绝经后妇女的雌激素缺乏与阿尔茨海默病的发病率相关，这一发现揭示了雌激素治疗可能会预防与阿尔茨海默氏病相关的一些神经变性和认知变化，老年化和其他与这种神经变性相关的疾病状况和认知衰退。

7. 发明授权

US06331505B1 Method for increasing plant productivity using glutamic acid and glycolic acid 失效
标题翻译：使用谷氨酸和乙醇酸提高植物生产力的方法
公开(公告)号：US06331505B1
公开(公告)日：2001-12-18
申请号：US09563669
申请日：2000-05-02
申请人： Alan M. Kinnersley
发明人： Alan M. Kinnersley
IPC分类号： A01N3736
CPC分类号： A01N3/00 , A01N37/36 , A01N37/44 , A01N2300/00 , A01N59/06
摘要： Compositions including glutamic acid and either glycolic acid or polyglycolic acid, salts of these compounds or combinations thereof are described as are such compositions that include a calcium salt, preferably calcium nitrate. Methods of treating a plant including treating the plant or seed with a composition including glutamic acid and either glycolic acid or polyglycolic acid, salts of the aforementioned compounds or combinations thereof, and optionally a calcium salt, are also described. The methods and compositions of the present invention are advantageous in increasing plant productivity, including helping plants resist the effects of a wide variety of plant stresses. Methods of stimulating microbial growth with the compositions of the present invention are also provided.
摘要翻译：包括谷氨酸和乙醇酸或聚乙醇酸的组合物，这些化合物的盐或其组合描述为包括钙盐，优选硝酸钙的组合物。还描述了处理植物的方法，包括用包含谷氨酸和乙醇酸或聚乙醇酸的组合物处理植物或种子，上述化合物的盐或其组合，以及任选的钙盐。本发明的方法和组合物有利于提高植物生产力，包括帮助植物抵抗各种植物胁迫的影响。还提供了利用本发明组合物刺激微生物生长的方法。

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