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1. 发明授权

US06799075B1 X-ray catheter 失效
标题翻译： X光导管
公开(公告)号：US06799075B1
公开(公告)日：2004-09-28
申请号：US08701764
申请日：1996-08-22
申请人： Victor I. Chornenky , Michael R. Forman
发明人： Victor I. Chornenky , Michael R. Forman
IPC分类号： A61B1818
CPC分类号： A61N5/1001 , A61N5/1002 , A61N2005/1003 , H01J35/32 , H01J2201/304 , H01J2201/306
摘要： A catheter for emitting radiation is disclosed, comprising a catheter shaft and an x-ray unit attached to the distal end of the catheter shaft. The x-ray unit comprises an anode and a cathode coupled to an insulator to define a vacuum chamber. The cathode is preferably a field emission cathode of graphite or graphite coated with titanium carbide, for example. The anode is preferably tungsten and the insulator is preferably pyrolytic boron nitride. The x-ray unit is preferably coupled to a voltage source through a coaxial cable. The anode is preferably a heavy metal such as tungsten. The cathode may also be a ferroelectric material. The x-ray unit can have a diameter less than about 4 mm and a length less than about 15 mm. Methods of use of the catheter are also disclosed. The catheter of the present invention can be used to irradiate the site of an angioplasty procedure to prevent restenosis. It can also be used to treat other conditions in any vessel, lumen or cavity of the body.
摘要翻译：公开了一种用于发射辐射的导管，包括导管轴和附接到导管轴的远端的x射线单元。 x射线单元包括阳极和阴极，其耦合到绝缘体以限定真空室。阴极优选为例如涂覆有碳化钛的石墨或石墨的场致发射阴极。阳极优选为钨，绝缘体优选为热解氮化硼。 X射线单元优选地通过同轴电缆耦合到电压源。阳极优选为重金属，例如钨。阴极也可以是铁电材料。 x射线单元的直径可以小于约4毫米，长度小于约15毫米。还公开了导管的使用方法。本发明的导管可用于照射血管成形术程序的部位以防止再狭窄。它也可以用于治疗身体的任何血管，腔或腔中的其他病症。

2. 发明授权

US07338487B2 Device for delivering localized x-ray radiation and method of manufacture 失效
标题翻译：用于递送局部X射线辐射的装置和制造方法
公开(公告)号：US07338487B2
公开(公告)日：2008-03-04
申请号：US10010911
申请日：2001-11-20
申请人： Victor I. Chornenky , Michael R. Forman
发明人： Victor I. Chornenky , Michael R. Forman
IPC分类号： A61B18/18 , A61B5/10
CPC分类号： A61N5/1001 , A61N5/1002 , A61N2005/1003 , H01J35/32 , H01J2201/304 , H01J2201/306
摘要： Generally, the present invention provides a device for insertion into a body of a subject being treated to deliver localized x-ray radiation, and a method for fabricating such a device. The device includes a cathode structure that has a thin, diamond film as a cathode. The device further comprises a vacuum housing and an anode. A method for fabricating a device for localized x-ray radiation is described which includes the formation of a thin diamond film on a getter at temperatures below an activation temperature of the getter.
摘要翻译：通常，本发明提供一种用于插入被处理以递送局部x射线辐射的对象的身体的装置，以及用于制造这种装置的方法。该器件包括具有薄的金刚石膜作为阴极的阴极结构。该装置还包括真空壳体和阳极。描述了一种用于制造用于局部x射线辐射的装置的方法，其包括在低于吸气剂的活化温度的温度下在吸气剂上形成薄金刚石膜。

3. 发明授权

US06280413B1 Thrombolytic filtration and drug delivery catheter with a self-expanding portion 失效
标题翻译：具有自膨胀部分的溶栓过滤和药物输送导管
公开(公告)号：US06280413B1
公开(公告)日：2001-08-28
申请号：US08889432
申请日：1997-07-08
申请人： David W. Clark , Souise S. Clark , Victor I. Chornenky , Michael R. Forman , Jeffrey A. Lee
发明人： David W. Clark , Souise S. Clark , Victor I. Chornenky , Michael R. Forman , Jeffrey A. Lee
IPC分类号： A61M2900
CPC分类号： A61M25/0082 , A61F2/013 , A61F2230/0006 , A61F2230/005 , A61M25/0071 , A61M25/0074 , A61M2025/0057
摘要： A thrombolytic filtration and drug delivery catheter is disclosed comprising a shaft which longitudinal ribs. The ribs are compressed while being advanced to the site of interest and are released at the site, flaring to a diameter greater than the diameter of the shaft. The ribs can be compressed by a sleeve or thread, for example. Drugs or other agents can be delivered through lumens in the shaft and ribs, out through ports in the ribs. Preferably, the ports are positioned to deliver the drugs or other agents between the ribs and within the region defined by the ribs.
摘要翻译：公开了溶栓过滤和药物递送导管，其包括纵轴的轴。肋骨被压缩，同时前进到感兴趣的部位，并在现场释放，扩张到比轴的直径大。例如，可以通过套筒或螺纹将肋压缩。药物或其他药剂可以通过轴和肋中的腔进出，通过肋中的端口排出。优选地，端口被定位成在肋之间并且在由肋限定的区域内递送药物或其它药剂。

4. 发明授权

US5925016A Systems and methods for drug delivery including treating thrombosis by driving a drug or lytic agent through the thrombus by pressure 失效
标题翻译：用于药物递送的系统和方法，包括通过压力通过血栓驱动药物或溶解剂来治疗血栓形成
公开(公告)号：US5925016A
公开(公告)日：1999-07-20
申请号：US534856
申请日：1995-09-27
申请人： Victor I. Chornenky , Michael R. Forman
发明人： Victor I. Chornenky , Michael R. Forman
IPC分类号： A61F2/958 , A61M25/00 , A61M29/00
CPC分类号： A61M25/09 , A61M25/10 , A61M2025/0047 , A61M2025/09008 , A61M2025/09083 , A61M2025/1052 , A61M2205/36 , A61M25/007 , A61M25/1011
摘要： Systems and methods for treating thrombosis by driving the drugs or lytic agents through the thrombus by pressure, are disclosed. The system preferably comprises a guide catheter with an occlusion balloon for isolating the region proximal to the thrombus, a guide wire with an occlusion balloon for isolating the region distal to the thrombus and an infusion catheter for delivering drugs or other agents into the region distal to the thrombus under pressure. A lumen of the guide catheter is preferably provided to evacuate material proximal to the thrombus, decreasing the pressure in the proximal to the thrombus. The lumen can be coupled to a thrombus filter to remove thrombolytic material from the drug or lytic agent evacuated from the proximal region. The filtered drug or lytic agent can then be redelivered into the distal region. Recycling of the drug or lytic agent in this manner decreases the costs of the procedure. The systems and methods of the invention can be used to treat other blockages in lumens or vessels in the body or to deliver drugs or other agents to lumens, vessels or cavities within the body, as well.
摘要翻译：公开了通过压力驱动药物或溶解剂通过血栓来治疗血栓形成的系统和方法。该系统优选地包括具有用于隔离接近血栓的区域的阻塞球囊的引导导管，具有用于隔离远离血栓的区域的闭塞气囊的导丝和用于将药物或其它药剂递送到远端的区域的输注导管血栓在压力下。优选地，引导导管的内腔用于抽吸靠近血栓的材料，从而降低血栓近端的压力。管腔可以联接到血栓过滤器以从药物或从近端区域排出的溶解剂中除去血栓溶解物质。然后将过滤的药物或溶解剂再次送入远端区域。以这种方式回收药物或溶解剂降低了程序的成本。本发明的系统和方法可用于治疗身体内腔或血管中的其它阻塞物，或者将药物或其它药物递送至体内的流明，血管或空腔。

5. 发明授权

US06377846B1 Device for delivering localized x-ray radiation and method of manufacture 失效
标题翻译：用于递送局部X射线辐射的装置和制造方法
公开(公告)号：US06377846B1
公开(公告)日：2002-04-23
申请号：US08806244
申请日：1997-02-21
申请人： Victor I. Chornenky , Michael R. Forman
发明人： Victor I. Chornenky , Michael R. Forman
IPC分类号： A61N130
CPC分类号： A61N5/1001 , A61N5/1002 , H01J35/32 , H01J2235/205
摘要： Generally, the present invention provides a device for insertion into a body of a subject being treated to deliver localized x-ray radiation, and a method for fabricating such a device. The device includes a cathode structure that has a thin, diamond film as a cathode. The device further comprises a vacuum housing and an anode. A method for fabricating a device for localized x-ray radiation is described which includes the formation of a thin diamond film on a getter at temperatures below an activation temperature of the getter.
摘要翻译：通常，本发明提供一种用于插入被处理以递送局部x射线辐射的对象的身体的装置，以及用于制造这种装置的方法。该器件包括具有薄的金刚石膜作为阴极的阴极结构。该装置还包括真空壳体和阳极。描述了一种用于制造用于局部x射线辐射的装置的方法，其包括在低于吸气剂的活化温度的温度下在吸气剂上形成薄金刚石膜。

6. 发明授权

US6095966A X-ray device having a dilation structure for delivering localized radiation to an interior of a body 失效
标题翻译：具有用于将局部辐射传送到身体内部的扩张结构的X射线装置
公开(公告)号：US6095966A
公开(公告)日：2000-08-01
申请号：US27010
申请日：1998-02-20
申请人： Victor I. Chornenky , Michael R. Forman , Robert A. Ganz
发明人： Victor I. Chornenky , Michael R. Forman , Robert A. Ganz
IPC分类号： A61N5/10 , H01J35/32
CPC分类号： A61N5/1001 , H01J35/32 , A61N5/1002 , H01J2235/205
摘要： Generally, the present invention provides a device for insertion into a body of a subject being treated to deliver localized x-ray radiation, and a method for use of such a device. The device includes an anode and a cathode, disposed within a vacuum housing. The device further includes a balloon coupled to and circumferentially surrounding the vacuum housing, and a fluid loop for circulating a cooling fluid proximate to the vacuum housing. A method for delivering localized x-ray radiation to an interior passage of a body is also described, including the steps of positioning an x-ray device at the passage to be treated and applying a high voltage to the x-ray producing unit to produce localized x-ray radiation.
摘要翻译：通常，本发明提供一种用于插入被处理以递送局部x射线辐射的对象的身体的装置，以及使用这种装置的方法。该装置包括设置在真空壳体内的阳极和阴极。该装置还包括联接到并围绕真空壳体并围绕真空壳体的气囊，以及用于使靠近真空壳体的冷却流体循环的流体回路。还描述了将局部X射线辐射递送到身体的内部通道的方法，包括以下步骤：将X射线装置定位在待治疗的通道处，并向x射线产生单元施加高电压以产生局部x射线辐射。

7. 发明授权

US5854822A Miniature x-ray device having cold cathode 失效
标题翻译：具有冷阴极的微型x射线装置
公开(公告)号：US5854822A
公开(公告)日：1998-12-29
申请号：US900609
申请日：1997-07-25
申请人： Victor I. Chornenky , Dale L. Schreiner , Michael R. Forman
发明人： Victor I. Chornenky , Dale L. Schreiner , Michael R. Forman
IPC分类号： H01J35/06 , A61N5/10 , H01J35/20 , H01J35/32
CPC分类号： A61N5/1001 , H01J35/32 , A61N5/1002
摘要： Generally, the present invention provides a device for insertion into a body and delivery of x-ray radiation, and a method for fabricating such a device. The device includes a connector, the vacuum housing, an anode and a cathode having a granular surface and being composed of a material that allows it to act as a getter. The cathode may also contain diamond material in one embodiment.
摘要翻译：通常，本发明提供了一种用于插入身体和X射线辐射的输送的装置，以及用于制造这种装置的方法。该装置包括连接器，真空壳体，具有颗粒表面的阳极和阴极，并且由允许其用作吸气剂的材料组成。在一个实施方案中，阴极还可以含有金刚石材料。

8. 发明授权

US06503224B1 Perfusion balloon catheter 有权
标题翻译：灌注气囊导管
公开(公告)号：US06503224B1
公开(公告)日：2003-01-07
申请号：US09631750
申请日：2000-08-04
申请人： Michael R. Forman , Jonathan S. Stinson , Michael N. Helmus
发明人： Michael R. Forman , Jonathan S. Stinson , Michael N. Helmus
IPC分类号： A61M2900
CPC分类号： A61M25/104 , A61B2017/00685 , A61M1/101 , A61M1/1018 , A61M1/1036 , A61M1/122 , A61M1/125 , A61M1/127 , A61M25/00 , A61M29/02 , A61M2025/1095
摘要： A balloon catheter having a perfusion lumen communicating with a blood vessel, and a magnetically driven impeller disposed in the perfusion lumen to increase blood flow through the catheter and the arteries.
摘要翻译：具有与血管连通的灌注腔的气囊导管和设置在灌注腔内的磁驱动叶轮以增加通过导管和动脉的血流。

9. 发明授权

US06265016B1 Process for the preparation of slippery, tenaciously adhering, hydrophilic polyurethane hydrogel coatings, coated polymer and metal substrate materials, and coated medical devices 有权
标题翻译：用于制备光滑，坚固粘附的亲水性聚氨酯水凝胶涂层，涂覆聚合物和金属基底材料以及涂覆的医疗装置的方法
公开(公告)号：US06265016B1
公开(公告)日：2001-07-24
申请号：US09531925
申请日：2000-03-21
申请人： Fritz Hostettler , David Rhum , Michael R. Forman , Michael N. Helmus , Ni Ding
发明人： Fritz Hostettler , David Rhum , Michael R. Forman , Michael N. Helmus , Ni Ding
IPC分类号： B05D302
CPC分类号： C08J7/047 , A61L29/085 , A61L31/10 , C08G18/10 , C08G18/283 , C08G2230/00 , C08J7/04 , C08J2475/00 , Y10T428/31554 , Y10T428/31562 , Y10T428/31565 , Y10T428/31569 , Y10T428/31587 , Y10T428/31678 , A61L31/145 , A61L29/145 , C08L75/04 , C08G18/307 , C08G18/3225
摘要： A process for the preparation of slippery, hydrophilic polyurethane hydrogel coating compositions, and materials composed of a polymeric plastic or rubber substrate or a metal substrate with a coating of a slippery, hydrophilic polyurethane hydrogel thereon, such that the coating composition tenaciously adheres to the substrate, are disclosed. The coating compositions and coated materials are non-toxic and biocompatible, and are ideally suited for use on medical devices, particularly, catheters, catheter balloons and stents. The coating compositions, coated materials and coated devices demonstrate low coefficients of friction in contact with body fluids, especially blood, as well as a high degree of wear permanence over prolonged use of the device. The hydrogel coating compositions are capable of being dried to facilitate storage of the devices to which they have been applied, and can be instantly reactivated for later use by exposure to water.
摘要翻译：用于制备光滑的亲水性聚氨酯水凝胶涂料组合物的方法，以及由聚合物塑料或橡胶基材或金属基材组成的材料，其上具有光滑的亲水性聚氨酯水凝胶涂层，使得涂料组合物顽固地粘附于基材，被披露。涂料组合物和涂层材料是无毒的和生物相容的，并且理想地适用于医疗装置，特别是导管，导管气囊和支架。涂层组合物，涂覆材料和涂覆的装置表现出与体液，特别是血液接触的低摩擦系数，以及在长时间使用该装置时高度的磨损持久性。水凝胶涂料组合物能够被干燥以促进其已被施加到其上的装置的储存，并且可以立即重新活化以便随后通过暴露于水中使用。

10. 发明授权

US6030656A Process for the preparation of slippery, tenaciously adhering, hydrophilic polyurethane hydrogel coatings, coated metal substrate materials, and coated medical devices 失效
标题翻译：用于制备光滑，坚固粘附，亲水性聚氨酯水凝胶涂层，涂覆金属基材和涂覆医疗装置的方法
公开(公告)号：US6030656A
公开(公告)日：2000-02-29
申请号：US126375
申请日：1998-03-24
申请人： Fritz Hostettler , David Rhum , Michael R. Forman , Michael N. Helmus , Ni Ding
发明人： Fritz Hostettler , David Rhum , Michael R. Forman , Michael N. Helmus , Ni Ding
IPC分类号： A61L29/08 , A61L31/10 , C08G18/10 , C08G18/28 , C08J7/04 , B05D7/14
CPC分类号： C08J7/047 , A61L29/085 , A61L31/10 , C08G18/10 , C08G18/283 , C08J7/04 , C08G2230/00 , C08J2475/00 , Y10T428/31554 , Y10T428/31562 , Y10T428/31565 , Y10T428/31569 , Y10T428/31587 , Y10T428/31678
摘要： A process for the preparation of slippery, hydrophilic polyurethane hydrogel coating compositions, and materials composed of a polymeric plastic or rubber substrate or a metal substrate with a coating of a slippery, hydrophilic polyurethane hydrogel thereon, such that the coating composition tenaciously adheres to the substrate, are disclosed. The coating compositions and coated materials are non-toxic and biocompatible, and are ideally suited for use on medical devices, particularly, catheters, catheter balloons and stents. The coating compositions, coated materials and coated devices demonstrate low coefficients of friction in contact with body fluids, especially blood, as well as a high degree of wear permanence over prolonged use of the device. The hydrogel coating compositions are capable of being dried to facilitate storage of the devices to which they have been applied, and can be instantly reactivated for later use by exposure to water.
摘要翻译：用于制备光滑的亲水性聚氨酯水凝胶涂料组合物的方法，以及由聚合物塑料或橡胶基材或金属基材组成的材料，其上具有光滑的亲水性聚氨酯水凝胶涂层，使得涂料组合物顽固地粘附于基材，被披露。涂料组合物和涂层材料是无毒的和生物相容的，并且理想地适用于医疗装置，特别是导管，导管气囊和支架。涂层组合物，涂覆材料和涂覆的装置表现出与体液，特别是血液接触的低摩擦系数，以及在长时间使用该装置时高度的磨损持久性。水凝胶涂料组合物能够被干燥以促进其已被施加到其上的装置的储存，并且可以立即重新活化以便随后通过暴露于水中使用。

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