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1. 发明专利

JP2002206994A HYBRID VALVE DEVICE, SYSTEM AND METHOD FOR FLUID OPERATION 审中-公开
公开(公告)号：JP2002206994A
公开(公告)日：2002-07-26
申请号：JP2001313732
申请日：2001-10-11
申请人： INNOVADYNE TECHNOLOGIES INC , UT BATTELLE LLC
发明人： JOHNSON JAMES E , PICHA NEIL R , DIKTYCZ MITCHEL J
IPC分类号： B01J19/00 , B67D7/02 , C12M1/00 , C40B60/14 , G01N1/00 , G01N1/14 , G01N35/10 , G01N37/00 , B67D5/02
摘要： PROBLEM TO BE SOLVED: To provide a hybrid valve device used together with an aspiration actuator and a dispensing actuator, for transferring a fluid to a test site on a substrate surface from a reservoir. SOLUTION: This hybrid valve has a valve assembly capable of being changed over between an aspiration state and a dispensing state, and a manifold connected to the valve assembly. The manifold has a fluid suction passage with a first aspiration port connected to the aspiration actuator. The other end of the aspiration passage has a second aspiration port selectively connected to the valve assembly, selectively aspirating a fluid sample from the reservoir into an individual sample path. The manifold has a fluid dispensing passage including a first dispensing port connected to the dispensing actuator and a second dispensing port selectively connected to the valve assembly. When the valve assembly is in the dispensing state, the sample path is connected to the dispensing actuator to selectively dispense at least one droplet of the fluid sample from the dispensing actuator and is shut off from the aspiration actuator. When the valve assembly is in the aspiration state, the sample path is connected to the aspiration actuator and is shut off from the dispensing actuator.

2. 发明专利

DE60124653D1 未知
公开(公告)号：DE60124653D1
公开(公告)日：2007-01-04
申请号：DE60124653
申请日：2001-09-28
申请人： INNOVADYNE TECHNOLOGIES INC , UT BATTELLE LLC
发明人： JOHNSON JAMES E , DIKTYCZ MITCHEL J , PICHA NEIL R
IPC分类号： F16K13/00 , B01J19/00 , B67D7/02 , C12M1/00 , C40B60/14 , G01N1/00 , G01N1/14 , G01N35/10 , G01N37/00
摘要： A manifold device for use with a valve assembly, an aspiration source and a dispensing source is described. The manifold body defines a plurality of fluid aspiration conduits each having an aspiration port in communication with an aspiration source, and a second aspiration port in selective fluid communication with a corresponding communication channel of the valve assembly to aspirate a respective liquid sample slug from a corresponding reservoir of sample fluid into discrete sample paths when the valve assembly is in the aspiration condition. The manifold body further defines a plurality of fluid dispensing conduits each having a first dispensing port in communication with the dispensing source, and a second dispensing port in selective fluid communication with a corresponding communication channel of the valve assembly to selectively dispense at least one droplet of the corresponding liquid sample slug from the corresponding sample path when the valve assembly is in the dispensing condition. In the aspiration condition, the sample paths are out of fluid communication with the dispensing source and in the dispensing condition the sample paths are out of fluid communication with the aspiration source.

3. 发明专利

AT346256T 未知
公开(公告)号：AT346256T
公开(公告)日：2006-12-15
申请号：AT01308303
申请日：2001-09-28
申请人： INNOVADYNE TECHNOLOGIES INC , UT BATTELLE LLC
发明人： JOHNSON JAMES E , DIKTYCZ MITCHEL J , PICHA NEIL R
IPC分类号： B01J19/00 , B67D7/02 , C12M1/00 , C40B60/14 , G01N1/00 , G01N1/14 , G01N35/10 , G01N37/00 , F16K13/00
摘要： A manifold device for use with a valve assembly, an aspiration source and a dispensing source is described. The manifold body defines a plurality of fluid aspiration conduits each having an aspiration port in communication with an aspiration source, and a second aspiration port in selective fluid communication with a corresponding communication channel of the valve assembly to aspirate a respective liquid sample slug from a corresponding reservoir of sample fluid into discrete sample paths when the valve assembly is in the aspiration condition. The manifold body further defines a plurality of fluid dispensing conduits each having a first dispensing port in communication with the dispensing source, and a second dispensing port in selective fluid communication with a corresponding communication channel of the valve assembly to selectively dispense at least one droplet of the corresponding liquid sample slug from the corresponding sample path when the valve assembly is in the dispensing condition. In the aspiration condition, the sample paths are out of fluid communication with the dispensing source and in the dispensing condition the sample paths are out of fluid communication with the aspiration source.

4. 发明专利

CA2358622C HYBRID VALVE APPARATUS, SYSTEM AND METHOD FOR FLUID HANDLING 未知
公开(公告)号：CA2358622C
公开(公告)日：2011-02-08
申请号：CA2358622
申请日：2001-10-09
申请人： INNOVADYNE TECHNOLOGIES INC , UT BATTELLE LLC
发明人： JOHNSON JAMES E , PICHA NEIL R , DOKTYCZ MITCHEL J
IPC分类号： G01N35/10 , B01J19/00 , B67D7/02 , C12M1/00 , C40B60/14 , G01N1/00 , G01N1/14 , G01N1/18 , G01N37/00
摘要： A hybrid valve apparatus for use with an aspiration actuator and a dispensing actuator to transfer fluid from a reservoir to a test site on a substrate surface. The hybrid valve includes a valve assembly movable between an aspiration condition and a dispensing condition, and a manifold device coupled to the valve assembly. The manifold device includes a fluid aspiration conduit having a first aspiration port in fluid communication with the aspiration actuator. On an opposite end of the aspiration conduit is a second aspiration port in selective fluid communication with the valve assembly to selectively aspirate a liquid sample slug from the reservoir into a discrete sample path when the valve assembly is in the aspiration condition. The manifold device further includes a fluid dispensing conduit having a first dispensing port in fluid communication with the dispensing actuator, and a second dispensing port in selective fluid communication with the valve assembly. When the valve assembly is in the dispensing condition, the sample path is fluidly coupled to the dispensing actuator to selectively dispense at least one droplet of the liquid sample slug therefrom, while simultaneously being out of fluid communication with the aspiration actuator. In contrast, in the aspiration condition, the sample path is in fluid communication with the aspiration actuator, while being out of fluid communication with the dispensing actuator.

5. 发明专利

DE60124653T2 未知
公开(公告)号：DE60124653T2
公开(公告)日：2007-03-08
申请号：DE60124653
申请日：2001-09-28
申请人： INNOVADYNE TECHNOLOGIES INC , UT BATTELLE LLC
发明人： JOHNSON JAMES E , DIKTYCZ MITCHEL J , PICHA NEIL R
IPC分类号： F16K13/00 , B01J19/00 , B67D7/02 , C12M1/00 , C40B60/14 , G01N1/00 , G01N1/14 , G01N35/10 , G01N37/00
摘要： A manifold device for use with a valve assembly, an aspiration source and a dispensing source is described. The manifold body defines a plurality of fluid aspiration conduits each having an aspiration port in communication with an aspiration source, and a second aspiration port in selective fluid communication with a corresponding communication channel of the valve assembly to aspirate a respective liquid sample slug from a corresponding reservoir of sample fluid into discrete sample paths when the valve assembly is in the aspiration condition. The manifold body further defines a plurality of fluid dispensing conduits each having a first dispensing port in communication with the dispensing source, and a second dispensing port in selective fluid communication with a corresponding communication channel of the valve assembly to selectively dispense at least one droplet of the corresponding liquid sample slug from the corresponding sample path when the valve assembly is in the dispensing condition. In the aspiration condition, the sample paths are out of fluid communication with the dispensing source and in the dispensing condition the sample paths are out of fluid communication with the aspiration source.

6. 发明专利

CA2358622A1 HYBRID VALVE APPARATUS, SYSTEM AND METHOD FOR FLUID HANDLING 未知
公开(公告)号：CA2358622A1
公开(公告)日：2002-04-11
申请号：CA2358622
申请日：2001-10-09
申请人： INNOVADYNE TECHNOLOGIES INC , UT BATTELLE LLC
发明人： JOHNSON JAMES E , DOKTYCZ MITCHEL J , PICHA NEIL R
IPC分类号： B01J19/00 , B67D7/02 , C12M1/00 , C40B60/14 , G01N1/00 , G01N1/14 , G01N35/10 , G01N37/00 , G01N1/18
摘要： A hybrid valve apparatus for use with an aspiration actuator and a dispensi ng actuator to transfer fluid from a reservoir to a test site on a substrate surface. The hybrid valve includes a valve assembly movable between an aspiratio n condition and a dispensing condition, and a manifold device coupled to the valve assembly. The manifold device includes a fluid aspiration conduit havi ng a first aspiration port in fluid communication with the aspiration actuator. On an opposite end of the aspiration conduit is a second aspiration port in selective fluid communication with the valve assembly to selectively aspirate a liquid sample slug from the reservoir into a discrete sample path when the valve assembly is in the aspiration condition. The manifold device further include s a fluid dispensing conduit having a first dispensing port in fluid communicati on with the dispensing actuator, and a second dispensing port in selective flui d communication with the valve assembly. When the valve assembly is in the dispensing condition, the sample path is fluidly coupled to the dispensing actuator to selectively dispense at least one droplet of the liquid sample slug therefrom, while simultaneously being out of fluid communication with the aspiration actuator. In contrast, in the aspiration condition, the sample pa th is in fluid communication with the aspiration actuator, while being out of flui d communication with the dispensing actuator.

7. 发明专利

JP2009162761A Gas purge method 有权
标题翻译：气体纯化方法
公开(公告)号：JP2009162761A
公开(公告)日：2009-07-23
申请号：JP2009007032
申请日：2009-01-15
申请人： Innovadyne Technologies Inc , イノベイダイン・テクノロジーズ・インコーポレーテッドInnovadyne Technologies Incorporated
发明人： JOHNSON JAMES E , PICHA NEIL R , STORMS CRAIG M , MARTIN DAVID A
IPC分类号： G01N35/10 , G01N37/00 , B01L3/02 , G01N35/00
CPC分类号： B01L3/021 , B01L3/0268 , B01L2200/143 , B01L2200/148 , B01L2300/14 , B01L2400/02 , B01L2400/0487 , B01L2400/06 , B01L2400/0633 , B01L2400/0666 , G01N35/00594 , G01N35/00712 , G01N35/1002 , G01N35/1016 , G01N35/1065 , G01N2035/00237 , G01N2035/1041 , G01N2035/1044 , Y10T137/3003 , Y10T436/15 , Y10T436/2575
摘要： PROBLEM TO BE SOLVED: To provide a method for dispensing the repetitive, precise, low-volume liquid from the dispensing orifice of a noncontact liquid dispensing burette. SOLUTION: In this method, the dispensed liquid is suctioned through the dispensing orifice to be led into communicating passage so that a relatively small volume of the suctioned gas fluid may form a minute simple air gap completely-encased in the area between the inner wall of the communicating passage and the liquid demarcation between a system fluid and the dispensed liquid included in the communicating passage. This air gap effectively inhibits scattering and dilution among them in the liquid demarcation. For dispensing, a rapid pressure pulse of prescribed pulse width is impressed on the system fluid in the upstream from the minute air gap so as to move from the minute air gap without virtual fluid compression of the minute air gap and then travel to the dispensed liquid. Thereby dispensing of liquid from the dispensing orifice, that is, dispensing of effectively accurate and relatively low-volume noncontact liquid will be enabled. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：提供一种从非接触式液体分配滴定管的分配孔分配重复，精确，低体积的液体的方法。解决方案：在这种方法中，分配的液体通过分配孔被抽吸以被引导到连通通道中，使得较小体积的抽吸气体流体可以形成完全包围在连通通道的内壁和系统流体与包括在连通通道中的分配液体之间的液体分界。这种气隙在液体分界中有效地抑制它们之间的散射和稀释。为了分配，将规定脉冲宽度的快速压力脉冲施加在来自微小空气间隙的上游的系统流体上，以便从微小空气间隙移动而无需微小空气间隙的虚拟流体压缩，然后行进到分配的液体。从而能够从分配孔分配液体，即分配有效精确且相对低体积的非接触液体。版权所有（C）2009，JPO＆INPIT

8. 发明专利

JP2009168816A Evaluation method related to dispensing of liquid 审中-公开
标题翻译：与液体分配相关的评估方法
公开(公告)号：JP2009168816A
公开(公告)日：2009-07-30
申请号：JP2009007035
申请日：2009-01-15
申请人： Innovadyne Technologies Inc , イノベイダイン・テクノロジーズ・インコーポレーテッドInnovadyne Technologies Incorporated
发明人： JOHNSON JAMES E , PICHA NEIL R , STORMS CRAIG M , MARTIN DAVID A
IPC分类号： G01N35/10 , G01N37/00 , B01J4/02 , B01L3/02 , G01N35/00
CPC分类号： B01L3/021 , B01L3/0268 , B01L2200/143 , B01L2200/148 , B01L2300/14 , B01L2400/02 , B01L2400/0487 , B01L2400/06 , B01L2400/0633 , B01L2400/0666 , G01N35/00594 , G01N35/00712 , G01N35/1002 , G01N35/1016 , G01N35/1065 , G01N2035/00237 , G01N2035/1041 , G01N2035/1044 , Y10T137/3003 , Y10T436/15 , Y10T436/2575
摘要： PROBLEM TO BE SOLVED: To provide a method for dispensing repetitive, precision, low volume liquid from a dispensing orifice of a non-contact liquid dispensing apparatus. SOLUTION: A system fluid is placed in a communication passageway extending substantially continuously from a system fluid reservoir to the dispensing orifice. A relatively small volume of gaseous fluid is aspirated through the dispensing orifice and led into the communication passageway in such a manner that the gaseous fluid extends substantially continuously across the transverse cross-sectional dimension of the communication passageway. An air gap substantially prevents dispersion and dilution at a liquid interface. To effect dispensing, a rapid pressure pulse with a predetermined pulse width is applied to the system fluid upstream from the minute air gap, causing the pressure pulse to traverse the minute air gap to the dispensing liquid without substantial fluid compression of the minute air gap. This enables substantially accurate, relatively small volume, non-contact liquid dispensing of the liquid from the dispensing orifice. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：提供一种从非接触式液体分配装置的分配孔分配重复，精密，低体积的液体的方法。解决方案：将系统流体放置在从系统流体储存器到分配孔基本上连续延伸的连通通道中。相对较小体积的气态流体通过分配孔被吸入，并以这样一种方式被引入连通通道，使得气态流体基本上连续地延伸穿过连通通道的横截面尺寸。气隙基本上防止在液体界面处的分散和稀释。为了实现分配，将具有预定脉冲宽度的快速压力脉冲施加到从微小空气间隙上游的系统流体，使得压力脉冲穿过分配液体的微小空气间隙，而不会明显地流体压缩微小气隙。这使得能够从分配孔口获得液体的基本准确的，相当小体积的非接触液体分配。版权所有（C）2009，JPO＆INPIT

9. 发明专利

CA2459730C SECONDARY LIQUID DISPENSING MODULE FOR LIQUID HANDLING SYSTEM 未知
公开(公告)号：CA2459730C
公开(公告)日：2011-12-13
申请号：CA2459730
申请日：2002-09-09
申请人： INNOVADYNE TECHNOLOGIES INC
发明人： JOHNSON JAMES E , PICHA NEIL R , MARTIN DAVID A , MCCOMB JOEL
IPC分类号： G01N1/00 , G01N35/10 , B01J4/00 , B01J19/00
摘要： A removable secondary liquid dispensing module (100) for use with an existing, automated liquid handling system that defines a work area having a plurality of discrete work stations. The secondary liquid dispensing module (100) includes a secondary liquid dispensing device which is self-contained and operationally independent from the primary liquid dispensing device. The secondary dispensing device is further adapted for selective non-contact-type dispensing of discrete quantities of fluid, in the range of about one (1) nanoliter to about ten (10) microliters, into the test sites of the microtiter-plate.

10. 发明专利

CA2473860A1 LOW VOLUME, NON-CONTACT LIQUID DISPENSING METHOD 未知
公开(公告)号：CA2473860A1
公开(公告)日：2003-08-07
申请号：CA2473860
申请日：2003-01-27
申请人： INNOVADYNE TECHNOLOGIES INC
发明人： PICHA NEIL R , JOHNSON JAMES E , STORMS CRAIG M , MARTIN DAVID A
IPC分类号： G01N37/00 , B01L3/02 , G01N35/00 , G01N35/10
摘要： An method for delivering repetitive, precision, low volume liquid dispensing from a dispensing orifice of a non-contact liquid dispensing apparatus. An elongated communication passageway of the dispensing apparatus is defined by interior walls having one end in fluid communication with a system fluid reservoir and an opposite end terminating at the dispensing orifice. A system fluid is placed in the communication passageway extending substantially continuously from the system fluid reservoir to the dispensing orifice. A relatively small volume of gaseous fluid is aspirated through the dispensing orifice, and into the communication passageway in a manner such that the gaseous fluid extends substantially continuously across the transverse cross- sectional dimension of the communication passageway. Subsequently, a dispensing liquid is aspirated through the dispensing orifice and into the communication passageway in a manner such that the relatively small volume of aspirated gaseous fluid forms a minute, unitary air gap fully enclosed between the interior walls of the communication passageway and a liquid interface between the system fluid and the dispensing liquid contained in the communication passageway. This minute air gap substantially prevents dispersion and dilution therebetween at the liquid interface. To effect dispensing, a rapid pressure pulse with a predetermined pulse width is applied to the system fluid upstream from the minute air gap, causing the pressure pulse to traverse the minute air gap to the dispensing liquid without substantial fluid compression of the minute air gap. This enables substantially accurate, relatively small volume, non-contact liquid dispensing of the dispensing liquid from the dispensing orifice.

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