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    • 5. 发明专利
    • Sampling probe for microarray read out using electrospray mass spectrometry
    • 采用电喷雾质谱法测定微量的采样探针
    • JP2009133868A
    • 2009-06-18
    • JP2009053183
    • 2009-03-06
    • Ut Battelle Llcユーティ―バテル エルエルシー
    • VAN BERKEL GARY J
    • G01N1/00G01N27/62G01N1/28G01N13/24G01N33/53G01N35/00G01N37/00H01J49/04H01J49/26
    • H01J49/0404G01N1/22G01N2035/00158H01J49/0463H01J49/165
    • PROBLEM TO BE SOLVED: To obtain samples from surface array spots having analytes by the automated sampling system and a method of analysis using an electronic spray. SOLUTION: The system includes at least one probe, the probe including an inlet for flowing at least one kind of eluting solvent to respective ones of a plurality of spots and an outlet for delivering the analyte away from the spots. An automatic positioning system is provided for translating the probe relative to the spot to permit sampling of any spot. An electrospray ion source having an input connected by fluidity to the probe receives the analyte and generates ions from the analyte. The ion source provides the generated ions to a structure for analysis to identify the analyte, preferably being a mass spectrometer. The probe can be a surface contact probe, where the probe forms an enclosing seal along the periphery of the array spot surface. COPYRIGHT: (C)2009,JPO&INPIT
    • 要解决的问题:通过自动采样系统从具有分析物的表面阵列点获得样品和使用电子喷雾的分析方法。 解决方案:该系统包括至少一个探针,该探针包括用于将至少一种洗脱溶剂流到多个斑点中的相应的一个点的出口和用于将分析物远离斑点的出口。 提供了一种自动定位系统,用于将探头相对于该点转换以允许对任何点进行采样。 具有通过流动性连接到探针的输入的电喷雾离子源接收分析物并从分析物产生离子。 离子源将生成的离子提供到用于分析的结构以鉴定分析物,优选为质谱仪。 探针可以是表面接触探针,其中探针沿着阵列光斑表面的周边形成封闭的密封。 版权所有(C)2009,JPO&INPIT
    • 6. 发明专利
    • High speed preamplifier circuit, detector electronics, and radiation detection system
    • 高速前置放大器电路,检测器电子和辐射检测系统
    • JP2013057676A
    • 2013-03-28
    • JP2012236597
    • 2012-10-26
    • Ut Battelle Llcユーティ―バテル エルエルシー
    • RICHARD A RIEDELALAN L WINTENBURGLLOYD G CLONTSRONALD G COOPER
    • G01T1/24G01N23/09G01T3/00H03F3/34H03F3/68
    • H03F3/08
    • PROBLEM TO BE SOLVED: To provide a high speed preamplifier circuit, detector electronics, and a radiation detection system.SOLUTION: A preamplifier circuit includes a transimpedance amplifier which receives a current signal from a radiation detector and generates an amplified voltage signal. An output of the transimpedance amplifier is coupled to a second amplification stage. Detector electronics include a first transimpedance amplifier which receives a current signal from a first location on a detector and generates a first voltage signal, and a second transimpedance amplifier which receives a current signal from a second location on the detector and generates a second voltage signal. The second amplification stage provides first and second amplified voltage signals. A differential output stage receives the first and second amplified voltage signals and provides a pair of outputs from each of the first and second amplified voltage signals. Readout circuitry has a processing structure for processing each of the pair of outputs. The processing structure provides a single digital output having a time-stamp therefrom.
    • 要解决的问题:提供高速前置放大器电路,检测器电路和辐射检测系统。 解决方案:前置放大器电路包括跨阻抗放大器,其接收来自辐射检测器的电流信号并产生放大的电压信号。 跨阻放大器的输出耦合到第二放大级。 检测器电子器件包括第一跨阻抗放大器,其接收来自检测器上的第一位置的电流信号并产生第一电压信号;以及第二跨阻抗放大器,其从检测器上的第二位置接收电流信号并产生第二电压信号。 第二放大级提供第一和第二放大电压信号。 差分输出级接收第一和第二放大电压信号,并从第一和第二放大电压信号中的每一个提供一对输出。 读出电路具有用于处理该对输出中的每一个的处理结构。 处理结构提供具有时间戳的单个数字输出。 版权所有(C)2013,JPO&INPIT