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1. 发明申请

WO2004047778A1 MATERIALS AND METHODS FOR PREVENTING AND TREATING MICROBE-MEDIATED EPITHELIAL DISORDERS 审中-公开
标题翻译：预防和治疗微血管介导的上皮疾病的材料与方法
公开(公告)号：WO2004047778A1
公开(公告)日：2004-06-10
申请号：PCT/US2002/037948
申请日：2002-11-26
申请人： UC TECH , ALVERDY, John, C., M.D.
发明人： ALVERDY, John, C., M.D.
IPC分类号： A61K7/06
CPC分类号： A61K31/765 , A23K20/105 , A23K50/10 , A23K50/20 , A23K50/30 , A23K50/40 , A23K50/75 , A23L33/10 , A23L33/40 , A61K31/198 , A61K31/721 , A61K31/77 , A61K2300/00
摘要： The present invention provides pharmaceutical compositions in the form of relatively high molecular weight biocompatible polymers such as polyethylene glycol, optionally supplemented with a protective polymer such ad dextran and/or essential pathogen nutrients such as L-glutamine. Also provided are methods for preventing or treating gut-derived sepsis attributable to intestinal pathogens such as Pseudomonas aeruginosa by administering high molecular weight polyethylene glycol as well as methods for monitoring the administration of high molecular weight polyethylene glycol, such as in methods of preventing, ameliorating or treating microbe-induced epithelial disorders, as exemplified by gut-derived sepsis. Frequently, gut-derived sepsis arises as a complication in mammals recovering from surgical intervention or suffering from a disease or disorder, providing indications of suitable animals to receive preventative treatment. Finally, the invention provides a composition comprising infant formula and polyethylene glycol and methods for using that composition.
摘要翻译：本发明提供了具有相对高分子量的生物相容性聚合物形式的药物组合物，例如聚乙二醇，任选地补充保护性聚合物如葡聚糖和/或必需的病原体营养物如L-谷氨酰胺。还提供了通过施用高分子量聚乙二醇来预防或治疗归因于肠道病原体如铜绿假单胞菌的肠源性败血症的方法以及用于监测高分子量聚乙二醇的施用的方法，例如在预防，改善或治疗微生物诱导的上皮疾病，例如肠源性败血症。通常，肠道衍生的败血症是由外科手术或患有疾病或病症而恢复的哺乳动物的并发症，提供合适动物接受预防治疗的适应症。最后，本发明提供包含婴儿配方和聚乙二醇的组合物和使用该组合物的方法。

2. 发明申请

US20060018524A1 Computerized scheme for distinction between benign and malignant nodules in thoracic low-dose CT 审中-公开
标题翻译：用于区分胸部低剂量CT的良性和恶性结节的计算机化方案
公开(公告)号：US20060018524A1
公开(公告)日：2006-01-26
申请号：US11181884
申请日：2005-07-15
申请人： Kenji Suzuki , Kunio Doi
发明人： Kenji Suzuki , Kunio Doi
IPC分类号： G06K9/00
CPC分类号： G06K9/3233 , G06K9/6292 , G06K2209/05 , G06T7/0012 , G06T2207/30061
摘要： A system, method, and computer program product for classifying a target structure in an image into abnormality types. The system has a scanning mechanism that scans a local window across sub-regions of the target structure by moving the local window across the image to obtain sub-region pixel sets. A mechanism inputs the sub-region pixel sets into a classifier to provide output pixel values based on the sub-region pixel sets, each output pixel value representing a likelihood that respective image pixels have a predetermined abnormality, the output pixel values collectively determining a likelihood distribution output image map. A mechanism scores the likelihood distribution map to classify the target structure into abnormality types. The classifier can be, e.g., a single-output or multiple-output massive training artificial neural network (MTANN).
摘要翻译：一种用于将图像中的目标结构分类为异常类型的系统，方法和计算机程序产品。该系统具有扫描机构，通过移动该图像上的局部窗口来扫描目标结构的子区域上的局部窗口，以获得子区域像素集。机构将子区域像素集合输入到分类器中以基于子区域像素集提供输出像素值，每个输出像素值表示各个图像像素具有预定异常的可能性，输出像素值共同确定似然分布输出图像映射。一种机制评估了可能性分布图，将目标结构分类为异常类型。分类器可以是例如单输出或多输出大规模训练人造神经网络（MTANN）。

3. 发明申请

US20050173622A1 Multiple optical vortices for manipulating particles 失效
标题翻译：用于操纵颗粒的多重光学旋涡
公开(公告)号：US20050173622A1
公开(公告)日：2005-08-11
申请号：US11059876
申请日：2005-02-17
申请人： Jennifer Curtis , Brian Koss , David Grier
发明人： Jennifer Curtis , Brian Koss , David Grier
IPC分类号： G01N15/02 , B01J19/12 , G01N30/00 , G01N30/02 , G21K1/00 , H05H3/04 , G02B27/00
CPC分类号： H05H3/04 , B01F13/0052 , B01F15/00551 , B01L3/50273 , B01L3/502761 , B01L2200/0647 , B01L2200/0668 , B01L2400/0409 , B01L2400/0454 , F04B19/006 , G01N30/00 , G01N30/02 , G01N2015/149 , G02B21/32 , G03H1/0005 , G03H1/08 , G03H1/2294 , G03H2001/0077 , G03H2001/085 , G03H2225/32 , B01D2015/3895
摘要： A method for creating large numbers of high-quality optical traps in arbitrary three-dimensional configurations and dynamically reconfiguring the traps under computer control. The method uses computer-generated diffractive optical elements to convert one or more optical tweezers into one or more optical vortices. The method involves combining the optical vortex technique with the holographic optical tweezer technique to create multiple optical vortices in arbitrary configurations. The method also involves employing the rotation induced in trapped particles by optical vortices to assemble clusters of particles into functional micromachines, to drive previously assembled micromachines, to pump fluids through microfluidics channels, to control flows of fluids through microfluidics channels, to mix fluids within microfluidics channels, to transport particles, to sort particles and to perform other related manipulations and transformations on matter over length scales
摘要翻译：一种用于在任意三维配置中创建大量高质量光阱的方法，并在计算机控制下动态地重构陷阱。该方法使用计算机产生的衍射光学元件将一个或多个光学镊子转换成一个或多个光学旋转。该方法涉及将光学旋涡技术与全息光学镊子技术组合以产生任意配置的多个光学旋涡。该方法还涉及通过光学旋涡在捕获的颗粒中诱导的旋转，以将颗粒簇组装成功能微机械，驱动先前组装的微机械，通过微流体通道泵送流体，以控制流体通过微流体通道，将微流体中的流体混合通道，运输粒子，对粒子进行分类，并对长度尺度上的物质进行其他相关的操作和转换

4. 发明公开

EP1595547A2 Use of the growth factor AMP for the treatment of gastrointestinal injuries and acute renal failure 审中-公开
标题翻译：使用生长因子AMP的用于治疗胃肠道损伤和急性肾功能衰竭
公开(公告)号：EP1595547A2
公开(公告)日：2005-11-16
申请号：EP05010217.7
申请日：2005-05-10
申请人： University of Chicago, UC-Tech Office of Technology & Intellectual Property
发明人： Toback, Gary F. , Walsh-Reitz, Margaret M. , Martin, Terrence E.
IPC分类号： A61K38/18 , A61P1/04 , A61P13/12
CPC分类号： C07K14/475 , A01K2217/075 , A01K2227/105 , A61K38/00 , C07K5/1008 , C07K16/18 , C07K2317/73 , C07K2317/76
摘要： A novel group of gastrokines called Gastric Antrum Mucosal Protein is characterized. A member of the group is designated AMP-18. AMP - 18 genomic DNA, cDNA and the AMP- 18 protein are sequenced for human, mouse and pig. The AMP-18 protein and active peptides derived from it are cellular growth factors. Surprisingly, peptides capable of inhibiting the effects of the complete protein, are also derived from the AMP - 18 protein. Cytoprotection and control of mammalian gastro-intestinal tissue growth and repair (restitution) is facilitated by the use of the proteins, making the proteins candidates for therapies in inflammatory bowel disease, mucositis, and gastric ulcers.
摘要翻译：称为胃窦粘膜蛋白gastrokines的一组新的特征。该组的成员被指定AMP-18 AMP - 18基因组DNA，cDNA和所述AMP 18蛋白测序对人，小鼠和猪。的AMP-18蛋白和从它派生活性肽是细胞生长因子。令人惊讶地，肽能够抑制完全蛋白质，即从AMP衍生的效果 - 蛋白第十八细胞保护作用和哺乳动物胃肠组织生长和修复（恢复原状）的控制是通过使用该蛋白的便利，使得该蛋白候选炎症性肠病，粘膜炎，和胃溃疡的治疗方法。

5. 发明公开

EP1567117A1 MATERIALS AND METHODS FOR PREVENTING AND TREATING MICROBE-MEDIATED EPITHELIAL DISORDERS 有权
标题翻译：防治芽发送EPITHELERKRANKUNGEN
公开(公告)号：EP1567117A1
公开(公告)日：2005-08-31
申请号：EP02789898.0
申请日：2002-11-26
申请人： UC Tech
发明人： ALVERDY, John, C., M.D.
IPC分类号： A61K7/06 , A61K39/108
CPC分类号： A61K31/765 , A23K20/105 , A23K50/10 , A23K50/20 , A23K50/30 , A23K50/40 , A23K50/75 , A23L33/10 , A23L33/40 , A61K31/198 , A61K31/721 , A61K31/77 , A61K2300/00
摘要： The present invention provides pharmaceutical compositions in the form of relatively high molecular weight biocompatible polymers such as polyethylene glycol, optionally supplemented with a protective polymer such ad dextran and/or essential pathogen nutrients such as L-glutantine. Also provided are methods for preventing or treating gut-derived sepsis attributable to intestinal pathogens such as Pseudomonas aeruginosa by administering high molecular weight polyethylene glycol as well as methods for monitoring the administration of high molecular weight polyethylene glycol, such as in methods of preventing, ameliorating or treating microbe-induced epithelial disorders, as exemplified by gut-derived sepsis. Frequently, gut-derived sepsis arises as a complication in mammals recovering from surgical intervention or suffering from a disease or disorder, providing indications of suitable animals to receive preventative treatment. Finally, the invention provides a composition comprising infant formula and polyethylene glycol and methods for using that composition.

6. 发明专利

BR0215954A 未知
公开(公告)号：BR0215954A
公开(公告)日：2005-09-13
申请号：BR0215954
申请日：2002-11-26
申请人： UC TECH
发明人： ALVERDY JOHN C M D
IPC分类号： A23K1/16 , A23K1/18 , A23L1/30 , A23L33/00 , A61K31/765 , A61K39/108 , A61K47/34 , A61K7/06
摘要： The present invention provides pharmaceutical compositions in the form of relatively high molecular weight biocompatible polymers such as polyethylene glycol, optionally supplemented with a protective polymer such as dextran and/or essential pathogen nutrients such as L-glutamine. Also provided are methods for preventing or treating gut-derived sepsis attributable to intestinal pathogens such as Pseudomonas aeruginosa by administering high molecular weight polyethylene glycol as well as methods for monitoring the administration of high molecular weight polyethylene glycol, such as in methods of preventing, ameliorating or treating microbe-induced epithelial disorders, as exemplified by gut-derived sepsis. Frequently, gut-derived sepsis arises as a complication in mammals recovering from surgical intervention or suffering from a disease or disorder, providing indications of suitable animals to receive preventative treatment. Finally, the invention provides a composition comprising infant formula and polyethylene glycol and methods for using that composition.

7. 发明专利

AU2002352938A1 MATERIALS AND METHODS FOR PREVENTING AND TREATING MICROBE-MEDIATED EPITHELIAL DISORDERS 未知
公开(公告)号：AU2002352938A1
公开(公告)日：2004-06-18
申请号：AU2002352938
申请日：2002-11-26
申请人： UC TECH
发明人： ALVERDY JOHN C M D
IPC分类号： A23K1/16 , A23K1/18 , A23L1/30 , A23L33/00 , A61K31/765 , A61K39/108 , A61K47/34 , A61K7/06
摘要： The present invention provides pharmaceutical compositions in the form of relatively high molecular weight biocompatible polymers such as polyethylene glycol, optionally supplemented with a protective polymer such as dextran and/or essential pathogen nutrients such as L-glutamine. Also provided are methods for preventing or treating gut-derived sepsis attributable to intestinal pathogens such as Pseudomonas aeruginosa by administering high molecular weight polyethylene glycol as well as methods for monitoring the administration of high molecular weight polyethylene glycol, such as in methods of preventing, ameliorating or treating microbe-induced epithelial disorders, as exemplified by gut-derived sepsis. Frequently, gut-derived sepsis arises as a complication in mammals recovering from surgical intervention or suffering from a disease or disorder, providing indications of suitable animals to receive preventative treatment. Finally, the invention provides a composition comprising infant formula and polyethylene glycol and methods for using that composition.

8. 发明专利

CA2507018A1 MATERIALS AND METHODS FOR PREVENTING AND TREATING MICROBE-MEDIATED EPITHELIAL DISORDERS 未知
公开(公告)号：CA2507018A1
公开(公告)日：2004-06-10
申请号：CA2507018
申请日：2002-11-26
申请人： UC TECH
发明人： ALVERDY JOHN C
IPC分类号： A61K31/765 , A23K1/16 , A23K1/18 , A23L1/30 , A23L33/00 , A61B1/00 , A61F6/04 , A61K39/108 , A61K47/34 , C12Q1/02 , G01N33/48
摘要： The present invention provides pharmaceutical compositions in the form of relatively high molecular weight biocompatible polymers such as polyethylene glycol, optionally supplemented with a protective polymer such ad dextran and/or essential pathogen nutrients such as L-glutamine. Also provided are methods for preventing or treating gut-derived sepsis attributable to intestinal pathogens such as Pseudomonas aeruginosa by administering high molecular weight polyethylene glycol as well as methods for monitoring the administration of high molecular weight polyethylene glycol, such as in methods of preventing, ameliorating or treating microbe-induced epithelial disorders, as exemplified by gut-derived sepsis. Frequently, gut-derived sepsis arises as a complication in mammals recovering from surgical intervention or suffering from a disease or disorder, providing indications of suitable animals to receive preventative treatment. Finally, the invention provides a composition comprising infant formula and polyethylene glycol and methods for using that composition.

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