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    • 2. 发明授权
    • Method for increasing plant productivity using glutamic acid and glycolic acid
    • 使用谷氨酸和乙醇酸提高植物生产力的方法
    • US06331505B1
    • 2001-12-18
    • US09563669
    • 2000-05-02
    • Alan M. Kinnersley
    • Alan M. Kinnersley
    • A01N3736
    • A01N3/00A01N37/36A01N37/44A01N2300/00A01N59/06
    • Compositions including glutamic acid and either glycolic acid or polyglycolic acid, salts of these compounds or combinations thereof are described as are such compositions that include a calcium salt, preferably calcium nitrate. Methods of treating a plant including treating the plant or seed with a composition including glutamic acid and either glycolic acid or polyglycolic acid, salts of the aforementioned compounds or combinations thereof, and optionally a calcium salt, are also described. The methods and compositions of the present invention are advantageous in increasing plant productivity, including helping plants resist the effects of a wide variety of plant stresses. Methods of stimulating microbial growth with the compositions of the present invention are also provided.
    • 包括谷氨酸和乙醇酸或聚乙醇酸的组合物,这些化合物的盐或其组合描述为包括钙盐,优选硝酸钙的组合物。 还描述了处理植物的方法,包括用包含谷氨酸和乙醇酸或聚乙醇酸的组合物处理植物或种子,上述化合物的盐或其组合,以及任选的钙盐。 本发明的方法和组合物有利于提高植物生产力,包括帮助植物抵抗各种植物胁迫的影响。 还提供了利用本发明组合物刺激微生物生长的方法。
    • 8. 发明授权
    • Methods for the biosynthesis of taurine or hypotaurine in cells
    • 牛磺酸或牛磺酸在细胞中生物合成的方法
    • US09267148B2
    • 2016-02-23
    • US13505415
    • 2010-10-29
    • Frank J. TuranoKathleen A. TuranoPeter S. CarlsonAlan M. Kinnersley
    • Frank J. TuranoKathleen A. TuranoPeter S. CarlsonAlan M. Kinnersley
    • C12N15/82A61K31/185
    • A61K31/145A23K10/12A23K20/10A23L33/10A23V2002/00A61K31/185C12N9/0069C12N15/8243C12N15/8253C12N15/8261C12N15/8271C12N15/8273C12N15/8279C12P13/001C12Y113/1102Y02A40/146Y02A50/473
    • The present invention describes an approach to increase taurine or hypotaurine production in prokaryotes or eukaryotes. More particularly, the invention relates to genetic transformation of organisms with genes that encode proteins that catalyze the conversion of cysteine to taurine, methionine to taurine, cysteamine to taurine, or alanine to taurine. The invention describes methods for the use of polynucleotides that encode functional cysteine dioxygenase (CDO), cysteine dioxygenase (CDO) and sulfinoalanine decarboxylase (SAD) or glutamate decarboxylase (GAD), cysteamine dioxygenase (ADO), taurine-pyruvate aminotransferase (TPAT), TPAT and sulfoacetaldehyde acetyltransferase (SA), taurine dioxygenase (TDO) or the small (ssTDeHase) and large subunits of taurine dehydrogenase (lsTDeHase) polypeptides in plants to increase taurine, hypotaurine or taurine precursor production. The preferred embodiment of the invention is in plants but other organisms may be used. Increased taurine production in plants will enhance plant growth and development, yield, or tolerance to biotic and/or abiotic stresses and could be used as nutraceutical, pharmaceutical, or therapeutic compounds or as a supplement in animal feed.
    • 本发明描述了在原核生物或真核生物中增加牛磺酸或海牛磺酸生产的方法。 更具体地,本发明涉及生物体的遗传转化,所述基因编码能催化半胱氨酸转化为牛磺酸,甲硫氨酸至牛磺酸,半胱胺,牛磺酸或丙氨酸至牛磺酸的蛋白质。 本发明描述了使用编码功能性半胱氨酸双加氧酶(CDO),半胱氨酸双加氧酶(CDO)和亚硫酰丙氨酸脱羧酶(SAD)或谷氨酸脱羧酶(GAD),半胱胺二加氧酶(ADO),牛磺酸 - 丙酮酸氨基转移酶(TPAT) TPAT和磺乙醛乙酰转移酶(SA),牛磺酸双加氧酶(TDO)或小型(ssTDeHase)和牛磺酸脱氢酶(lsTDeHase)多肽的大亚基,增加牛磺酸,牛磺酸或牛磺酸前体产物。 本发明的优选实施方案在植物中,但可以使用其他生物体。 增加植物中的牛磺酸生产将增强植物的生长和发育,产量或对生物和/或非生物胁迫的耐受性,并且可以用作营养药物,药物或治疗化合物或作为动物饲料中的补充物。