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1. 发明申请

WO2004047778A1 MATERIALS AND METHODS FOR PREVENTING AND TREATING MICROBE-MEDIATED EPITHELIAL DISORDERS 审中-公开
标题翻译：预防和治疗微血管介导的上皮疾病的材料与方法
公开(公告)号：WO2004047778A1
公开(公告)日：2004-06-10
申请号：PCT/US2002/037948
申请日：2002-11-26
申请人： UC TECH , ALVERDY, John, C., M.D.
发明人： ALVERDY, John, C., M.D.
IPC分类号： A61K7/06
CPC分类号： A61K31/765 , A23K20/105 , A23K50/10 , A23K50/20 , A23K50/30 , A23K50/40 , A23K50/75 , A23L33/10 , A23L33/40 , A61K31/198 , A61K31/721 , A61K31/77 , A61K2300/00
摘要： The present invention provides pharmaceutical compositions in the form of relatively high molecular weight biocompatible polymers such as polyethylene glycol, optionally supplemented with a protective polymer such ad dextran and/or essential pathogen nutrients such as L-glutamine. Also provided are methods for preventing or treating gut-derived sepsis attributable to intestinal pathogens such as Pseudomonas aeruginosa by administering high molecular weight polyethylene glycol as well as methods for monitoring the administration of high molecular weight polyethylene glycol, such as in methods of preventing, ameliorating or treating microbe-induced epithelial disorders, as exemplified by gut-derived sepsis. Frequently, gut-derived sepsis arises as a complication in mammals recovering from surgical intervention or suffering from a disease or disorder, providing indications of suitable animals to receive preventative treatment. Finally, the invention provides a composition comprising infant formula and polyethylene glycol and methods for using that composition.
摘要翻译：本发明提供了具有相对高分子量的生物相容性聚合物形式的药物组合物，例如聚乙二醇，任选地补充保护性聚合物如葡聚糖和/或必需的病原体营养物如L-谷氨酰胺。还提供了通过施用高分子量聚乙二醇来预防或治疗归因于肠道病原体如铜绿假单胞菌的肠源性败血症的方法以及用于监测高分子量聚乙二醇的施用的方法，例如在预防，改善或治疗微生物诱导的上皮疾病，例如肠源性败血症。通常，肠道衍生的败血症是由外科手术或患有疾病或病症而恢复的哺乳动物的并发症，提供合适动物接受预防治疗的适应症。最后，本发明提供包含婴儿配方和聚乙二醇的组合物和使用该组合物的方法。

2. 发明公开

EP1595547A2 Use of the growth factor AMP for the treatment of gastrointestinal injuries and acute renal failure 审中-公开
标题翻译：使用生长因子AMP的用于治疗胃肠道损伤和急性肾功能衰竭
公开(公告)号：EP1595547A2
公开(公告)日：2005-11-16
申请号：EP05010217.7
申请日：2005-05-10
申请人： University of Chicago, UC-Tech Office of Technology & Intellectual Property
发明人： Toback, Gary F. , Walsh-Reitz, Margaret M. , Martin, Terrence E.
IPC分类号： A61K38/18 , A61P1/04 , A61P13/12
CPC分类号： C07K14/475 , A01K2217/075 , A01K2227/105 , A61K38/00 , C07K5/1008 , C07K16/18 , C07K2317/73 , C07K2317/76
摘要： A novel group of gastrokines called Gastric Antrum Mucosal Protein is characterized. A member of the group is designated AMP-18. AMP - 18 genomic DNA, cDNA and the AMP- 18 protein are sequenced for human, mouse and pig. The AMP-18 protein and active peptides derived from it are cellular growth factors. Surprisingly, peptides capable of inhibiting the effects of the complete protein, are also derived from the AMP - 18 protein. Cytoprotection and control of mammalian gastro-intestinal tissue growth and repair (restitution) is facilitated by the use of the proteins, making the proteins candidates for therapies in inflammatory bowel disease, mucositis, and gastric ulcers.
摘要翻译：称为胃窦粘膜蛋白gastrokines的一组新的特征。该组的成员被指定AMP-18 AMP - 18基因组DNA，cDNA和所述AMP 18蛋白测序对人，小鼠和猪。的AMP-18蛋白和从它派生活性肽是细胞生长因子。令人惊讶地，肽能够抑制完全蛋白质，即从AMP衍生的效果 - 蛋白第十八细胞保护作用和哺乳动物胃肠组织生长和修复（恢复原状）的控制是通过使用该蛋白的便利，使得该蛋白候选炎症性肠病，粘膜炎，和胃溃疡的治疗方法。

3. 发明公开

EP1567117A1 MATERIALS AND METHODS FOR PREVENTING AND TREATING MICROBE-MEDIATED EPITHELIAL DISORDERS 有权
标题翻译：防治芽发送EPITHELERKRANKUNGEN
公开(公告)号：EP1567117A1
公开(公告)日：2005-08-31
申请号：EP02789898.0
申请日：2002-11-26
申请人： UC Tech
发明人： ALVERDY, John, C., M.D.
IPC分类号： A61K7/06 , A61K39/108
CPC分类号： A61K31/765 , A23K20/105 , A23K50/10 , A23K50/20 , A23K50/30 , A23K50/40 , A23K50/75 , A23L33/10 , A23L33/40 , A61K31/198 , A61K31/721 , A61K31/77 , A61K2300/00
摘要： The present invention provides pharmaceutical compositions in the form of relatively high molecular weight biocompatible polymers such as polyethylene glycol, optionally supplemented with a protective polymer such ad dextran and/or essential pathogen nutrients such as L-glutantine. Also provided are methods for preventing or treating gut-derived sepsis attributable to intestinal pathogens such as Pseudomonas aeruginosa by administering high molecular weight polyethylene glycol as well as methods for monitoring the administration of high molecular weight polyethylene glycol, such as in methods of preventing, ameliorating or treating microbe-induced epithelial disorders, as exemplified by gut-derived sepsis. Frequently, gut-derived sepsis arises as a complication in mammals recovering from surgical intervention or suffering from a disease or disorder, providing indications of suitable animals to receive preventative treatment. Finally, the invention provides a composition comprising infant formula and polyethylene glycol and methods for using that composition.

4. 发明专利

BR0215954A 未知
公开(公告)号：BR0215954A
公开(公告)日：2005-09-13
申请号：BR0215954
申请日：2002-11-26
申请人： UC TECH
发明人： ALVERDY JOHN C M D
IPC分类号： A23K1/16 , A23K1/18 , A23L1/30 , A23L33/00 , A61K31/765 , A61K39/108 , A61K47/34 , A61K7/06
摘要： The present invention provides pharmaceutical compositions in the form of relatively high molecular weight biocompatible polymers such as polyethylene glycol, optionally supplemented with a protective polymer such as dextran and/or essential pathogen nutrients such as L-glutamine. Also provided are methods for preventing or treating gut-derived sepsis attributable to intestinal pathogens such as Pseudomonas aeruginosa by administering high molecular weight polyethylene glycol as well as methods for monitoring the administration of high molecular weight polyethylene glycol, such as in methods of preventing, ameliorating or treating microbe-induced epithelial disorders, as exemplified by gut-derived sepsis. Frequently, gut-derived sepsis arises as a complication in mammals recovering from surgical intervention or suffering from a disease or disorder, providing indications of suitable animals to receive preventative treatment. Finally, the invention provides a composition comprising infant formula and polyethylene glycol and methods for using that composition.

5. 发明专利

AU2002352938A1 MATERIALS AND METHODS FOR PREVENTING AND TREATING MICROBE-MEDIATED EPITHELIAL DISORDERS 未知
公开(公告)号：AU2002352938A1
公开(公告)日：2004-06-18
申请号：AU2002352938
申请日：2002-11-26
申请人： UC TECH
发明人： ALVERDY JOHN C M D
IPC分类号： A23K1/16 , A23K1/18 , A23L1/30 , A23L33/00 , A61K31/765 , A61K39/108 , A61K47/34 , A61K7/06
摘要： The present invention provides pharmaceutical compositions in the form of relatively high molecular weight biocompatible polymers such as polyethylene glycol, optionally supplemented with a protective polymer such as dextran and/or essential pathogen nutrients such as L-glutamine. Also provided are methods for preventing or treating gut-derived sepsis attributable to intestinal pathogens such as Pseudomonas aeruginosa by administering high molecular weight polyethylene glycol as well as methods for monitoring the administration of high molecular weight polyethylene glycol, such as in methods of preventing, ameliorating or treating microbe-induced epithelial disorders, as exemplified by gut-derived sepsis. Frequently, gut-derived sepsis arises as a complication in mammals recovering from surgical intervention or suffering from a disease or disorder, providing indications of suitable animals to receive preventative treatment. Finally, the invention provides a composition comprising infant formula and polyethylene glycol and methods for using that composition.

6. 发明专利

CA2507018A1 MATERIALS AND METHODS FOR PREVENTING AND TREATING MICROBE-MEDIATED EPITHELIAL DISORDERS 未知
公开(公告)号：CA2507018A1
公开(公告)日：2004-06-10
申请号：CA2507018
申请日：2002-11-26
申请人： UC TECH
发明人： ALVERDY JOHN C
IPC分类号： A61K31/765 , A23K1/16 , A23K1/18 , A23L1/30 , A23L33/00 , A61B1/00 , A61F6/04 , A61K39/108 , A61K47/34 , C12Q1/02 , G01N33/48
摘要： The present invention provides pharmaceutical compositions in the form of relatively high molecular weight biocompatible polymers such as polyethylene glycol, optionally supplemented with a protective polymer such ad dextran and/or essential pathogen nutrients such as L-glutamine. Also provided are methods for preventing or treating gut-derived sepsis attributable to intestinal pathogens such as Pseudomonas aeruginosa by administering high molecular weight polyethylene glycol as well as methods for monitoring the administration of high molecular weight polyethylene glycol, such as in methods of preventing, ameliorating or treating microbe-induced epithelial disorders, as exemplified by gut-derived sepsis. Frequently, gut-derived sepsis arises as a complication in mammals recovering from surgical intervention or suffering from a disease or disorder, providing indications of suitable animals to receive preventative treatment. Finally, the invention provides a composition comprising infant formula and polyethylene glycol and methods for using that composition.

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