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    • 2. 发明授权
    • Systems and methods for drug delivery including treating thrombosis by
driving a drug or lytic agent through the thrombus by pressure
    • 用于药物递送的系统和方法,包括通过压力通过血栓驱动药物或溶解剂来治疗血栓形成
    • US5925016A
    • 1999-07-20
    • US534856
    • 1995-09-27
    • Victor I. ChornenkyMichael R. Forman
    • Victor I. ChornenkyMichael R. Forman
    • A61F2/958A61M25/00A61M29/00
    • A61M25/09A61M25/10A61M2025/0047A61M2025/09008A61M2025/09083A61M2025/1052A61M2205/36A61M25/007A61M25/1011
    • Systems and methods for treating thrombosis by driving the drugs or lytic agents through the thrombus by pressure, are disclosed. The system preferably comprises a guide catheter with an occlusion balloon for isolating the region proximal to the thrombus, a guide wire with an occlusion balloon for isolating the region distal to the thrombus and an infusion catheter for delivering drugs or other agents into the region distal to the thrombus under pressure. A lumen of the guide catheter is preferably provided to evacuate material proximal to the thrombus, decreasing the pressure in the proximal to the thrombus. The lumen can be coupled to a thrombus filter to remove thrombolytic material from the drug or lytic agent evacuated from the proximal region. The filtered drug or lytic agent can then be redelivered into the distal region. Recycling of the drug or lytic agent in this manner decreases the costs of the procedure. The systems and methods of the invention can be used to treat other blockages in lumens or vessels in the body or to deliver drugs or other agents to lumens, vessels or cavities within the body, as well.
    • 公开了通过压力驱动药物或溶解剂通过血栓来治疗血栓形成的系统和方法。 该系统优选地包括具有用于隔离接近血栓的区域的阻塞球囊的引导导管,具有用于隔离远离血栓的区域的闭塞气囊的导丝和用于将药物或其它药剂递送到远端的区域的输注导管 血栓在压力下。 优选地,引导导管的内腔用于抽吸靠近血栓的材料,从而降低血栓近端的压力。 管腔可以联接到血栓过滤器以从药物或从近端区域排出的溶解剂中除去血栓溶解物质。 然后将过滤的药物或溶解剂再次送入远端区域。 以这种方式回收药物或溶解剂降低了程序的成本。 本发明的系统和方法可用于治疗身体内腔或血管中的其它阻塞物,或者将药物或其它药物递送至体内的流明,血管或空腔。