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1. 发明专利

JPS58180162A Anti-thrombosis medical material 失效
标题翻译：抗血栓药物
公开(公告)号：JPS58180162A
公开(公告)日：1983-10-21
申请号：JP6505482
申请日：1982-04-19
申请人： Koken Kk
发明人： NOITSUSHIKI YASUHARU , MIYATA TERUO
IPC分类号： A61L33/10 , A61L33/00
CPC分类号： A61L33/0029 , Y10S128/08 , Y10S623/916 , C08L89/00

2. 发明专利

JPS5937945A Prevention of oxidation of natural tissue in transplanter 失效
公开(公告)号：JPS5937945A
公开(公告)日：1984-03-01
申请号：JP11175083
申请日：1983-06-20
申请人： Extracorporeal Medical
发明人： ERIZABESU MARII POROTSUKU
IPC分类号： A61L27/00 , A61L27/36
CPC分类号： A61L27/3687 , A61L2400/02 , Y10S623/915 , Y10S623/916

3. 发明申请

WO2006118461A2 MODULAR BIORESORBABLE OR BIOMEDICAL, BIOLOGICALLY ACTIVE SUPRAMOLECULAR MATERIALS 审中-公开
标题翻译：生物多样性或生物医学，生物活性分子材料
公开(公告)号：WO2006118461A2
公开(公告)日：2006-11-09
申请号：PCT/NL2006/050107
申请日：2006-05-03
申请人： SUPRAPOLIX B. V. , DANKERS, Patricia, Yvonne, Wilhelmina , VAN GEMERT, Gaby, Maria, Leonarda , JANSSEN, Henricus, Marie , MEIJER, Egbert, Willem , BOSMAN, Anton, Willem
发明人： DANKERS, Patricia, Yvonne, Wilhelmina , VAN GEMERT, Gaby, Maria, Leonarda , JANSSEN, Henricus, Marie , MEIJER, Egbert, Willem , BOSMAN, Anton, Willem
CPC分类号： A61F2/00 , A61L27/18 , A61L27/26 , A61L27/34 , A61L27/54 , A61L27/56 , A61L27/58 , A61L29/085 , A61L29/16 , A61L31/06 , A61L31/10 , A61L31/16 , A61L2300/216 , A61L2300/224 , A61L2300/236 , A61L2300/25 , A61L2420/06 , C08G18/246 , C08G18/3848 , C08G18/4202 , C08G18/4238 , C08G18/4277 , C08G18/4833 , C08G18/672 , C08G18/73 , C08G18/755 , C08G83/008 , Y10S623/916 , Y10S623/926
摘要： The present invention relates to a modular supramolecular bioresorbable or biomedical material comprising (i) a polymer comprising at least two 4H-units and (ii) a biologically active compound. Optionally, the supramolecular bioresorbable or bio medical material comprises a bioresorbable or biomedical polymer as third component to tune its properties (mechanical and bioresorption properties). The supramolecular bioresorbable or biomedical material is especially suitable for biomedical applications such as controlled release of drugs, materials for tissue-engineering, materials for the manufacture of a prosthesis or an implant, medical imaging technologies.
摘要翻译：本发明涉及模块化超分子生物可再吸收或生物医学材料，其包含（i）包含至少两个4H-单元的聚合物和（ii）生物活性化合物。任选地，超分子生物可再吸收或生物医学材料包括生物可再吸收或生物医学聚合物作为调节其性质（机械和生物吸收性质）的第三组分。超分子生物可吸收或生物医学材料特别适用于生物医学应用，例如药物的控制释放，用于组织工程的材料，用于制造假体或植入物的材料，医学成像技术。

4. 发明申请

WO0239882A3 VEIN HARVESTING SYSTEM AND METHOD 审中-公开
标题翻译： VEIN收获系统和方法
公开(公告)号：WO0239882A3
公开(公告)日：2003-04-03
申请号：PCT/US0145166
申请日：2001-11-15
申请人： EMBRO VASCULAR
发明人： KNIGHTON DAVID , FIEGEL VANCE
IPC分类号： A61B17/00 , A61B19/00 , A61F2/04 , A61B17/22 , A61B17/32 , A61M29/00 , A61B17/36
CPC分类号： A61B17/00008 , A61B2017/00252 , A61B2017/00969 , A61B2090/306 , Y10S623/916 , Y10S623/917
摘要： A system and a method for harvesting a section of a blood vessel (V) from a patient's body for further use. The system includes an expandable hood (10) that creates a workspace for the dissection and removal of the vessel and a telescoping device that has tools at its distal end. The blood vessel (V) is cut at a distal location and a light catheter inserted to illuminate the area of dissection. The system can remove a section of the saphenous vein for use in coronary bypass surgery.
摘要翻译：一种用于从患者身体收获血管（V）的一部分用于进一步使用的系统和方法。该系统包括可扩张的罩（10），其产生用于容器的解剖和移除的工作空间和在其远端具有工具的伸缩装置。血管（V）在远侧位置处被切割，并且插入光导管以照射解剖区域。该系统可以移除隐静脉的一部分用于冠状动脉旁路手术。

5. 发明申请

WO00010620A1 IMPLANT MATERIAL 审中-公开
标题翻译：植物材料
公开(公告)号：WO00010620A1
公开(公告)日：2000-03-02
申请号：PCT/AU1999/000670
申请日：1999-08-20
IPC分类号： A61L27/38 , A61L27/50 , A61L27/00
CPC分类号： A61L27/3804 , A61L27/507 , Y10S623/916
摘要： The present invention relates generally to tissue implant material for use in grafting procedures. More particularly, the present invention provides non-vascular tissue for use as vascular graft material. The present invention further contemplates a method of vascular grafting using non-vascular tissue. The tissue of the present invention is preferably autologous relative to the recipient of the graft and is conveniently prepared around or on a molding support inserted into a body cavity of the intended recipient of the graft. The tissues and methods of the present invention are particularly useful in the treatment or prophylaxis of diseased or damaged blood vessels such as in atherosclerosis.
摘要翻译：本发明一般涉及用于接枝过程的组织植入材料。更具体地，本发明提供用作血管移植材料的非血管组织。本发明还考虑使用非血管组织进行血管移植的方法。本发明的组织优选相对于移植物的接受者是自体的，并且方便地在插入到移植物的预期受体的体腔内的模制支架上或周围制备。本发明的组织和方法特别可用于治疗或预防动脉粥样硬化中患病或受损的血管。

6. 发明申请

WO1995009659A1 LOCAL POLYMERIC GEL CELLULAR THERAPY 审中-公开
标题翻译：局部聚合凝胶细胞治疗
公开(公告)号：WO1995009659A1
公开(公告)日：1995-04-13
申请号：PCT/US1994011304
申请日：1994-10-06
申请人： SLEPIAN, Marvin , MASSIA, Stephen, P.
IPC分类号： A61L27/00
CPC分类号： A61M25/104 , A61F2/062 , A61F2/82 , A61F2/88 , A61F2/95 , A61F2/958 , A61F2210/0004 , A61F2250/0067 , A61L24/0015 , A61L24/0031 , A61L24/0042 , A61L24/046 , A61L24/06 , A61L27/16 , A61L27/34 , A61L27/52 , A61L27/54 , A61L27/58 , A61L31/10 , A61L31/145 , A61L31/16 , A61L2300/40 , A61L2300/602 , A61L2300/606 , A61M25/0043 , A61M25/1011 , A61M35/00 , A61M2025/1052 , A61M2025/1095 , Y10S623/916 , A61F2/06 , C08L67/04
摘要： A method for providing a synthetic barrier made of biocompatible polymeric materials in vivo which involves application of a material to a tissue or cellular surface such as the interior surface of a blood vessel, tissue lumen or other hollow space, is disclosed herein. The material may also be applied to tissue contacting surfaces of implantable medical devices. The polymeric materials are characterized by a fluent state which allows application to and, preferably adhesion to, tissue lumen surfaces, which can be increased or altered to a second less fluent state in situ; controlled permeability and degradability; and, in the preferred embodiments, incorporation of bioactive materials for release in vivo, either to the tissue lumen surface or to the interior of the lumen, which alter cell-to-cell interactions. It has also been discovered that tenascin is a mediator of smooth muscle cell migration through interaction with specific integrin components of the cells.
摘要翻译：本文公开了一种用于在体内提供由生物相容性聚合物材料制成的合成屏障的方法，其涉及将材料施加到组织或细胞表面，例如血管，组织腔或其它中空空间的内表面。该材料也可以应用于可植入医疗装置的组织接触表面。聚合物材料的特征在于流动状态，其允许施用于组织内腔表面，优选粘附于组织内腔表面，其可以原位增加或改变为第二个较不流畅的状态; 控制渗透性和降解性; 并且在优选实施方案中，将用于在体内释放的生物活性材料结合到改变细胞与细胞相互作用的组织腔表面或内腔内。还发现腱生蛋白是通过与细胞的特定整联蛋白成分相互作用而平滑肌细胞迁移的介质。

7. 发明申请

WO0232224A9 SYSTEM AND METHOD TO SIMULATE HEMODYNAMICS 审中-公开
标题翻译：用于模拟血液动力学的系统和方法
公开(公告)号：WO0232224A9
公开(公告)日：2006-11-09
申请号：PCT/US0142576
申请日：2001-10-09
申请人： DANCU MICHAEL B , TARBELL JOHN M
发明人： DANCU MICHAEL B , TARBELL JOHN M
IPC分类号： A01N1/00 , A61F2/04 , C12M1/36 , G01N15/00 , G09B23/28
CPC分类号： G09B23/28 , Y10S623/916 , Y10S623/917 , Y10S623/921
摘要： A system for hemodynamic simulation comprises a vessel (12) having properties of a blood vessel, a reservoir (14) containing a quantity of fluid, tubing (24) connecting the vessel (12) and reservoir (14), and at least one pump (22) for circulating the fluid within the system. Fluid can be tissue culture medium or blood analog fluid, and the vessel (12) may include mammalian cells attached to its inside. A drive system (44), comprising two reciprocating drive shafts (50, 52) that are coupled by a cam (54), enables the uncoupling of pulsatile flow and pulsatile pressure to provide independent control over wall shear stress and cirumferential strain. The shaft drives two pumps that are 180 degrees out-of-phase and are connected upstream and downstream of the vessel, and effect this uncoupling.
摘要翻译：一种用于血液动力学模拟的系统包括具有血管特性的容器（12），容纳一定量流体的储存器（14），连接容器（12）和贮存器（14）的管道（24）以及至少一个泵（22），用于使系统内的流体循环。流体可以是组织培养基或血液类似物流体，血管（12）可以包括附着在其内部的哺乳动物细胞。包括由凸轮（54）联接的两个往复运动驱动轴（50,52）的驱动系统（44）使脉冲流和脉动压力的解耦能够提供对壁剪切应力和推力应变的独立控制。轴驱动两个相位相差180度的泵，并连接在容器的上游和下游，并实现了这种解耦。

8. 发明申请

WO01037884A2 IMPROVED TISSUE ENGINEERED BLOOD VESSELS AND METHODS AND APPARATUS FOR THEIR MANUFACTURE 审中-公开
标题翻译：改进的组织工程血液容器及其制造方法和装置
公开(公告)号：WO01037884A2
公开(公告)日：2001-05-31
申请号：PCT/US2000/042239
申请日：2000-11-22
IPC分类号： A61F2/06 , A61K35/12 , A61L27/36 , A61L27/38 , A61L27/50 , C12N5/071 , A61L
CPC分类号： A61L27/3886 , A61F2/06 , A61K35/12 , A61L27/3804 , A61L27/3808 , A61L27/507 , C12M21/08 , C12M23/06 , C12M27/12 , C12N5/0691 , C12N2502/1323 , Y10S623/916
摘要： The invention is a tissue engineered blood vessel (TEBV) made from a cultured fibroblast sheet rolled into a multilayer vessel which has sufficient burst strength to withstand physiological blood pressure without the inclusion of smooth muscle cells or synthetic scaffolding. The TEBV is made in a bioreactor having an enclosed chamber, a sheet growth module, a rollable mandrel and a clamp for holding the sheet to the mandrel for rolling.
摘要翻译：本发明是由培养的成纤维细胞片制成的组织工程化血管（TEBV），其被卷成多层容器，其具有足够的破裂强度以抵抗生理血压而不包括平滑肌细胞或合成脚手架。 TEBV在具有封闭室的生物反应器中制造，片材生长模块，可卷起的心轴和用于将片材保持在心轴上用于滚动的夹具。

9. 发明申请

WO1998004299A1 METHODS FOR MITIGATING CALCIFICATION AND IMPROVING DURABILITY IN GLUTARALDEHYDE-FIXED BIOPROSTHESES AND ARTICLES MANUFACTURED BY SUCH METHODS 审中-公开
标题翻译：用于减少葡萄糖固定生物碱的计算和改善耐久性的方法和通过这些方法制备的制品
公开(公告)号：WO1998004299A1
公开(公告)日：1998-02-05
申请号：PCT/US1997010712
申请日：1997-06-19
申请人： BAXTER INTERNATIONAL INC.
发明人： BAXTER INTERNATIONAL INC. , YANG, Jun , SHEN, Shih-Hwa
IPC分类号： A61L27/00
CPC分类号： A61L27/3687 , A61L27/3604 , A61L2400/02 , Y10S623/916 , Y10S623/918 , Y10S623/92 , Y10S623/921
摘要： Methods for treating glutaraldehyde-fixed collagenous tissues to mitigate their propensity for subsequent calcification and to improve durability. Collagenous tissues which have been harvested and cross-linked by glutaraldehyde are exposed to a carboxyl activating agent to convert the free carboxyl (COOH) groups of the collagen molecules to activated carboxyl moieties (e.g., o-acylisourea). Thereafter, the collagenous tissue is exposed to a compound capable of reacting with the activated carboxyl moieties (e.g., o-acylisourea) to form non-carboxyl side groups. Monofunctional and multi-functional amines are examples of compounds which may be utilized to react with the activated carboxyl moieties to form such non-carboxyl side groups. Thereafter, the collagenous tissue is again exposed to glutaraldehyde. If the non-carboxyl side groups have functional amino groups (NH2), such additional exposure to glutaraldehyde will result in additional glutaraldehyde cross-linking of the collagen molecules and resultant improvement of durability.
摘要翻译：用于治疗戊二醛固定的胶原组织以减轻其后续钙化倾向并改善耐久性的方法。已经通过戊二醛收获和交联的胶原组织暴露于羧基活化剂，以将胶原分子的游离羧基（COOH）基团转化成活化的羧基部分（例如邻酰基异脲）。此后，将胶原组织暴露于能够与活化的羧基部分反应的化合物（例如，O-酰基异脲）以形成非羧基侧基。单官能和多官能胺是可用于与活化的羧基部分反应以形成这种非羧基侧基的化合物的实例。此后，胶原组织再次暴露于戊二醛。如果非羧基侧基具有官能氨基（NH 2），则另外暴露于戊二醛将导致胶原分子的另外的戊二醛交联，从而提高耐久性。

10. 发明授权

EP1230939B1 Bioartifizielle, primär vaskularisierte Gewebematrix und bioartifizielles, primär vaskularisiertes Gewebe 有权
标题翻译：生物人工主要血管化的组织基质和生物人工主要血管化的组织
公开(公告)号：EP1230939B1
公开(公告)日：2006-10-04
申请号：EP01103327.1
申请日：2001-02-13
申请人： corLife GbR
发明人： Haverich, Axel, Prof., Dr. , Mertsching, Heike, Dr.
IPC分类号： A61L27/36 , A61L27/38
CPC分类号： A61L27/3683 , A61L27/3625 , A61L27/3629 , A61L27/38 , Y10S623/916

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