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1. 发明申请

WO2004091476A2 METHOD OF SCREENING REMEDY FOR HEART DISEASE AND MEDICINAL COMPOSITION FOR TREATING HEART DISEASE 审中-公开
标题翻译：用于治疗心脏疾病的心脏疾病和药物组合物的筛选方法
公开(公告)号：WO2004091476A2
公开(公告)日：2004-10-28
申请号：PCT/JP2004005382
申请日：2004-04-15
申请人： ONO PHARMACEUTICAL CO , HONJO TASUKU , OKAZAKI TAKU
发明人： HONJO TASUKU , OKAZAKI TAKU
IPC分类号： A61K20060101 , A61K38/17 , A61K45/00 , A61P9/00 , C12Q1/02 , G01N33/15 , G01N33/50 , G01N33/53 , G01N33/564 , A61K
CPC分类号： G01N33/564 , A61K38/17 , G01N33/5061 , G01N2800/325
摘要： A method of screening a substance inhibiting the onset of a disease in which an anti-myocardial troponin I autoantibody participates; a medicinal composition for treating a heart disease and a base material for treating a heart disease containing a substance produced by the above method; an apparatus for treating a heart disease in which an anti-myocardial troponin I autoantibody participates whereby the above antibody is removed; a method of constructing an animal for evaluating a heart disease which comprises administering an anti-myocardial troponin I autoantibody; a method of selecting a remedy for a heart disease with the use of the above animal; and a method of diagnosing dilated cardiomyopathy which comprises quantifying an anti-myocardial troponin I autoantibody. The above-described treatment apparatus whereby the anti-myocardial troponin I autoantibody is removed and the medicinal composition for treating a disease in which the antibody participate are useful in treating and/or preventing a heart disease.
摘要翻译：一种筛选抑制其中抗心肌肌钙蛋白I自身抗体参与的疾病发作的物质的方法; 用于治疗心脏病的药物组合物和用于治疗含有通过上述方法生产的物质的心脏病的基础材料; 用于治疗心肌疾病的装置，其中抗心肌肌钙蛋白I自身抗体参与，从而除去上述抗体; 一种构建用于评估心脏病的动物的方法，其包括施用抗心肌肌钙蛋白I自身抗体; 使用上述动物选择心脏病的补救方法; 以及诊断扩张型心肌病的方法，其包括定量抗心肌肌钙蛋白I自身抗体。除去抗心肌肌钙蛋白I自身抗体的上述治疗装置和用于治疗抗体参与的疾病的药物组合物可用于治疗和/或预防心脏病。

2. 发明专利

JP2003189872A NEW POLYPEPTIDE ESDN, METHOD FOR PRODUCING THE SAME, cDNA ENCODING ESDN, VECTOR COMPRISING THE cDNA, HOST CELL TRANSFORMED BY THE VECTOR, ESDN ANTIBODY, PHARMACEUTICAL COMPOSITION CONTAINING ESDN OR THE ANTIBODY, METHOD FOR ASSAYING ESDN, REAGENT FOR ASSAYING ESDN AND METHOD FOR SCREENING USING ESDN 审中-公开
公开(公告)号：JP2003189872A
公开(公告)日：2003-07-08
申请号：JP2001397725
申请日：2001-12-27
申请人： ONO PHARMACEUTICAL CO , HONJO TASUKU
发明人： HONJO TASUKU , TASHIRO HIROSHI , OBUIE KAZUHIRO
IPC分类号： G01N33/50 , A61K38/00 , A61K39/395 , A61P9/10 , A61P43/00 , C07K14/47 , C07K14/705 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12P21/02 , C12P21/08 , G01N33/15 , G01N33/53
摘要： PROBLEM TO BE SOLVED: To provide a new ESDN (endothelial and smooth muscle cell-derived neuropilin-like molecule) protein (polypeptide ESDN) which is expressed in coronary cells and smooth muscle cells and also in the vascular smooth muscle of balloon-damaged arteries or the tunica media of arteria carotis communis, thus useful in treating the restenosis after PTCA in circulatory organ regions or arteriosclerosis. SOLUTION: The new polpeptide ESDN, a method for producing the same, a cDNA encoding the same, a vector comprising the cDNA, a host cell transformed with the vector, an ESDN antibody, a pharmaceutical composition containing the ESDN or the antibody, a method for assaying the ESDN, a reagent for assaying the ESDN, and a method for screening using the ESDN, are provided, respectively. COPYRIGHT: (C)2003,JPO

3. 发明专利

JP2019094340A 癌治療剤审中-公开
公开(公告)号：JP2019094340A
公开(公告)日：2019-06-20
申请号：JP2019018057
申请日：2019-02-04
申请人： ONO PHARMACEUTICAL CO , HONJO TASUKU
发明人： HONJO TASUKU , MINATO NAGAHIRO , IWAI YOSHIKO , SHIBAYAMA SHIRO
IPC分类号： A61K35/17 , A61K31/7088 , A61K35/14 , A61K39/00 , A61K39/395 , A61P31/00 , A61P35/00 , A61P35/02 , A61P35/04 , A61P37/04 , C07K16/42 , C12N15/02 , C12P21/08 , C12Q1/02 , G01N33/50 , G01N33/574
摘要：【課題】遺伝子改変によりPD−1発現が阻害されたリンパ球を有効成分として含む癌治療剤に関する。【解決手段】遺伝子改変によりPD−1発現が阻害されたリンパ球は癌に対する治療に有用である。【選択図】なし

4. 发明专利

HUE10161767T1 Immunpotenciáló kompozíciók, amelyek anti-PD-L1 antitesteket tartalmaznak 未知
公开(公告)号：HUE10161767T1
公开(公告)日：2019-03-28
申请号：HUE10161767
申请日：2003-07-02
申请人： ONO PHARMACEUTICAL CO , HONJO TASUKU
发明人： HONJO TASUKU , MINATO NAGAHIRO , IWAI YOSHIKO , SHIBAYAMA SHIRO
IPC分类号： A61K45/00 , A61K31/00 , A61K31/7088 , A61K33/00 , A61K35/00 , A61K35/14 , A61K38/17 , A61K39/395 , A61P31/00 , A61P35/00 , A61P35/04 , A61P37/04 , C07K16/28 , C07K16/42 , C07K16/46 , C12N5/10 , C12N15/02 , C12P21/08 , C12Q1/02 , G01N33/50 , G01N33/574

5. 发明专利

DK1537878T3 Immunpotenserende sammensætninger 未知
公开(公告)号：DK1537878T3
公开(公告)日：2011-01-24
申请号：DK03741154
申请日：2003-07-02
申请人： ONO PHARMACEUTICAL CO , HONJO TASUKU
发明人： HONJO TASUKU , MINATO NAGAHIRO , SHIBAYAMA SHIRO , IWAI YOSHIKO
IPC分类号： A61K45/00 , A01K67/027 , A61K31/00 , A61K31/7088 , A61K33/00 , A61K35/00 , A61K35/14 , A61K38/17 , A61K39/395 , A61P31/00 , A61P35/00 , A61P35/04 , A61P37/04 , C07K14/705 , C07K16/28 , C07K16/42 , C07K16/46 , C12N5/10 , C12N15/02 , C12P21/08 , C12Q1/02 , G01N33/50 , G01N33/574

6. 发明专利

CA2429042A1 PD-1-LACKING MOUSE AND USE THEREOF 未知
公开(公告)号：CA2429042A1
公开(公告)日：2002-05-23
申请号：CA2429042
申请日：2001-11-14
申请人： ONO PHARMACEUTICAL CO , HONJO TASUKU
发明人： NISHIMURA HIROYUKI , HONJO TASUKU
IPC分类号： C07K14/47 , C07K14/705 , C07K16/18 , C12N15/12 , C12N15/85 , A01K67/027 , G01N33/15 , C07K16/42 , G01N33/50
摘要： A BALB/c mouse lacking programmed cell death-1 receptor (PD-1); a method of screening a remedy for an autoimmune disease by using this mouse; an IgG autoreactive antibody specifically produced by the mouse; a protein produced in the heart which specifically reacts with this antibody; and a method of diagnosing dilated cardiomyopathy with the use of this protein. Because of spontaneously suffering from autoimmune diseases, in particular, dilated cardiomyopathy, the PD-1-lacking BALB/c mouse is useful in screening remedies for these diseases.

7. 发明专利

DE3882611T2 未知
公开(公告)号：DE3882611T2
公开(公告)日：1993-12-23
申请号：DE3882611
申请日：1988-08-01
申请人： HONJO TASUKU , ONO PHARMACEUTICAL CO
发明人： HONJO TASUKU , HAMA KAZUAKI , KAWASAKI AKIYOSHI
IPC分类号： A61K38/00 , C07K14/54 , F02B75/02 , C12P21/02 , C12N15/24
摘要： The present invention provides novel human interleukin 4 (IL4) having immune-activating effects, which is characterized by (a) a total molecular weight of 17000 to 19000, and (b) a sugar chain molecular weight of 2000 to 4000; and also provides novel expression vectors for the human IL4 which comprises: (i) a DNA sequence encoding human interleukin 4 at a position downstream from an SV40 early promoter, and (ii) a DNA sequence encoding dihydrofolate reductase at a position downstream from a promoter operating in eukaryotic cells; and further provides transformants obtained by transfecting dihydrofolate reductase-defective Chinese hamster ovary cells with the expression vector for human IL4. The human IL4 is useful for the treatment and prevention of cancer, infections, AIDS, functional immune deficiency etc.

8. 发明专利

ES2729974T3 Anticuerpo específico de PD-1 y CD3 humanas 未知
公开(公告)号：ES2729974T3
公开(公告)日：2019-11-07
申请号：ES10176748
申请日：2004-01-22
申请人： ONO PHARMACEUTICAL CO , HONJO TASUKU
发明人： HONJO TASUKU , SHIBAYAMA SHIRO , TAKEDA KAZUHIKO , MATSUO MASAYOSHI , YOSHIDA TAKAO , MIYAMOTO MASAKAZU
IPC分类号： C12N15/13 , A61K39/395 , C07K16/28 , C07K16/46 , C12N5/10 , C12P21/08
摘要： Un anticuerpo biespecifico para su uso en el tratamiento de una enfermedad autoinmunitaria, en donde el anticuerpo biespecifico es una proteina de fusion que comprende: (i) una region variable de la cadena pesada de un anticuerpo anti-PD-1 humana, (ii) una region variable de la cadena ligera de un anticuerpo anti-PD-1 humana, (iii) una region variable de la cadena pesada de un anticuerpo anti-CD3 humana, y (iv) una region variable de la cadena ligera de un anticuerpo anti-CD3 humana, y que se une simultaneamente a la PD-1 humana y a la CD3 humana, en donde dicha CD3 humana se expresa en la misma celula que se expresa dicha PD-1 humana; y en donde la enfermedad autoinmunitaria se selecciona del grupo que consiste en nefritis glomerular, artritis, enfermedad tipo miocardiopatia dilatada, colitis ulcerosa, sindrome de Sjogren, enfermedad de Crohn, lupus eritematoso sistemico, artritis reumatoide cronica, esclerosis multiple, psoriasis, dermatitis de contacto alergica, polimiositis, paquidermia, periarteritis nodosa, fiebre reumatica, vitiligo vulgaris, diabetes mellitus dependiente de insulina, enfermedad de Behcet, enfermedad de Hashimoto, enfermedad de Addison, dermatomiositis, miastenia gravis, sindrome de Reiter, enfermedad de Graves, anemia perniciosa, sindrome de Goodpasture, esterilidad patologica, hepatitis activa cronica, penfigo, purpura trombocitopenica autoinmunitaria y anemia hemolitica autoinmunitaria.

9. 发明专利

CA2429042C PD-1 DEFICIENT MICE AND THE USE 未知
公开(公告)号：CA2429042C
公开(公告)日：2012-09-25
申请号：CA2429042
申请日：2001-11-14
申请人： ONO PHARMACEUTICAL CO , HONJO TASUKU
发明人： NISHIMURA HIROYUKI , HONJO TASUKU
IPC分类号： A01K67/027 , C07K14/47 , C07K14/705 , C07K16/18 , C07K16/42 , C12N15/12 , C12N15/85 , G01N33/15 , G01N33/50
摘要： It relates to BALB/c mice that defect programmed cell death-1 receptor (PD-1), a screening method of autoimmune disease medicine by use of these mice, IgG self-reactivity antibody that the mice produce specifically, protein specifically reacted to the antibody and produced in heart, and an diagnostic method in dilated cardiomyopathy by use of the protein. Because PD-1 deficient BALB/c mice spontaneously develop autoimmune disease, specifically dilated cardiomyopathy, they are useful to screening for medicines against these diseases.

10. 发明专利

AT540579T 未知
公开(公告)号：AT540579T
公开(公告)日：2012-01-15
申请号：AT01996311
申请日：2001-11-14
申请人： ONO PHARMACEUTICAL CO , HONJO TASUKU
发明人： HONJO TASUKU , NISHIMURA HIROYUKI
IPC分类号： A01K67/027 , C07K14/47 , C07K14/705 , C07K16/18 , C07K16/42 , C12N15/12 , C12N15/85 , G01N33/15 , G01N33/50
摘要： It relates to BALB/c mice that defect programmed cell death-1 receptor (PD-1), a screening method of autoimmune disease medicine by use of these mice, IgG self-reactivity antibody that the mice produce specifically, protein specifically reacted to the antibody and produced in heart, and an diagnostic method in dilated cardiomyopathy by use of the protein. Because PD-1 deficient BALB/c mice spontaneously develop autoimmune disease, specifically dilated cardiomyopathy, they are useful to screening for medicines against these diseases.

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