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    • 8. 发明授权
    • Antiviral compounds
    • 抗病毒化合物
    • US5476859A
    • 1995-12-19
    • US376213
    • 1995-01-20
    • Richard A. PartisFrancis J. KoszykRichard A. Mueller
    • Richard A. PartisFrancis J. KoszykRichard A. Mueller
    • C07D211/46C07D401/06C07D491/04A61K31/445
    • C07D401/06C07D211/46C07D491/04
    • A method of inhibiting lentivirus is disclosed which comprises mammalian host susceptible to said lentivirus with a virally inhibitory effective amount of an O-acylated derivative of 1,5-dideoxy-1,5-imino-D-glucitol and their N-alkyl, N-acyl and N-aroyl derivatives in which from one to four of the free hydroxyl groups are O-acylated with carboxylic alkanoyl radicals selected from the group consisting of .omega.,.omega.,.omega.-trifluoroalkanoyl having from three to eight carbon atoms, carboxylic cycloalkanoyl groups having from four to eight carbon atoms and carboxylic acyclic alkanoyl groups having from two to ten carbon atoms, wherein the N-aroyl groups contain from 7 to 14 carbon atoms, the N-acyl groups contain from 4 to 8 carbon atoms and the N-alkyl groups contain from 1 to 14 carbon atoms.
    • 公开了一种抑制慢病毒的方法,其包括对所述慢病毒敏感的哺乳动物宿主,其具有病毒抑制有效量的1,5-二脱氧-1,5-亚氨基-D-葡萄糖醇的O-酰化衍生物及其N-烷基,N 酰基和N-芳酰基衍生物,其中1至4个游离羟基与选自具有3至8个碳原子的ω,ω,ω-三氟烷酰基的羧基烷酰基进行O-酰化,羧基环烷酰基 具有4至8个碳原子和具有2至10个碳原子的羧酸非环烷酰基,其中N-芳酰基含有7至14个碳原子,N-酰基含有4至8个碳原子, 烷基含有1至14个碳原子。