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1. 发明授权

US09063145B2 Multivalent opsonophagocytic assay using bead array and imaging 有权
标题翻译：使用珠阵列和成像的多重调理吞噬测定
公开(公告)号：US09063145B2
公开(公告)日：2015-06-23
申请号：US13342417
申请日：2012-01-03
申请人： Paul Lehmann
发明人： Paul Lehmann
IPC分类号： G01N33/564 , G01N33/58 , B82Y15/00 , G01N33/50 , G01N33/543 , B82Y5/00
CPC分类号： G01N33/588 , B82Y5/00 , B82Y15/00 , G01N33/5055 , G01N33/54326 , G01N33/564 , G01N33/585
摘要： Embodiments of the present invention relate to devices and methods for detecting opsonophagocytotic antibodies using detection particles having product-specific detection reagents and having a characteristic spectral feature. Detection substrates, include microwells. Phagocytic cells are grown in the microwells, and a sample of serum or other bodily fluid from a patient is introduced into the wells, along with a set of detection particles, each set having an antigen recognized by opsonophagocytotic antibodies. The detection particles bind to the antibodies present in the sample and the phagocytic cells then take up the detection particles, labeling the phagocytic cells. The cells are then visualized via image analysis, thereby detecting the presence of, and the types of the opsonophagocytotic antibodies in the sample.
摘要翻译：本发明的实施方案涉及使用具有产品特异性检测试剂并具有特征光谱特征的检测微粒检测调理吞噬细胞抗体的装置和方法。检测底物包括微孔。吞噬细胞在微孔中生长，并且将来自患者的血清或其他体液的样品与一组检测颗粒一起引入孔中，每组检测颗粒具有被调理性吞噬抗体识别的抗原。检测颗粒结合存在于样品中的抗体，然后吞噬细胞吸收检测颗粒，标记吞噬细胞。然后通过图像分析显示细胞，从而检测样品中调理吞噬细胞抗体的存在和类型。

2. 发明申请

US20130157288A1 IMMOBILISED-BEAD IMMUNOMULTIPLEX ASSAY 有权
标题翻译：固定珠免疫测定
公开(公告)号：US20130157288A1
公开(公告)日：2013-06-20
申请号：US13580083
申请日：2011-03-04
申请人： Stephen Kilfeather , Alberto Taurozzi , Paul Lehmann , Elaine Linglee
发明人： Stephen Kilfeather , Alberto Taurozzi , Paul Lehmann , Elaine Linglee
IPC分类号： G01N21/75
CPC分类号： G01N21/75 , B01L3/5085 , G01N21/6428 , G01N33/54306 , G01N33/54313 , G01N33/54326 , G01N33/582 , G01N2021/6441 , G01N2500/00
摘要： Embodiments of this invention include image-based systems and methods for detection of one or more analytes. A surface has identifiable analyte-specific capture particle(s) immobilised thereto at any point of an assay, to which different analytes attach due to the affinity of analyte-specific capture molecule(s) linked to the surface of the capture particle(s) for the analyte. Analyte-specific detector molecules with conjugated detection moieties are then attached to the analyte, and a computer assisted, image-based detection system captures images of the capture particles with or without attached analytes and detector molecules. By using different subsets of analyte-specific capture molecules, each subset having a characteristic identifiable feature; it is now possible to perform capture particle-based, rapid multiplex assays of biological and non-biological analytes without flow. These image-based systems can be used to aid in diagnosis of disease, evaluation of therapy for disease, or laboratory investigation.
摘要翻译：本发明的实施方案包括基于图像的系统和用于检测一种或多种分析物的方法。在测定的任何点处，表面具有固定在其上的可识别的分析物特异性捕获颗粒，由于与捕获颗粒的表面连接的分析物特异性捕获分子的亲和力，不同的分析物附着于其上，用于分析物。然后将具有共轭检测部分的分析物特异性检测器分子连接到分析物，并且计算机辅助的基于图像的检测系统捕获具有或不具有附着的分析物和检测器分子的捕获颗粒的图像。通过使用分析物特异性捕获分子的不同子集，每个子集具有特征可识别特征; 现在可以在没有流动的情况下进行生物和非生物分析物的捕获粒子，快速多重测定。这些基于图像的系统可用于帮助诊断疾病，评估疾病治疗或实验室检查。

3. 发明授权

US07416857B2 Differential diagnosis with hepcidin 失效
标题翻译：与铁调素的鉴别诊断
公开(公告)号：US07416857B2
公开(公告)日：2008-08-26
申请号：US10972101
申请日：2004-10-22
申请人： Paul Lehmann , Ralf Roeddiger
发明人： Paul Lehmann , Ralf Roeddiger
IPC分类号： C12Q1/37
CPC分类号： G01N33/6893
摘要： The present invention concerns the use of hepcidin as a marker for detecting inflammatory chronic diseases and especially for a differential diagnosis to detect inflammatory chronic diseases and/or non-inflammatory chronic diseases. The present invention also concerns a method for detecting inflammatory chronic diseases, non-inflammatory chronic diseases and/or acute phase reactions comprising the determination of hepcidin.
摘要翻译：本发明涉及铁调素作为检测炎性慢性疾病的标志物的用途，特别是鉴别诊断以检测炎性慢性疾病和/或非炎性慢性疾病。本发明还涉及一种用于检测炎性慢性疾病，非炎性慢性疾病和/或急性期反应的方法，其包括测定铁调素。

4. 发明授权

US07459436B2 Treatment of disturbances of iron distribution 有权
标题翻译：处理铁分布紊乱
公开(公告)号：US07459436B2
公开(公告)日：2008-12-02
申请号：US10706701
申请日：2003-11-12
申请人： Paul Lehmann , Ralf Roeddiger , Ruth Walter-Matsui
发明人： Paul Lehmann , Ralf Roeddiger , Ruth Walter-Matsui
IPC分类号： A61K38/00
CPC分类号： A61K38/1816 , A61K47/60
摘要： The present invention relates to the use of erythropoietin for the treatment of disturbances of iron distribution in heart diseases.
摘要翻译：本发明涉及红细胞生成素用于治疗心脏疾病中铁分布紊乱的用途。

5. 发明授权

US07459435B2 Treatment of disturbances of iron distribution 有权
标题翻译：处理铁分布紊乱
公开(公告)号：US07459435B2
公开(公告)日：2008-12-02
申请号：US10634477
申请日：2003-08-04
申请人： Paul Lehmann , Ralf Roeddiger , Ruth Walter-Matsui
发明人： Paul Lehmann , Ralf Roeddiger , Ruth Walter-Matsui
IPC分类号： A61K38/00
CPC分类号： A61K38/1816
摘要： A method of, and pharmaceutical composition for, treating disturbances of iron distribution in diabetes using erythropoietin are disclosed.
摘要翻译：公开了一种使用红细胞生成素治疗糖尿病铁分布紊乱的方法和药物组合物。

6. 发明申请

US20060105392A1 Differential diagnosis of vitamin B12, vitamin B6, and folic acid disorders 审中-公开
标题翻译：维生素B12，维生素B6和叶酸疾病的鉴别诊断
公开(公告)号：US20060105392A1
公开(公告)日：2006-05-18
申请号：US11225287
申请日：2005-09-13
申请人： Paul Lehmann , Ralf Roddiger , Horst Klima
发明人： Paul Lehmann , Ralf Roddiger , Horst Klima
IPC分类号： G01N33/53 , G01N33/00
CPC分类号： G01N33/82 , G01N2800/52
摘要： The invention concerns a method for determining vitamin B12, B6 or/and folic acid disorders and in particular the differential diagnosis of vitamin B12, vitamin B6 or/and folic acid disorders by means of three or four independent parameters. The differential diagnosis can be used to detect a vitamin B12, vitamin B6 or/and folic acid disorder and to recommend the required treatment and to monitor the course and success of treatment.
摘要翻译：本发明涉及一种通过三个或四个独立参数确定维生素B12，B6或/和叶酸疾病的方法，特别是维生素B12，维生素B6和/和叶酸疾病的鉴别诊断。鉴别诊断可用于检测维生素B12，维生素B6或/和叶酸疾病，并推荐所需治疗，并监测治疗过程和成功。

7. 发明申请

US20050148025A1 Differential diagnosis with hepcidin 失效
标题翻译：与铁调素的鉴别诊断
公开(公告)号：US20050148025A1
公开(公告)日：2005-07-07
申请号：US10972101
申请日：2004-10-22
申请人： Paul Lehmann , Ralf Roeddiger
发明人： Paul Lehmann , Ralf Roeddiger
IPC分类号： C12Q1/25 , G01N33/00 , G01N33/50 , G01N33/53 , G01N33/68
CPC分类号： G01N33/6893
摘要： The present invention concerns the use of hepcidin as a marker for detecting inflammatory chronic diseases and especially for a differential diagnosis to detect inflammatory chronic diseases and/or non-inflammatory chronic diseases. The present invention also concerns a method for detecting inflammatory chronic diseases, non-inflammatory chronic diseases and/or acute phase reactions comprising the determination of hepcidin.
摘要翻译：本发明涉及铁调素作为检测炎性慢性疾病的标志物的用途，特别是鉴别诊断以检测炎性慢性疾病和/或非炎性慢性疾病。本发明还涉及一种用于检测炎性慢性疾病，非炎性慢性疾病和/或急性期反应的方法，其包括测定铁调素。

8. 发明申请

US20140255346A1 CNS ANTIGEN-SPECIFIC B CELL, T CELL AND ANTIBODY ASSAYS AND THEIR USES IN DIAGNOSIS AND TREATMENT OF MULTIPLE SCLEROSIS 审中-公开
标题翻译： CNS抗原特异性B细胞，细胞和抗体测定及其在诊断和治疗多发性硬化症中的应用
公开(公告)号：US20140255346A1
公开(公告)日：2014-09-11
申请号：US14113740
申请日：2012-05-03
申请人： Stefanie Kuerten , Paul Lehmann
发明人： Stefanie Kuerten , Paul Lehmann
IPC分类号： G01N33/569
摘要： Embodiments of this invention include methods for detecting in vitro the presence in peripheral blood mononuclear cells (PBMCs), and in serum or plasma, of antibodies reactive to and of lymphocytes that are responsive to CNS antigens associated with Multiple Sclerosis (MS). These CNS antigens include, but are not limited to whole brain lysate and the myelin antigens myelin basic protein (MBP), myelin oligodendrocyte glycoprotein (MOG), MOG peptides (MOGps), proteolipid protein (PLP), and PLP peptides (PLPps). Stimulating PBMCs from patients with MS by CNS antigens cause B-lymphocytes to produce antibodies specific for CNS antigen, and causes T-lymphocytes to produce T-lymphocyte-specific cytokines, including interferon gamma (IFN-y), interleukin-2 (IL-2), or interleukin-17 (IL-17). In contrast, stimulating PBMCs from subjects without MS do not produce such responses.
摘要翻译：本发明的实施方案包括在体外检测对与多发性硬化（MS）相关的CNS抗原有反应性的抗体和淋巴细胞的抗体的外周血单核细胞（PBMC）和血清或血浆中的存在的方法。这些CNS抗原包括但不限于全脑裂解物和髓鞘抗原髓鞘碱性蛋白（MBP），髓鞘少突胶质细胞糖蛋白（MOG），MOG肽（MOGPS），蛋白脂蛋白（PLP）和PLP肽（PLPps）。通过CNS抗原刺激MS患者的PBMC可使B淋巴细胞产生对CNS抗原特异性的抗体，并引起T淋巴细胞产生T淋巴细胞特异性细胞因子，包括干扰素γ（IFN-γ），白细胞介素-2（IL- 2）或白细胞介素-17（IL-17）。相比之下，刺激来自没有MS的受试者的PBMC不产生这样的反应。

9. 发明授权

US07459429B2 Method of treating disturbances of iron distribution in inflammatory intestinal diseases 有权
标题翻译：治疗炎症性肠病中铁分布紊乱的方法
公开(公告)号：US07459429B2
公开(公告)日：2008-12-02
申请号：US11013560
申请日：2004-12-16
申请人： Horst Klima , Paul Lehmann , Ralf Roeddiger , Ruth Walter-Matsui
发明人： Horst Klima , Paul Lehmann , Ralf Roeddiger , Ruth Walter-Matsui
IPC分类号： A61K38/16
CPC分类号： A61K38/1816
摘要： The present invention relates to the use of erythropoietin for the treatment of disturbances of iron distribution in chronic inflammatory intestinal diseases.
摘要翻译：本发明涉及促红细胞生成素用于治疗慢性炎性肠疾病中铁分布紊乱的用途。

10. 发明申请

US20050197281A1 Pharmaceutical combination preparations containing erythropoietin and modified haemoglobins 审中-公开
标题翻译：含有红细胞生成素和改性血红蛋白的药物组合制剂
公开(公告)号：US20050197281A1
公开(公告)日：2005-09-08
申请号：US11091876
申请日：2005-03-28
申请人： Paul Lehmann , Jurgen Feuerstein , Michael Town
发明人： Paul Lehmann , Jurgen Feuerstein , Michael Town
IPC分类号： A61K38/16 , A61K38/18 , A61K38/22 , A61K38/42 , A61P7/06
CPC分类号： A61K38/42 , A61K2300/00
摘要： A kit comprising an erythropoietin and a modified hemoglobin is disclosed.
摘要翻译：公开了一种包含促红细胞生成素和修饰血红蛋白的试剂盒。

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