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1. 发明申请

WO2009039716A1 CAROTENOID FORMULATIONS AND USE THEREOF, AND FEEDS CONTAINING THE FORMULATION AND PROCESSES FOR THE PREPARATION OF THE FEEDS 审中-公开
标题翻译：含有制剂及其用途的饲料及其饲料，以及饲料的制备和方法
公开(公告)号：WO2009039716A1
公开(公告)日：2009-04-02
申请号：PCT/CN2008/000545
申请日：2008-03-19
申请人： ZHEJIANG MEDICINE CO., LTD. XINCHANG PHARMACEUTICAL FACTORY , SHAO, Bin , XU, Xinde , ZHOU, DI , WANG, Yanfeng , HONG, Yimin
发明人： SHAO, Bin , XU, Xinde , ZHOU, DI , WANG, Yanfeng , HONG, Yimin
IPC分类号： A23K1/16 , A23L1/275 , A61K47/06 , C07C403/24
CPC分类号： A23D9/007 , A23K20/179 , A23K40/30 , A23L5/44 , A61K9/10 , A61K47/14 , A61K47/44
摘要： A carotenoid formulation in oil suspensions, comprises a carotenoid with an average particle size of 10μm or less, an antioxidant and an edible oil. A feed contains the said carotenoid formulation, a method for preparing the feed and use of the carotenoid formulation as an additive of animal feeds, foods, cosmetics and/or pharmaceuticals. The active ingredients in the feed granules are homogeneously distributed in the feed granules, majority of which are substantially distributed inside the granules, to reduce the loss caused by oxidation on the surface.
摘要翻译：油悬浮液中的类胡萝卜素制剂包含平均粒度为10μm以下的类胡萝卜素，抗氧化剂和食用油。饲料含有所述类胡萝卜素制剂，一种制备饲料的方法和使用类胡萝卜素制剂作为动物饲料，食品，化妆品和/或药物的添加剂。进料颗粒中的活性成分均匀分布在进料颗粒中，其中大部分基本上分布在颗粒内，以减少由表面氧化引起的损失。

2. 发明公开

EP3363532A1 METHOD FOR GRANULATING, FORMING, AND DRYING FAT SOLUBLE NUTRIENT MICROCAPSULE PARTICLES 有权
公开(公告)号：EP3363532A1
公开(公告)日：2018-08-22
申请号：EP15905988.0
申请日：2015-10-12
申请人： Zhejiang Medicine Co., Ltd. Xinchang Pharmaceutical Factory
发明人： XU, Xinde , ZHOU, Di , ZHANG, Lihua , SHAO, Bin
IPC分类号： B01J13/04
CPC分类号： B01J13/04
摘要： The present invention provides a method for drying high-stability microcapsule particles containing multiple double bonds fat soluble nutrients comprises: a) preparing a microcapsule emulsion containing multiple double bonds fat soluble nutrients, performing spray granulation on the microcapsule emulsion in a spray system (1), and meanwhile blasting air into the spray system (1), the blasted air wrapping adsorption materials, and the microcapsule emulsion being immediately solidified and sized after coming into contact with the air, so as to obtain liquid droplets having surfaces to which adsorption materials are adsorbed; b) performing fluidized drying on the liquid droplets having surfaces to which the adsorption materials are adsorbed in the step a) in a multi-stage fluidized bed system (5); c) collecting non-adsorbed adsorption materials by means of an adsorption material dust removal, recovery and circulation system; and d) collecting microcapsule particle products.

3. 发明公开

EP3202876A1 FIXED BED DECOLORIZATION PROCESS FOR UNSATURATED FATTY ACID 有权
标题翻译：不饱和脂肪酸的固定床脱色工艺
公开(公告)号：EP3202876A1
公开(公告)日：2017-08-09
申请号：EP15840668.6
申请日：2015-09-09
申请人： Zhejiang Medicine Co., Ltd. Xinchang Pharmaceutical Factory
发明人： XIANG, Xuebing , XU, Xinde , SHAO, Bin , LI, Chong
IPC分类号： C11B3/00
CPC分类号： A23L5/49 , A23L33/12 , A23V2002/00 , C11B3/00 , C11B3/10
摘要： The present invention relates to a fixed bed decolorization process for an polyunsaturated fatty acid, comprising a polyunsaturated fatty acid or a polyunsaturated fatty acid solution is either passed directly through a filler of the fixed bed or recycled in a filler of the fixed bed, a colorless or light-colored polyunsaturated fatty acid product is ultimately produced, at the same time, other than the color, other qualities of the polyunsaturated fatty acid remain unaffected. The decolorization process allows continuous operation or intermittent operation. The filler of the fixed bed comprises one or a mixture of activated carbon, diatomite, carclazyte, silicone and an ion-exchange resin. An upper or a middle or a bottom or a combination thereof is employed to feed a polyunsaturated fatty acid feedstock or a polyunsaturated fatty acid solution. The filler in the fixed bed can be used repeatedly. The filler can be reused after being washed when decolorization effects thereof become deteriorated or ineffective.
摘要翻译：本发明涉及用于多不饱和脂肪酸的固定床脱色方法，其包含多不饱和脂肪酸或多不饱和脂肪酸溶液直接通过固定床的填料或循环到固定床的填料中，无色或最终产生浅色多不饱和脂肪酸产物，同时，除了颜色之外，多不饱和脂肪酸的其他品质不受影响。脱色过程允许连续操作或间歇操作。固定床的填料包含活性炭，硅藻土，carlozyte，硅酮和离子交换树脂中的一种或混合物。采用上部或中部或底部或其组合来供给多不饱和脂肪酸原料或多不饱和脂肪酸溶液。固定床中的填充物可以重复使用。当其脱色效果变差或无效时，填料可以在清洗后重新使用。

4. 发明公开

EP3181544A1 METHOD FOR PREPARING HIGH-CONTENT CONJUGATED LINOLEIC ACID THROUGH PURIFICATION OF VEGETABLE OIL AS RAW MATERIAL 有权
标题翻译：用于生产高浓度的共轭亚油酸BY植物油为原料CLEANING
公开(公告)号：EP3181544A1
公开(公告)日：2017-06-21
申请号：EP15841810.3
申请日：2015-09-17
申请人： ZheJiang Medicine Co., Ltd. Xinchang Pharmaceutical Factory
发明人： PENG, Yongjian , XU, Xinde , SHAO, Bin , ZHANG, Lihua
IPC分类号： C07C57/12 , C07C51/09 , C11C3/10
CPC分类号： C07C51/09 , C07C67/02 , C11B7/0041 , C11B7/0058 , C11C1/08 , C11C1/10 , C11C3/003 , C11C3/10 , G01N30/02 , G01N2030/027
摘要： This invention involves a method for preparing high-contentconjugated linoleic acid (CLA) products with common vegetable oil. This invention includes alcoholysis, purification and isomerization of vegetable oil. Alcoholysis is for preparing correspondingmethyl ester or ethyl ester with glyceride; purification of methyl ester or ethyl ester is for obtaining methyl linoleate or ethyl linoleate of content over 85% through silver-basedsilicagel columnchromatography; high-content CLA is obtained after alkali-catalyzed conjugation of methyl linoleate or ethyl linoleate, and CLA products are prepared as needed. This invention changes the status quo of preparing high-content CLA with safflower oil alone, expands sources of CLA, and develops an efficient technology for separation and purification of linoleic acid. The CLA obtained is of high purity and meets applications in pharmaceutical, health care products and other industries.
摘要翻译：本发明包括一种制备高contentconjugated亚油酸（CLA）的产品与普通植物油的方法。本发明包括醇解，纯化和植物油的异构化反应。醇解是制备correspondingmethyl酯或乙基酯与甘油酯; 甲基酯或乙基酯的纯化是用于获得亚油酸甲酯或通过银basedsilicagel柱色谱超过85％的亚油酸乙酯含量; 含量高CLA是亚油酸甲酯或亚油酸乙酯的碱催化偶联后获得，并且根据需要CLA产品制备。本发明改变制备高含量的CLA与红花油现状单独，Expand的CLA的来源，和高效的技术开发出的亚油酸的分离和纯化。获得该CLA是高纯度的，满足药物应用，保健品等行业。

5. 发明公开

EP3072883A1 CAROTENOID COMPOUND COMING FROM PLANT AND CONTAINING NATURAL ASTAXANTHIN, PREPARATION METHOD THEREFOR, AND COMPOSITION 有权
标题翻译：与天然虾青素，类胡萝卜素工艺产品蔬菜产生和组成
公开(公告)号：EP3072883A1
公开(公告)日：2016-09-28
申请号：EP14848508.9
申请日：2014-09-23
申请人： Zhejiang Medicine Co., Ltd. Xinchang Pharmaceutical Factory
发明人： XU, Xinde , SHAO, Bin , PENG, Yongjian , WANG, Shengnan
IPC分类号： C07C403/24 , A23L33/10 , A23K20/00
CPC分类号： A61K31/122 , A23K20/179 , A23L33/105 , A61K8/97 , A61K36/71 , A61K2236/33 , A61K2236/37 , A61K2236/51 , A61K2236/53 , A61K2800/10 , A61K2800/43 , A61Q19/00 , C07C403/24 , C07C2601/14 , C07C2601/16
摘要： The present invention provides a high-content carotenoid compound from adonis amurensis. The content of the total carotenoid of the carotenoid compound is higher than 95%. The content of all-trans (3S, 3'S)-carotenoid is higher than 80%. The carotenoid crystals have a high purity, and can be used in multiple forms in the fields of a dietary supplement of a human being, a food additive, a feed additive and a cosmetic product. In addition, the present invention also provides a method for manufacturing the compound.
摘要翻译：本发明提供了从冰凉花高含量的类胡萝卜素化合物。类胡萝卜素化合物的总类胡萝卜素的含量高于95％。全反式的含量（3S，3'S）-carotenoid是高于80％。类胡萝卜素晶体具有高纯度，并且可以在一个人，食品添加剂，饲料添加剂和化妆品产品的膳食补充剂的字段的多个形式使用。此外，本发明因此提供了用于制造该化合物的方法。

6. 发明授权

EP3208257B1 METHOD FOR RECYCLING UREA IN UREA ADDUCT PROCESS 有权
公开(公告)号：EP3208257B1
公开(公告)日：2019-12-11
申请号：EP15850981.0
申请日：2015-10-12
申请人： Zhejiang Medicine Co., Ltd. Xinchang Pharmaceutical Factory
发明人： PENG, Yongjian , XU, Xinde , MA, Jinping , ZHANG, Yanwen , SHAO, Bin
IPC分类号： C07C27/02 , C07C57/12 , C11C3/00

7. 发明公开

EP3208259A1 PREPARATION METHOD FOR POLYUNSATURATED FATTY ACID-CALCIUM 有权
标题翻译：多不饱和脂肪酸钙的制备方法
公开(公告)号：EP3208259A1
公开(公告)日：2017-08-23
申请号：EP15851044.6
申请日：2015-10-12
申请人： Zhejiang Medicine Co., Ltd. Xinchang Pharmaceutical Factory
发明人： XIANG, Xuebing , XU, Xinde , SHAO, Bin , MENG, Yufang , LI, Chong
IPC分类号： C07C51/41 , C07C57/03 , C07C57/12
CPC分类号： C07C51/412 , A23K20/158 , C07C51/09 , C07C51/41 , C07C57/03 , C07C57/12 , C11C1/025 , C11C3/126 , C07C57/02
摘要： The present invention relates to a preparation method for a polyunsaturated fatty acid-calcium, primarily comprising directly reacting a polyunsaturated fatty acid material with a water-soluble calcium compound to obtain a polyunsaturated fatty acid-calcium salt. The present invention has a simple technical process, short reaction time, and high reaction yield. The produced polyunsaturated fatty acid-calcium product is of high quality, and relatively less byproducts and waste water are produced. The process is overall environmentally friendly and has small safety risks, and is suitable for scaled production.
摘要翻译：本发明涉及多不饱和脂肪酸钙的制备方法，主要包括使多不饱和脂肪酸物质与水溶性钙化合物直接反应以获得多不饱和脂肪酸钙盐。本发明工艺简单，反应时间短，反应收率高。生产的多不饱和脂肪酸钙产品质量高，副产品和废水少。该工艺整体环保，安全风险小，适合规模化生产。

8. 发明授权

EP2522655B1 PREPARING METHOD FOR XANTHOPHYLL CRYSTALS WITH HIGHER CONTENT OF ZEAXANTHIN FROM PLANT OLEORESIN 有权
标题翻译：植物松油醇高含量黄芩苷的XTHTHLYLL晶体的制备方法
公开(公告)号：EP2522655B1
公开(公告)日：2017-07-19
申请号：EP10841903.7
申请日：2010-03-18
申请人： ZheJiang Medicine Co., Ltd. Xinchang Pharmaceutical Factory
发明人： XU, Xinde , SHAO, Bin , CHAO, Hongjuan , LAO, Xuejun , SUN, Xiaoxia
IPC分类号： C07C403/24 , C09B61/00
CPC分类号： C07C403/24 , C07C2601/16 , C09B61/00

9. 发明授权

EP2712928B1 METHOD FOR PRODUCING NATURAL -CAROTENE BY FERMENTATION AND USE THEREOF 有权
标题翻译：用于生产天然β-胡萝卜素对发酵和应用方法
公开(公告)号：EP2712928B1
公开(公告)日：2015-07-22
申请号：EP12789051.5
申请日：2012-05-15
申请人： Zhejiang Medicine Co., Ltd. Xinchang Pharmaceutical Factory
发明人： XU, Xinde , JIAO, Mingqing , SHAO, Dong , SHAO, Bin , YU, Leiming
IPC分类号： C12P23/00 , A23L1/303 , A61K31/07 , A61K8/67 , A61P3/02 , C07C403/24 , C12N1/14 , C12R1/645
CPC分类号： C12P23/00 , A23L5/44 , A23L33/155 , A23V2002/00 , A61K31/015 , A23V2250/702

10. 发明公开

EP2873659A1 METHOD FOR PREPARING HIGH LEVEL OF ZEAXANTHIN 有权
标题翻译：制备高含量紫杉醇的方法
公开(公告)号：EP2873659A1
公开(公告)日：2015-05-20
申请号：EP13816427.2
申请日：2013-07-09
申请人： ZheJiang Medicine Co., Ltd. Xinchang Pharmaceutical Factory
发明人： SHAO, Bin , ZHANG, Lihua , XU, Xinde , SUN, Xiaoxia
IPC分类号： C07C403/24 , B01J31/02
CPC分类号： C07C29/56 , B01J31/02 , C07B2200/13 , C07C403/24 , C07C2601/16
摘要： The invention discloses a method for preparing high-content zeaxanthin. In the conventional preparation methods, some methods adopt certain toxic organic solvents; some methods require the multi-step crystallization process; and some methods are featured by long reaction time, high temperature and lower product yield, thus being not suitable for industrial production. The invention adopts lutein crystal or its fatty acid ester as the raw material and utilizes isomerization reaction to produce zeaxanthin, and is characterized in that a mixed catalyst consisting of an organic base catalyst and a cocatalyst is used in the isomerization reaction, wherein the cocatalyst is palladium carbon. The invention has the advantages of simple process route, low reaction temperature, short reaction time, good product purity and high yield, thus being suitable for industrial production, and no poisonous and harmful organic solvent residues in the product, thus being suitable for the use as a food additive or drug.
摘要翻译：本发明公开了一种高含量玉米黄质的制备方法。在常规制备方法中，有些方法采用某些有毒有机溶剂; 一些方法需要多步骤结晶过程; 有些方法反应时间长，温度高，产品收率低，不适合工业化生产。本发明采用叶黄素结晶或其脂肪酸酯为原料，利用异构化反应生成玉米黄素，其特征在于在异构化反应中使用由有机碱催化剂和助催化剂组成的混合催化剂，助催化剂为钯碳。本发明工艺路线简单，反应温度低，反应时间短，产品纯度高，收率高，适合工业化生产，产品无有毒有害有机溶剂残留，适合用途作为食品添加剂或药物。

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