专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO1996020959A1 NOVEL MONOCLONAL ANTIBODY HAVING INHIBITORY EFFECT ON TYPE II PHOSPHOLIPASE A2 AND PROTEIN CONTAINING A PART OF THE SAME 审中-公开
标题翻译：对类型II磷脂酶A2和蛋白质含有其一部分的蛋白质具有抑制作用的新型单克隆抗体
公开(公告)号：WO1996020959A1
公开(公告)日：1996-07-11
申请号：PCT/JP1995002714
申请日：1995-12-27
申请人： YAMANOUCHI PHARMACEUTICAL CO., LTD. , KAWAUCHI, Yasushi , TAKASAKI, Jun , YASUNAGA, Tomoe , MASUHO, Yasuhiko
发明人： YAMANOUCHI PHARMACEUTICAL CO., LTD.
IPC分类号： C07K16/40
CPC分类号： C07K16/40 , A61K38/00
摘要： A novel monoclonal antibody inhibiting the activity of type II phospholipase A2. The antibody inhibits the activity of human type II phospholipase A2 and those of ape type II phospholipase A2 and/or mouse type II phospholipase A2, which makes it not only clinically useful but also usable as such in preclinical tests with the use of ape or mouse. The antibody, which has a completely novel characteristic of releasing type II phospholipase A2 bound to cell membrane, seems to strongly inhibit the type II phospholipase A2 activity via a novel mechanism. A protein containing the monoclonal antibody or a part of the same and being usable as a remedy for heart infarction, brain infarction, etc. in which type II phospholipase A2 participates.
摘要翻译：抑制II型磷脂酶A2活性的新型单克隆抗体。抗体抑制人II型磷脂酶A2和猿II型磷脂酶A2和/或小鼠II型磷脂酶A2的活性，这使其不仅在临床上有用，而且也可用于使用猿或小鼠的临床前试验。具有与细胞膜结合的II型磷脂酶A2完全新颖特征的抗体似乎通过新的机制强烈地抑制II型磷脂酶A2活性。含有单克隆抗体或其一部分的蛋白质并且可用作II型磷脂酶A2参与的心肌梗塞，脑梗死等的补救剂。

2. 发明申请

WO1996010426A1 OSTEOPLASTIC GRAFT 审中-公开
标题翻译：电磁波
公开(公告)号：WO1996010426A1
公开(公告)日：1996-04-11
申请号：PCT/JP1995001970
申请日：1995-09-28
申请人： YAMANOUCHI PHARMACEUTICAL CO., LTD. , YOKOTA, Shoji , SHIMOKAWA, Seitaro , SONOHARA, Ritsu , OKADA, Akira , TAKAHASHI, Koichiro
发明人： YAMANOUCHI PHARMACEUTICAL CO., LTD.
IPC分类号： A61L27/00
CPC分类号： A61L27/44 , A61L27/18 , A61L27/20 , A61L27/22 , A61L27/54 , A61L27/56 , A61L2300/252 , A61L2300/414 , A61L2300/602 , A61L2430/02 , A61F2/28 , C08L89/06 , C08L89/00 , C08L67/04 , C08L5/08 , C08L5/04
摘要： An osteoplastic graft comprising a bone inducer supported on a composite porous body comprising a porous structure of a bioabsorbable hydrophilic material and a surface layer of a bioabsorbable polymeric material. Preferably, the hydrophilic material comprises at least one member selected from the group consisting of gelatin, hyaluronic acid and derivatives thereof, collagen and derivatives thereof, chitosan and derivatives thereof, and triethanolammonium alginate, while the polymeric material comprises at least one member selected from the group consisting of polylactic acid, polylactic acid-polyglycolic acid copolymer, and poly[bis(p-carboxyphenoxy)propane] anhydride-sebacid acid copolymer. As the graft is excellent in moldability and operability and has an internal structure suitable for in vivo bone neogenesis, bone grafting occurs not only at the periphery of the graft but also within the graft.
摘要翻译：一种骨形成移植物，其包含支撑在复合多孔体上的骨诱导剂，所述复合多孔体包含生物可吸收亲水材料的多孔结构和生物可吸收聚合材料的表面层。优选地，亲水性材料包括选自明胶，透明质酸及其衍生物，胶原及其衍生物，壳聚糖及其衍生物和海藻酸三乙醇铵中的至少一种，而聚合物材料包含至少一种选自由聚乳酸，聚乳酸 - 聚乙醇酸共聚物和聚[双（对 - 羧基苯氧基）丙烷]酐 - 癸二酸共聚物组成的组。由于移植物具有优异的成型性和可操作性，并且具有适合于体内骨新生的内部结构，不仅在移植物的周围，而且在移植物内发生骨移植。

3. 发明申请

WO1995033469A1 SOLID ANTACID AND PROCESS FOR PRODUCING THE SAME 审中-公开
标题翻译：固体防锈剂及其制造方法
公开(公告)号：WO1995033469A1
公开(公告)日：1995-12-14
申请号：PCT/JP1995001094
申请日：1995-06-05
申请人： YAMANOUCHI PHARMACEUTICAL CO., LTD. , SHIOZAWA, Hiroyoshi , HASHIMOTO, Yoshimi , TSUSHIMA, Keiko , SETOGUCHI, Yoichi
发明人： YAMANOUCHI PHARMACEUTICAL CO., LTD.
IPC分类号： A61K33/06
CPC分类号： A61K33/08 , A61K9/0056 , A61K9/2081 , A61K9/5026 , A61K9/5036 , A61K9/5084 , A61K2300/00
摘要： A pharmaceutical composition useful for providing a solid antacid which has the effect of rapidly neutralizing acidity without unnecessarily enhancing the initial pH immediately after administration, is excellent in the effect of persistence of the optimum pH, and exhibits an excellent antacid effect based on the above effects. The composition contains as the active ingredient a combination of a lowly neutralizing antacid (one having an initial pH of less than 6 when tested by the modified Fuchs method using 30 ml of 0.05 N hydrochloric acid and a single dose of the sample, e.g. dry aluminum hydroxide gel) and a highly neutralizing antacid (one having an initial pH of 6 or above when tested similarly, e.g. magnesium hydroxide) coated with a pH-independent water-insoluble macromolecular base (e.g. aqueous ethylcellulose dispersion).
摘要翻译：用于提供固体抗酸剂的药物组合物，其具有快速中和酸度而不会在施用后立即提高初始pH，具有优异的最佳pH的持久性的效果，并且基于上述效果显示出优异的抗酸作用。该组合物含有低中和抗酸剂（当通过改良的Fuchs法使用30ml的0.05N盐酸和单一剂量的样品测试时，初始pH小于6的组合物，例如干铝氢氧化物凝胶）和高度中和的抗酸剂（类似地测试时的初始pH为6或以上的抗酸剂，例如氢氧化镁），其涂覆有不依赖于pH的水不溶性大分子基质（例如乙基纤维素水分散体）。

4. 发明申请

WO1995020380A1 INTRAORALLY SOLUBLE COMPRESSED MOLDING AND PROCESS FOR PRODUCING THE SAME 审中-公开
标题翻译：真空可压缩成型及其制造方法
公开(公告)号：WO1995020380A1
公开(公告)日：1995-08-03
申请号：PCT/JP1995000102
申请日：1995-01-27
申请人： YAMANOUCHI PHARMACEUTICAL CO., LTD. , MIZUMOTO, Takao , MASUDA, Yoshinori , FUKUI, Muneo
发明人： YAMANOUCHI PHARMACEUTICAL CO., LTD.
IPC分类号： A61K09/20
CPC分类号： A61K9/0056 , A61K9/2018
摘要： An intraorally soluble compressed molding prepared by granulating a difficultly moldable sugar with a readily moldable sugar. It has high disintegrability and solubility and a suitable hardness in the oral cavity.
摘要翻译：通过将容易成型的糖制成难以成型的糖制备的经口溶性压缩成型品。它在口腔中具有高的崩解性和溶解性和合适的硬度。

5. 发明申请

WO1995003305A1 FUSED BENZAZEPINE DERIVATIVE AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME 审中-公开
标题翻译：含有BENZAZEPINE衍生物和药物组合物
公开(公告)号：WO1995003305A1
公开(公告)日：1995-02-02
申请号：PCT/JP1994001183
申请日：1994-07-19
申请人： YAMANOUCHI PHARMACEUTICAL CO., LTD. , TANAKA, Akihiro , KOSHIO, Hiroyuki , TANIGUCHI, Nobuaki , MATSUHISA, Akira , SAKAMOTO, Ken-ichiro , YAMAZAKI, Atsuki , YATSU, Takeyuki
发明人： YAMANOUCHI PHARMACEUTICAL CO., LTD.
IPC分类号： C07D487/04
CPC分类号： C07D209/48 , C07D223/16 , C07D487/04 , C07D513/04
摘要： A nitrogenous aromatic 5-membered fused benzazepine derivative represented by general formula (I) and useful as an arginine vasopressin antagonist, a salt thereof, and a pharmaceutical composition containing the same as the active ingredient wherein B represents a nitrogenous aromatic 5-membered ring that may be substituted, has at least one nitrogen atom and may further have one oxygen or sulfur atom; R and R represent each independently hydrogen, halogen, lower alkyl, amino which may be substituted by lower alkyl, or lower alkoxy; A represents a single bond or -NHCO-(CR R )n-; n represents an integer of 0 to 3; R and R represent each independently hydrogen or lower alkyl, provided R and R may be combined together to form a C2-C7 alkylene; and C represents an optionally substituted benzene ring.
摘要翻译：由通式（I）表示的可用作精氨酸加压素拮抗剂的含氮芳族5元稠合苯并氮杂衍生物及其盐，以及含有该活性成分的药物组合物，其中B表示含氮芳族五元环，可以被取代，具有至少一个氮原子，并且还可以具有一个氧原子或硫原子; R 1和R 2各自独立地表示氢，卤素，低级烷基，可以被低级烷基或低级烷氧基取代的氨基; A表示单键或-NHCO-（CR 3 R 4）n - ; n表示0〜3的整数， R 3和R 4各自独立地表示氢或低级烷基，条件是R 3和R 4可以组合在一起形成C 2 -C 7亚烷基; C代表任选取代的苯环。

6. 发明申请

WO1995001964A1 NOVEL CRYSTAL OF BENZODIAZEPINE DERIVATIVE 审中-公开
标题翻译：苯并噻吩衍生物的新水晶
公开(公告)号：WO1995001964A1
公开(公告)日：1995-01-19
申请号：PCT/JP1994001094
申请日：1994-07-05
申请人： YAMANOUCHI PHARMACEUTICAL CO., LTD. , NAKAMURA, Makoto , WATANABE, Kouichi
发明人： YAMANOUCHI PHARMACEUTICAL CO., LTD.
IPC分类号： C07D243/24
CPC分类号： C07D243/24
摘要： A type B crystal of (R)-1-[2,3-dihydro-1-(2'-methylphenacyl)-2-oxo-5-phenyl-1H-1,4-benzodi azepin-3-yl]-3-(3-tolyl)urea. It is produced by conducting recrystallization in a solvent mixture composed of 5 parts by volume of alcohol and at least 1 part by volume of water. It is so excellent in filterability and flow that it is extremely easy to filter in the mass production thereof and to handle in the production of a pharmaceutical preparation therefrom, thus being useful in the industrial production thereof.
摘要翻译：（R）-1- [2,3-二氢-1-（2'-甲基苯酰基）-2-氧代-5-苯基-1H-1,4-苯并二氮杂-3-基] -3 - （3-甲苯基）脲。通过在由5体积份醇和至少1体积份的水组成的溶剂混合物中进行重结晶而制备。过滤性和流动性优异，在其大规模生产中过滤非常容易，并且可以处理从其制备药物制剂，因此可用于其工业生产。

7. 发明申请

WO1994029293A1 NOVEL 8-(2-AMINOALKOXY)FLUOROCHROMAN DERIVATIVE 审中-公开
标题翻译：新型8-（2-氨基烷氧基）氟代吡啶衍生物
公开(公告)号：WO1994029293A1
公开(公告)日：1994-12-22
申请号：PCT/JP1994000923
申请日：1994-06-08
申请人： YAMANOUCHI PHARMACEUTICAL CO., LTD. , YASUNAGA, Tomoyuki , KIMURA, Takenori , NAITO, Ryo , KONTANI, Toru , YAMAGUCHI, Tokio , WANIBUCHI, Fumikazu
发明人： YAMANOUCHI PHARMACEUTICAL CO., LTD.
IPC分类号： C07D311/22
CPC分类号： C07D407/12 , C07D311/22
摘要： An 8-(2-aminoalkoxy)fluorochroman derivative represented by general formula (I) or a salt thereof, both having a selective affinity for 5-HT1A receptors and being useful for treating psychoneurotic diseases such as anxiety, manic-depressive state and schizophrenia, sex disorder, eating disorder, sleep disorder, and drug dependence: wherein R, R2 and R3 represent each lower alkoxy, etc., or R1 and R2 may be combined together to represent -O-(CH2)m-O- (wherein m is an integer of 1 to 3), etc.; R4 represents hydrogen, lower alkyl or aralkyl; R represent hydroxy, amino or lower alkoxy; R6 represents hydrogen or lower alkyl, provided R5, R6 and the carbon atom to which they are bonded are combined together to represent carbonyl; A represents an ethylene group which may be substituted by lower alkyl; and B represents optionally branched C1-C10 alkylene.
摘要翻译：对通式（I）表示的8-（2-氨基烷氧基）氟苯并喃喃衍生物或其盐对5-HT 1A受体具有选择性亲和力，可用于治疗焦虑，躁狂抑郁状态和精神分裂症等精神病性疾病，性障碍，进食障碍，睡眠障碍和药物依赖性：其中R，R 2和R 3表示各个低级烷氧基等，或者R 1和R 2可以组合在一起代表-O-（CH 2）m O-（其中m是 1〜3的整数）等; R4代表氢，低级烷基或芳烷基; R 5代表羟基，氨基或低级烷氧基; R6表示氢或低级烷基，其中R5，R6和它们所键合的碳原子结合在一起代表羰基; A表示可被低级烷基取代的亚乙基; B表示任选支链的C 1 -C 10亚烷基。

8. 发明申请

WO1994025450A1 SERINE DERIVATIVE 审中-公开
标题翻译：丝氨酸衍生物
公开(公告)号：WO1994025450A1
公开(公告)日：1994-11-10
申请号：PCT/JP1994000697
申请日：1994-04-26
申请人： YAMANOUCHI PHARMACEUTICAL CO., LTD. , NODA, Ichio , IWATA, Masahiro , SAKAMOTO, Shuichi , KOSHIYA, Kazuo , MORITA, Takuma , KOHARA, Atsuyuki
发明人： YAMANOUCHI PHARMACEUTICAL CO., LTD.
IPC分类号： C07D307/52
CPC分类号： C07D409/06 , C07D307/52 , C07D307/54 , C07D333/20 , C07D333/24 , Y02P20/55
摘要： A serine derivative represented by general formula (I) or a pharmaceutically acceptable salt thereof, having an anti-PCP(phencyclidine) activity and being useful as a psychotropic, wherein X represents sulfur or oxygen; Y represents nitrogen or CH; R and R represent each independently hydrogen, lower alkyl or an amino-protecting group, or R and R may be combined together to form 4- to 9-membered nitrogenous cycloalkyl; R represents hydrogen, carboxy, protected carboxy, aralkyl, or lower alkyl which may be hydroxylated; R represents hydrogen or hydroxy; R represents hydrogen or lower alkyl; A represents lower alkylene; B represents (1) an (un)saturated 4- to 10-membered nitrogenous cycloalkyl group which may be substituted by lower alkyl or aralkyl, or (2) a bicyclic nitrogenous hydrocarbon ring group comprising a 4- to 8-membered nitrogenous cycloalkyl group and a benzene ring fused together; and . &cir& _. &cir& _. &cir& _ represents a single or a double bond.
摘要翻译：由通式（I）表示的丝氨酸衍生物或其药学上可接受的盐，具有抗PCP（苯环利定）活性，可用作精神药物，其中X表示硫或氧; Y表示氮或CH; R 1和R 2各自独立地表示氢，低级烷基或氨基保护基，或者R 1和R 2可以组合在一起形成4-至9-元含氮环烷基; R 3表示氢，羧基，保护的羧基，芳烷基或可被羟基化的低级烷基; R 4表示氢或羟基; R 5表示氢或低级烷基; A表示低级亚烷基; B表示（1）可被低级烷基或芳烷基取代的（未）饱和的4-至10-元含氮环烷基，或（2）包含4-至8-元含氮环烷基的双环含氮环烃基和苯环稠合在一起; 和。＆cir＆_。＆cir＆_。＆cir＆_代表单一或双重债券。

9. 发明申请

WO1994020473A1 COMPOUND WITH VASOPRESSIN ANTAGONISM 审中-公开
标题翻译：化合物与VASOPRESSIN ANTAGONISM
公开(公告)号：WO1994020473A1
公开(公告)日：1994-09-15
申请号：PCT/JP1994000391
申请日：1994-03-10
申请人： YAMANOUCHI PHARMACEUTICAL CO., LTD. , MATSUHISA, Akira , TANAKA, Akihiro , SAKAMOTO, Ken-ichiro , MATSUMOTO, Yuzo , KIKUCHI, Kazumi , TANIGUCHI, Nobuaki , YATSU, Takeyuki , YANAGISAWA, Isao
发明人： YAMANOUCHI PHARMACEUTICAL CO., LTD.
IPC分类号： C07D223/16
CPC分类号： C07D223/16 , C07D243/12 , C07D401/12
摘要： A dihydrobenzazepine derivative of general formula (I-A), a tetrahydrobenzodiazepine derivative of general formula (I-B) or a tetrahydrobenzazepine derivative of general formula (I-C), a pharmaceutically acceptable salt thereof, and a pharmaceutical composition thereof, useful as an arginine vasopressin antagonist.
摘要翻译：通式（I-A）的二氢苯并吖庚因衍生物，通式（I-B）的四氢苯并二氮杂衍生物或通式（I-C）的四氢苯并吖庚因衍生物，其药学上可接受的盐及其药物组合物，可用作精氨酸加压素拮抗剂。

10. 发明申请

WO1994018195A1 NOVEL BENZOXAZINE DERIVATIVE, MEDICINE CONTAINING THE SAME, AND INTERMEDIATE THEREFOR 审中-公开
标题翻译：新的苯并噻嗪衍生物，含有它们的药物及其中间体
公开(公告)号：WO1994018195A1
公开(公告)日：1994-08-18
申请号：PCT/JP1994000174
申请日：1994-02-04
申请人： YAMANOUCHI PHARMACEUTICAL CO., LTD. , MATSUMOTO, Yuzo , UCHIDA, Wataru , YANAGISAWA, Isao
发明人： YAMANOUCHI PHARMACEUTICAL CO., LTD.
IPC分类号： C07D413/04
CPC分类号： C07D413/04 , C07D265/36
摘要： A benzoxazine derivative useful as a potassium channel activator and represented by general formula (I), a pharmaceutically acceptable salt thereof, a stereo-chemical isomer thereof, a medicinal composition containing the same, another benzoxazine derivative useful as an intermediate for the production thereof and represented by general formula (II), and a salt thereof. In formula (I), R represents hydrogen, lower alkyl, lower alkanoyl, carbamoyl, mono- or di(lower alkyl)carbamoyl or nitro; R represents lower alkyl; R represents nitro; m represents an integer of 1 to 4; and n represents 0 or 1. In formula (II), R , R , R and m are each as defined above.
摘要翻译：用作钾通道活化剂并由通式（I）表示的苯并恶嗪衍生物，其药学上可接受的盐，其立体化学异构体，含有它们的药用组合物，可用作其制备中间体的另一种苯并恶嗪衍生物和由通式（II）表示的化合物及其盐。在式（I）中，R 1表示氢，低级烷基，低级烷酰基，氨基甲酰基，一或二（低级烷基）氨基甲酰基或硝基; R 2表示低级烷基; R 3表示硝基; m表示1〜4的整数，并且n表示0或1.在式（II）中，R 1，R 2，R 3和m各自如上所定义。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式