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1. 发明公开

EP0518940A4 METHOD AND APPARATUS FOR TREATMENT OF TUBULAR ORGANS 失效
标题翻译：用于治疗管状器官的方法和装置
公开(公告)号：EP0518940A4
公开(公告)日：1993-05-12
申请号：EP91905598
申请日：1991-02-25
申请人： SLEPIAN, MARVIN J.
发明人： SLEPIAN, MARVIN J.
IPC分类号： A61M25/00 , A61F2/958 , A61M29/02 , B82B1/00 , A61M25/10
CPC分类号： A61M25/1011 , A61M2025/1052 , A61M2025/1095

2. 发明公开

EP1803476A2 Local polymeric gel cellular therapy 失效
标题翻译： Lokale Polymergelzelltherapie
公开(公告)号：EP1803476A2
公开(公告)日：2007-07-04
申请号：EP07007682.3
申请日：1994-10-06
申请人： SLEPIAN, Marvin J. , Massia, Stephen P.
发明人： SLEPIAN, Marvin J. , Massia, Stephen P.
IPC分类号： A61L27/54 , A61L27/34 , A61L27/52 , A61L31/10 , A61L31/14 , A61L31/16 , A61L24/00
CPC分类号： A61M25/104 , A61F2/062 , A61F2/82 , A61F2/88 , A61F2/95 , A61F2/958 , A61F2210/0004 , A61F2250/0067 , A61L24/0015 , A61L24/0031 , A61L24/0042 , A61L24/046 , A61L24/06 , A61L27/16 , A61L27/34 , A61L27/52 , A61L27/54 , A61L27/58 , A61L31/10 , A61L31/145 , A61L31/16 , A61L2300/40 , A61L2300/602 , A61L2300/606 , A61M25/0043 , A61M25/1011 , A61M35/00 , A61M2025/1052 , A61M2025/1095 , Y10S623/916 , A61F2/06 , C08L67/04
摘要： A method for providing a synthetic barrier made of biocompatible polymeric materials in vivo which involves application of a material to a tissue or cellular surface such as the interior surface of a blood vessel, tissue lumen or other hollow space, is disclosed herein. The material may also be applied to tissue contacting surfaces of implantable medical devices. The polymeric materials are characterized by a fluent state which allows application to and, preferably adhesion to, tissue lumen surfaces, which can be increased or altered to a second less fluent state in situ; controlled permeability and degradability; and, in the preferred embodiments, incorporation of bioactive materials for release in vivo , either to the tissue lumen surface or to the interior of the lumen, which alter cell-to-cell interactions. It has also been discovered that tenascin is a mediator of smooth muscle cell migration through interaction with specific integrin components of the cells.
摘要翻译：本文公开了一种用于在体内提供由生物相容性聚合材料制成的合成屏障的方法，其涉及将材料施加到组织或细胞表面，例如血管，组织腔或其它中空空间的内表面。该材料也可以应用于可植入医疗装置的组织接触表面。聚合物材料的特征在于流动状态，其允许施用于组织内腔表面，并且优选粘附于组织腔表面，其可以原位增加或改变为第二个不太流畅的状态; 控制渗透性和降解性; 并且在优选的实施方案中，将生物活性材料并入体内释放到组织内腔表面或内腔内部，其改变细胞与细胞的相互作用。还已经发现，腱生蛋白是通过与细胞的特异性整联蛋白成分相互作用而平滑肌细胞迁移的介质。

3. 发明公开

EP2765954A1 POLYMERIC HEART VALVE 有权转让
标题翻译： POLYMERE HERZKLAPPE
公开(公告)号：EP2765954A1
公开(公告)日：2014-08-20
申请号：EP12840473.8
申请日：2012-10-12
申请人： The Research Foundation Of State University Of New York , Slepian, Marvin
发明人： SLEPIAN, Marvin , BLUESTEIN, Danny , CLAIBORNE, Thomas E.
IPC分类号： A61F2/24
CPC分类号： A61F2/2418 , A61F2/2412 , A61F2/2415 , A61F2250/0036
摘要： A polymeric valve which may include a heart valve, and also may include a trileaflet heart valve includes a stent having a base and a plurality of outwardly extending posts from the base and equidistant from each other. A plurality of leaflets each connected to a corresponding one of the posts at one end, and each of the leaflets connected to the base. Each of the leaflets having an operative end opposite the end connected to the post, and the operative ends of the leaflets being biased in a closed position such that the operative ends abut each other. The operative ends are configured to rhythmically open and close in relation to each other, and the leaflets include multiple cross sectional thicknesses at different portions of the leaflets.
摘要翻译：可以包括心脏瓣膜的聚合物阀，并且还可以包括三叶片心脏瓣膜，其包括具有基部的支架和从基部并且彼此等距离的多个向外延伸的柱。多个传单分别连接到一端的对应的一个柱，并且每个传单连接到基座。每个传单具有与连接到柱的端部相对的操作端，并且传单的操作端被偏置在关闭位置，使得操作端部彼此邻接。操作端构造成相对于彼此有节奏地打开和关闭，并且传单在传单的不同部分处包括多个横截面厚度。

4. 发明授权

EP0431046B1 BIODEGRADABLE POLYMERIC ENDOLUMINAL SEALING 失效
标题翻译：与BISDEGRADIERBAREN聚合物腔内密封件。
公开(公告)号：EP0431046B1
公开(公告)日：1995-05-03
申请号：EP89909957.6
申请日：1989-08-23
申请人： SLEPIAN, Marvin J.
发明人： SLEPIAN, Marvin, J. , SCHINDLER, Anton
IPC分类号： A61M29/00
CPC分类号： A61F2/958 , A61F2/062 , A61F2/82 , A61F2/88 , A61F2/945 , A61F2/95 , A61F2002/30062 , A61F2002/30583 , A61F2002/30677 , A61F2210/0004 , A61F2210/0085 , A61F2250/0067 , A61L24/0015 , A61L24/0031 , A61L24/0042 , A61L24/046 , A61L24/06 , A61L27/16 , A61L27/18 , A61L27/34 , A61L27/54 , A61L27/58 , A61L29/085 , A61L31/10 , A61L2300/412 , A61L2300/604 , A61L2300/64 , A61M25/0043 , A61M25/1002 , A61M25/1011 , A61M35/00 , A61M37/00 , F16B37/122 , F16B39/06 , Y10S623/92 , Y10S623/921 , Y10T29/49906 , C08L67/04
摘要： A novel process for paving or sealing the interior surface of a tissue lumen by entering the interior of the tissue lumen and applying a polymer to the interior surface of the tissue lumen. This is accomplished using a catheter which delivers the polymer to the tissue lumen (134) and causes it to conform to the interior surface of lumen. The polymer can be delivered to the lumen as a monomer or prepolymer solution, or as an at least partially preformed layer on an expansible member (133).

5. 发明申请

WO2017218907A1 SYSTEMS, DEVICES, AND METHODS FOR DETERMINING AN OVERALL STRENGTH ENVELOPE 审中-公开
标题翻译：用于确定整体强度包络的系统，装置和方法
公开(公告)号：WO2017218907A1
公开(公告)日：2017-12-21
申请号：PCT/US2017/037898
申请日：2017-06-16
申请人： ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA , SLEPIAN, Marvin J.
发明人： SLEPIAN, Marvin J.
IPC分类号： A61B5/00 , A61B5/11 , A61B5/113 , G01L1/00 , G01P7/00 , G08B23/00
CPC分类号： A61B5/1121 , A61B5/0022 , A61B5/0205 , A61B5/021 , A61B5/02405 , A61B5/1071 , A61B5/1079 , A61B5/1114 , A61B5/1128 , A61B5/14546 , A61B5/224 , A61B5/4266 , A61B5/486 , A61B5/6801 , A61B5/6867 , A61B5/7425 , A61B2562/0219 , A61B2562/0261 , G01L1/00
摘要： Systems, methods, and software products determine an overall motion, flexibility and/or strength envelope for an individual. Force, movement and position data of the individual is captured and processed to generate an overall motion, flexibility and/or strength envelope for the individual that defines overall motion, flexibility and/or strength of the individual. The system includes a flexibility server with memory and a processor that are adapted to receive force, movement and position data of the individual. A motion, flexibility and/or strength analyzer of the system, implemented as machine readable instructions stored in the memory and executed by the digital processor, is capable of processing the force, movement and position data to generate an overall motion, flexibility and/or strength envelope for the individual that defines the overall motion, flexibility and/or strength of the individual.
摘要翻译：系统，方法和软件产品确定个体的整体运动，灵活性和/或强度包络。捕获和处理个体的力，运动和位置数据以产生个体的整体运动，灵活性和/或强度包络，其定义个体的整体运动，灵活性和/或力量。该系统包括具有存储器和处理器的灵活性服务器，其适于接收个体的力，运动和位置数据。系统的运动，灵活性和/或强度分析器被实现为存储在存储器中并由数字处理器执行的机器可读指令，能够处理力，运动和位置数据以产生整体运动，灵活性和/或个人的强度包围，定义个体的整体运动，灵活性和/或力量。

6. 发明申请

WO2008077059A3 PORTABLE ORGAN AND TISSUE PRESERVATION APPARATUS, KIT AND METHODS 审中-公开
标题翻译：便携式组织和组织保存装置，工具包和方法
公开(公告)号：WO2008077059A3
公开(公告)日：2009-04-23
申请号：PCT/US2007087975
申请日：2007-12-18
申请人： ORGAN TRANSP SYSTEMS INC , FRANKLIN THOMAS D , HYATT STACIE L , WARNER HOWELL E , WENRICH MARSHALL , SLEPIAN MARVIN J , LAMBERT SHELL
发明人： FRANKLIN THOMAS D , HYATT STACIE L , WARNER HOWELL E , WENRICH MARSHALL , SLEPIAN MARVIN J , LAMBERT SHELL
IPC分类号： A01N1/02 , F25B21/02 , F25D3/08
CPC分类号： A01N1/02 , A01N1/0252
摘要： An organ and tissue preservation and transport apparatus comprising a chamber, a temperature control mechanism and a system monitor. A medium bathes an organ within the chamber. The temperature control mechanism adjusts the temperature of the medium. The system monitor receiving and records the temperature of the chamber.
摘要翻译：一种器官和组织保存和输送设备，包括腔室，温度控制机构和系统监测器。中等沐浴室内的器官。温度控制机构调节介质的温度。系统监视器接收和记录室的温度。

7. 发明申请

WO2007047368A1 CHANNELED ENDOMURAL THERAPY 审中-公开
标题翻译：通道内分泌治疗
公开(公告)号：WO2007047368A1
公开(公告)日：2007-04-26
申请号：PCT/US2006/039891
申请日：2006-10-13
申请人： ENDOLUMINAL THERAPEUTICS, INC. , SLEPIAN, Marvin, J.
发明人： SLEPIAN, Marvin, J.
IPC分类号： A61B17/22 , A61B17/00 , A61B18/24 , A61B17/88
CPC分类号： A61B17/3207 , A61B17/00491 , A61B17/12022 , A61B17/12186 , A61B17/1219 , A61B17/12195 , A61B17/22 , A61B18/24 , A61B2017/00247 , A61B2017/1205 , A61B2017/22077 , A61B2018/00392 , A61K35/545
摘要： Diseases, aging, trauma, environmental exposure, infection and other events or agents can alter tissue function. In one embodiment, treatment is provided by therapeutically altering tissue function. This may be by continuing normal tissue function, suppressing tissue function, or enhancing tissue function. In a preferred embodiment, this treatment is effectuated by penetrating an organ, organ component or tissue structure and placing a supplemental material in a newly created space. This space is generally referred to herein as a "privileged space", i.e. a space not otherwise present in native tissue. Supplemental materials can be deposited and secured within the zone. Supplemental materials include materials forming barriers, supports, and/or materials that deliver agents having a pharmacologic, biochemical, or physiologic effect in vivo. Suitable supplemental materials include polymeric and non-polymeric materials, pharmacologic agents, cells, tissue fragments, microorganisms, viral agents, or other reagents modifying tissue function. The supplemental material is typically in the form of a reservoir/depot, or continuous or discontinuous layer. In one embodiment, supplemental materials, and methods of use thereof, are provided for the continuous or discontinuous therapy of defined regions of an organ, organ component or tissue structure. The supplemental materials may be delivered directly to any one or more of the three zones, endoluminal (or ectomural, for solid organs), endomural, or ectoluminal, of organs, organ components, or tissue structures. The supplemental materials can include natural or synthetic polymeric materials that are biodegradable or non-biodegradable. The supplemental materials can also contain bioactive agents to effectuate a change in an organ or organ component in need thereof. For example, agents that result in a reduced/hyponormal response or an amplified/hypernormal response may be included in the supplemental materials.
摘要翻译：疾病，衰老，创伤，环境暴露，感染和其他事件或代理可以改变组织功能。在一个实施方案中，通过治疗改变组织功能来提供治疗。这可以通过继续正常的组织功能，抑制组织功能，或增强组织功能。在一个优选的实施方案中，这种治疗是通过穿透器官，器官组织或组织结构并将补充材料放置在新创建的空间中来实现的。这个空间在本文中通常被称为“特许空间”，即不存在于天然组织中的空间。补充材料可以在区域内沉积和固定。补充材料包括形成障碍，支持物和/或材料的材料，其在体内递送具有药理学，生物化学或生理学作用的试剂。合适的补充材料包括聚合物和非聚合物材料，药理学试剂，细胞，组织片段，微生物，病毒剂或修饰组织功能的其他试剂。补充材料通常以储库/储库或连续或不连续层的形式存在。在一个实施方案中，补充材料及其使用方法被提供用于器官，器官组分或组织结构的限定区域的连续或不连续治疗。补充材料可以直接递送至三个区域中的任何一个或多个区域，腔内（或外部，用于实体器官），器官，器官组织或组织结构的腔内或腔外。补充材料可以包括可生物降解或不可生物降解的天然或合成聚合物材料。补充材料还可以含有生物活性剂以实现有需要的器官或器官组分的变化。例如，导致降低的/低反应性反应或扩增/超常反应的药剂可以包括在补充材料中。

8. 发明公开

EP0649637A1 Material for endoluminal paving and sealing 失效
标题翻译： Werkstoff zum endoluminalen Verpflastern und Abdichten。
公开(公告)号：EP0649637A1
公开(公告)日：1995-04-26
申请号：EP94203046.1
申请日：1989-08-23
申请人： SLEPIAN, Marvin J.
发明人： Slepian, Marvin J. , Schindler, Anton
IPC分类号： A61F2/06
CPC分类号： A61F2/958 , A61F2/062 , A61F2/82 , A61F2/88 , A61F2/945 , A61F2/95 , A61F2002/30062 , A61F2002/30583 , A61F2002/30677 , A61F2210/0004 , A61F2210/0085 , A61F2250/0067 , A61L24/0015 , A61L24/0031 , A61L24/0042 , A61L24/046 , A61L24/06 , A61L27/16 , A61L27/18 , A61L27/34 , A61L27/54 , A61L27/58 , A61L29/085 , A61L31/10 , A61L2300/412 , A61L2300/604 , A61L2300/64 , A61M25/0043 , A61M25/1002 , A61M25/1011 , A61M35/00 , A61M37/00 , F16B37/122 , F16B39/06 , Y10S623/92 , Y10S623/921 , Y10T29/49906 , C08L67/04
摘要： An at least partially preformed polymeric product for paving or sealing the interior surface of a tissue lumen (171) by entering the interior of the tissue lumen (171) and applying said polymer to the interior surface of the tissue lumen (171). The polymer can be delivered to the lumen (171) as a monomer or prepolymer solution, or as an at least partially preformed layer (172).
摘要翻译：一种至少部分预制的聚合产品，用于通过进入组织腔（171）的内部并将所述聚合物施加到组织腔（171）的内表面来铺放或密封组织腔（171）的内表面。聚合物可以作为单体或预聚物溶液或作为至少部分预先形成的层（172）递送到内腔（171）。

9. 发明公开

EP0518940A1 METHOD AND APPARATUS FOR TREATMENT OF TUBULAR ORGANS 失效
标题翻译：方法和一种用于治疗管体，。
公开(公告)号：EP0518940A1
公开(公告)日：1992-12-23
申请号：EP91905598.0
申请日：1991-02-25
申请人： SLEPIAN, Marvin J.
发明人： SLEPIAN, Marvin J.
IPC分类号： A61M25 , A61F2 , B82B1 , A61M29
CPC分类号： A61M25/1011 , A61M2025/1052 , A61M2025/1095
摘要： Un dispositif à cathéter de traitement d'organes tubulaires et d'autres passages du corps comprend un élément tubulaire ayant une pluralité de passages, des premier et deuxième éléments gonflables (150, 151) agencés sur l'élément tubulaire, un ballon d'angioplastie (153) situé entre les éléments gonflables (150, 151) et un réservoir (159) qui contient un agent thérapeutique.

10. 发明公开

EP0431046A1 BIODEGRADABLE POLYMERIC ENDOLUMINAL SEALING 失效
标题翻译：与BISDEGRADIERBAREN聚合物腔内密封件。
公开(公告)号：EP0431046A1
公开(公告)日：1991-06-12
申请号：EP89909957.0
申请日：1989-08-23
申请人： SLEPIAN, Marvin J.
发明人： SLEPIAN, Marvin, J. , SCHINDLER, Anton
IPC分类号： A61F2 , A61L24 , A61L27 , A61L29 , A61L31 , A61M25 , A61M29 , A61M35 , A61M37 , F16B39 , F16B37
CPC分类号： A61F2/958 , A61F2/062 , A61F2/82 , A61F2/88 , A61F2/945 , A61F2/95 , A61F2002/30062 , A61F2002/30583 , A61F2002/30677 , A61F2210/0004 , A61F2210/0085 , A61F2250/0067 , A61L24/0015 , A61L24/0031 , A61L24/0042 , A61L24/046 , A61L24/06 , A61L27/16 , A61L27/18 , A61L27/34 , A61L27/54 , A61L27/58 , A61L29/085 , A61L31/10 , A61L2300/412 , A61L2300/604 , A61L2300/64 , A61M25/0043 , A61M25/1002 , A61M25/1011 , A61M35/00 , A61M37/00 , F16B37/122 , F16B39/06 , Y10S623/92 , Y10S623/921 , Y10T29/49906 , C08L67/04
摘要： L'invention concerne un nouveau procédé d'étanchéification de la surface intérieure d'une lumière d'un organe du corps humain, ce nouveau procédé consistant à appliquer un polymère sur ladite surface intérieure de la lumière. Ceci est effectué en utilisant un cathéter qui achemine le polymère sur la surface intérieure de la lumière (134), le polymère épousant la forme de cette surface intérieure. Le polymère peut être amené à la lumière sous la forme d'une solution monomère ou prépolymère, ou bien sous la forme d'une couche au moins partiellement préformée sur un organe extensible (133).

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