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1. 发明申请

US20120330298A1 SYSTEM AND METHOD OF TREATING ABNORMAL TISSUE IN THE HUMAN ESOPHAGUS 审中-公开
标题翻译：在人类ESOPHAGUS中治疗异常组织的系统和方法
公开(公告)号：US20120330298A1
公开(公告)日：2012-12-27
申请号：US13530464
申请日：2012-06-22
申请人： Robert A. Ganz , Brian D. Zelickson , Roger A. Stern
发明人： Robert A. Ganz , Brian D. Zelickson , Roger A. Stern
IPC分类号： A61B18/18
CPC分类号： A61B18/18 , A61B18/1485 , A61B18/1492 , A61B2018/00214 , A61B2018/0022 , A61B2018/00482 , A61B2018/00553 , A61B2018/00577 , A61B2018/00738 , A61B2018/00797 , A61B2018/126 , A61B2018/1467
摘要： An ablation catheter system and method of use is provided to endoscopically access portions of the human esophagus experiencing undesired growth of columnar epithelium. The ablation catheter system and method includes controlled depth of ablation features and use of either radio frequency spectrum, non-ionizing ultraviolet radiation, warm fluid or microwave radiation, which may also be accompanied by improved sensitizer agents.
摘要翻译：提供了一种消融导管系统和使用方法，用于内窥镜检查经历柱状上皮不期望生长的人食管部分。消融导管系统和方法包括受控的消融深度特征以及无线电频谱，非电离紫外线辐射，暖流体或微波辐射的使用，还可伴随改进的敏化剂。

2. 发明授权

US07761169B2 Device and method for treatment of gastroesophageal reflux disease 失效
标题翻译：用于治疗胃食管反流病的装置和方法
公开(公告)号：US07761169B2
公开(公告)日：2010-07-20
申请号：US12136730
申请日：2008-06-10
申请人： Brian D. Zelickson , Robert A. Ganz
发明人： Brian D. Zelickson , Robert A. Ganz
IPC分类号： A61B18/18
CPC分类号： A61B18/1815 , A61B1/00082 , A61B1/018 , A61B18/08 , A61B18/1492 , A61B18/20 , A61B2018/00011 , A61B2018/00214 , A61B2018/00553
摘要： A lower esophageal sphincter tightening device for treating gastroesophageal reflux disease which includes an insertion device, an energy source, and an energy transmitting device. The insertion device, by insertion through a body opening, positions the energy transmitting device in the proximity of the lower esophageal sphincter. The energy source generates and transmits energy via the insertion device to the energy transmitting device which directs the transmitted energy onto the lower esophageal sphincter which is comprised largely of collagen. The energy source transmits energy at a level sufficient to cause heating of the sphincter's collagen resulting in a shrinkage of the collagen and a tightening of the sphincter.
摘要翻译：一种用于治疗胃食管反流病的下食道括约肌紧固装置，其包括插入装置，能量源和能量传递装置。插入装置通过插入体开口将能量传递装置定位在食管下括约肌附近。能量源通过插入装置产生能量并将能量传递到能量传递装置，该能量传递装置将传播的能量引导到主要由胶原蛋白组成的下部食管括约肌上。能量源以足以引起括约肌胶原加热的水平传输能量，从而导致胶原蛋白的收缩和括约肌紧缩。

3. 发明授权

US07553326B2 Method and apparatus for preventing dialysis graft intimal hyperplasia 有权
标题翻译：用于预防透析移植物内膜增生的方法和装置
公开(公告)号：US07553326B2
公开(公告)日：2009-06-30
申请号：US10994623
申请日：2004-11-22
申请人： Richard M. Sweet , Robert A. Ganz
发明人： Richard M. Sweet , Robert A. Ganz
IPC分类号： A61F2/06
CPC分类号： A61F2/06 , A61F2250/0001 , A61L29/16 , A61L2300/416 , A61N5/0601 , Y10S623/903
摘要： To prevent intimal hyperplasia within a dialysis graft, a flexible tube comprising the dialysis graft is coated interiorly before placement with an anticarcinogen or mitosis-inhibiting agent for preventing cell division. The graft can also be irradiated with light energy by directing light into the lumen of the tube that has been grafted in place, thereby preventing or reducing dialysis graft intimal hyperplasia and reducing inflammation. The light source can be a light emitting diode (LED) or a chemical light source, i.e., a chemiluminescent substance for producing cool light energy within the graft to prevent or reduce the symptoms of GIH. When phototherapy is used, the body is exposed to light radiation at the site of the graft in sufficient amount to prevent undesired cell proliferation within the vessels, the graft, or surrounding tissue where the invention is used without detectable damage to body tissue.
摘要翻译：为了防止透析移植物中的内膜增生，包含透析移植物的柔性管在放置前涂覆有用于防止细胞分裂的抗癌剂或有丝分裂抑制剂。也可以通过将光引入已被移植到位的管的内腔中，从而防止或减少透析移植物内膜增生并减少炎症，也可以用光能照射移植物。光源可以是发光二极管（LED）或化学光源，即用于在移植物内产生冷光能的化学发光物质，以防止或减少GIH的症状。当使用光疗时，身体暴露于移植物位置处的光辐射足够的量以防止使用本发明的血管，移植物或周围组织中不期望的细胞增殖，而对身体组织无可察觉的损伤。

4. 发明授权

US07043307B1 Device and method for treatment of gastroesophageal reflux disease 失效
公开(公告)号：US07043307B1
公开(公告)日：2006-05-09
申请号：US10633820
申请日：2003-08-04
申请人： Brian D. Zelickson , Robert A. Ganz
发明人： Brian D. Zelickson , Robert A. Ganz
IPC分类号： A61B18/18
CPC分类号： A61B18/1815 , A61B1/00082 , A61B1/018 , A61B18/08 , A61B18/1492 , A61B18/20 , A61B2018/00011 , A61B2018/00214 , A61B2018/00553
摘要： A lower esophageal sphincter tightening device for treating gastroesophageal reflux disease which includes an insertion device, an energy source, and an energy transmitting device. The insertion device, by insertion through a body opening, positions the energy transmitting device in the proximity of the lower esophageal sphincter. The energy source generates and transmits energy via the insertion device to the energy transmitting device which directs the transmitted energy onto the lower esophageal sphincter which is comprised largely of collagen. The energy source transmits energy at a level sufficient to cause heating of the sphincter's collagen resulting in a shrinkage of the collagen and a tightening of the sphincter.

5. 发明授权

US06321121B1 Device and method for treatment of gastroesophageal reflux disease 有权
标题翻译：用于治疗胃食管反流病的装置和方法
公开(公告)号：US06321121B1
公开(公告)日：2001-11-20
申请号：US09475580
申请日：1999-12-30
申请人： Brian D. Zelickson , Robert A. Ganz
发明人： Brian D. Zelickson , Robert A. Ganz
IPC分类号： A61F200
CPC分类号： A61B18/1815 , A61B1/00082 , A61B1/018 , A61B18/08 , A61B18/1492 , A61B18/20 , A61B2018/00011 , A61B2018/00214 , A61B2018/00553
摘要： A lower esophageal sphincter tightening device for treating gastroesophageal reflux disease which includes an insertion device, an energy source, and an energy transmitting device. The insertion device, by insertion through a body opening, positions the energy transmitting device in the proximity of the lower esophageal sphincter. The energy source generates and transmits energy via the insertion device to the energy transmitting device which directs the transmitted energy onto the lower esophageal sphincter which is comprised largely of collagen. The energy source transmits energy at a level sufficient to cause heating of the sphincter's collagen resulting in a shrinkage of the collagen and a tightening of the sphincter.
摘要翻译：一种用于治疗胃食管反流病的下食道括约肌紧固装置，其包括插入装置，能量源和能量传递装置。插入装置通过插入体开口将能量传递装置定位在食管下括约肌附近。能量源通过插入装置产生能量并将能量传递到能量传递装置，该能量传递装置将传播的能量引导到主要由胶原蛋白组成的下部食管括约肌上。能量源以足以引起括约肌胶原加热的水平传输能量，从而导致胶原蛋白的收缩和括约肌紧缩。

6. 发明申请

US20230052625A1 OBESITY TREATMENT DEVICES, SYSTEMS, AND METHODS 有权
公开(公告)号：US20230052625A1
公开(公告)日：2023-02-16
申请号：US17963159
申请日：2022-10-10
申请人： Alexander S. Ganz , Robert A. Ganz , Travis Sessions , Steven Berhow , Michael W. Augustine
发明人： Alexander S. Ganz , Robert A. Ganz , Travis Sessions , Steven Berhow , Michael W. Augustine
IPC分类号： A61F5/00
摘要： Various devices, systems, and methods that can be used in the treatment of obesity and related illnesses are disclosed. In some instances, a medical device includes a body that is configured to transition from a low-profile state, in which the medical device is passed through the bowel of an obese patient and into the cecum of the patient, to an expanded state, in which the medical device distends the cecum of the patient to a pathophysiological size.

7. 发明申请

US20220296495A1 DEODORANT COMPOSITIONS 有权
公开(公告)号：US20220296495A1
公开(公告)日：2022-09-22
申请号：US17618256
申请日：2020-06-11
申请人： Marisa Ann PLESCIA , Robert A. GANZ , Mo E. SAREMI , G&S Laboratories, Inc.
发明人： Marisa Ann Plescia , Robert A. Ganz , Mo E. Saremi
IPC分类号： A61K8/9728 , A61K8/34 , A61K8/49 , A61K8/60 , A61K8/37 , A61K8/368 , A61K8/9789 , A61K8/92 , A61K8/9794 , A61Q15/00
摘要： This disclosure relates to topical personal care compositions comprising one or more of a yeast component; a Bacillaceae extract; and 13-methyltetradecanoate; and B) one or more of: a phytochemical; an organic acid; and an antimicrobial peptide. In some embodiments, a composition as described herein can include a yeast component present in an amount of at least about 0.5% w/w of the composition; caffeine present in an amount of about 0.05% to about 5% w/w of the composition; a lemon grass extract present in an amount of at least about 0.01% to about 5% w/w of the composition; and an citrus fruit extract present in an amount of at least about 0.01% to about 5% w/w of the composition. In some embodiments, the composition further comprises a dermatologically acceptable carrier. Such compositions are useful for reducing body odor.

8. 发明申请

US20180177623A1 OBESITY TREATMENT DEVICES, SYSTEMS, AND METHODS 审中-公开
公开(公告)号：US20180177623A1
公开(公告)日：2018-06-28
申请号：US15853793
申请日：2017-12-23
申请人： Alexander S. Ganz , Robert A. Ganz
发明人： Alexander S. Ganz , Robert A. Ganz
IPC分类号： A61F5/00
摘要： Various devices, systems, and methods that can be used in the treatment of obesity and related illnesses are disclosed. In some instances, a portion of the bowel of an obese patient is distended for a therapeutically effective period. The distention may be achieved by introduction of an object that is of foreign origin relative to the body of the patient into the bowel of the patient. In some instances, the distention is achieved by a medical device that transitions from an undeployed state, in which the medical device is introduced into the bowel of the patient, to an expanded state in which the medical device distends the bowel by an amount sufficient to trigger an intestinal-gastric brake in the patient.

9. 发明授权

US08442645B2 Device and method for treatment of gastroesophageal reflux disease 有权
公开(公告)号：US08442645B2
公开(公告)日：2013-05-14
申请号：US13071192
申请日：2011-03-24
申请人： Brian D. Zelickson , Robert A. Ganz
发明人： Brian D. Zelickson , Robert A. Ganz
IPC分类号： A61B12/00 , A61B18/18
CPC分类号： A61B18/1815 , A61B1/00082 , A61B1/018 , A61B18/08 , A61B18/1492 , A61B18/20 , A61B2018/00011 , A61B2018/00214 , A61B2018/00553
摘要： A lower esophageal sphincter tightening device for treating gastroesophageal reflux disease which includes an insertion device, an energy source, and an energy transmitting device. The insertion device, by insertion through a body opening, positions the energy transmitting device in the proximity of the lower esophageal sphincter. The energy source generates and transmits energy via the insertion device to the energy transmitting device which directs the transmitted energy onto the lower esophageal sphincter which is comprised largely of collagen. The energy source transmits energy at a level sufficient to cause heating of the sphincter's collagen resulting in a shrinkage of the collagen and a tightening of the sphincter.

10. 发明授权

US07530979B2 Method of treating abnormal tissue in the human esophagus 有权
标题翻译：治疗人食管异常组织的方法
公开(公告)号：US07530979B2
公开(公告)日：2009-05-12
申请号：US10370645
申请日：2003-02-19
申请人： Robert A. Ganz , Brian D. Zelickson , Roger A. Stern
发明人： Robert A. Ganz , Brian D. Zelickson , Roger A. Stern
IPC分类号： A61B18/18
CPC分类号： A61B18/18 , A61B18/1485 , A61B18/1492 , A61B2018/00214 , A61B2018/0022 , A61B2018/00482 , A61B2018/00553 , A61B2018/00577 , A61B2018/00738 , A61B2018/00797 , A61B2018/126 , A61B2018/1467
摘要： An ablation catheter system and method of use is provided to endoscopically access portions of the human esophagus experiencing undesired growth of columnar epithelium. The ablation catheter system and method includes controlled depth of ablation features and use of either radio frequency spectrum, non-ionizing ultraviolet radiation, warm fluid or microwave radiation, which may also be accompanied by improved sensitizer agents.
摘要翻译：提供了一种消融导管系统和使用方法，用于内窥镜检查经历柱状上皮不期望生长的人食管部分。消融导管系统和方法包括受控的消融深度特征以及无线电频谱，非电离紫外线辐射，暖流体或微波辐射的使用，还可伴随改进的敏化剂。

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