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1. 发明申请

WO2009039716A1 CAROTENOID FORMULATIONS AND USE THEREOF, AND FEEDS CONTAINING THE FORMULATION AND PROCESSES FOR THE PREPARATION OF THE FEEDS 审中-公开
标题翻译：含有制剂及其用途的饲料及其饲料，以及饲料的制备和方法
公开(公告)号：WO2009039716A1
公开(公告)日：2009-04-02
申请号：PCT/CN2008/000545
申请日：2008-03-19
申请人： ZHEJIANG MEDICINE CO., LTD. XINCHANG PHARMACEUTICAL FACTORY , SHAO, Bin , XU, Xinde , ZHOU, DI , WANG, Yanfeng , HONG, Yimin
发明人： SHAO, Bin , XU, Xinde , ZHOU, DI , WANG, Yanfeng , HONG, Yimin
IPC分类号： A23K1/16 , A23L1/275 , A61K47/06 , C07C403/24
CPC分类号： A23D9/007 , A23K20/179 , A23K40/30 , A23L5/44 , A61K9/10 , A61K47/14 , A61K47/44
摘要： A carotenoid formulation in oil suspensions, comprises a carotenoid with an average particle size of 10μm or less, an antioxidant and an edible oil. A feed contains the said carotenoid formulation, a method for preparing the feed and use of the carotenoid formulation as an additive of animal feeds, foods, cosmetics and/or pharmaceuticals. The active ingredients in the feed granules are homogeneously distributed in the feed granules, majority of which are substantially distributed inside the granules, to reduce the loss caused by oxidation on the surface.
摘要翻译：油悬浮液中的类胡萝卜素制剂包含平均粒度为10μm以下的类胡萝卜素，抗氧化剂和食用油。饲料含有所述类胡萝卜素制剂，一种制备饲料的方法和使用类胡萝卜素制剂作为动物饲料，食品，化妆品和/或药物的添加剂。进料颗粒中的活性成分均匀分布在进料颗粒中，其中大部分基本上分布在颗粒内，以减少由表面氧化引起的损失。

2. 发明公开

US20230174461A1 METHOD FOR PREPARING CHIRAL 4-ARYL-ß-AMINO ACID DERIVATIVE 审中-公开
公开(公告)号：US20230174461A1
公开(公告)日：2023-06-08
申请号：US17924261
申请日：2021-03-12
申请人： Zhejiang Medicine Co., Ltd. Xinchang Pharmaceutical Factory , Zhejiang Changhai Pharmaceutical Co., Ltd.
发明人： Li SHENG , Xufeng WU , Dadong SHEN , Gang FAN , Pengcheng LIU , Dengfeng DONG
IPC分类号： C07C231/12 , C07D487/04 , C07C227/32
CPC分类号： C07C231/12 , C07D487/04 , C07C227/32 , C07B2200/07
摘要： The present invention provides a method for preparing a chiral 4-aryl-β-amino acid derivative. The preparation method comprises hydrogenating an enamine compound having a structure as shown in Formula III in an organic solvent in the presence of a catalyst containing a transition metal and BIBOPs. The preparation method of the present invention uses a small amount of a selected asymmetric catalyst, and has a simple operation, mild reaction conditions, a high yield, a high stereoselectivity, and better industrial application and economic values.

3. 发明公开

US20230172876A1 Carotenoid Compound Coming From Plant And Containing Natural Astaxanthin, Preparation Method Therefor, And Composition 审中-公开
公开(公告)号：US20230172876A1
公开(公告)日：2023-06-08
申请号：US17946485
申请日：2022-09-16
申请人： Zhejiang Medicine Co., Ltd. Xinchang Pharmaceutical Factory
发明人： Xinde Xu , Bin Shao , Yongjian Peng , Shengnan Wang
IPC分类号： A61K31/122 , C07C403/24 , A61K36/71 , A61Q19/00 , A23K20/179 , A23L33/105 , A61K8/9789
CPC分类号： A61K31/122 , C07C403/24 , A61K36/71 , A61Q19/00 , A23K20/179 , A23L33/105 , A61K8/9789 , A61K2800/10 , A61K2800/43 , C07C2601/16 , C07C2601/14 , A61K2236/33 , A61K2236/37 , A61K2236/51 , A61K2236/53
摘要： The present invention provides a high-content carotenoid compound from Adonis amurensis. The content of the total carotenoid of the carotenoid compound is higher than 95%. The content of all-trans (3S, 3′S)-carotenoid is higher than 80%. The carotenoid crystals have a high purity, and can be used in multiple forms in the fields of a dietary supplement of a human being, a food additive, a feed additive and a cosmetic product. In addition, the present invention also provides a method for manufacturing the compound.

4. 发明申请

US20210047609A1 Method For Promoting Synthesis Of Sorbitol Dehydrogenase And Coenzyme Pyrroloquinoline Quinone From Gluconobacter Oxydans 有权
公开(公告)号：US20210047609A1
公开(公告)日：2021-02-18
申请号：US16964999
申请日：2019-01-24
申请人： ZHEJIANG UNIVERSITY OF TECHNOLOGY , Zhejiang Medicine Co., Ltd. Xinchang Pharmaceutical Factory
发明人： Yuguo ZHENG , Xia KE , Yanghui LU , Zhongce HU , Yang WU
IPC分类号： C12N1/20 , C12P17/02
摘要： The present invention discloses a method for promoting the fermentation of Gluconobacter oxydans to produce D-sorbitol dehydrogenase and pyrroloquinoline quinone. The method comprises: Gluconobacter oxydans is inoculated to a fermentation culture medium, fermented and cultured under the conditions of 28-32° C. and 150-180 rpm for 6-24 hours, the fermented solution is centrifuged, and wet bacteria are collected, thus acquiring bacteria cells containing D-sorbitol dehydrogenase and pyrroloquinoline quinone. The method promotes the synthesis of coenzyme pQQ and the enzyme activity of per unit volume D-sorbitol dehydrogenase, Gluconobacter oxydans cultured and acquired using the method is biotransformed to synthesize miglitol precursor 6-deoxy-6-amino(N-hydroxyethyl)-α-L-furan sorbose (6NSL), the conversion progress of the product 6NSL is increased by 21-35%, and a biotransformation step cycle is reduced from 48 hours to 36 hours. In addition, under a same substrate concentration (60 g/L), the cumulative concentration of the product 6NSL is increased by 10 g/L or more.

5. 发明授权

US09260449B2 Method for preparing D-biotin 有权
标题翻译： D-生物素的制备方法
公开(公告)号：US09260449B2
公开(公告)日：2016-02-16
申请号：US14483147
申请日：2014-09-10
申请人： Zhejiang Medicine Co., Ltd., Xinchang Pharmaceutical Factory
发明人： Yajin Pan , Shiqing Pi , Wenzhen Ding , Lixin Gu , Angfeng Wei , Yimin He
IPC分类号： C07D495/04
CPC分类号： C07D495/04
摘要： The invention discloses a D-biotin preparation method. In the prior art, with a synthesis method utilizing malonic acid diester as raw materials, impurities are also produced along with the obtained D-biotin. The D-biotin preparation method is characterized in that with the presence of dimethyl sulfoxide and inorganic base as catalysts, methane tricarboxylic acid trialkyl ester and (3aR, 8aS, 8bS)-1,3-dibenzyl-2-oxo-10H-iminazole [3,4-d] thiophene [1,2-a] sulfuryl halide are subjected to condensation reaction in methylbenzene solvent to obtain intermediate (3 aS,4S,6aR)-1,3-dibenzyl-4-(ω,ω,ω-3-methoxycarbonylbutyl)-4H-1H-thiophene[3,4-d]iminazol e-2,4(1H)-ketone, and the D-biotin is obtained after the intermediate is treated by the aftertreatment method. By the D-biotin preparation method, production of the impurities is avoided, quality of the biotin is greatly improved on the existing basis, and side reaction is avoided too.
摘要翻译：本发明公开了一种D-生物素的制备方法。在现有技术中，利用以丙二酸二酯为原料的合成方法，与所得的D-生物素一起也产生杂质。 D-生物素制备方法的特征在于，在二甲基亚砜和无机碱作为催化剂的存在下，甲烷三羧酸三烷基酯和（3aR，8aS，8bS）-1,3-二苄基-2-氧代-10H-咪唑[ 3,4-d]噻吩[1,2-a]磺酰卤在甲苯溶剂中进行缩合反应，得到中间体（3 aS，4S，6aR）-1,3-二苄基-4-（ω，ω，ω -3-甲氧基羰基丁基）-4H-1H-噻吩[3,4-d]亚胺唑e-2,4（1H） - 酮，并且通过后处理方法处理中间体后得到D-生物素。通过D-生物素制备方法，避免了杂质的生成，生物素的质量在现有的基础上大大提高，并且也避免副反应。

6. 发明授权

US08846968B2 Intermediate of lycopene and preparation method of intermediate thereof 有权
标题翻译：番茄红素中间体及其中间体的制备方法
公开(公告)号：US08846968B2
公开(公告)日：2014-09-30
申请号：US13692694
申请日：2012-12-03
申请人： ZheJiang Medicine Co., Ltd. Xinchang Pharmaceutical Factory , Shaoxing University
发明人： Runpu Shen , Chunlei Lv , Xiaoyue Jiang , Xuejun Lao , Weidong Ye , Luo Liu , Xiaohua Song , Chunlei Wu
IPC分类号： C07C43/303 , C07F9/40 , C07B47/00 , C07C41/50 , C07C41/48
CPC分类号： C07C41/50 , C07B47/00 , C07C41/48 , C07C43/303 , C07F9/4015 , C07F9/4078
摘要： The present invention relates to an intermediate (12) of lycopene of 2,6,10-trimethyl-1,1-dialkoxyl-3,5,9-undecantriene of formula, (12) and its intermediate of 4-methyl-5,5-dialkoxyl-1-pentenyl-1-phosphonic acid dialkyl ester of formula (10), and their preparation methods. The process route is simple, the starting materials are available easily, the cost is low, and it is valuable in industry.
摘要翻译：本发明涉及式（12）的2,6,10-三甲基-1,1-二烷氧基-3,5,9-十一三烯的番茄红素中间体（12）及其4-甲基-5的中间体，式（10）的5-二烷氧基-1-戊烯基-1-膦酸二烷基酯及其制备方法。工艺路线简单，起始材料易于使用，成本低廉，在工业上是有价值的。

7. 发明申请

US20120330048A1 Lycopene Intermediate 1, 3, 6, 10-Tetra-Double Bond Pentadec-Carbon Phosphonate as well as Preparation Method and Use Thereof 有权
标题翻译：番茄红素中间体1,3,6,10-四 - 双键十五碳膦酸酯及其制备方法和用途
公开(公告)号：US20120330048A1
公开(公告)日：2012-12-27
申请号：US13583635
申请日：2011-03-09
申请人： Xuejun Lao , Runpu Shen , Weidong Ye , Xiaohua Song , Luo Liu , Chunlei Wu , Yibin Wu , Liujiang Hu
发明人： Xuejun Lao , Runpu Shen , Weidong Ye , Xiaohua Song , Luo Liu , Chunlei Wu , Yibin Wu , Liujiang Hu
IPC分类号： C07F9/40
CPC分类号： C07F9/4015
摘要： The invention relates to a novel important lycopene intermediate 3,7, 11-trimethyl-1,3,6,10-tetraene-dodecyl diethyl phosphonate. A current lycopene intermediate 2,4,6,10-tetra-double bond pentadec-carbon phosphonate is difficult to synthesize. The invention provides a novel intermediate, which has the following synthesis steps of: preparing 2,6,10-trimethyl-3,5,9-undecane triene-1-aldehyde from pseudoionone; preparing 2,6,10-trimethyl-2,5,9-undecane triene-1-aldehyde from the 2,6,10-trimethyl-3, 5,9-undecane triene-1-aldehyde; and subjecting the 2,6,10-trimethyl-2,5,9-undecane triene-1-aldehyde and tetraethyl methylenediphosphonate to condensation reaction to obtain target product. The invention can generate novel intermediate from raw material pseudoionone only by four reactions, thus the reactions are easy to control and great industrial value are achieved.
摘要翻译：本发明涉及一种新型重要的番茄红素中间体3,7,11-三甲基-1,3,6,10-四烯十二烷基二乙基膦酸酯。目前的番茄红素中间体2,4,6,10-四 - 双十五碳酸膦难以合成。本发明提供了一种新的中间体，其具有以下合成步骤：由假雄酮制备2,6,10-三甲基-3,5,9-十一烷三烯-1-醛; 由2,6,10-三甲基-3,9,9-十一烷三烯-1-醛制备2,6,10-三甲基-2,5,9-十一烷三烯-1-醛; 并使2,6,10-三甲基-2,5,9-十一烷三烯-1-醛和四亚乙基二膦酸四乙酯进行缩合反应，得到目标产物。本发明只能通过四个反应从原料假雄酮生成新的中间体，因此反应易于控制，实现了巨大的工业价值。

8. 发明授权

US11920175B2 Method for extracting and isolating lutein crystal from vegetable oil resin containing lutein diester 有权
公开(公告)号：US11920175B2
公开(公告)日：2024-03-05
申请号：US17259161
申请日：2019-07-09
申请人： Zhejiang Medicine Co., Ltd. Xinchang Pharmaceutical Factory
发明人： Xinde Xu , Tian Xie , Shengfan Wang , Qiuyan Wang , Jianyong Zheng , Zhaowu Zeng , Xiaopu Yin , Xuejun Lao , Kangzhong Shao
IPC分类号： C07C403/24 , C12P23/00
CPC分类号： C12P23/00 , C07C403/24 , C07B2200/13 , C07C2601/16
摘要： A method for extracting and isolating a lutein crystal from a vegetable oil resin containing a lutein diester, comprises: dissolving lipase into deionized water to form an enzyme solution; dissolving a lutein extract into an alcohol solvent containing the deionized water to form a uniform alcohol solution; adding the enzyme solution to the alcohol solution for performing hydrolysis, and stirring same to obtain a lutein solution; filtering and performing filtration isolation on the lutein solution to obtain a crystalline; re-dissolving the crystalline into a non-polar organic solvent, and using deionized water for washing a water-soluble impurity; recycling and cooling the organic solvent to obtain a recrystallization; and isolating and drying the recrystallization to obtain the lutein crystal. In this method, selectivity is strong, reaction time is short, no waste water is produced, process is environment-friendly and suitable for industrial production, and obtained lutein crystal is high in purity and yield.

9. 发明公开

US20230183259A1 Crystal Form Of Thiofuran Pyridazine Compound, Preparation Method Therefor And Application Thereof 审中-公开
公开(公告)号：US20230183259A1
公开(公告)日：2023-06-15
申请号：US17915101
申请日：2020-04-17
申请人： ZHEJIANG MEDICINE CO., LTD. XINCHANG PHARMACEUTICAL FACTORY , Zhejiang Changhai Pharmaceutical Co., Ltd.
发明人： Dadong SHEN , Yonghui LV , Guofeng WU , Dingfeng ZHANG , Ruiwei CAO
IPC分类号： C07D495/04
CPC分类号： C07D495/04 , C07B2200/13
摘要： The present invention provides a crystal form of a thiofuran pyridazine compound, a preparation method therefor and an application thereof. The crystal form of the thiofuran pyridazine compound is (S)-2-(4-fluorophenyl)-4-(piperidine-3-aminomethyl)thieno[2,3-d] pyridazine-7-carboxamide hydrochloride of formula (I). The crystal form of the thiofuran pyridazine compound in the present invention has higher stability and is stored especially in high humidity conditions, and thus is suitable for preparing various forms of drugs.

10. 发明授权

US10035750B2 Preparation method for polyunsaturated fatty acid-calcium 有权
公开(公告)号：US10035750B2
公开(公告)日：2018-07-31
申请号：US15519086
申请日：2015-10-12
申请人： Zhejiang Medicine Co., Ltd. Xinchang Pharmaceutical Factory
发明人： Xuebing Xiang , Xinde Xu , Bin Shao , Yufang Meng , Chong Li
IPC分类号： C07C51/41 , C11C1/02 , C11C3/12 , A23K20/158
CPC分类号： C07C51/412 , A23K20/158 , C07C51/09 , C07C51/41 , C07C57/03 , C07C57/12 , C11C1/025 , C11C3/126 , C07C57/02
摘要： The present invention relates to a preparation method for a polyunsaturated fatty acid-calcium, primarily comprising directly reacting a polyunsaturated fatty acid material with a water-soluble calcium compound to obtain a polyunsaturated fatty acid-calcium salt. The present invention has a simple technical process, short reaction time, and high reaction yield. The produced polyunsaturated fatty acid-calcium product is of high quality, and relatively less byproducts and waste water are produced. The process is overall environmentally friendly and has small safety risks, and is suitable for scaled production.

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