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1. 发明申请

WO2005014609A3 METHOD OF PRODUCING A HIGHLY STEREOREGULAR PHOSPHORUS ATOM-MODIFIED NUCLEOTIDE ANALOGUE 审中-公开
标题翻译：生产高分子磷酸亚胺修饰核酸模拟物的方法
公开(公告)号：WO2005014609A3
公开(公告)日：2005-04-28
申请号：PCT/JP2004011524
申请日：2004-08-04
申请人： TOUDAI TLO LTD , SAIGO KAZUHIKO , WADA TAKESHI
发明人： SAIGO KAZUHIKO , WADA TAKESHI
IPC分类号： A61K31/7115 , A61K48/00 , C07H19/10 , C07H19/11 , C07H19/207 , C07H19/213 , C07H21/00 , C07H23/00 , C07H19/00
CPC分类号： C07H19/213 , C07H19/10 , C07H19/11 , C07H21/00
摘要： To provide an efficient production method for a highly stereoregular phosphorus atom-modified nucleotide where a conformation on a phosphorus atom is controlled. A production method for a highly stereoregular phosphorus atom-modified nucleotide analogue represented by the general formula (4) et (5), characterized by comprising condensing optically-active nucleoside 3'-phosphoramidite with nucleoside using an activator, followed by reaction with an electrophilic reagent and deprotection.
摘要翻译：为了提供高度立构规整的磷原子修饰的核苷酸的高效制备方法，其中控制磷原子上的构象。一种由通式（4）等（5）表示的高度立构规整的磷原子修饰的核苷酸类似物的制造方法，其特征在于，使用活化剂将光活性核苷3'-亚磷酰胺与核苷缩合，然后与亲电子试剂和去保护。

2. 发明专利

JP2005089441A Manufacturing method of highly stereoregular phosphorus atom-modified nucleotide analogue 审中-公开
标题翻译：高分子磷酸盐修饰核苷类似物的制备方法
公开(公告)号：JP2005089441A
公开(公告)日：2005-04-07
申请号：JP2004089150
申请日：2004-03-25
申请人： Toudai Tlo Ltd , 株式会社東京大学Tlo
发明人： SAIGO KAZUHIKO , WADA TAKESHI
IPC分类号： A61K31/7115 , A61K48/00 , C07H19/10 , C07H19/11 , C07H19/207 , C07H19/213 , C07H21/00 , C07H23/00
CPC分类号： C07H19/213 , C07H19/10 , C07H19/11 , C07H21/00
摘要： PROBLEM TO BE SOLVED: To provide an efficient manufacturing method of a highly stereoregular phosphorus atom-modified nucleotide wherein the structure on the phosphorus atom is stereocontrolled.
SOLUTION: The manufacturing method of the highly stereoregular phosphorus atom-modified nucleotide analogue represented by general formula (4) or (5), characteristically performs a reaction with an electrophilic reagent and deprotection after condensing an optically active nucleoside 3'-phosphoroamidite and a nucleoside by using an activating agent.
COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：要解决的问题：提供高度立构规整的磷原子修饰的核苷酸的有效制造方法，其中磷原子上的结构是立体控制的。解决方案：由通式（4）或（5）表示的高度立构规整的磷原子修饰的核苷酸类似物的制造方法，特征在于使亲电子试剂进行反应，并在冷凝光学活性核苷3'-亚磷酰胺后进行脱保护和通过使用活化剂的核苷。版权所有（C）2005，JPO＆NCIPI

3. 发明申请

WO0173381A3 PARTICLE SENSOR 审中-公开
标题翻译：颗粒传感器
公开(公告)号：WO0173381A3
公开(公告)日：2002-02-07
申请号：PCT/JP0102539
申请日：2001-03-28
申请人： MATSUSHITA ELECTRIC WORKS LTD , OKA SHOICHI , HAYASHI MASANORI , KIRIHATA SHINJI , NISHIKAWA TAKAYUKI , SAKAMOTO KOJI , WADA TAKESHI
发明人： OKA SHOICHI , HAYASHI MASANORI , KIRIHATA SHINJI , NISHIKAWA TAKAYUKI , SAKAMOTO KOJI , WADA TAKESHI
IPC分类号： G01N15/06 , G01N21/53 , H03G1/00 , G01N15/02 , H03F1/30 , H03F3/45
CPC分类号： G01N21/53 , G01N2201/127 , H03G1/0088
摘要： A particle sensor has a gain control and an offset voltage adjustment so as to provide a consistent sensor output indicative of the particle density in match with a predetermined relationship between the sensor output and the particle density, while compensating for background noises. The gain control and the offset voltage adjustment are realized respectively by digitally controllable variable resistor networks each having a plurality of switches. A memory module is included in the sensor to store instruction data for control of the switches and therefore responsible for the gain control and the offset voltage adjustment. In particular, the particle sensor includes a memory interface which enables the selective use of two types of memory means, one is an intelligent memory module composed of EEPROM and a microcomputer, and the other is a normal memory module consisting of EEPROM.
摘要翻译：颗粒传感器具有增益控制和偏移电压调整，以便在补偿背景噪声的同时，提供指示颗粒密度与传感器输出和颗粒密度之间的预定关系匹配的一致的传感器输出。增益控制和偏移电压调整分别由具有多个开关的数字可控可变电阻网络实现。传感器中包含存储器模块以存储用于控制开关的指令数据，因此负责增益控制和偏移电压调整。特别地，粒子传感器包括能够选择性地使用两种存储装置的存储器接口，一个是由EEPROM和微计算机组成的智能存储器模块，另一个是由EEPROM组成的通常存储器模块。

4. 发明申请

WO2010064146A3 METHOD FOR THE SYNTHESIS OF PHOSPHORUS ATOM MODIFIED NUCLEIC ACIDS 审中-公开
标题翻译：磷酸基改性核酸的合成方法
公开(公告)号：WO2010064146A3
公开(公告)日：2010-10-28
申请号：PCT/IB2009007923
申请日：2009-12-02
申请人： CHIRALGEN LTD , WADA TAKESHI , SHIMIZU MAMORU
发明人： WADA TAKESHI , SHIMIZU MAMORU
IPC分类号： C07H21/00
CPC分类号： C07H21/00 , C07H1/00
摘要： Described herein are methods of syntheses of phosphorous atom-modified nucleic acids comprising chiral X-phosphonate moieties. The methods described herein provide backbone-modified nucleic acids in high diasteteomeric purity via an asymmetric reaction of an achiral molecule comprising a chemically stable H-phophonate moiety with a nucleoside/nucleotide.
摘要翻译：本文描述了合成包含手性X-膦酸酯部分的磷原子修饰的核酸的方法。本文所述的方法通过含有化学稳定的H-膦酸酯部分的非手性分子与核苷/核苷酸的不对称反应提供高非离子纯度的骨架修饰的核酸。

5. 发明专利

JPS5545755A PHOTODEGRADABLE MACROMOLECULAR FILM 失效
公开(公告)号：JPS5545755A
公开(公告)日：1980-03-31
申请号：JP11960378
申请日：1978-09-27
申请人： KAGITANI TSUTOMU , WADA TAKESHI , NOMURA TAKAFUMI
发明人： KAGITANI TSUTOMU , WADA TAKESHI , NOMURA TAKAFUMI
IPC分类号： C08L101/00 , C08F8/00 , C08F8/06 , C08F8/08 , C08J3/00 , C08L1/00 , C08L7/00 , C08L21/00 , C08L23/00 , C08L27/00 , C08L33/00 , C08L33/02
摘要： PURPOSE:To photodegradable macromolecular film that is prepared by making ozone act on a synthetic macromolecular film, thus costing inexpensively in manufacture and causing no secondary pollution after used in agriculture, because it is photodegradable under natural conditions. CONSTITUTION:Said photodegradable film is made by making ozone act on various kinds of synthetic macromolecular films or by processing a composition containing powdery or granular synthetic macromolecules on which ozone has beforehand been made to act. The synthetic macromolecular film is , e.g., homo- or copolymer of ethylene, vinyl chloride or so and 5-1000 microns in thickness. The ozone concentration of the gas containing ozone is 0.01-100% and the reaction temeprature is lower than the melting point of the synthetic macromolecule and the reaction time is tens sec to tens hr.

6. 发明专利

JPH0134623B2 失效
公开(公告)号：JPH0134623B2
公开(公告)日：1989-07-20
申请号：JP3814884
申请日：1984-02-29
申请人： JEKUSU KK , WADA TAKESHI
发明人： KAWAMURA MITSUO , YAMASHITA HISAO , WADA TAKESHI , GOTO TOMONOBU
IPC分类号： A61J11/00 , A61J11/02

7. 发明专利

JPS527442A METHOD FOR QUANTITATIVE ADMIXING OF LIQUID ADDITIVES 失效
公开(公告)号：JPS527442A
公开(公告)日：1977-01-20
申请号：JP8360675
申请日：1975-07-09
申请人： WADA TAKESHI
发明人： WADA TAKESHI
IPC分类号： B65B3/04 , A01N25/18 , B67D3/00 , B67D7/00
摘要： PURPOSE:A method for quantitative addmixing of liquid addtiones to liquid absorptive solid substances without using solvents.

8. 发明专利

JPS60182949A NIPPLE 失效
公开(公告)号：JPS60182949A
公开(公告)日：1985-09-18
申请号：JP3814884
申请日：1984-02-29
申请人： JEKUSU KK , WADA TAKESHI
发明人： KAWAMURA MITSUO , YAMASHITA HISAO , WADA TAKESHI , GOTOU TOMONOBU
IPC分类号： A61J11/00 , A61J11/02

9. 发明专利

JPH03149437A STEERING MACHINE 失效
公开(公告)号：JPH03149437A
公开(公告)日：1991-06-26
申请号：JP28603889
申请日：1989-11-04
申请人： WADA TAKESHI
发明人： WADA TAKESHI
IPC分类号： B62D11/08 , F16H48/08
摘要： PURPOSE:To realize an easy and accurate steering with a simple structure, by providing output side gears that are on the same axis, on both sides of the rotary surface of a motive power side gear, and providing between both output side gears a common means by which planetary gear groups respectively and interveniently furnished can rotate in mutually opposite directions. CONSTITUTION:Output side gears 2, 3 in the same axial direction are provided on both sides of a motive power side gear 1, and planetary gears 4a, 4b, 5a, 5b constituting planetary gear groups are provided among gears 1, 2, 3. These planetary gears 4a, 4b; 5a, 5b mesh with the input side gear 1, output side gears 2, 3, and the shafts of planetary gears 4a, 4b; 5a, 5b are mutually fixed, and fixation is made at planetary gear group rotation gears 6, 7 meshing with a steering input gear 8 so that rotation gears 6, 7 meshing with a steering input gear 8 so that rotation may be made within a surface parallel with the rotary surface of the motive power side gear 1 with the median point among these centers as the center. Accordingly, the rotation of output side gears 2, 3 becomes in the same or reverse direction by the rotation of the input gear 8, and an accurate steering can be done easily with a simple structure.

10. 发明专利

JPH01207069A NURSING NIPPLE 失效
公开(公告)号：JPH01207069A
公开(公告)日：1989-08-21
申请号：JP3255988
申请日：1988-02-15
申请人： MINKII KK , WADA TAKESHI
发明人： KAWAMURA MITSUO , WADA TAKESHI
IPC分类号： A61J11/00
摘要： PURPOSE:To obtain a nursing nipple permitting an infant to efficiently drink milk by the movement of a tongue, by a method wherein a nipple part is formed into such a slightly flat and almost oval cross-sectional shape, that the part near to the leading end of one of flat parts and the central part of the other flat part are thick and the region from both side parts of the nipple part to the head part thereof is thin, and an emitting port is formed to the leading end part of the nipple part. CONSTITUTION:A nipple part 4 is inserted in the mouth of an infant so that one flat part 5 of said nipple part is turned to the upper jaw of the infant and the other flat part 6 thereof is turned to the tongue of the infant. The infant receives the nipple part 4 in the oral cavity thereof and the body part 3 of a nipple is supported by the upper and lower lips 8 and gum 9 of the infant, and the nipple part 4 is grasped between the tongue 10 and upper jaw of the infant. The infant sucks the under surface of the nipple part 4 toward the leading end thereof while pushes up the nipple part 4 toward the upper jaw 11 by the tongue 10. At this time, since the central part of the flat part 6 of the nipple part 4 is formed thickly, it is prevented that only the part to which the tongue is applied is locally depressed and the whole of the flat part 6 is pushed up toward the opposed flat part 5 and milk is emitted from an emitting orifice 7. since the flat part 5 is flat and the part near to the leading end thereof is thick, said flat part 5 is easily deformed along the upper jaw 11 of the infant and the nipple is stable in the oral cavity.

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