专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO1994014796A1 NOVEL N-(PYRIDYLCARBONYL)BENZAZEPINE DERIVATIVE AND INTERMEDIATE THEREFOR 审中-公开
标题翻译：新型N-（吡咯烷基）苯并噻吩衍生物及其中间体
公开(公告)号：WO1994014796A1
公开(公告)日：1994-07-07
申请号：PCT/JP1993001838
申请日：1993-12-17
申请人： YAMANOUCHI PHARMACEUTICAL CO., LTD. , MATSUMOTO, Yuzo , TANAKA, Akihiro , MATSUHISA, Akira , KIKUCHI, Kazumi , SAKAMOTO, Ken-ichiro , YATSU, Takeyuki , YANAGISAWA, Isao
发明人： YAMANOUCHI PHARMACEUTICAL CO., LTD.
IPC分类号： C07D401/06
CPC分类号： C07D401/06
摘要： An N-(pyridylcarbonyl)benzazepine derivative represented by general formula (I) or a pharmaceutically acceptable salt thereof, useful for preventing and treating cardiac failure, hyponatremia, syndrome of inappropriate secretion of vasopressin (SIADH), hypertension, renal failure, edema, water metabolism disorder, and the like on the basis of arginine vasopressin receptor antagonism; and a benzazepinylcarbonylpyridine derivative represented by general formula (II) or a salt thereof, useful as an intermediate for the production of the compound (I) and so forth, wherein R represents hydrogen, lower alkyl, lower alkoxy, halogen, or phenyl which may be substituted by lower alkyl; X represents -NHCO- or -CON(R )-; n represents 0 or 1; and R represents hydrogen or (a) wherein R is as defined above, wherein n is as defined above; and Y represents COOH, activated carboxy, protected carboxy, or optionally protected HN(R )-.
摘要翻译：用于预防和治疗心力衰竭，低钠血症，加压素分泌不良综合征（SIADH），高血压，肾衰竭，水肿，水分的通式（I）表示的N-（吡啶基羰基）苯并氮杂衍生物或其药学上可接受的盐代谢障碍等，基于精氨酸加压素受体拮抗作用; 和由通式（II）表示的苯并氮杂基羰基吡啶衍生物或其盐，可用作制备化合物（I）等的中间体，其中R表示氢，低级烷基，低级烷氧基，卤素或苯基，被低级烷基取代; X表示-NHCO-或-CON（R 1） - ; n表示0或1; 并且R 1表示氢或（a）其中R如上定义，其中n如上所定义; 和Y代表COOH，活化的羧基，保护的羧基或任选被保护的HN（R 1） - 。

2. 发明申请

WO1995003305A1 FUSED BENZAZEPINE DERIVATIVE AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME 审中-公开
标题翻译：含有BENZAZEPINE衍生物和药物组合物
公开(公告)号：WO1995003305A1
公开(公告)日：1995-02-02
申请号：PCT/JP1994001183
申请日：1994-07-19
申请人： YAMANOUCHI PHARMACEUTICAL CO., LTD. , TANAKA, Akihiro , KOSHIO, Hiroyuki , TANIGUCHI, Nobuaki , MATSUHISA, Akira , SAKAMOTO, Ken-ichiro , YAMAZAKI, Atsuki , YATSU, Takeyuki
发明人： YAMANOUCHI PHARMACEUTICAL CO., LTD.
IPC分类号： C07D487/04
CPC分类号： C07D209/48 , C07D223/16 , C07D487/04 , C07D513/04
摘要： A nitrogenous aromatic 5-membered fused benzazepine derivative represented by general formula (I) and useful as an arginine vasopressin antagonist, a salt thereof, and a pharmaceutical composition containing the same as the active ingredient wherein B represents a nitrogenous aromatic 5-membered ring that may be substituted, has at least one nitrogen atom and may further have one oxygen or sulfur atom; R and R represent each independently hydrogen, halogen, lower alkyl, amino which may be substituted by lower alkyl, or lower alkoxy; A represents a single bond or -NHCO-(CR R )n-; n represents an integer of 0 to 3; R and R represent each independently hydrogen or lower alkyl, provided R and R may be combined together to form a C2-C7 alkylene; and C represents an optionally substituted benzene ring.
摘要翻译：由通式（I）表示的可用作精氨酸加压素拮抗剂的含氮芳族5元稠合苯并氮杂衍生物及其盐，以及含有该活性成分的药物组合物，其中B表示含氮芳族五元环，可以被取代，具有至少一个氮原子，并且还可以具有一个氧原子或硫原子; R 1和R 2各自独立地表示氢，卤素，低级烷基，可以被低级烷基或低级烷氧基取代的氨基; A表示单键或-NHCO-（CR 3 R 4）n - ; n表示0〜3的整数， R 3和R 4各自独立地表示氢或低级烷基，条件是R 3和R 4可以组合在一起形成C 2 -C 7亚烷基; C代表任选取代的苯环。

3. 发明申请

WO1994020473A1 COMPOUND WITH VASOPRESSIN ANTAGONISM 审中-公开
标题翻译：化合物与VASOPRESSIN ANTAGONISM
公开(公告)号：WO1994020473A1
公开(公告)日：1994-09-15
申请号：PCT/JP1994000391
申请日：1994-03-10
申请人： YAMANOUCHI PHARMACEUTICAL CO., LTD. , MATSUHISA, Akira , TANAKA, Akihiro , SAKAMOTO, Ken-ichiro , MATSUMOTO, Yuzo , KIKUCHI, Kazumi , TANIGUCHI, Nobuaki , YATSU, Takeyuki , YANAGISAWA, Isao
发明人： YAMANOUCHI PHARMACEUTICAL CO., LTD.
IPC分类号： C07D223/16
CPC分类号： C07D223/16 , C07D243/12 , C07D401/12
摘要： A dihydrobenzazepine derivative of general formula (I-A), a tetrahydrobenzodiazepine derivative of general formula (I-B) or a tetrahydrobenzazepine derivative of general formula (I-C), a pharmaceutically acceptable salt thereof, and a pharmaceutical composition thereof, useful as an arginine vasopressin antagonist.
摘要翻译：通式（I-A）的二氢苯并吖庚因衍生物，通式（I-B）的四氢苯并二氮杂衍生物或通式（I-C）的四氢苯并吖庚因衍生物，其药学上可接受的盐及其药物组合物，可用作精氨酸加压素拮抗剂。

4. 发明申请

WO1995006035A1 BENZAZEPINE DERIVATIVE, PHARMACEUTICAL COMPOSITION CONTAINING THE SAME, AND INTERMEDIATE FOR THE SAME 审中-公开
标题翻译：苯并噻吩衍生物，含有该化合物的药物组合物及其中间体
公开(公告)号：WO1995006035A1
公开(公告)日：1995-03-02
申请号：PCT/JP1994001409
申请日：1994-08-25
申请人： YAMANOUCHI PHARMACEUTICAL CO., LTD. , TANIGUCHI, Nobuaki , TANAKA, Akihiro , MATSUHISA, Akira , SAKAMOTO, Ken-ichiro , KISHIO, Hiroyuki , YATSU, Takeyuki
发明人： YAMANOUCHI PHARMACEUTICAL CO., LTD.
IPC分类号： C07D223/16
CPC分类号： C07D223/16 , C07D231/12 , C07D233/56 , C07D249/08 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D453/02
摘要： A benzazepine derivative, represented by general formula (I), useful as an arginine vasopressing antagonist; a pharmaceutically acceptable salt thereof; a pharmaceutical composition containing the same; and difluorobenzazepinone derivatives, represented by general formulae (II) and (III), useful as intermediates for producing the compound (I).
摘要翻译：由通式（I）表示的苯并氮杂衍生物可用作精氨酸血管加压拮抗剂; 其药学上可接受的盐; 含有该组合物的药物组合物; 和由通式（II）和（III）表示的二氟苯并氮杂酮衍生物，可用作制备化合物（I）的中间体。

5. 发明申请

WO1994012476A1 BENZANILIDE DERIVATIVE 审中-公开
标题翻译：苯扎林衍生物
公开(公告)号：WO1994012476A1
公开(公告)日：1994-06-09
申请号：PCT/JP1993001691
申请日：1993-11-18
申请人： YAMANOUCHI PHARMACEUTICAL CO., LTD. , KIKUCHI, Kazumi , TANAKA, Akihiro , MATSUHISA, Akira , MATSUMOTO, Yuzo , SAKAMOTO, Ken-ichiro , YATSU, Takeyuki , YANAGISAWA, Isao
发明人： YAMANOUCHI PHARMACEUTICAL CO., LTD.
IPC分类号： C07D223/16
CPC分类号： C07D223/16
摘要： A benzanilide derivative represented by general formula (I) or a pharmaceutically acceptable salt thereof, useful for preventing or treating cardiac insuffiency, hyponatremia, syndrome of inappropriate secretion of antidiuretic hormone (SIADH), hypertension, renal insufficiency, edema, water metabolism disorder, and so forth based on arginine vasopressin receptor antagonism. In formula (I), R represents optionally halogenated lower alkyl, hydroxy, lower alkoxy, nitro, amino, mono- or di(lower alkyl)amino, or lower alkanoylamino.
摘要翻译：用于预防或治疗心脏缺血，低钠血症，抗利尿激素分泌不良综合症（SIADH），高血压，肾功能不全，水肿，水代谢紊乱的通式（I）表示的苯甲酰苯胺衍生物或其药学上可接受的盐，因此基于精氨酸加压素受体拮抗作用。在式（I）中，R代表任选卤代的低级烷基，羟基，低级烷氧基，硝基，氨基，一或二（低级烷基）氨基或低级烷酰基氨基。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式