专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2005029028A1 OPTICAL TACTILE SENSOR AND METHOD OF RECONSTRUCTING FORCE VECTOR DISTRIBUTION USING THE SENSOR 审中-公开
标题翻译：光学传感器和使用传感器重建力矢量分布的方法
公开(公告)号：WO2005029028A1
公开(公告)日：2005-03-31
申请号：PCT/JP2004/007285
申请日：2004-05-21
申请人： TOUDAI TLO, LTD. , MIZOTA, Terukazu , KAMIYAMA, Kazuto , KAJIMOTO, Hiroyuki , KAWAKAMI, Naoki , TACHI, Susumu
发明人： MIZOTA, Terukazu , KAMIYAMA, Kazuto , KAJIMOTO, Hiroyuki , KAWAKAMI, Naoki , TACHI, Susumu
IPC分类号： G01L5/16
CPC分类号： G01L1/24 , B25J13/084 , G01L5/166 , G01L5/228
摘要： The invention relates to a tactile sensor capable of obtaining information for a plurality of degrees of freedom at each point on a surface. An optical tactile sensor is provided with a sensing part and a photographing device, the sensing part comprising a transparent elastic body and a plurality of groups of markers provided inside the elastic body, each marker group being made up of a number of colored markers, with markers making up different marker groups having different colors for each group. The elastic body has an arbitrary curved surface. The behavior of the colored markers when an object touches the curved surface of the elastic body is obtained as image information of markers by photographing device. The sensor further comprises a force vector distribution reconstructing device for reconstructing forces applied to said surface from information as to the behavior of markers that is obtained from said image information of markers.
摘要翻译：本发明涉及一种能够在表面上的每个点处获得多个自由度的信息的触觉传感器。光学触觉传感器设置有感测部分和拍摄装置，感测部分包括透明弹性体和设置在弹性体内部的多组标记，每个标记组由多个彩色标记组成，具有组成不同标记组的标记，每组具有不同的颜色。弹性体具有任意的曲面。通过拍摄装置获得当物体接触到弹性体的曲面时的着色标记的行为作为标记的图像信息。该传感器还包括一个力向量分布重建装置，用于根据从标记的所述图像信息获得的标记的行为的信息重构施加到所述表面的力。

2. 发明申请

WO2005063170A3 METHODS OF IDENTIFYING IMMUNOREGULATORY AGENTS, IMMUNOREGULATORY AGENTS, AND USES THEREOF 审中-公开
标题翻译：鉴定免疫调节剂，免疫调节剂及其用途的方法
公开(公告)号：WO2005063170A3
公开(公告)日：2005-11-10
申请号：PCT/JP2004019846
申请日：2004-12-28
申请人： TOUDAI TLO LTD , MORIMOTO CHIKAO , OHNUMA KEI
发明人： MORIMOTO CHIKAO , OHNUMA KEI
IPC分类号： C12N15/113 , G01N33/50 , G01N33/68 , G01N33/94 , A61K38/00 , C12N15/11
CPC分类号： C12N15/113 , C12N15/1138 , C12N2310/14 , G01N33/505 , G01N33/9493
摘要： The present invention provides methods of identifying a substance that down-regulates or up-regulates an immune response and kits used for the identification methods. A method of this invention comprises detecting a substance that inhibits or enhances the interaction between CD26 and caveolin-1. Another method comprises detecting a substance that inhibits or enhances the interaction between caveolin-1 and Tollip. Still another method comprises detecting a substance that inhibits or enhances the interaction among caveolin-1, Tollip, and IRAK-1. The present invention also relates to immunoregulatory agents comprising a substance that down-regulates an immune response, such as siRNA against caveolin-1 or Tollip. The invention further provides immunoregulatory agents comprising a substance that up-regulates an immune response. These agents are useful for treating inflammatory diseases, autoimmune diseases, or other immune-mediated disorders.
摘要翻译：本发明提供了鉴定下调或上调免疫应答的物质的方法和用于鉴定方法的试剂盒。本发明的方法包括检测抑制或增强CD26和窖蛋白-1之间相互作用的物质。另一种方法包括检测抑制或增强窖蛋白-1与Tollip之间相互作用的物质。另一种方法包括检测抑制或增强小窝蛋白-1，Tollip和IRAK-1之间相互作用的物质。本发明还涉及免疫调节剂，其包含下调免疫应答的物质，例如针对小窝蛋白-1或Tollip的siRNA。本发明进一步提供了包含上调免疫应答的物质的免疫调节剂。这些药剂可用于治疗炎性疾病，自身免疫性疾病或其他免疫介导的疾病。

3. 发明申请

WO2006081537A2 NOVEL AROMATIC PRENYLTRANSFERASES, NUCLEIC ACIDS ENCODING SAME AND USES THEREFOR 审中-公开
标题翻译：新型芳香乳酸酯，编码其的核酸及其用途
公开(公告)号：WO2006081537A2
公开(公告)日：2006-08-03
申请号：PCT/US2006003161
申请日：2006-01-27
申请人： SALK INST FOR BIOLOGICAL STUDI , TOUDAI TLO LTD , KUZUYAMA TOMOHISA , NOEL JOSEPH P , RICHARD STEPHANE P
发明人： KUZUYAMA TOMOHISA , NOEL JOSEPH P , RICHARD STEPHANE P
IPC分类号： C07H21/04
CPC分类号： C12N9/1085
摘要： In accordance with the present invention, a novel aromatic prenyltransferase., Orf2 from Streptomyces sp. strain CL190, involved in naphterpin biosynthesis has been identified and the structure thereof elucidated. This prenyltransferase catalyzes the formation of a C-C bond between a prenyl group and a compound containing an aromatic nucleus, and also displays C-O bond formation activity. Numerous crystallographic structures of the prenyltransferase have been solved and refined, e.g., (1) prenyltransferase complexed with a buffer molecule (TAPS), (2) prenyltransferase as a binary complex with geranyl diphosphate (GPP) and Mg 2+ , and prenyltransferase as ternary complexes with a non-hydrolyzable substrate analogue, geranyl S-thiolodiphosphate (GSPP) and either (3) 1,6-dihydroxynaphthalene (1,6-DHN), or (4) flaviolin (i.e., 2,5,7-trihydroxy-1,4-naphthoquinone, which is the oxidized product of 1,3,6,8-tetrahydroxynaphthalene (THN)). These structures have been solved and refined to 1.5Å, 2.25Å, 1.95Å and 2.02Å, respectively. This first structure of an aromatic prenyltransferase displays an unexpected and non-canonical (ß/a)-barrel architecture. The complexes with both aromatic substrates and prenyl containing substrates and analogs delineate the active site and are consistent with a proposed electrophilic mechanism of prenyl group transfer. These structures also provide a mechanistic basis for understanding prenyl chain length determination and aromatic co-substrate recognition in this structurally unique family of aromatic prenyltransferases. This structural information is useful for predicting the aromatic prenyltransferase activity of proteins.
摘要翻译：根据本发明，一种新的芳族异戊烯转移酶，来自链霉菌属的Orf2。已经鉴定了涉及萘二苯生物合成的菌株CL190，其结构被阐明。该异戊烯基转移酶催化异戊烯基与含有芳香核的化合物之间的C-C键的形成，也显示出C-O键的形成活性。已经解决和改进了异戊烯基转移酶的许多晶体结构，例如，（1）与缓冲分子（TAPS）络合的异戊烯基转移酶，（2）作为与香叶基二磷酸（GPP）和Mg 2+的二元复合物的异戊烯基转移酶，（3）1,6-二羟基萘（1,6-DHN），或（4）黄堇素（即2种），可以与不可水解的底物类似物，香叶基S-硫代二磷酸（GSPP）和（3），5,7-三羟基-1,4-萘醌，其为1,3,6,8-四羟基萘（THN）的氧化产物）。这些结构分别被解析并精炼成1.5A，2.25，1.95和2.02。芳族异戊烯基转移酶的这种第一结构显示出意想不到的和非规范的（ß/ a） - 桶状结构。具有芳香底物和含异戊烯基的底物和类似物的配合物描绘了活性位点，并且与异戊烯基转移所提出的亲电子机制一致。这些结构还提供了在这个结构独特的芳族异戊烯基转移酶家族中理解异戊烯基链长度测定和芳香族共底物识别的机理基础。该结构信息可用于预测蛋白质的芳族异戊烯基转移酶活性。

4. 发明申请

WO2005063980A8 METHOD OF ENZYMATICALLY CONSTRUCTING RNAi LIBRARY 审中-公开
标题翻译：方法构建RNAi库
公开(公告)号：WO2005063980A8
公开(公告)日：2006-02-09
申请号：PCT/JP2004019612
申请日：2004-12-28
申请人： TOUDAI TLO LTD , HIROSE KENZO , SHIRANE DAISUKE , SUGAO KOHTAROH , NAMIKI SHIGEYUKI , IINO MASAMITSU
发明人： HIROSE KENZO , SHIRANE DAISUKE , SUGAO KOHTAROH , NAMIKI SHIGEYUKI , IINO MASAMITSU
IPC分类号： C12N15/10 , C12N15/11 , C12N15/09 , C12Q1/68 , G01N33/15 , G01N33/50
CPC分类号： C12N15/1034 , C12N15/111 , C12N2310/14 , C12N2330/30
摘要： It is intended to provide a method of enzymatically preparing a systematic RNAi library from a target DNA. According to this method, a target DNA can be prepared not only from the cDNA or genomic sequence of a specific gene but also from a cDNA library. It is also intended to provide a screening method whereby a clone carrying an iRNA expression construct having a desired silencing activity can be selected from an RNAi library. In this screening, more efficient selection can be made by fusing a reporter gene or a negative selection marker with a target DNA.
摘要翻译：旨在提供从目标DNA酶制备系统RNAi文库的方法。根据该方法，不仅可以从特定基因的cDNA或基因组序列，也可以从cDNA文库制备靶DNA。还旨在提供一种筛选方法，由此可以从RNAi文库中选择携带具有所需沉默活性的iRNA表达构建体的克隆。在该筛选中，可以通过将报告基因或负选择标记与靶DNA融合来进行更有效的选择。

5. 发明申请

WO03046186A8 siRNA EXPRESSION SYSTEM AND METHOD FOR PRODUCING FUNCTIONAL GENE KNOCK-DOWN CELLS USING THE SYSTEM 审中-公开
标题翻译：用于使用该系统产生功能性基因锁定细胞的siRNA表达系统和方法
公开(公告)号：WO03046186A8
公开(公告)日：2005-09-29
申请号：PCT/JP0212447
申请日：2002-11-28
申请人： TOUDAI TLO LTD , TAIRA KAZUNARI , MIYAGISHI MAKOTO
发明人： TAIRA KAZUNARI , MIYAGISHI MAKOTO
IPC分类号： C12N15/11 , C12N15/113 , C12N15/67 , A01K67/027 , A61K45/00 , A61K48/00 , C12N5/00 , C12Q1/68
CPC分类号： C12N15/111 , A01K2217/05 , C12N15/113 , C12N2310/111 , C12N2310/14 , C12N2310/53 , C12N2320/12
摘要： An in vivo siRNA expression system whereby an si(small interfering)RNA is expressed in cells. This system has an antisense code DNA encoding an antisense RNA to a domain of a target gene mRNA, a sense code DNA encoding a sense RNA in a domain of the target gene mRNA, and one or more promoters for expressing the above-described antisense RNA and the above-described sense RNA by the above-described antisense code DNA and the above-described sense code DNA.
摘要翻译：体内siRNA表达系统，其中si（小干扰）RNA在细胞中表达。该系统具有编码靶基因mRNA的域的反义RNA的反义代码DNA，编码目标基因mRNA的结构域中的有义RNA的感应码DNA和用于表达上述反义RNA的一种或多种启动子和上述正义RNA的上述反义代码DNA和上述感应码DNA。

6. 发明申请

WO2005063170A2 METHODS OF IDENTIFYING IMMUNOREGULATORY AGENTS, IMMUNOREGULATORY AGENTS, AND USES THEREOF 审中-公开
标题翻译：识别免疫原性试剂，免疫检测试剂及其用途的方法
公开(公告)号：WO2005063170A2
公开(公告)日：2005-07-14
申请号：PCT/JP2004/019846
申请日：2004-12-28
申请人： TOUDAI TLO, LTD. , MORIMOTO, Chikao , OHNUMA, Kei
发明人： MORIMOTO, Chikao , OHNUMA, Kei
IPC分类号： A61K
CPC分类号： C12N15/113 , C12N15/1138 , C12N2310/14 , G01N33/505 , G01N33/9493
摘要： The present invention provides methods of identifying a substance that down-regulates or up-regulates an immune response and kits used for the identification methods. A method of this invention comprises detecting a substance that inhibits or enhances the interaction between CD26 and caveolin-1. Another method comprises detecting a substance that inhibits or enhances the interaction between caveolin-1 and Tollip. Still another method comprises detecting a substance that inhibits or enhances the interaction among caveolin-1, Tollip, and IRAK-1. The present invention also relates to immunoregulatory agents comprising a substance that down-regulates an immune response, such as siRNA against caveolin-1 or Tollip. The invention further provides immunoregulatory agents comprising a substance that up-regulates an immune response. These agents are useful for treating inflammatory diseases, autoimmune diseases, or other immune-mediated disorders.
摘要翻译：本发明提供鉴定下调或上调免疫应答的物质的方法和用于鉴定方法的试剂盒的方法。本发明的方法包括检测抑制或增强CD26和小窝蛋白-1之间相互作用的物质。另一种方法包括检测抑制或增强窖1与Tollip之间相互作用的物质。另一种方法包括检测抑制或增强窖1，Tollip和IRAK-1之间相互作用的物质。本发明还涉及免疫调节剂，其包含下调免疫应答的物质，例如针对窖1或Tollip的siRNA。本发明进一步提供了包含上调免疫应答的物质的免疫调节剂。这些药剂可用于治疗炎性疾病，自身免疫疾病或其他免疫介导的疾病。

7. 发明申请

WO2006081537A3 NOVEL AROMATIC PRENYLTRANSFERASES, NUCLEIC ACIDS ENCODING SAME AND USES THEREFOR 审中-公开
公开(公告)号：WO2006081537A3
公开(公告)日：2006-08-03
申请号：PCT/US2006/003161
申请日：2006-01-27
申请人： THE SALK INSTITUTE FOR BIOLOGICAL STUDIES , TOUDAI TLO, LTD , KUZUYAMA, Tomohisa , NOEL, Joseph, P. , RICHARD, Stephane, P.
发明人： KUZUYAMA, Tomohisa , NOEL, Joseph, P. , RICHARD, Stephane, P.
IPC分类号： C07H21/04
摘要： In accordance with the present invention, a novel aromatic prenyltransferase., Orf2 from Streptomyces sp. strain CL190, involved in naphterpin biosynthesis has been identified and the structure thereof elucidated. This prenyltransferase catalyzes the formation of a C-C bond between a prenyl group and a compound containing an aromatic nucleus, and also displays C-O bond formation activity. Numerous crystallographic structures of the prenyltransferase have been solved and refined, e.g., (1) prenyltransferase complexed with a buffer molecule (TAPS), (2) prenyltransferase as a binary complex with geranyl diphosphate (GPP) and Mg 2+ , and prenyltransferase as ternary complexes with a non-hydrolyzable substrate analogue, geranyl S-thiolodiphosphate (GSPP) and either (3) 1,6-dihydroxynaphthalene (1,6-DHN), or (4) flaviolin (i.e., 2,5,7-trihydroxy-1,4-naphthoquinone, which is the oxidized product of 1,3,6,8-tetrahydroxynaphthalene (THN)). These structures have been solved and refined to 1.5Å, 2.25Å, 1.95Å and 2.02Å, respectively. This first structure of an aromatic prenyltransferase displays an unexpected and non-canonical ( β/α )-barrel architecture. The complexes with both aromatic substrates and prenyl containing substrates and analogs delineate the active site and are consistent with a proposed electrophilic mechanism of prenyl group transfer. These structures also provide a mechanistic basis for understanding prenyl chain length determination and aromatic co-substrate recognition in this structurally unique family of aromatic prenyltransferases. This structural information is useful for predicting the aromatic prenyltransferase activity of proteins.

8. 发明申请

WO2005014609A3 METHOD OF PRODUCING A HIGHLY STEREOREGULAR PHOSPHORUS ATOM-MODIFIED NUCLEOTIDE ANALOGUE 审中-公开
标题翻译：生产高分子磷酸亚胺修饰核酸模拟物的方法
公开(公告)号：WO2005014609A3
公开(公告)日：2005-04-28
申请号：PCT/JP2004011524
申请日：2004-08-04
申请人： TOUDAI TLO LTD , SAIGO KAZUHIKO , WADA TAKESHI
发明人： SAIGO KAZUHIKO , WADA TAKESHI
IPC分类号： A61K31/7115 , A61K48/00 , C07H19/10 , C07H19/11 , C07H19/207 , C07H19/213 , C07H21/00 , C07H23/00 , C07H19/00
CPC分类号： C07H19/213 , C07H19/10 , C07H19/11 , C07H21/00
摘要： To provide an efficient production method for a highly stereoregular phosphorus atom-modified nucleotide where a conformation on a phosphorus atom is controlled. A production method for a highly stereoregular phosphorus atom-modified nucleotide analogue represented by the general formula (4) et (5), characterized by comprising condensing optically-active nucleoside 3'-phosphoramidite with nucleoside using an activator, followed by reaction with an electrophilic reagent and deprotection.
摘要翻译：为了提供高度立构规整的磷原子修饰的核苷酸的高效制备方法，其中控制磷原子上的构象。一种由通式（4）等（5）表示的高度立构规整的磷原子修饰的核苷酸类似物的制造方法，其特征在于，使用活化剂将光活性核苷3'-亚磷酰胺与核苷缩合，然后与亲电子试剂和去保护。

9. 发明申请

WO2005014609A2 METHOD OF PRODUCING A HIGHLY STEREOREGULAR PHOSPHORUS ATOM-MODIFIED NUCLEOTIDE ANALOGUE 审中-公开
标题翻译：生产高分子磷酸亚胺修饰核酸模拟物的方法
公开(公告)号：WO2005014609A2
公开(公告)日：2005-02-17
申请号：PCT/JP2004/011524
申请日：2004-08-04
申请人： TOUDAI TLO, LTD. , SAIGO, Kazuhiko , WADA, Takeshi
发明人： SAIGO, Kazuhiko , WADA, Takeshi
IPC分类号： C07H19/00
CPC分类号： C07H19/213 , C07H19/10 , C07H19/11 , C07H21/00
摘要： To provide an efficient production method for a highly stereoregular phosphorus atom-modified nucleotide where a conformation on a phosphorus atom is controlled. A production method for a highly stereoregular phosphorus atom-modified nucleotide analogue represented by the general formula (4) et (5), characterized by comprising condensing optically-active nucleoside 3’-phosphoramidite with nucleoside using an activator, followed by reaction with an electrophilic reagent and deprotection:
摘要翻译：为了提供高度立构规整的磷原子修饰的核苷酸的高效制备方法，其中控制磷原子上的构象。一种由通式（4）等（5）表示的高度立构规整的磷原子修饰的核苷酸类似物的制造方法，其特征在于，使用活化剂将光活性核苷3'-亚磷酰胺与核苷缩合，然后与亲电子试剂和脱保护：

10. 发明专利

CY1110233T1 ΣΥΜΠΛΟΚΟ ΣΥΝΤΟΝΙΣΜΟΥ ΤΟΥ ΔΙΑΜΙΝΟΚΥΚΛΟΕΞΑΝΟ ΛΕΥΚΟΧΡΥΣΟΥ(ΙΙ) ΜΕ ΜΠΛΟΚ ΣΥΜΠΟΛΥΜΕΡΕΣ ΠΟΥ ΠΕΡΙΕΧΕΙ ΤΜΗΜΑ ΠΟΛΥ(ΚΑΡΒΟΞΥΛΙΚΟΥ ΟΞΕΟΣ) ΚΑΙ ΠΑΡΑΓΟΝΤΑ ΚΑΤΑ ΤΟΥ ΟΓΚΟΥ ΠΟΥ ΠΕΡΙΛΑΜΒΑΝΕΙ ΑΥΤΟ 未知
公开(公告)号：CY1110233T1
公开(公告)日：2015-01-14
申请号：CY101100171
申请日：2010-02-19
申请人： TOUDAI TLO LTD
发明人： KATAOKA KAZUNORI , NISHIYAMA NOBUHIRO , CABRAL HORACIO , OKAZAKI SOICHIRO
IPC分类号： C08G81/00 , A61K9/107 , A61K45/06 , A61K47/34 , A61K47/48
摘要： Παρέχεταισύμπλοκοσυντονισμούδιαμινοκυκλοέξανολευκοχρύσου (II) μεέναμπλοκσυμπολυμερέςπουπεριλαμβάνειτμήμαπολυ(αιθυλένογλυκόλης) καιένατμήμαπολυ(καρβοξυλικούοξέος). Τοσύμπλοκομπορείικανοποιητικάναχρησιμοποιείταισεθεραπείεςγιαόγκους, συγκεκριμένακακοήθειςόγκους.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式