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1. 发明申请

WO2004091476A2 METHOD OF SCREENING REMEDY FOR HEART DISEASE AND MEDICINAL COMPOSITION FOR TREATING HEART DISEASE 审中-公开
标题翻译：用于治疗心脏疾病的心脏疾病和药物组合物的筛选方法
公开(公告)号：WO2004091476A2
公开(公告)日：2004-10-28
申请号：PCT/JP2004005382
申请日：2004-04-15
申请人： ONO PHARMACEUTICAL CO , HONJO TASUKU , OKAZAKI TAKU
发明人： HONJO TASUKU , OKAZAKI TAKU
IPC分类号： A61K20060101 , A61K38/17 , A61K45/00 , A61P9/00 , C12Q1/02 , G01N33/15 , G01N33/50 , G01N33/53 , G01N33/564 , A61K
CPC分类号： G01N33/564 , A61K38/17 , G01N33/5061 , G01N2800/325
摘要： A method of screening a substance inhibiting the onset of a disease in which an anti-myocardial troponin I autoantibody participates; a medicinal composition for treating a heart disease and a base material for treating a heart disease containing a substance produced by the above method; an apparatus for treating a heart disease in which an anti-myocardial troponin I autoantibody participates whereby the above antibody is removed; a method of constructing an animal for evaluating a heart disease which comprises administering an anti-myocardial troponin I autoantibody; a method of selecting a remedy for a heart disease with the use of the above animal; and a method of diagnosing dilated cardiomyopathy which comprises quantifying an anti-myocardial troponin I autoantibody. The above-described treatment apparatus whereby the anti-myocardial troponin I autoantibody is removed and the medicinal composition for treating a disease in which the antibody participate are useful in treating and/or preventing a heart disease.
摘要翻译：一种筛选抑制其中抗心肌肌钙蛋白I自身抗体参与的疾病发作的物质的方法; 用于治疗心脏病的药物组合物和用于治疗含有通过上述方法生产的物质的心脏病的基础材料; 用于治疗心肌疾病的装置，其中抗心肌肌钙蛋白I自身抗体参与，从而除去上述抗体; 一种构建用于评估心脏病的动物的方法，其包括施用抗心肌肌钙蛋白I自身抗体; 使用上述动物选择心脏病的补救方法; 以及诊断扩张型心肌病的方法，其包括定量抗心肌肌钙蛋白I自身抗体。除去抗心肌肌钙蛋白I自身抗体的上述治疗装置和用于治疗抗体参与的疾病的药物组合物可用于治疗和/或预防心脏病。

2. 发明申请

WO1996001843A1 POLYPEPTIDE PRODUCED BY STROMAL CELL 审中-公开
标题翻译：由细胞产生的多肽
公开(公告)号：WO1996001843A1
公开(公告)日：1996-01-25
申请号：PCT/JP1995001342
申请日：1995-07-05
申请人： ONO PHARMACEUTICAL CO., LTD. , HONJO, Tasuku , NAKANO, Tohru , HIRANO, Atsushi , SIBAYAMA, Shiro , OHNO, Hiroyuki
发明人： ONO PHARMACEUTICAL CO., LTD.
IPC分类号： C07K14/435
CPC分类号： C07K14/47 , A61K38/00
摘要： A polypeptide produced by mouse marrow stromal cells and composed of 211 amino acid residues, and a human homolog thereof; a process for producing the polypeptide; a DNA coding for the polypeptide; a fragment hybridizing selectively with the DNA sequence; a replication or expression vector comprising the DNA; a host cell transformed by the vector; an antibody against the polypeptide; and a pharmaceutical composition containing the polypeptide or the antibody. The polypeptide is usable for the prevention or treatment of the hypoplasia or abnormal growth of hematopoietic cells, the hyperergasia or hypergasia of the nervous system, diseases related to the hyperergasia or hypergasia of the immune system, such as inflammatory diseases, the decrease of hematopoietic cells after bone marrow transplantation, the decrease of leucocytes, platelets, B cells or T cells after radiation therapy, anemia and infectious diseases; the prevention or treatment of cancer, leukemia and AIDS; the prevention or treatment of various degenerative diseases and nerve injury; the prevention of treatment of metabolic disorder of the bone; and tissue repair.
摘要翻译：由小鼠骨髓基质细胞产生并由211个氨基酸残基组成的多肽及其人类同源物; 一种生产该多肽的方法; 编码该多肽的DNA; 与DNA序列选择性杂交的片段; 包含DNA的复制或表达载体; 由载体转化的宿主细胞; 抗多肽的抗体; 和含有多肽或抗体的药物组合物。该多肽可用于预防或治疗造血细胞发育不全或异常生长，神经系统的高血压或高血压，与免疫系统的高血压或高血压有关的疾病，如炎性疾病，造血细胞减少骨髓移植后，放射治疗后，白细胞，血小板，B细胞或T细胞减少，贫血和感染性疾病; 预防或治疗癌症，白血病和艾滋病; 预防或治疗各种退行性疾病和神经损伤; 预防骨代谢紊乱的治疗; 和组织修复。

3. 发明申请

WO1994026895A1 HUMAN IMMUNOGLOBULIN VH GENE AND DNA FRAGMENT CONTAINING THE SAME 审中-公开
标题翻译：人类免疫调节蛋白VH基因和包含其的DNA片段
公开(公告)号：WO1994026895A1
公开(公告)日：1994-11-24
申请号：PCT/JP1993000603
申请日：1993-05-10
申请人： JAPAN TOBACCO INC. , HONJO, Tasuku , MATSUDA, Fumihiko
发明人： JAPAN TOBACCO INC.
IPC分类号： C12N15/13
CPC分类号： C07K16/00
摘要： The DNA fragment of the invention is one having about 800 kilobase pairs as shown in the figure. The human immunoglobulin VH genes of the invention are ones contained in the above fragment and include 50 novel ones. The base sequences of these genes are shown in the sequence listing. The invention also provides a DNA fragment containing two or more of the VH genes.
摘要翻译：本发明的DNA片段是具有如图所示的约800千碱基对的DNA片段。本发明的人免疫球蛋白VH基因是上述片段中包含的，包括50个新的。这些基因的碱基序列显示在序列表中。本发明还提供了含有两个或多个VH基因的DNA片段。

4. 发明专利

HUE10161767T1 Immunpotenciáló kompozíciók, amelyek anti-PD-L1 antitesteket tartalmaznak 未知
公开(公告)号：HUE10161767T1
公开(公告)日：2019-03-28
申请号：HUE10161767
申请日：2003-07-02
申请人： ONO PHARMACEUTICAL CO , HONJO TASUKU
发明人： HONJO TASUKU , MINATO NAGAHIRO , IWAI YOSHIKO , SHIBAYAMA SHIRO
IPC分类号： A61K45/00 , A61K31/00 , A61K31/7088 , A61K33/00 , A61K35/00 , A61K35/14 , A61K38/17 , A61K39/395 , A61P31/00 , A61P35/00 , A61P35/04 , A61P37/04 , C07K16/28 , C07K16/42 , C07K16/46 , C12N5/10 , C12N15/02 , C12P21/08 , C12Q1/02 , G01N33/50 , G01N33/574

5. 发明专利

DK1537878T3 Immunpotenserende sammensætninger 未知
公开(公告)号：DK1537878T3
公开(公告)日：2011-01-24
申请号：DK03741154
申请日：2003-07-02
申请人： ONO PHARMACEUTICAL CO , HONJO TASUKU
发明人： HONJO TASUKU , MINATO NAGAHIRO , SHIBAYAMA SHIRO , IWAI YOSHIKO
IPC分类号： A61K45/00 , A01K67/027 , A61K31/00 , A61K31/7088 , A61K33/00 , A61K35/00 , A61K35/14 , A61K38/17 , A61K39/395 , A61P31/00 , A61P35/00 , A61P35/04 , A61P37/04 , C07K14/705 , C07K16/28 , C07K16/42 , C07K16/46 , C12N5/10 , C12N15/02 , C12P21/08 , C12Q1/02 , G01N33/50 , G01N33/574

6. 发明专利

CA2429042A1 PD-1-LACKING MOUSE AND USE THEREOF 未知
公开(公告)号：CA2429042A1
公开(公告)日：2002-05-23
申请号：CA2429042
申请日：2001-11-14
申请人： ONO PHARMACEUTICAL CO , HONJO TASUKU
发明人： NISHIMURA HIROYUKI , HONJO TASUKU
IPC分类号： C07K14/47 , C07K14/705 , C07K16/18 , C12N15/12 , C12N15/85 , A01K67/027 , G01N33/15 , C07K16/42 , G01N33/50
摘要： A BALB/c mouse lacking programmed cell death-1 receptor (PD-1); a method of screening a remedy for an autoimmune disease by using this mouse; an IgG autoreactive antibody specifically produced by the mouse; a protein produced in the heart which specifically reacts with this antibody; and a method of diagnosing dilated cardiomyopathy with the use of this protein. Because of spontaneously suffering from autoimmune diseases, in particular, dilated cardiomyopathy, the PD-1-lacking BALB/c mouse is useful in screening remedies for these diseases.

7. 发明专利

CA2162577A1 HUMAN IMMUNOGLOBULIN VH GENE SEGMENTS AND DNA FRAGMENTS CONTAINING THE SAME 未知
公开(公告)号：CA2162577A1
公开(公告)日：1994-11-24
申请号：CA2162577
申请日：1993-05-10
申请人： HONJO TASUKU , JAPAN TOBACCO INC
发明人： HONJO TASUKU , MATSUDA FUMIHIKO
IPC分类号： C07K16/00 , C12N15/13
摘要： Novel human immunoglobulin VH segments and DNA fragments containing the same are disclosed. The DNA fragment according to the present invention is the fragment having a size of about 800 kbp which is shown in Fig. 1. The human immunoglobulin VH segments according to the present invention are contained in the fragment of this DNA fragment of about 800 kbp, and there are 50 novel segments. The base sequences of these segments are shown in the Sequence Listing. The present invention also provides DNA fragments which contain two or more of these VH segments.

8. 发明专利

DE3882611T2 未知
公开(公告)号：DE3882611T2
公开(公告)日：1993-12-23
申请号：DE3882611
申请日：1988-08-01
申请人： HONJO TASUKU , ONO PHARMACEUTICAL CO
发明人： HONJO TASUKU , HAMA KAZUAKI , KAWASAKI AKIYOSHI
IPC分类号： A61K38/00 , C07K14/54 , F02B75/02 , C12P21/02 , C12N15/24
摘要： The present invention provides novel human interleukin 4 (IL4) having immune-activating effects, which is characterized by (a) a total molecular weight of 17000 to 19000, and (b) a sugar chain molecular weight of 2000 to 4000; and also provides novel expression vectors for the human IL4 which comprises: (i) a DNA sequence encoding human interleukin 4 at a position downstream from an SV40 early promoter, and (ii) a DNA sequence encoding dihydrofolate reductase at a position downstream from a promoter operating in eukaryotic cells; and further provides transformants obtained by transfecting dihydrofolate reductase-defective Chinese hamster ovary cells with the expression vector for human IL4. The human IL4 is useful for the treatment and prevention of cancer, infections, AIDS, functional immune deficiency etc.

9. 发明专利

DE3586830T2 未知
公开(公告)号：DE3586830T2
公开(公告)日：1993-04-22
申请号：DE3586830
申请日：1985-04-24
申请人： HONJO TASUKU
发明人： HONJO TASUKU
IPC分类号： C12N15/09 , A61K39/395 , C07K16/00 , C12N15/10 , C12N15/85 , C12N15/867 , C12P21/08 , C12R1/19 , C12R1/91 , C07K15/00

10. 发明专利

DE3767629D1 未知
公开(公告)号：DE3767629D1
公开(公告)日：1991-02-28
申请号：DE3767629
申请日：1987-09-21
申请人： HONJO TASUKU
发明人： HONJO TASUKU , TAKATU KIYOSHI , SEVERINSON EVA
IPC分类号： C12N15/09 , C07H21/04 , C07K1/20 , C07K1/22 , C07K14/00 , C07K14/52 , C07K14/54 , C12N5/00 , C12N5/10 , C12N15/00 , C12P21/02 , C12R1/91

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