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1. 发明申请

WO2006017759A2 TUMOR ENDOTHELIAL MARKER-1 (TEM1) BINDING ANTIBODIES AND USES THEREOF 审中-公开
标题翻译：肿瘤内皮标记-1（TEM1）结合抗体及其应用
公开(公告)号：WO2006017759A2
公开(公告)日：2006-02-16
申请号：PCT/US2005/027938
申请日：2005-08-05
申请人： KIRIN BREWERY CO., LTD. , GENZYME CORPORATION , TEICHER, Beverly , ROBERTS, Bruce , KATAOKA, Shiro , TAHARA, Tomoyuki , HONMA, Nakayuki
发明人： TEICHER, Beverly , ROBERTS, Bruce , KATAOKA, Shiro , TAHARA, Tomoyuki , HONMA, Nakayuki
IPC分类号： A61K39/395
CPC分类号： C07K16/2851 , A61K2039/505 , C07K2317/21 , C07K2317/732 , C07K2317/734
摘要： The present invention relates to antibodies that bind tumor endothelial marker 1 (TEM1) and effectively inhibit angiogenesis, tumor growth, or both. Pharmaceutical compositions and uses thereof for the treatment of angiogenesis-associated diseases including cancer, polycystic kidney disease, diabetic retinopathy, age-related macular degenerations, rheumatoid arthritis, and psoriasis are also disclosed. Also disclosed are methods of identifying such antibodies by assessing (1) the inhibitory activity of candidate antibodies in proliferation and tube formation assays using endothelial cells, endothelial precursor cells and pericytes, and (2) the antibody-dependent cellular cytotoxic, phagocytosis, and complement-dependent cytotoxic activities of candidate antibodies.
摘要翻译：本发明涉及结合肿瘤内皮标志物1（TEM1）并有效抑制血管生成，肿瘤生长或两者的抗体。还公开了用于治疗血管生成相关疾病（包括癌症，多囊肾病，糖尿病性视网膜病，年龄相关性黄斑变性，类风湿性关节炎和牛皮癣）的药物组合物及其用途。还公开了通过评估（1）候选抗体在使用内皮细胞，内皮前体细胞和周细胞的增殖和管形成分析中的抑制活性和（2）抗体依赖性细胞毒性，吞噬作用和补体候选抗体的细胞毒活性。

2. 发明申请

WO2005086713A2 ROLE OF HUMAN ENDOTHELIAL PRECURSOR CELLS AND VASCULAR PERICYTES TUMOR IN ANGIOGENESIS 审中-公开
标题翻译：人类内皮祖细胞和血管炎患者血管生成的作用
公开(公告)号：WO2005086713A2
公开(公告)日：2005-09-22
申请号：PCT/US2005/007154
申请日：2005-03-04
申请人： KIRIN BREWERY CO., LTD. , GENZYME CORPORATION , TEICHER, Beverly , ROBERTS, Bruce , KATAOKA, Shiro , TAHARA, Tomoyuki , HONMA, Nakayuki
发明人： TEICHER, Beverly , ROBERTS, Bruce , KATAOKA, Shiro , TAHARA, Tomoyuki , HONMA, Nakayuki
IPC分类号： G01N33/50 , G01N33/53 , G01N33/574
CPC分类号： G01N33/5011 , C07K2317/732 , G01N33/5064
摘要： The present invention relates to methods of identifying such antibodies by assessing (1) the inhibitory activity of candidate antibodies in proliferation and tube formation assays using endothelial cells, endothelial precursor cells and pericytes, and (2) the antibody-dependent cellular cytotoxic, phagocytosis, and complement-dependent cytotoxic activities of candidate antibodies.
摘要翻译：本发明涉及通过评估（1）候选抗体在使用内皮细胞，内皮前体细胞和周细胞的增殖和管形成测定中的抑制活性，以及（2）抗体依赖性细胞毒性，吞噬作用，和候选抗体的补体依赖性细胞毒活性。

3. 发明申请

WO2004044156A2 TRANSGENIC UNGULATES HAVING REDUCED PRION PROTEIN ACTIVITY AND USES THEREOF 审中-公开
标题翻译：具有降低的朊蛋白活性的转基因组合物及其用途
公开(公告)号：WO2004044156A2
公开(公告)日：2004-05-27
申请号：PCT/US2003/035720
申请日：2003-11-10
申请人： HEMATECH, LLC , KIRIN BREWERY CO., LTD. , ROBL, James , KUROIWA, Yoshimi , COLLAS, Philippe , SULLIVAN, Eddie , KASINATHAN, Poothappillai , TOMIZUKA, Kazuma , ISHIDA, Isao
发明人： ROBL, James , KUROIWA, Yoshimi , COLLAS, Philippe , SULLIVAN, Eddie , KASINATHAN, Poothappillai , TOMIZUKA, Kazuma , ISHIDA, Isao
IPC分类号： C12N
CPC分类号： C12N15/8509 , A01K67/0271 , A01K67/0276 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2217/072 , A01K2227/101 , A01K2267/01 , A01K2267/02 , C07K16/00 , C07K2317/12 , C07K2317/21 , C12N2800/30
摘要： The invention provides cloned transgenic ungulates (e.g., bovines) in which prion protein activity is reduced by one or more genetically engineered mutations. Desirably, these transgenic bovines are also genetically modified to express xenogenous (e.g., human) antibodies. Because of their resistance to prion-related diseases such as bovine spongiform encephalopy (also known as mad cow disease), these bovines are a safer source of human antibodies for pharmaceutical uses and safer source of agricultural products.
摘要翻译：本发明提供了克隆的转基因有蹄类动物（例如牛），其中朊病毒蛋白质活性被一种或多种基因工程突变降低。理想地，这些转基因牛也被遗传修饰以表达异种（例如人）抗体。由于它们对朊病毒相关疾病如牛海绵状脑病（也称为疯牛病）的抵抗力，这些牛是用于制药用途和更安全的农产品来源的更安全的人抗体来源。

4. 发明申请

WO1998029564A1 METHOD FOR JUDGING EARLY FLOCCULATION 审中-公开
标题翻译：评估早期絮凝的方法
公开(公告)号：WO1998029564A1
公开(公告)日：1998-07-09
申请号：PCT/JP1997004654
申请日：1997-12-17
申请人： KIRIN BREWERY CO., LTD. , NAKAMURA, Takashi , CHIBA, Kazuhiro
发明人： KIRIN BREWERY CO., LTD.
IPC分类号： C12Q01/40
CPC分类号： C12C1/00
摘要： A method by which the ability of untreated barley to cause early flocculation, i.e., whether or not a factor causing the early flocculation of yeast is present in untreated barley, can be judged much more easily in a shortened period as compared with the methods of the prior art. Specifically, a method for judging the ability of untreated barley to cause early flocculation by the fermentation test using yeast, which comprises adding an enzyme to the barley to conduct the enzymatic treatment of the barley, adding the product of the enzymatic treatment or a high-molecular fraction separated from the product to a synthetic wort to prepare a sample for the fermentation test, subjecting the sample to the fermentation test, and determining the turbidity of the sample after 48 hours for judging whether or not such a factor is present in the barley.
摘要翻译：未经处理的大麦能够引起早期絮凝的能力，即，在未处理的大麦中是否存在引起酵母早期絮凝的因素的方法，在缩短的时间内可以更容易地判断，与现有技术具体地说，一种判断未经处理的大麦通过使用酵母的发酵试验引起早期絮凝能力的方法，其包括向大麦中加入酶进行大麦的酶处理，加入酶处理的产物或高效液相色谱法，从产物分离成合成麦芽汁以制备用于发酵试验的样品，对样品进行发酵试验，并在48小时后测定样品的浊度，以判断这种因素是否存在于大麦中。

5. 发明申请

WO2006029045A2 ENDOTHELIAL CELL SPECIFIC ANTIBODIES AND USES THEREOF 审中-公开
标题翻译：内皮细胞特异性抗体及其用途
公开(公告)号：WO2006029045A2
公开(公告)日：2006-03-16
申请号：PCT/US2005/031453
申请日：2005-09-02
申请人： KIRIN BREWERY CO., LTD. , GENZYME CORPORATION , TEICHER, Beverly , ROBERTS, Bruce , KATAOKA, Shiro , HONMA, Nakayuki , YOSHIDA, Hitoshi
发明人： TEICHER, Beverly , ROBERTS, Bruce , KATAOKA, Shiro , HONMA, Nakayuki , YOSHIDA, Hitoshi
IPC分类号： C07K16/30
CPC分类号： C07K16/30 , A61K2039/505 , C07K16/2851 , C07K2317/21 , C07K2317/73
摘要： Methods and compositions provided herein relate to the inhibition of proliferation, migration, and tubule formation of endothelial cells and are thus useful in treating angiogenesis associated diseases, including cancer, polycystic kidney disease, diabetic retinopathy, rheumatoid arthritis, and psoriasis. Disclosed are methods of inhibiting endothelial cell proliferation, migration, and tubule formation by administering an antibody specific for Tumor EndothPelial Markers (TEMs). Also disclosed are methods of inhibiting angiogenesis and tumor growth by administering a TEM-specific antibody and antibody compositions useful in such methods.
摘要翻译：本文提供的方法和组合物涉及抑制内皮细胞的增殖，迁移和小管形成，因此可用于治疗血管生成相关疾病，包括癌症，多囊肾病，糖尿病性视网膜病，类风湿性关节炎和牛皮癣。公开了通过施用针对肿瘤内侧标记（TEM）特异的抗体来抑制内皮细胞增殖，迁移和小管形成的方法。还公开了通过施用在这些方法中有用的TEM特异性抗体和抗体组合物来抑制血管发生和肿瘤生长的方法。

6. 发明授权

US5376548A Bioreactor apparatus 失效
标题翻译：生物反应器装置
公开(公告)号：US5376548A
公开(公告)日：1994-12-27
申请号：US75335
申请日：1993-06-11
申请人： Shigeru Matsuo , Masato Nishimura
发明人： Shigeru Matsuo , Masato Nishimura
IPC分类号： C12M3/00 , C12M3/06 , C12M3/04
CPC分类号： C12M25/18 , C12M29/04
摘要： A bioreactor apparatus for producing metabolites from bioorganisms by depositing the animal cells on a carrier made of a porous material. The apparatus includes a hermetically sealed container (1) having a first supply channel A, for supplying a liquid containing animal cells into the inside thereof, a second supply channel (B) for supplying a culture solution and a substrate solution into the inside thereof, a first exhaust channel (a) for exhausting a liquid containing suspended animal cells from the inside thereof, and a second exhaust channel (b) for exhausting a residual part of the culture solution, a residual part of the substrate solution and a solution containing metabolites of the animal cells from the inside thereof. Disposed within the container is an animal culture base including a porous carrier (31, 33, 34) and a culture bed (4) arranged so that liquid supplied from the supply channels (A, B) are brought into contact therewith while flowing in the inside of the container (1). Further, the apparatus includes a filtration membrane (6) arranged across the second exhaust channel (b) in the inside of the container (1) and provided for filtrating a liquid to be exhausted through the second exhaust channel (b).
摘要翻译：一种用于通过将动物细胞沉积在由多孔材料制成的载体上从生物体产生代谢物的生物反应器装置。该装置包括一个具有第一供应通道A的密封容器（1），用于将含有动物细胞的液体供应到其内部;第二供应通道（B），用于向其内部供应培养溶液和基质溶液，用于从其内部排出含有悬浮动物细胞的液体的第一排气通道（a）和用于排出培养液残留部分的第二排出通道（b），底物溶液的残留部分和含有代谢物的溶液的动物细胞。设置在容器内的动物培养基是包括多孔载体（31,33,34）和培养床（4）的动物培养基，培养床（4）布置成使得从供给通道（A，B）供应的液体与在容器（1）的内部。此外，该装置包括在容器（1）的内部横跨第二排气通道（b）布置的过滤膜（6），用于过滤通过第二排气通道（b）排出的液体。

7. 发明授权

US5105982A Beverage mixing and dispensing unit 失效
标题翻译：饮料混合和分配单元
公开(公告)号：US5105982A
公开(公告)日：1992-04-21
申请号：US332982
申请日：1989-04-04
申请人： Yutaka Takahashi , Ikuo Harashima , Shunichi Nakayama , Yasuyuki Arai , Yasushi Takayanagi , Ryoichi Sekiguchi , Tomomitsu Abe , Hiroshi Hayakawa
发明人： Yutaka Takahashi , Ikuo Harashima , Shunichi Nakayama , Yasuyuki Arai , Yasushi Takayanagi , Ryoichi Sekiguchi , Tomomitsu Abe , Hiroshi Hayakawa
IPC分类号： B67D1/00
CPC分类号： B67D1/0079
摘要： A dispensing unit for mixing and dispensing a beverage which consists of several constituents, including syrup. The unit dispenses beverage from a bottle having a bottom outlet portion and through a syrup path controlled by a manually operable valve. A gas path in the dispensing unit supplies gas into the bottle for urging the syrup from the bottle and into the syrup path. An additional liquid is permitted to flow to a mixing chamber along with the syrup where they are mixed.

8. 发明授权

US4960228A Portable post-mix beverage dispenser unit 失效
标题翻译：便携式后混合饮料机组
公开(公告)号：US4960228A
公开(公告)日：1990-10-02
申请号：US281070
申请日：1988-12-08
申请人： Yutaka Takahashi , Ikuo Harashima , Sunichi Nakayama , Yasuyuki Arai , Yasushi Takayanagi , Ryoichi Sekiguchi , Tomomitsu Abe , Hiroshi Hayakawa
发明人： Yutaka Takahashi , Ikuo Harashima , Sunichi Nakayama , Yasuyuki Arai , Yasushi Takayanagi , Ryoichi Sekiguchi , Tomomitsu Abe , Hiroshi Hayakawa
IPC分类号： B67D1/04 , B01F3/04 , B01F15/06 , B67D1/00 , B67D1/07 , B67D1/08
CPC分类号： B67D1/0074 , B01F3/04808 , B01F3/04815 , B67D1/0034 , B67D1/0068 , B01F2015/061 , B67D2210/00104 , B67D2210/00157 , Y10S261/07
摘要： A post-mix beverage dispensing system including a cabinet having top, front, back, side and bottom panels for housing various components is disclosed. The components of the system include a carbonator for producing carbonated water by mixing cooled potable water with CO.sub.2. Potable water is stored in a portable tank means and is supplied to the carbonator through a first pipe. The portable tank is easily detachable from the cabinet. The system further includes a cooling reservoir containing cooled water. A serpentine section of the first pipe, along with the carbonator is disposed in the cooling reservoir. A CO.sub.2 tank supplies CO.sub.2 to the carbonator. Syrup packages dispense a selected syrup. Carbonated water from the carbonator, cool water from the portable tank, and syrup from the syrup packages are mixed in a valve and dispensed through a nozzle. The cooled water may be continuously supplied to the carbonator through the first pipe. Second and third pipes link the carbonator with the valve, and the CO.sub.2 to the syrup packages for dispensing CO.sub.2 therefrom, respectively.

9. 发明授权

US4951836A Easy-open container 失效
标题翻译：易开集装箱
公开(公告)号：US4951836A
公开(公告)日：1990-08-28
申请号：US421117
申请日：1989-10-13
申请人： Kunitoshi Yoshimura , Akira Nakata , Hitoshi Terai , Sakayu Iida
发明人： Kunitoshi Yoshimura , Akira Nakata , Hitoshi Terai , Sakayu Iida
IPC分类号： B65D17/28 , B65D17/34 , B65D17/40 , B65D41/32 , B65D77/30
CPC分类号： B65D17/168 , B65D41/32 , B65D77/30
摘要： An easy-open container includes a container barrel having an open end and a container end including a panel, a peripheral wall joined to and depending from a peripheral edge of the panel, and a pull tab joined to a lower edge of the peripheral wall. The peripheral wall is scored to provide a tear-off line joined to a side edge of the pull tab. The peripheral wall is fitted over the open end of the container barrel. An outer surface of the open end of the container barrel and an inner surface of the peripheral wall of the container end are bonded to each other through a bonded region. The tear-off line comprises a first continuous portion extending from the side edge of the pull tab through a bonded region of the peripheral wall above the pull tab into a non-bonded region of the peripheral wall above an upper edge of the bonded region, a second dotted-line portion joined to the first continuous portion and extending along the non-bonded region of the peripheral wall above the upper edge of the bonded region, and a third continuous portion joined to the second dotted-line portion and extending along the non-bonded region of the peripheral wall above the upper edge of the bonded region.
摘要翻译：容易开放的容器包括具有开口端的容器筒和包括面板的容器端，连接到面板的周缘并从其移除的周壁，以及连接到周壁的下边缘的拉片。周边壁被刻痕以提供连接到拉片的侧边缘的撕开线。周壁安装在容器桶的开口端上。容器筒的开口端的外表面和容器端部的周壁的内表面通过接合区域彼此接合。撕开线包括从拉片的侧边缘延伸穿过拉片上方的周壁的接合区域到位于接合区域的上边缘上方的周壁的非接合区域的第一连续部分，第二虚线部分，其连接到第一连续部分并且沿着接合区域的上边缘上方的周壁的非接合区域延伸;以及第三连续部分，其连接到第二虚线部分并沿着在接合区域的上边缘上方的周壁的非接合区域。

10. 植物专利

USPP18735P2 Lobelia plant named ‘Kirilo-LV63’ 有权
标题翻译：山茱萸植物名叫“Kirilo-LV63”
公开(公告)号：USPP18735P2
公开(公告)日：2008-04-15
申请号：US11489196
申请日：2006-07-19
申请人： Daigaku Takeshita
发明人： Daigaku Takeshita
IPC分类号： A01H5/00
CPC分类号： A01H5/02
摘要： A new and distinct cultivar of Lobelia plant named ‘Kirilo-LV63’, characterized by its low mounding, outwardly spreading to cascading plant habit; freely branching habit; dense and bushy plant form; continuously and freely flowering habit; dark blue-colored flowers; relatively tolerant to high temperatures; and good garden performance.
摘要翻译：一种新颖而独特的山茱萸植物名为“Kirilo-LV63”的植物，其特征在于其低堆积，向外扩展到级联植物习性; 自由分支习惯; 密集和浓密的植物形式; 持续自由的开花习惯; 深蓝色的花朵; 相对容忍高温; 和良好的花园表演。

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