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1. 发明授权

US5656644A Pyridyl imidazoles 失效
标题翻译：吡啶基咪唑
公开(公告)号：US5656644A
公开(公告)日：1997-08-12
申请号：US277804
申请日：1994-07-20
申请人： Jerry Leroy Adams , Timothy Francis Gallagher , John C. Lee , John Richard White
发明人： Jerry Leroy Adams , Timothy Francis Gallagher , John C. Lee , John Richard White
IPC分类号： C07D401/04 , C07D403/04 , C07D409/14 , C07D413/14 , C07F9/6506 , C07F9/6558 , A61K31/44
CPC分类号： C07D401/04 , C07D403/04 , C07D409/14 , C07D413/14 , C07F9/65062 , C07F9/65583
摘要： Novel 2,4,5-triaryl imidazole compounds and compositions for use in therapy.
摘要翻译：新型2,4,5-三芳基咪唑化合物和用于治疗的组合物。

2. 发明授权

US5326905A Benzylphosphonic acid tyrosine kinase inhibitors 失效
标题翻译：苄基膦酸酪氨酸激酶抑制剂
公开(公告)号：US5326905A
公开(公告)日：1994-07-05
申请号：US934469
申请日：1992-09-16
申请人： Robert L. Dow , Steven W. Goldstein
发明人： Robert L. Dow , Steven W. Goldstein
IPC分类号： A61K31/66 , A61K31/675 , A61P35/00 , A61P43/00 , C07F9/38 , C07F9/553 , C07F9/572 , C07F9/59 , C07F9/6506 , C07F9/44
CPC分类号： C07F9/65062 , C07F9/3882 , C07F9/5537
摘要： Certain benzylphosphonic acid compounds, and their pharmaceutically-acceptable salts, are inhibitors of tyrosine kinase enzymes, and so are useful for the control of tyrosine kinase dependent diseases (e.g., cancer, atherosclerosis).
摘要翻译： PCT No.PCT / US91 / 01731 Sec。 371日期：1992年9月16日 102（e）日期1992年9月16日PCT 1991年3月14日PCT公布。公开号WO91 / 15495 1991年10月17日。苄基膦酸化合物及其药学上可接受的盐是酪氨酸激酶的抑制剂，因此可用于控制酪氨酸激酶依赖性疾病（例如癌症，动脉粥样硬化）。

3. 发明授权

US5306727A Phosphoramidates useful as antitumor agents 失效
标题翻译：用作抗肿瘤剂的磷酰胺化物
公开(公告)号：US5306727A
公开(公告)日：1994-04-26
申请号：US55964
申请日：1993-04-30
申请人： Richard F. Borch , James P. Schmidt
发明人： Richard F. Borch , James P. Schmidt
IPC分类号： A61K31/66 , A61K31/675 , A61P35/00 , C07F9/572 , C07F9/6506 , C07F9/655 , C07F9/6553 , A61K31/415 , A61K31/34 , A61K31/38 , A61K31/40
CPC分类号： C07F9/65062 , C07F9/5722 , C07F9/65515 , C07F9/655345
摘要： Cyclophosphamide analogs are provided of the general formula: ##STR1## wherein R.sup.1 and R.sup.2 are each (C.sub.2 -C.sub.6)alkyl, substituted with a leaving group such as halo or alkylsulfonyl, R.sup.3 and R.sup.4 are the same as R.sup.1 and R.sup.2 or are H and Ar is a heteroaromatic ring and the pharmaceutically acceptable salts thereof.
摘要翻译：环磷酰胺类似物由以下通式提供：其中R 1和R 2各自为（C 2 -C 6）烷基，被离去基团如卤素或烷基磺酰基取代，R 3和R 4与R 1和R 2相同或为H和 Ar是杂芳环和其药学上可接受的盐。

4. 发明授权

US5206253A Disphosphonic acid derivatives, processes for their production and pharmaceutical preparations containing these compounds 失效
标题翻译：二磷酸衍生物及其制备方法及含有这些化合物的药物制剂
公开(公告)号：US5206253A
公开(公告)日：1993-04-27
申请号：US776407
申请日：1991-11-25
申请人： Elmar Bosies , Frieder Bauss
发明人： Elmar Bosies , Frieder Bauss
IPC分类号： A61K31/675 , A61P3/00 , A61P3/14 , C07D233/54 , C07F9/38 , C07F9/40 , C07F9/6503 , C07F9/6506 , C07F9/6518 , C07F9/653 , C07F9/6539
CPC分类号： C07D233/64 , C07F9/6503 , C07F9/65061 , C07F9/65062
摘要： The present invention concerns novel disphosphonates having the general formula I ##STR1## in which Het represents a heterocyclic five-membered ring with 2-4 heteroatoms which is substituted, if desired, and which can also be partially hydrogenated,R.sub.1 -R.sub.7 each denote, independently of each other, hydrogen or C.sub.1 -C.sub.5 alkyl,X=denotes hydrogen, OH or the group --NR.sub.8 R.sub.9, in which R.sub.8 and R.sub.9 should each be, independently of each other, hydrogen or C.sub.1 -C.sub.5 alkyl,m and n denote, independently of each other, 0, 1 or 2,as well as their pharmacologically safe salts and optically active forms.
摘要翻译： PCT No.PCT / EP90 / 00798 Sec。 371日期：1991年11月25日 102（e）1991年11月25日日期PCT提交1990年5月18日PCT公布。 WO90 / 14348 PCT出版物日本1990年11月29日。本发明涉及具有通式I（I）的新型脱膦酸酯，其中Het表示具有2-4个杂原子的杂环五元环，如果需要，其被取代，并且还可以部分氢化，R 1 -R 7各自独立地表示氢或C 1 -C 5烷基，X =表示氢，OH或基团-NR 8 R 9，其中R 8和R 9各自各自独立地为氢或 C1-C5烷基，m和n彼此独立地表示0,1或2，以及它们的药理学上安全的盐和光学活性形式。

5. 发明授权

US4215217A Process for preparing 4-substituted imidazole compounds 失效
标题翻译：制备4-取代咪唑化合物的方法
公开(公告)号：US4215217A
公开(公告)日：1980-07-29
申请号：US915497
申请日：1978-06-14
申请人： Joseph J. Lewis , Robert L. Webb
发明人： Joseph J. Lewis , Robert L. Webb
IPC分类号： C07D233/84 , C07D233/88 , C07F9/6506 , C07D233/64 , C07D401/06 , C07D413/06
CPC分类号： C07D233/88 , C07D233/84 , C07F9/65062
摘要： A process for preparing 4-(oxy, thio or amino)methylimidazole compounds via displacement of the trisubstituted phosphonium group from 4-(trisubstituted phosphonium)-methylimidazole compounds is disclosed.
摘要翻译：公开了通过从4-（三取代的鏻） - 甲基咪唑化合物置换三取代的鏻基团来制备4-（氧基，硫代或氨基）甲基咪唑化合物的方法。

6. 发明授权

US4163858A Process for preparing new imidazolemethylphosphonium salts 失效
标题翻译：制备新咪唑甲基鏻盐的方法
公开(公告)号：US4163858A
公开(公告)日：1979-08-07
申请号：US884658
申请日：1978-03-08
申请人： Clifford S. Labaw , Robert L. Webb , George R. Wellman
发明人： Clifford S. Labaw , Robert L. Webb , George R. Wellman
IPC分类号： C07D233/64 , C07D233/84 , C07D233/90 , C07F9/6506 , C07D231/14
CPC分类号： C07F9/65062
摘要： New imidazolemethylphosphonium salts having a degradable group at the 2-position which are useful intermediates for preparing histamine H.sub.2 antagonists. This invention concerns the preparation of imidazolemethylphosphonium salts having no substituent at the 2-position by heating the compounds referred to above.
摘要翻译：在2-位具有可降解基团的新的咪唑甲基鏻盐是制备组胺H 2拮抗剂的有用中间体。本发明涉及通过加热上述化合物来制备在2-位没有取代基的咪唑甲基鏻盐。

7. 发明授权

US4138569A 5-Substituted phosphonate hydantoins and derivatives thereof 失效
公开(公告)号：US4138569A
公开(公告)日：1979-02-06
申请号：US885060
申请日：1978-03-09
申请人： Luther A. R. Hall , David A. Gordon
发明人： Luther A. R. Hall , David A. Gordon
IPC分类号： C08G59/00 , C07D233/72 , C07F9/6506 , C08G59/10 , C07D405/06
CPC分类号： C07F9/65062
摘要： Hydantoins of the formula ##STR1## wherein R.sub.1 is hydrogen or alkyl of 1 to 8 carbon atoms, R.sub.2 is ##STR2## R.sub.3 is alkyl of 1 to 8 carbon atoms, and X is a straight or branched chain alkylene of 1 to 4 carbon atoms or a straight or branched chain alkylene of 3 to 6 carbon atoms containing an internal carbamido group; or R.sub.1 and R.sub.2 together are Y where Y is a straight or branched chain alkylene of 4 to 8 carbon atoms having a pendant ##STR3## moiety are prepared by reacting first .alpha.,.beta.-unsaturated aldehydes or ketones with alkyl phosphites to form a phosphonate aldehyde or ketone followed by a classical Bucherer hydantoin synthesis.These compounds are intermediates for the preparation of polyglycidyl compounds useful in making flame-retardant epoxy resins. These hydantoins are also intermediates useful in preparing flame-retardant polyesters and polyurethanes.

8. 发明授权

US3185699A Heterocyclic phosphorothioates 失效
标题翻译：杂环硫代磷酸酯
公开(公告)号：US3185699A
公开(公告)日：1965-05-25
申请号：US2113360
申请日：1960-04-11
申请人： ICI LTD
发明人： EDWARD SHERLOCK
IPC分类号： A01N57/16 , A01N57/24 , C07F9/6503 , C07F9/6506 , C07F9/6512 , C07F9/6521 , C07F9/6524 , C07F9/6539 , C07F9/6558
CPC分类号： C07F9/6539 , A01N57/16 , A01N57/24 , C07F9/65033 , C07F9/65062 , C07F9/65122 , C07F9/65212 , C07F9/6524 , C07F9/65583
摘要： The invention comprises s-triazine derivatives of the formula:- in which D1 and D2 are methyl or ethyl radicals; D3 is a hydrogen atom; D4, D5 and D6 which can be the same or different are each a hydrogen atom or a methyl, ethyl, propyl or butyl radical, or D5 and D6 together with their adjacent nitrogen atom constitute a piperidino ring; D7 is a methyl, ethyl, propyl, or butyl radical, and X is an oxygen or sulphur atom; and acid addition salts thereof, e.g. hydrochlorides, oxalates, p-toluene sulphonates, methane sulphonates and isethionates. They may be obtained by reacting a compound of the formula: with a haloalkyl-s-triazine of the formula:- wherein D1 to D7 and X are as defined above, M is an atom of an alkali metal, e.g. sodium, or is an ammonium radical, and Y is a halogen atom e.g. bromine. The process is preferably effected at between 20 DEG and 150 DEG C. and the reactants may be used in solution or dispersion in a suitable solvent or diluent e.g. water, methanol, or ethanol. The products have pesticidal properties (see Group VI). Haloalkyl-s-triazines of the above formula may be obtained by reacting a compound Y.CH(D7).COOD8 with a triguanide of the formula:- wherein D3 to D7 and Y are as defined above and D8 is a lower alkyl radical, e.g. methyl or ethyl.ALSO:A pesticidal composition comprises a suitable diluent or carrier and as active ingredient a compound of the formula wherein D1 and D2 are methyl or ethyl radicals; D3 is a hydrogen atom; D4, D5 and D6 which can be the same or different are cach a hydrogen atom or a methyl, ethyl, propyl or butyl radical, or D5 and D6 together with their adjacent nitrogen atom constitute a piperidino ring; D7 X is an oxygen or sulphur atom or an acid addition salt thereof, e.g. a hydrochloride, oxalate, p-toluene sulphonate, methane sulphonate, or isethionate (see Group IV (b)). Specified diluents or carriers are water, organic solvents e.g. methanol, tetrahydrofurfuryl alcohol, diacetone alcohol, and beta-ethoxyethanol; fuller's earth, tale, kaolin, kieselguhr and bentonite. Wetting or dispersing agents may also be present. The active ingredient or the compositions containing it may be used for the treatment of seed before sowing to provide subsequent protection against aphids for the plants grown from the seed.

9. 发明公开

KR1020170102024A 유기 전자기기에서 ｎ-도펀트로서의 아미노 포스파젠 염기 审中-实审
标题翻译：在有机电子器件中，氨基磷腈碱
公开(公告)号：KR1020170102024A
公开(公告)日：2017-09-06
申请号：KR1020177023143
申请日：2015-12-07
申请人： 지멘스 악티엔게젤샤프트
发明人： 케슬러,플로리안 , 레겐스부르거,스테판 , 슈미트,귄터
IPC分类号： H01L51/00 , C07F9/06 , C07F9/6506 , C07F9/6593 , C07F9/6584 , H01L51/50
CPC分类号： H01L51/005 , C07F9/065 , C07F9/5721 , C07F9/65062 , C07F9/6524 , C07F9/65815 , C07F9/65848 , C09D5/24 , H01L51/002 , H01L51/0052 , H01L51/0072 , H01L51/5076 , H01L51/0059 , H01L51/5072
摘要： 본발명은유기전자수송물질을도핑(doping)하기위한 n-도펀트(n-dopant)로서, n-도펀트는인 원자(phosphorus atom)에결합된 4개의질소원자를갖는적어도하나의, 하기화학식 1에따른아미노포스파젠기(amino phosphazene group)를포함하는 n-도펀트에관한것이다:(1)
摘要翻译：在本发明中的至少一个，从四个氮原子具有用于掺杂（掺杂）的有机电子传输材料，正掺杂剂结合为n-掺杂剂（n-掺杂剂）与磷原子1的式（磷原子）包含根据（1）的氨基磷腈基团的掺杂剂：

10. 发明授权

US5731299A Phosphonosulfonate compounds, pharmaceutical compositions, and methods for treating abnormal calcium and phosphate metabolism 失效
标题翻译：膦酸磺酸盐化合物，药物组合物和治疗异常钙和磷酸盐代谢的方法
公开(公告)号：US5731299A
公开(公告)日：1998-03-24
申请号：US55809
申请日：1993-05-07
申请人： Frank Hallock Ebetino , Allan Vincent Bayless , Susan Mary Dansereau
发明人： Frank Hallock Ebetino , Allan Vincent Bayless , Susan Mary Dansereau
IPC分类号： A61K31/66 , A61K31/675 , A61K31/685 , A61P3/00 , A61P3/14 , A61P19/10 , A61P29/00 , A61P43/00 , C07F9/38 , C07F9/553 , C07F9/572 , C07F9/576 , C07F9/58 , C07F9/59 , C07F9/60 , C07F9/6506 , C07F9/6512 , C07F9/6561 , C07F13/00 , C07F15/02 , C07F9/40 , C07D213/69 , C07C143/68 , A61K49/00
CPC分类号： C07F9/6561 , C07F9/3808 , C07F9/3821 , C07F9/3865 , C07F9/3873 , C07F9/5532 , C07F9/5721 , C07F9/5722 , C07F9/5726 , C07F9/5765 , C07F9/582 , C07F9/588 , C07F9/592 , C07F9/598 , C07F9/60 , C07F9/65061 , C07F9/65062 , C07F9/65127
摘要： The present invention relates to phosphonsulfonates and the pharmaceutically-acceptable salts and esters thereof, having the following structure according to formula (I): ##STR1## The present invention further relates to pharmaceutical compositions containing a safe and effective amount of a compound of the present invention, and pharmaceutically-acceptable excipients. Finally, the present invention relates to methods for treating or preventing pathological conditions characterized by abnormal calcium and phosphate metabolism in humans or other mammals, including treating or preventing osteoporosis and arthritis, especially rheumatoid arthritis and osteoarthritis. This method comprises administering to a human or other mammal in need of such treatment of a safe and effective amount of a compound or composition of the present invention.
摘要翻译：本发明涉及具有根据式（I）的以下结构的膦酰基磺酸盐及其药学上可接受的盐和酯：（I）本发明还涉及含有安全有效量的化合物和药学上可接受的赋形剂。最后，本发明涉及用于治疗或预防以人或其他哺乳动物异常钙和磷酸盐代谢为特征的病理状态的方法，包括治疗或预防骨质疏松症和关节炎，特别是类风湿性关节炎和骨关节炎。该方法包括向需要这种治疗的人或其他哺乳动物施用安全有效量的本发明的化合物或组合物。

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