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1. 发明申请

WO2005063170A3 METHODS OF IDENTIFYING IMMUNOREGULATORY AGENTS, IMMUNOREGULATORY AGENTS, AND USES THEREOF 审中-公开
标题翻译：鉴定免疫调节剂，免疫调节剂及其用途的方法
公开(公告)号：WO2005063170A3
公开(公告)日：2005-11-10
申请号：PCT/JP2004019846
申请日：2004-12-28
申请人： TOUDAI TLO LTD , MORIMOTO CHIKAO , OHNUMA KEI
发明人： MORIMOTO CHIKAO , OHNUMA KEI
IPC分类号： C12N15/113 , G01N33/50 , G01N33/68 , G01N33/94 , A61K38/00 , C12N15/11
CPC分类号： C12N15/113 , C12N15/1138 , C12N2310/14 , G01N33/505 , G01N33/9493
摘要： The present invention provides methods of identifying a substance that down-regulates or up-regulates an immune response and kits used for the identification methods. A method of this invention comprises detecting a substance that inhibits or enhances the interaction between CD26 and caveolin-1. Another method comprises detecting a substance that inhibits or enhances the interaction between caveolin-1 and Tollip. Still another method comprises detecting a substance that inhibits or enhances the interaction among caveolin-1, Tollip, and IRAK-1. The present invention also relates to immunoregulatory agents comprising a substance that down-regulates an immune response, such as siRNA against caveolin-1 or Tollip. The invention further provides immunoregulatory agents comprising a substance that up-regulates an immune response. These agents are useful for treating inflammatory diseases, autoimmune diseases, or other immune-mediated disorders.
摘要翻译：本发明提供了鉴定下调或上调免疫应答的物质的方法和用于鉴定方法的试剂盒。本发明的方法包括检测抑制或增强CD26和窖蛋白-1之间相互作用的物质。另一种方法包括检测抑制或增强窖蛋白-1与Tollip之间相互作用的物质。另一种方法包括检测抑制或增强小窝蛋白-1，Tollip和IRAK-1之间相互作用的物质。本发明还涉及免疫调节剂，其包含下调免疫应答的物质，例如针对小窝蛋白-1或Tollip的siRNA。本发明进一步提供了包含上调免疫应答的物质的免疫调节剂。这些药剂可用于治疗炎性疾病，自身免疫性疾病或其他免疫介导的疾病。

2. 发明专利

CA2551912A1 METHODS OF IDENTIFYING IMMUNOREGULATORY AGENTS, IMMUNOREGULATORY AGENTS, AND USES THEREOF 未知
公开(公告)号：CA2551912A1
公开(公告)日：2005-07-14
申请号：CA2551912
申请日：2004-12-28
申请人： TOUDAI TLO LTD
发明人： MORIMOTO CHIKAO , OHNUMA KEI
IPC分类号： G01N33/68 , A61K38/00 , C12N15/113 , G01N33/50 , G01N33/94
摘要： The present invention provides methods of identifying a substance that down- regulates or up-regulates an immune response and kits used for the identification methods. A method of this invention comprises detecting a substance that inhibits or enhances the interaction between CD26 and caveoli n- 1. Another method comprises detecting a substance that inhibits or enhances the interaction between caveolin-1 and Tollip. Still another method comprise s detecting a substance that inhibits or enhances the interaction among caveol in- 1, Tollip, and IRAK-1. The present invention also relates to immunoregulator y agents comprising a substance that down-regulates an immune response, such a s siRNA against caveolin-1 or Tollip. The invention further provides immunoregulatory agents comprising a substance that up-regulates an immune response. These agents are useful for treating inflammatory diseases, autoimmune diseases, or other immune-mediated disorders.

3. 发明申请

WO2007014169A3 ANTI-CD26 ANTIBODIES AND METHODS OF USE THEREOF 审中-公开
标题翻译：抗CD26抗体及其使用方法
公开(公告)号：WO2007014169A3
公开(公告)日：2007-05-10
申请号：PCT/US2006028702
申请日：2006-07-24
申请人： Y S THERAPEUTICS INC , AOYAGI TEIKICHI , LUO PEIZHI , ZHONG PINGYU , HSIEH MARK , LI YAN , WANG CAILI C , MORIMOTO CHIKAO
发明人： AOYAGI TEIKICHI , LUO PEIZHI , ZHONG PINGYU , HSIEH MARK , LI YAN , WANG CAILI C , MORIMOTO CHIKAO
IPC分类号： C07K16/28 , A61K39/395 , A61P35/00 , A61P37/00 , C07K16/40 , C12N15/13
CPC分类号： C07K16/2896 , A61K38/00 , A61K2039/505 , C07K2317/24 , C07K2317/34 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/92 , G01N33/574 , G01N2333/70596 , G01N2500/00
摘要： The present invention provides novel anti-CD26 antibodies and other, related polypeptides, as well as novel polynucleotides encoding the antibodies and polypeptides. The invention also provides methods of making the antibodies and polypeptides. Compositions and cells comprising the antibodies or polypeptides are further provided. Methods of using the antibodies and/or polypeptides, such as to inhibit cell proliferation and in the treatment of conditions associated with CD26, are also provided.
摘要翻译：本发明提供了新的抗CD26抗体和其他相关多肽，以及编码该抗体和多肽的新型多核苷酸。本发明还提供了制备抗体和多肽的方法。还提供了包含抗体或多肽的组合物和细胞。还提供了使用抗体和/或多肽的方法，例如抑制细胞增殖和治疗与CD26相关的病症。

4. 发明申请

WO2004045497A3 CD26-BASED THERAPIES FOR CANCERS AND IMMUNE DISEASE 审中-公开
标题翻译：基于CD26的治疗癌症和免疫疾病
公开(公告)号：WO2004045497A3
公开(公告)日：2006-01-12
申请号：PCT/US0315499
申请日：2003-05-15
申请人： UNIV TEXAS , DANG NAM HOANG , MORIMOTO CHIKAO
发明人： DANG NAM HOANG , MORIMOTO CHIKAO
IPC分类号： A61K31/7088 , A61K38/17 , A61K45/06 , A61K47/48 , A61K38/43
CPC分类号： A61K31/7088 , A61K38/1709 , A61K45/06 , A61K47/6811 , A61K2300/00
摘要： Therapeutic methods comprising administering a composition comprising CD26 thereof in conjunction with chemotherapeutic agents or radiotherapeutic agents for the prevention and treatment of cancers are provided. Also provided are methods for potentiating immune responses comprising administering a composition comprising CD26.
摘要翻译：提供了治疗方法，其包括给予包含CD26的组合物与用于预防和治疗癌症的化学治疗剂或放射治疗剂。还提供了增强免疫应答的方法，包括施用包含CD26的组合物。

5. 发明申请

WO2004084911A3 USE OF ROXITHROMYCIN OR ITS DERIVATIVES FOR THE MODULATION OF IMMUNE RESPONSES 审中-公开
标题翻译：使用罗红霉素或其衍生物调节免疫应答
公开(公告)号：WO2004084911A3
公开(公告)日：2005-04-14
申请号：PCT/JP2004004049
申请日：2004-03-24
申请人： Y S THERAPEUTICS CO LTD , MORIMOTO CHIKAO
发明人： MORIMOTO CHIKAO
IPC分类号： A61K31/70
CPC分类号： A61K31/70
摘要： The present invention relates generally to modulation of immune responses by administration of compositions comprising macrolide antibiotics, such as roxithromycin, and use of those compositions in methods for treating or preventing diseases or disorders involving transendothelial migration of T cells and activated T cells, proinflammatory cytokine production from T cells, and IL-6 production from macrophages. The present invention further relates to the use of such macrolide antibiotic compositions to treat or prevent arthritic and rheumatic disorders, such as rheumatoid arthritis, and to inhibit the development or progression of or one or more of the symptoms of such as a disorder, including joint swelling and tenderness, synovial membrane proliferation, pannus formation, and bone and cartilage destruction.
摘要翻译：本发明一般涉及通过施用包含大环内酯类抗生素（例如罗红霉素）的组合物来调节免疫反应，以及这些组合物在治疗或预防涉及T细胞和活化的T细胞的跨内皮迁移的疾病或病症的方法中的用途，促炎细胞因子产生来自T细胞，以及来自巨噬细胞的IL-6产生。本发明还涉及这种大环内酯类抗生素组合物用于治疗或预防关节炎和风湿性疾病如类风湿性关节炎的用途，并且抑制诸如包括关节在内的病症的发展或进展或一种或多种症状肿胀和压痛，滑膜增生，血管us形成和骨和软骨破坏。

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