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1. 发明专利

CA909645A POWER SAW BLADE ATTACHMENT 未知
公开(公告)号：CA909645A
公开(公告)日：1972-09-12
申请号：CA909645D
申请人： SAKAMOTO SHUICHI , SAKAMOTO MINORU , NAGATO TOKUICHI
发明人： SAKAMOTO MINORU , NAGATO TOKUICHI

2. 发明申请

WO1995029891A1 N-(3-PYRROLIDINYL)BENZAMIDE DERIVATIVE 审中-公开
标题翻译： N-（3-吡咯烷基）苯甲酰胺衍生物
公开(公告)号：WO1995029891A1
公开(公告)日：1995-11-09
申请号：PCT/JP1995000818
申请日：1995-04-26
申请人： YAMANOUCHI PHARMACEUTICAL CO., LTD. , OHMORI, Junya , MAENO, Kyoichi , HIDAKA, Kazuyuki , NAKATO, Kazuhiro , SAKAMOTO, Shuichi , TSUKAMOTO, Shin-ichi
发明人： YAMANOUCHI PHARMACEUTICAL CO., LTD.
IPC分类号： C07D207/14
CPC分类号： C07D207/14
摘要： An N-(3-pyrrolidinyl)benzamide derivative represented by general formula (I) or a pharmaceutically acceptable salt thereof and a medicine containing the same, having a potent and selective antagonism against dopamine D3 and/or D4 receptors and useful as a psychotropic agent, schizophrenia remedy, and so forth. In said formula, R represents hydrogen, lower alkyl, aralkyl, or three- to eight-membered cycloalkyl or cycloalkyl-lower alkyl; R represents four- to sixteen-membered bi- or tricyclic bridged hydrocarbon group; R represents lower alkoxy, amino, or mono- or di(lower alkyl)amino; R represents hydrogen, halogen, optionally hydroxylated lower alkyl, lower alkoxy, cyano, nitro, amino, mono- or di(lower alkyl)amino, acyl or -S(O)m-R ; R represents lower alkyl, amino or mono- or di(lower alkyl)amino; m represents 0, 1 or 2; X represents a bond, -O-, -S(O)n-, -NH- or -CONH-; and n represents 0, 1 or 2; provided when R represents cycloalkyl, the case where X represents -CONH-, R represents lower alkoxy and R represents halogen is excepted.
摘要翻译：由通式（I）表示的N-（3-吡咯烷基）苯甲酰胺衍生物或其药学上可接受的盐和含有它们的药物，具有对多巴胺D3和/或D4受体的有效和选择性拮抗作用并用作精神药物，精神分裂症补救等等。在所述式中，R 1表示氢，低级烷基，芳烷基或三至八元环烷基或环烷基 - 低级烷基; R 2表示四至十六元的二环或三环桥连烃基; R 3表示低级烷氧基，氨基或单或二（低级烷基）氨基; R 4表示氢，卤素，任选羟基化的低级烷基，低级烷氧基，氰基，硝基，氨基，单或二（低级烷基）氨基，酰基或-S（O）m -R 5。 R 5表示低级烷基，氨基或一或二（低级烷基）氨基; m表示0,1或2; X表示键，-O - ， - S（O）n - ， - NH-或-CONH-; n表示0,1或2; 当R 1表示环烷基时，其中X表示-CONH-，R 3表示低级烷氧基，R 4表示卤素的情况除外。

3. 发明申请

WO1994026737A1 IMIDAZOLYLQUINOXALINEDIONE DERIVATIVE AND PHARMACEUTICAL COMPOSITION THEREOF 审中-公开
标题翻译：咪唑啉酮衍生物及其药物组合物
公开(公告)号：WO1994026737A1
公开(公告)日：1994-11-24
申请号：PCT/JP1994000758
申请日：1994-05-11
申请人： YAMANOUCHI PHARMACEUTICAL CO., LTD. , SAKAMOTO, Shuichi , SHISHIKURA, Jun-ichi , IWATA, Masahiro , OKADA, Masamichi , SASAMATA, Masao
发明人： YAMANOUCHI PHARMACEUTICAL CO., LTD.
IPC分类号： C07D403/04
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08
摘要： An imidazolylquinoxalinedione derivative, represented by general formula (I), useful as a glutamate receptor antagonist, a pharmaceutically acceptable salt thereof, and a pharmaceutical composition containing the same as the active ingredient, wherein R represents hydrogen or lower alkyl; R represents hydrogen or hydroxy; X represents -O-, -NR - or -S(O)n-; R represents hydrogen or lower alkyl; n represents 0, 1 or 2; A represents a direct bond or lower alkylene; and R represents (1) lower alkyl, (2) carboxy, or (3) phenyl, cycloalkyl or mono- or bicyclic heterocyclic group wherein the heteroatom(s) is(are) N and/or S, each of which may be substituted.
摘要翻译：用作谷氨酸受体拮抗剂的通式（I）表示的咪唑并喹喔啉二酮衍生物及其药学上可接受的盐，以及含有该活性成分的药物组合物，其中R 1表示氢或低级烷基; R 2表示氢或羟基; X表示-O-，-NR 4 - 或-S（O）n - ; R 4代表氢或低级烷基; n表示0,1或2; A表示直接键或低级亚烷基; 并且R 3表示（1）低级烷基，（2）羧基或（3）苯基，环烷基或单环或双环杂环基，其中杂原子为（或）N和/或S，可以被替代。

4. 发明申请

WO1993020718A1 FOOD COMPOSITION WHICH INHIBITS FORMATION OF INTESTINAL PUTREFACTION PRODUCT 审中-公开
标题翻译：抑制肠内营养产品形成的食品组合物
公开(公告)号：WO1993020718A1
公开(公告)日：1993-10-28
申请号：PCT/JP1993000436
申请日：1993-04-02
申请人： OTSUKA PHARMACEUTICAL CO., LTD. , TAKAICHI, Akihisa , OKAMOTO, Toshihiko , AZUMA, Yoshihide , WATANABE, Yoshinari , MATSUMOTO, Toshiaki , MIYATA, Katsuya , SAKAMOTO, Shuichi , OKAMATSU, Hiroshi , KUMEMURA, Megumi
发明人： OTSUKA PHARMACEUTICAL CO., LTD.
IPC分类号： A23L01/30
CPC分类号： A23G3/346 , A23G2200/06 , A23L2/40 , A23L2/60 , A23L5/00 , A23L29/30 , A23L33/125 , A61K31/70 , A61K45/06 , Y10S426/804 , A61K2300/00
摘要： A food composition which inhibits the formation of intestinal putrefaction products and which contains lactosucrose as the active ingredient. It is efficacious in preventing various cancers wherein the putrefaction products may play a role as a promoter, because it is lowly calorific in virtue of the difficult digestibility of the lactosucrose and it can reduce the amount of intestinal putrefaction products.
摘要翻译：一种抑制肠腐败产品形成并含有乳糖作为活性成分的食物组合物。由于由于乳糖蔗糖的难消化率而导致低热量，因此可以预防各种癌症，其中腐败产品可能起促进剂的作用，并且可以减少肠腐败产物的量。

5. 发明申请

WO1994025450A1 SERINE DERIVATIVE 审中-公开
标题翻译：丝氨酸衍生物
公开(公告)号：WO1994025450A1
公开(公告)日：1994-11-10
申请号：PCT/JP1994000697
申请日：1994-04-26
申请人： YAMANOUCHI PHARMACEUTICAL CO., LTD. , NODA, Ichio , IWATA, Masahiro , SAKAMOTO, Shuichi , KOSHIYA, Kazuo , MORITA, Takuma , KOHARA, Atsuyuki
发明人： YAMANOUCHI PHARMACEUTICAL CO., LTD.
IPC分类号： C07D307/52
CPC分类号： C07D409/06 , C07D307/52 , C07D307/54 , C07D333/20 , C07D333/24 , Y02P20/55
摘要： A serine derivative represented by general formula (I) or a pharmaceutically acceptable salt thereof, having an anti-PCP(phencyclidine) activity and being useful as a psychotropic, wherein X represents sulfur or oxygen; Y represents nitrogen or CH; R and R represent each independently hydrogen, lower alkyl or an amino-protecting group, or R and R may be combined together to form 4- to 9-membered nitrogenous cycloalkyl; R represents hydrogen, carboxy, protected carboxy, aralkyl, or lower alkyl which may be hydroxylated; R represents hydrogen or hydroxy; R represents hydrogen or lower alkyl; A represents lower alkylene; B represents (1) an (un)saturated 4- to 10-membered nitrogenous cycloalkyl group which may be substituted by lower alkyl or aralkyl, or (2) a bicyclic nitrogenous hydrocarbon ring group comprising a 4- to 8-membered nitrogenous cycloalkyl group and a benzene ring fused together; and . &cir& _. &cir& _. &cir& _ represents a single or a double bond.
摘要翻译：由通式（I）表示的丝氨酸衍生物或其药学上可接受的盐，具有抗PCP（苯环利定）活性，可用作精神药物，其中X表示硫或氧; Y表示氮或CH; R 1和R 2各自独立地表示氢，低级烷基或氨基保护基，或者R 1和R 2可以组合在一起形成4-至9-元含氮环烷基; R 3表示氢，羧基，保护的羧基，芳烷基或可被羟基化的低级烷基; R 4表示氢或羟基; R 5表示氢或低级烷基; A表示低级亚烷基; B表示（1）可被低级烷基或芳烷基取代的（未）饱和的4-至10-元含氮环烷基，或（2）包含4-至8-元含氮环烷基的双环含氮环烃基和苯环稠合在一起; 和。＆cir＆_。＆cir＆_。＆cir＆_代表单一或双重债券。

6. 发明申请

WO1994010858A1 FEEDING COMPOSITION 审中-公开
标题翻译：饲料组合物
公开(公告)号：WO1994010858A1
公开(公告)日：1994-05-26
申请号：PCT/JP1993001624
申请日：1993-11-08
申请人： OTSUKA PHARMACEUTICAL CO., LTD. , SAKAMOTO, Shuichi , OKAMATSU, Hiroshi , OKAMURA, Koji , TAKAICHI, Akihisa , OKAMOTO, Toshihiko , FUKUDA, Tetsuo
发明人： OTSUKA PHARMACEUTICAL CO., LTD.
IPC分类号： A23L01/28
CPC分类号： A23L33/175
摘要： A feeding composition containing an insulin-secretomotor amino acid and an antioxidant food material as the essential ingredients, which is useful in feeding for making up for the loss of stamina after exercise and the fatigue, inhibiting free-radical formation due to hyperpnea occurring during exercise, and furnishing vitamins.
摘要翻译：含有胰岛素分泌运动氨基酸和抗氧化食品材料作为必需成分的饲料组合物，其可用于补充运动后的耐力丧失和疲劳，抑制由于运动期间发生的呼吸过多引起的自由基形成，并提供维生素。

7. 发明申请

WO1992007847A1 FUSED PYRAZINE DERIVATIVE 审中-公开
标题翻译：熔化的吡嗪衍生物
公开(公告)号：WO1992007847A1
公开(公告)日：1992-05-14
申请号：PCT/JP1991001498
申请日：1991-11-01
申请人： YAMANOUCHI PHARMACEUTICAL CO., LTD. , SAKAMOTO, Shuichi , OHMORI, Jun-ya , KUBOTA, Hirokazu , SASAMATA, Masao , OKADA, Masamichi , HIDAKA, Kazuyuki
发明人： YAMANOUCHI PHARMACEUTICAL CO., LTD.
IPC分类号： C07D403/04
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08 , C07D403/04
摘要： A pyrazine derivative which inhibits glutamate receptor, represented by general formula (Ia) wherein Z represents C or N, provided that two Zs are not N atoms at the same time; R1 represents (1a) wherein X represents N or R8C, R6 represents H or alkyl, and R?7 and R8¿ represent each H, alkyl, nitro or phenyl, or alternatively R?7 and R8¿ are combined together to represent butadienylene or 1,4-butylene; R?2 and R3¿ represent each H, F, cyano, acyl, nitro, alkyl, morpholino or R?1; R4 and R5¿ represent each H, hydroxy, alkyl, cycloalkyl, heterocycle, pherryl or Y-substituted alkyl; Y represents hydroxy, acyloxy, F-substituted methyl, cycloalkyl, tetrahydrofuryl, carboxyl, alkoxy carbonyl or NR?9R10; and R9 and R10¿ represent H or alkyl, or alternatively R?9 and R10¿ are combined together to represent a 5- or 6-membered cyclic group which may contain oxygen atom(s).

8. 发明申请

WO1996010023A1 1,2,3,4-TETRAHYDROQUINOXALINDIONE DERIVATIVE 审中-公开
标题翻译： 1,2,3,4-四氢喹啉酮衍生物
公开(公告)号：WO1996010023A1
公开(公告)日：1996-04-04
申请号：PCT/JP1995001922
申请日：1995-09-25
申请人： YAMANOUCHI PHARMACEUTICAL CO., LTD. , SHISHIKURA, Jun-ichi , INAMI, Hiroshi , SAKAMOTO, Shuichi , TSUKAMOTO, Shin-ichi , SASAMATA, Masao , OKADA, Masamichi , FUJII, Mitsuo
发明人： YAMANOUCHI PHARMACEUTICAL CO., LTD.
IPC分类号： C07D403/04
CPC分类号： C07D231/12 , C07D233/56 , C07D241/44 , C07D249/08
摘要： A 1,2,3,4-tetrahydroquinoxalindione derivative represented by general formula (I) or a salt thereof, an NMDA-glycine receptor and/or AMPA receptor antagonist and a kainate neurocytotoxicity inhibitor each containing the same, and a medicinal composition comprising the above-mentioned compound and pharmaceutically acceptable carriers: wherein X represents N or CH; R represents imidazolyl or di(lower alkyl)amino; R represents (1) halogeno, nitro, cyano, carboxy, amino, mono- or di(lower alkyl)amino, lower alkanoyl, lower alkylthio, lower alkylsulfinyl, lower alkylsulfonyl, or carbamoyl, (2) lower alkyl or lower alkoxy which may be substituted by halogeno, carboxy or aryl, or (3) phenyloxy which may be substituted by lower alkoxycarbonyl or carboxy; R represents hydroxy, lower alkoxy, amino, or mono- or di(lower alkyl)amino; and A represents optionally substituted alkylene or -O-B- (B being lower alkylene); provided the case wherein R represents imidazolyl, R represents cyano, A represents ethylene and R represents hydroxy is excepted.
摘要翻译：由通式（I）表示的1,2,3,4-四氢喹喔啉二酮衍生物或其盐，NMDA-甘氨酸受体和/或AMPA受体拮抗剂和各自含有它们的红藻氨酸神经细胞毒素抑制剂，以及药物组合物，上述化合物和药学上可接受的载体：其中X表示N或CH; R代表咪唑基或二（低级烷基）氨基; R 1表示（1）卤代，硝基，氰基，羧基，氨基，单或二（低级烷基）氨基，低级烷酰基，低级烷硫基，低级烷基亚磺酰基，低级烷基磺酰基或氨基甲酰基，（2）低级烷基或低级可被卤素，羧基或芳基取代的烷氧基，或（3）可被低级烷氧基羰基或羧基取代的苯氧基; R 2表示羟基，低级烷氧基，氨基或单或二（低级烷基）氨基; 和A表示任选取代的亚烷基或-O-B-（B是低级亚烷基）; 条件是其中R表示咪唑基，R 1表示氰基，A表示亚乙基，R 2表示羟基。

9. 发明申请

WO1994026133A1 ANTIOXIDANT FOOD, ANTIOXIDANT PREPARATION AND ANTIOXIDIZATION METHOD 审中-公开
标题翻译：抗氧化剂，抗氧化剂制剂和抗氧化方法
公开(公告)号：WO1994026133A1
公开(公告)日：1994-11-24
申请号：PCT/JP1994000753
申请日：1994-05-09
申请人： OTSUKA PHARMACEUTICAL CO., LTD. , TOBA, Masamichi , UCHIYAMA, Shigeto , OHTA, Reiko , SHIMIZU, Seiichi , SAKAMOTO, Shuichi
发明人： OTSUKA PHARMACEUTICAL CO., LTD.
IPC分类号： A23L03/3472
CPC分类号： A23C9/1234 , A23B7/10 , A23C9/1307 , A23F3/10 , A23L3/3472 , A23L3/3571 , A23Y2220/67 , A61K35/747 , A61K36/82 , A61K2300/00
摘要： An antioxidant food comprising a product of fermentation of a food containing a manganese-containing natural material, such as tea leaves, by using a microbe having a catalase activity, such as Lactobacillus plantarum. It has both a superoxide dismutase-like activity and a catalase activity and hence exhibits an antioxidant activity in the body of a living organism, including the digestive tract. Therefore it is efficacious in preventing diseases caused by active oxygen.
摘要翻译：一种抗氧化食品，其通过使用具有过氧化氢酶活性的微生物，如植物乳杆菌（Lactobacillus plantarum），包含含有含锰天然物质的食物如茶叶的发酵产物。它具有超氧化物歧化酶样活性和过氧化氢酶活性，因此在包括消化道在内的活体的体内表现出抗氧化活性。因此，有效预防活性氧引起的疾病。

10. 发明申请

WO1993020077A1 FUSED QUINOXALINONE DERIVATIVE AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME 审中-公开
标题翻译：熔化的喹唑啉酮衍生物和含有它们的药物组合物
公开(公告)号：WO1993020077A1
公开(公告)日：1993-10-14
申请号：PCT/JP1993000357
申请日：1993-03-25
申请人： YAMANOUCHI PHARMACEUTICAL CO., LTD. , SAKAMOTO, Shuichi , OHMORI, Jun-ya , SASAMATA, Masao , OKADA, Masamichi , HIDAKA, Kazyuki
发明人： YAMANOUCHI PHARMACEUTICAL CO., LTD.
IPC分类号： C07D487/04
CPC分类号： C07D487/04
摘要： A fused quinoxalinone derivative represented by general formula (I), a tautomeric isomer thereof, a pharmaceutically acceptable salt or hydrate thereof, or a pharmaceutical composition containing the same, which has a glutamate receptor antagonism and is useful as anti-ischemic and pshychotropic, wherein alpha represents a 5-membered heterocyclic group containing two or three nitrogen atoms, R represents nitro or trifluoromethyl, X represents (a), (b), (c) or (d), and R , R , R , R and R may be the same or different from one another and each represents hydrogen or lower alkyl which may be substituted by mono- or di(lower alkyl)amino.
摘要翻译：由通式（I）表示的稠合喹喔啉酮衍生物，其互变异构体，其药学上可接受的盐或水合物或含有该稠合喹喔啉酮衍生物的药物组合物，其具有谷氨酸受体拮抗作用并且可用作抗缺血性和嗜中性焦虑剂，其中 α表示含有两个或三个氮原子的5元杂环基，R 1表示硝基或三氟甲基，X表示（a），（b），（c）或（d），R 2， R 3，R 5和R 6可以彼此相同或不同，并且各自表示氢或可以被一或二（低级烷基）氨基取代的低级烷基。

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