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1. 发明申请

WO2004091476A2 METHOD OF SCREENING REMEDY FOR HEART DISEASE AND MEDICINAL COMPOSITION FOR TREATING HEART DISEASE 审中-公开
标题翻译：用于治疗心脏疾病的心脏疾病和药物组合物的筛选方法
公开(公告)号：WO2004091476A2
公开(公告)日：2004-10-28
申请号：PCT/JP2004005382
申请日：2004-04-15
申请人： ONO PHARMACEUTICAL CO , HONJO TASUKU , OKAZAKI TAKU
发明人： HONJO TASUKU , OKAZAKI TAKU
IPC分类号： A61K20060101 , A61K38/17 , A61K45/00 , A61P9/00 , C12Q1/02 , G01N33/15 , G01N33/50 , G01N33/53 , G01N33/564 , A61K
CPC分类号： G01N33/564 , A61K38/17 , G01N33/5061 , G01N2800/325
摘要： A method of screening a substance inhibiting the onset of a disease in which an anti-myocardial troponin I autoantibody participates; a medicinal composition for treating a heart disease and a base material for treating a heart disease containing a substance produced by the above method; an apparatus for treating a heart disease in which an anti-myocardial troponin I autoantibody participates whereby the above antibody is removed; a method of constructing an animal for evaluating a heart disease which comprises administering an anti-myocardial troponin I autoantibody; a method of selecting a remedy for a heart disease with the use of the above animal; and a method of diagnosing dilated cardiomyopathy which comprises quantifying an anti-myocardial troponin I autoantibody. The above-described treatment apparatus whereby the anti-myocardial troponin I autoantibody is removed and the medicinal composition for treating a disease in which the antibody participate are useful in treating and/or preventing a heart disease.
摘要翻译：一种筛选抑制其中抗心肌肌钙蛋白I自身抗体参与的疾病发作的物质的方法; 用于治疗心脏病的药物组合物和用于治疗含有通过上述方法生产的物质的心脏病的基础材料; 用于治疗心肌疾病的装置，其中抗心肌肌钙蛋白I自身抗体参与，从而除去上述抗体; 一种构建用于评估心脏病的动物的方法，其包括施用抗心肌肌钙蛋白I自身抗体; 使用上述动物选择心脏病的补救方法; 以及诊断扩张型心肌病的方法，其包括定量抗心肌肌钙蛋白I自身抗体。除去抗心肌肌钙蛋白I自身抗体的上述治疗装置和用于治疗抗体参与的疾病的药物组合物可用于治疗和/或预防心脏病。

2. 发明专利

AT494549T 未知
公开(公告)号：AT494549T
公开(公告)日：2011-01-15
申请号：AT04727715
申请日：2004-04-15
申请人： ONO PHARMACEUTICAL CO , HONJO TASUKU
发明人： HONJO TASUKU , OKAZAKI TAKU
IPC分类号： G01N33/50 , A61K20060101 , A61K38/17 , A61K45/00 , A61P9/00 , C12Q1/02 , G01N33/15 , G01N33/53 , G01N33/564
摘要： A method for screening a substance that inhibits the onset of anti-cardiac troponin I autoantibody-related disease, a pharmaceutical composition and a base material for therapy of cardiac disease that contains the substance obtained by aforesaid method thereof, a therapeutic apparatus that removes anti-troponin I autoantibody for aforesaid antibody related disease, a method of making an animal model for evaluating cardiac disease characterized by administrating anti-cardiac troponin I antibody, a method of selection of a therapeutic substance for cardiac disease characterized by using aforesaid animals, and a diagnosis of dilated cardiomyopathy characterized by measuring anti-cardiac troponin I autoantibody. An apparatus of the present invention that removes anti-cardiac troponin I antibody and a pharmaceutical composition for therapy of the antibody related disease may be useful for a therapy and/or prevention of cardiac disease.

3. 发明专利

DE602004030898D1 SCREENING-VERFAHREN FÜR HEILMITTEL GEGEN HERZKRANKHEIT UND MEDIZINISCHE ZUSAMMENSETZUNG ZUR BEHANDLUNG VON HERZKRANKHEIT 未知
公开(公告)号：DE602004030898D1
公开(公告)日：2011-02-17
申请号：DE602004030898
申请日：2004-04-15
申请人： HONJO TASUKU , ONO PHARMACEUTICAL CO
发明人： HONJO TASUKU , OKAZAKI TAKU
IPC分类号： G01N33/50 , A61K20060101 , A61K38/17 , A61K45/00 , A61P9/00 , C12Q1/02 , G01N33/15 , G01N33/53 , G01N33/564

4. 发明公开

EP1619498A4 METHOD OF SCREENING REMEDY FOR HEART DISEASE AND MEDICINAL COMPOSITION FOR TREATING HEART DISEASE 有权
标题翻译：筛选方法，手段对付心脏病和药物组合物用于治疗心脏病
公开(公告)号：EP1619498A4
公开(公告)日：2006-06-14
申请号：EP04727715
申请日：2004-04-15
申请人： ONO PHARMACEUTICAL CO , HONJO TASUKU
发明人： HONJO TASUKU , OKAZAKI TAKU
IPC分类号： A61K20060101 , A61K38/17 , A61K45/00 , A61P9/00 , C12Q1/02 , G01N33/15 , G01N33/50 , G01N33/53 , G01N33/564
CPC分类号： G01N33/564 , A61K38/17 , G01N33/5061 , G01N2800/325

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