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1. 发明授权

US5376548A Bioreactor apparatus 失效
标题翻译：生物反应器装置
公开(公告)号：US5376548A
公开(公告)日：1994-12-27
申请号：US75335
申请日：1993-06-11
申请人： Shigeru Matsuo , Masato Nishimura
发明人： Shigeru Matsuo , Masato Nishimura
IPC分类号： C12M3/00 , C12M3/06 , C12M3/04
CPC分类号： C12M25/18 , C12M29/04
摘要： A bioreactor apparatus for producing metabolites from bioorganisms by depositing the animal cells on a carrier made of a porous material. The apparatus includes a hermetically sealed container (1) having a first supply channel A, for supplying a liquid containing animal cells into the inside thereof, a second supply channel (B) for supplying a culture solution and a substrate solution into the inside thereof, a first exhaust channel (a) for exhausting a liquid containing suspended animal cells from the inside thereof, and a second exhaust channel (b) for exhausting a residual part of the culture solution, a residual part of the substrate solution and a solution containing metabolites of the animal cells from the inside thereof. Disposed within the container is an animal culture base including a porous carrier (31, 33, 34) and a culture bed (4) arranged so that liquid supplied from the supply channels (A, B) are brought into contact therewith while flowing in the inside of the container (1). Further, the apparatus includes a filtration membrane (6) arranged across the second exhaust channel (b) in the inside of the container (1) and provided for filtrating a liquid to be exhausted through the second exhaust channel (b).
摘要翻译：一种用于通过将动物细胞沉积在由多孔材料制成的载体上从生物体产生代谢物的生物反应器装置。该装置包括一个具有第一供应通道A的密封容器（1），用于将含有动物细胞的液体供应到其内部;第二供应通道（B），用于向其内部供应培养溶液和基质溶液，用于从其内部排出含有悬浮动物细胞的液体的第一排气通道（a）和用于排出培养液残留部分的第二排出通道（b），底物溶液的残留部分和含有代谢物的溶液的动物细胞。设置在容器内的动物培养基是包括多孔载体（31,33,34）和培养床（4）的动物培养基，培养床（4）布置成使得从供给通道（A，B）供应的液体与在容器（1）的内部。此外，该装置包括在容器（1）的内部横跨第二排气通道（b）布置的过滤膜（6），用于过滤通过第二排气通道（b）排出的液体。

2. 发明授权

US09188708B2 Film having low refractive index film and method for producing the same, anti-reflection film and method for producing the same, coating liquid set for low refractive index film, substrate having microparticle-laminated thin film and method for producing the same, and optical member 有权
$Film having low refractive index film and method for producing the same, anti-reflection film and method for producing the same, coating liquid set for low refractive index film, substrate having microparticle-laminated thin film and method for producing the same, and optical member$
标题翻译：具有低折射率膜的膜及其制造方法，防反射膜及其制造方法，低折射率膜用涂布液，具有微粒层叠薄膜的基板及其制造方法以及光学部件
公开(公告)号：US09188708B2
公开(公告)日：2015-11-17
申请号：US12998363
申请日：2009-10-13
申请人： Nobuaki Takane , Tomomi Kawamura , Masato Nishimura
发明人： Nobuaki Takane , Tomomi Kawamura , Masato Nishimura
IPC分类号： B05D5/06 , G02B1/118 , B29D11/00 , C09D5/00 , C09D7/12 , G02B1/113 , G02B5/02 , C08K3/22 , C08K7/26
CPC分类号： G02B1/118 , B29D11/00865 , C08K3/22 , C08K7/26 , C09D5/006 , C09D7/61 , C09D7/67 , G02B1/113 , G02B1/115 , G02B5/0242 , G02B5/0268 , G02B5/0278 , G02B5/0294 , G02B2207/107 , G02B2207/109 , Y10T428/24893
摘要： Provided is a film having a low refractive index, which can be formed under normal temperature and pressure while obtaining a lower refractive index, has excellent adhesion with a solid substrate, and does not lose geometric optical properties, such as the diffusibility or light-harvesting capability attributed to the microstructure. Also disclosed is a method for producing the same. The film having a low refractive index is obtained by causing an electrolyte polymer and microparticles to be alternately adsorbed on the surface of a solid substrate and bringing the resulting microparticle-laminated film into contact with a silicon compound solution in order to bond the solid substrate with microparticles and microparticles with microparticles. The silicon compound solution is selected from (1) the hydrolysis product of alkoxysilane (I) wherein the functional groups are formed from hydrolyzable groups and non-hydrolyzable organic groups, and the condensation reaction product thereof, (2) the hydrolysis product of a mixture of alkoxysilane (I) and alkoxysilane (II) wherein the functional groups are formed from hydrolyzable groups alone, and the condensation reaction product thereof; and (3) a mixture of hydrolysis product and condensation product thereof according to (1) and alkoxysilane (II).
摘要翻译：提供一种具有低折射率的膜，其可以在常温和压力下形成，同时获得较低的折射率，与固体基材具有优异的粘附性，并且不会失去几何光学性质，例如扩散性或光收集归因于微结构的能力。还公开了其制造方法。通过使电解质聚合物和微粒交替吸附在固体基材的表面上并使得到的微粒层叠膜与硅化合物溶液接触以使固体基材与具有微粒的微粒和微粒。硅化合物溶液选自（1）其中官能团由可水解基团和不可水解的有机基团形成的烷氧基硅烷（I）的水解产物及其缩合反应产物，（2）混合物的水解产物的烷氧基硅烷（I）和烷氧基硅烷（II），其中官能团由可水解基团单独形成，及其缩合反应产物; 和（3）根据（1）的水解产物及其缩合产物和烷氧基硅烷（II）的混合物。

3. 发明授权

US09138419B2 Patch preparation 有权
标题翻译：补丁准备
公开(公告)号：US09138419B2
公开(公告)日：2015-09-22
申请号：US13983134
申请日：2012-02-01
申请人： Yasuaki Okada , Katsuhiro Okada , Masato Nishimura , Yuji Kawaharada
发明人： Yasuaki Okada , Katsuhiro Okada , Masato Nishimura , Yuji Kawaharada
IPC分类号： A61K9/70 , A61K31/167 , A61K31/4453 , A61K31/496
CPC分类号： A61K9/7038 , A61K9/7061 , A61K31/167 , A61K31/4453 , A61K31/496
摘要： The problem of the present invention is to provide a patch preparation containing a drug (excluding 2-(4-ethyl-1-piperazinyl)-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine and a physiologically acceptable acid addition salt thereof), which is superior in both the skin permeability of a drug, and adhesiveness in the presence of water.A patch preparation containing a support and an adhesive layer on one surface of the support, wherein the adhesive layer contains a drug excluding 2-(4-ethyl-1-piperazinyl)-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine and a physiologically acceptable acid addition salt thereof, an acrylic polymer, lactic acid and magnesium aluminometasilicate.
摘要翻译：本发明的问题在于提供含有药物（不含2-（4-乙基-1-哌嗪基）-4-（4-氟苯基）-5,6,7,8,9,10-六氢环辛酸 [b]吡啶及其生理上可接受的酸加成盐），其在药物的皮肤渗透性方面都优异，并且在水存在下的粘合性。在载体的一个表面上含有载体和粘合剂层的贴片制剂，其中所述粘合剂层含有除2-（4-乙基-1-哌嗪基）-4-（4-氟苯基）-5,6,7 ，8,9,10-六氢环辛基[b]吡啶及其生理上可接受的酸加成盐，丙烯酸聚合物，乳酸和硅酸铝镁。

4. 发明授权

US08309119B2 Drug containing adhesive preparation 失效
标题翻译：药物含胶粘剂制剂
公开(公告)号：US08309119B2
公开(公告)日：2012-11-13
申请号：US12071867
申请日：2008-02-27
申请人： Masato Nishimura , Sachiko Terashi , Shiro Satoda , Keigo Inosaka , Kensuke Matsuoka
发明人： Masato Nishimura , Sachiko Terashi , Shiro Satoda , Keigo Inosaka , Kensuke Matsuoka
IPC分类号： A61K9/70 , A61K31/4468 , A61F13/02
CPC分类号： A61L24/0015 , A61L15/58 , A61L24/04 , A61L2300/402
摘要： The present invention aims at providing an adhesive preparation wherein a drug is sufficiently dissolved in an adhesive layer and is not easily separated from the adhesive layer even during preservation of the adhesive preparation.The present invention provides an adhesive preparation having an adhesive layer on at least one surface of a support, wherein the adhesive layer comprises a first synthetic rubber having a viscosity average molecular weight of 1,600,000-6,500,000, a drug, an organic liquid component and a tackifier. The present invention further provides the aforementioned adhesive preparation, wherein the organic liquid component is contained in the adhesive layer in a proportion of 20 wt % or above relative to the total weight of the adhesive layer.
摘要翻译：本发明的目的在于提供一种粘合剂制剂，其中药物在粘合剂层中充分溶解，并且即使在粘合剂制备过程中也不容易与粘合层分离。本发明提供一种在支撑体的至少一个表面上具有粘合剂层的粘合剂制剂，其中粘合剂层包括粘均分子量为1,600,000-6,500,000的第一合成橡胶，药物，有机液体组分和增粘剂。本发明还提供了上述粘合剂制剂，其中粘合剂层中的有机液体组分相对于粘合剂层的总重量为20重量％以上。

5. 发明申请

US20060034901A1 Adhesive material and adhesive preparation 有权
标题翻译：胶粘材料和粘合剂制备
公开(公告)号：US20060034901A1
公开(公告)日：2006-02-16
申请号：US11196936
申请日：2005-08-04
申请人： Hitoshi Akemi , Kazuhisa Ninomiya , Hidetoshi Kuroda , Kensuke Matsuoka , Yuji Saeki , Masato Nishimura
发明人： Hitoshi Akemi , Kazuhisa Ninomiya , Hidetoshi Kuroda , Kensuke Matsuoka , Yuji Saeki , Masato Nishimura
IPC分类号： A61L15/16 , C08F136/00
CPC分类号： A61K9/7053
摘要： The present invention provides an adhesive material to be adhered to the skin etc., which maintains, for a certain time period after adhesion thereof to the skin surface, suitable adhesiveness that does not allow easy peeling or cause irritation to the skin, and which permits, when it is to be peeled off from the skin surface after the lapse of a desired certain time period, easy peeling without causing pain or physical irritation, and an adhesive preparation containing the adhesive material and a percutaneously absorbable drug in the adhesive layer. Specifically, the present invention provides an adhesive material containing a support and an adhesive layer laminated on one surface of the support, wherein the adhesive layer has an apparent viscosity at 30° C. of 0.2×104 to 10×104Pa.s and comprises two kinds of synthetic rubbers having different flowability.
摘要翻译：本发明提供粘附到皮肤等上的粘合剂材料，其在粘附到皮肤表面上一段时间后保持适合的粘合性，其不容易剥离或对皮肤产生刺激，并且允许当在期望的特定时间段之后要从皮肤表面剥离时，容易剥离而不引起疼痛或身体刺激，以及在粘合剂层中含有粘合剂材料和经皮吸收药物的粘合剂。具体而言，本发明提供了一种粘合剂材料，其包含层压在载体的一个表面上的载体和粘合剂层，其中粘合剂层在30℃下的表观粘度为0.2×10 4至10×10 6 包括两种具有不同流动性的合成橡胶。

6. 发明申请

US20140023695A1 PATCH PREPARATION 审中-公开
标题翻译：配对准备
公开(公告)号：US20140023695A1
公开(公告)日：2014-01-23
申请号：US13983166
申请日：2012-02-01
申请人： Yasuaki Okada , Katsuhiro OKada , Masato Nishimura , Yuji Kawaharada , Hiroo Maeda , Kazumitsu Yamamoto , Masayasu Tanaka
发明人： Yasuaki Okada , Katsuhiro OKada , Masato Nishimura , Yuji Kawaharada , Hiroo Maeda , Kazumitsu Yamamoto , Masayasu Tanaka
IPC分类号： A61K31/496 , A61K9/70
CPC分类号： A61K31/496 , A61K9/7061
摘要： A patch preparation containing a support and an adhesive layer formed on one surface of the support, wherein the adhesive layer contains 2-(4-ethyl-1-piperazinyl)-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine or a physiologically acceptable acid addition salt thereof, an acrylic polymer, lactic acid, sesame oil and one or more kinds of stabilizers selected from 2-mercaptobenzimidazole, 2,6-di-tert-butyl-4-methylphenol and propyl gallate.A patch preparation containing a support and an adhesive layer containing lactic acid and magnesium aluminometasilicate and formed on at least one surface of the support, which preparation is superior in both skin permeability and adhesiveness in the presence of water.
摘要翻译：一种贴剂，其包含支撑体和形成在支持体的一个表面上的粘合剂层，其中粘合剂层含有2-（4-乙基-1-哌嗪基）-4-（4-氟苯基）-5,6,7,8 ，9,10-六氢环辛[b]吡啶或其生理上可接受的酸加成盐，丙烯酸聚合物，乳酸，芝麻油和一种或多种选自2-巯基苯并咪唑，2,6-二叔丁基 -4-甲基苯酚和没食子酸丙酯。一种贴剂，其含有载体和含有乳酸和硅酸铝镁的粘合剂层，并形成在载体的至少一个表面上，该制剂在水的存在下具有优异的皮肤渗透性和粘合性。

7. 发明授权

US08394404B2 Adhesive material and adhesive preparation 有权
标题翻译：胶粘材料和粘合剂制备
公开(公告)号：US08394404B2
公开(公告)日：2013-03-12
申请号：US11196936
申请日：2005-08-04
申请人： Hitoshi Akemi , Kazuhisa Ninomiya , Hidetoshi Kuroda , Kensuke Matsuoka , Yuji Saeki , Masato Nishimura
发明人： Hitoshi Akemi , Kazuhisa Ninomiya , Hidetoshi Kuroda , Kensuke Matsuoka , Yuji Saeki , Masato Nishimura
IPC分类号： A61L15/16 , C08F136/00
CPC分类号： A61K9/7053
摘要： The present invention provides an adhesive material to be adhered to the skin etc., which maintains, for a certain time period after adhesion thereof to the skin surface, suitable adhesiveness that does not allow easy peeling or cause irritation to the skin, and which permits, when it is to be peeled off from the skin surface after the lapse of a desired certain time period, easy peeling without causing pain or physical irritation, and an adhesive preparation containing the adhesive material and a percutaneously absorbable drug in the adhesive layer. Specifically, the present invention provides an adhesive material containing a support and an adhesive layer laminated on one surface of the support, wherein the adhesive layer has an apparent viscosity at 30° C. of 0.2×104 to 10×104 Pa·s and comprises two kinds of synthetic rubbers having different flowability.
摘要翻译：本发明提供粘附到皮肤等上的粘合剂材料，其在粘附到皮肤表面上一段时间后保持适合的粘合性，其不容易剥离或对皮肤产生刺激，并且允许当在期望的特定时间段之后要从皮肤表面剥离时，易于剥离而不引起疼痛或身体刺激，以及在粘合剂层中含有粘合剂材料和经皮吸收药物的粘合剂。具体地说，本发明提供了一种粘合剂材料，其包含层叠在载体的一个表面上的载体和粘合剂层，其中所述粘合剂层在30℃下的表观粘度为0.2×10 4至10×10 4 Pa·s，并且包含两种具有不同流动性的合成橡胶。

8. 发明授权

US06812252B2 Acylsulfonamide derivatives 失效
标题翻译：酰基磺酰胺衍生物
公开(公告)号：US06812252B2
公开(公告)日：2004-11-02
申请号：US10335868
申请日：2003-01-03
申请人： Hiroshi Ikawa , Masato Nishimura , Keiji Okada , Takashi Nakamura , Kazuhiro Kojima , Hideki Kosono
发明人： Hiroshi Ikawa , Masato Nishimura , Keiji Okada , Takashi Nakamura , Kazuhiro Kojima , Hideki Kosono
IPC分类号： A61K3118
CPC分类号： C07C311/51 , A61K31/18
摘要： The present invention provides new acylsulfonamide derivatives such as 4-(3-trifluoromethyl)phenylethynyl-N-(2-(5-ketohexanoylamino)sulfonylphenyl)benzamide, 4-(3-trifluoromethyl)phenylethynyl-N-(2-(2-propyloxyacetylamino)sulfonylphenyl)benzamide or analogues thereof. These acylsulfonamide derivatives have a hypoglycemic effect equal to or superior to the effects of the conventional hypoglycemic agents and they are free from the side effects unlike the glitazone compounds.
摘要翻译：本发明提供新的酰基磺酰胺衍生物，例如4-（3-三氟甲基）苯基乙炔基-N-（2-（5-酮基己酰氨基）磺酰基苯基）苯甲酰胺，4-（3-三氟甲基）苯基乙炔基-N-（2-（2-丙氧基乙酰氨基）磺酰苯基）苯甲酰胺或其类似物。这些酰基磺酰胺衍生物具有等于或优于常规降血糖剂的效果的降血糖作用，并且它们与格列酮类化合物不同，没有副作用。

9. 发明授权

US5616711A Methods of producing aminobutene derivatives 失效
标题翻译：生产氨基丁衍生物的方法
公开(公告)号：US5616711A
公开(公告)日：1997-04-01
申请号：US102819
申请日：1993-08-06
申请人： Hiroshi Ikawa , Hajime Matsumoto , Masakatsu Matsumoto , Yasuo Sekine , Masato Nishimura , Akihiko Hosoda
发明人： Hiroshi Ikawa , Hajime Matsumoto , Masakatsu Matsumoto , Yasuo Sekine , Masato Nishimura , Akihiko Hosoda
IPC分类号： C07C215/24 , C07D213/64 , C07D307/38 , C07D309/10 , C07D405/12 , C07D407/12 , C07C233/00 , C07D211/36 , C07D211/68 , C07D217/22
CPC分类号： C07D213/64 , C07C215/24 , C07D307/38 , C07D309/10 , C07D405/12 , C07D407/12
摘要： A method of producing an aminobutene derivative of formula (I) by allowing a butenol derivative of formula (II) to react with an amide derivative of formula (III) is disclosed. The aminobutene derivative of formula (I) can be deprotected to produce an aminobutene derivative of formula (I-1) or an aminobutene derivative of formula (I-2): ##STR1## The aminobutene derivative of formula (I-A) can also be deprotected to produce the aminobutene derivative of formula (I-B). Any or all of the above aminobutene derivatives are useful as intermediates for producing anti-ulcer drugs, and anti-ulcer drugs having an inhibitory effect on gastric acid secretion based on the antagonism against histamine H.sub.2 receptor.
摘要翻译：公开了通过使式（II）的丁烯醇衍生物与式（III）的酰胺衍生物反应来制备式（I）的氨基丁衍生物的方法。式（I）的氨基丁衍生物可以去保护以产生式（I-1）的氨基丁衍生物或式（I-2）的氨基丁衍生物：IA）也可以被去保护以产生式（IB）。任何或所有上述氨基丁衍生物可用作制备抗溃疡药物的中间体，以及基于对组胺H 2受体的拮抗作用对胃酸分泌具有抑制作用的抗溃疡药物。

10. 发明申请

US20120001640A1 POWER SUPPLY DEVICE CAPABLE OF DETECTING DISCONNECTION OF GROUND LINE 审中-公开
标题翻译：检测接地线断开的电源装置
公开(公告)号：US20120001640A1
公开(公告)日：2012-01-05
申请号：US13171923
申请日：2011-06-29
申请人： Masahiko HASHIMOTO , Masato Nishimura
发明人： Masahiko HASHIMOTO , Masato Nishimura
IPC分类号： G01N27/416
CPC分类号： G01R31/026 , B60L3/0069 , B60L53/51 , B60L2240/547 , B60L2270/145 , G01R31/382 , Y02T10/7088 , Y02T90/12
摘要： A power supply device includes negative-side and positive-side battery blocks serially connected to each other through a resistor element 19. The ends of the element 19 correspond to reference and auxiliary ground points 8A and 8B. A voltage detector 3 detects the voltages of battery modules 2 of a load-driving battery 1. The detector 3 includes an asymmetric resistor circuit that is asymmetrically constructed with respect to the reference point 8A. The detector 3 detects the voltage of the auxiliary point 8B with respect to the reference point 8A in a load driven state. A disconnection detecting circuit 20 compares the detected voltage with a reference voltage of the auxiliary point 8B with respect to the reference point 8A not in the load driven state, and determines that the line 9 is disconnected in the load driven state if the deviation of the detected voltage from the reference voltage falls out of a predetermined range.
摘要翻译：电源装置包括通过电阻元件19串联连接的负侧电池块和正极侧电池块。元件19的端部对应于参考和辅助接地点8A和8B。电压检测器3检测负载驱动电池1的电池模块2的电压。检测器3包括相对于参考点8A非对称构造的不对称电阻电路。检测器3在负载驱动状态下检测辅助点8B相对于参考点8A的电压。断线检测电路20将检测到的电压与辅助点8B的基准电压相对于不处于负载驱动状态的基准点8A进行比较，并且如果在负载驱动状态下的偏差确定线路9断开，来自参考电压的检测电压落在预定范围之外。

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