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1. 发明申请

WO2006110589A3 GAMMARETROVIRUS ASSOCIATED WITH CANCER 审中-公开
公开(公告)号：WO2006110589A3
公开(公告)日：2006-10-19
申请号：PCT/US2006/013167
申请日：2006-04-07
申请人： THE CLEVELAND CLINIC FOUNDATION , THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , SILVERMAN, Robert , KLEIN, Eric, A. , DERISI, Joseph , GANEM, Don , CASEY, Graham
发明人： SILVERMAN, Robert , KLEIN, Eric, A. , DERISI, Joseph , GANEM, Don , CASEY, Graham
IPC分类号： C12N7/00 , C12N15/11 , C07K14/15 , C12N15/63 , C12N5/10 , C12Q1/68 , G01N33/569 , G01N33/50 , A61K39/21 , C12N7/02
摘要： The present invention provides for isolated nucleic acid sequences encoding viruses; isolated polypeptides comprising amino acid sequences of the virus; vectors comprising the viral nucleic acid sequences; cells comprising the vectors; antibodies and antigen binding fragments thereof which have binding specificity for the virus; methods of detecting or screening for the virus (e.g., in an individual); methods of identifying agents that inhibit the virus; methods of inducing an immune response to the virus; methods of treating disease associated with the presence of XMRV in an individual (e.g., cancer such as prostate cancer); methods of detecting asymptomatic cancer (e.g., prostate cancer); methods of identifying an individual at risk for developing cancer (e.g., prostate cancer); and kits for detecting the virus.

2. 发明申请

WO2006110589A8 GAMMARETROVIRUS ASSOCIATED WITH CANCER 审中-公开
标题翻译： GAMMARETROVIRUS与癌症相关
公开(公告)号：WO2006110589A8
公开(公告)日：2007-03-01
申请号：PCT/US2006013167
申请日：2006-04-07
申请人： CLEVELAND CLINIC FOUNDATION , UNIV CALIFORNIA , SILVERMAN ROBERT , KLEIN ERIC A , DERISI JOSEPH , GANEM DON , CASEY GRAHAM
发明人： SILVERMAN ROBERT , KLEIN ERIC A , DERISI JOSEPH , GANEM DON , CASEY GRAHAM
IPC分类号： C12N7/00 , A61K39/21 , C07K14/15 , C12N5/10 , C12N7/02 , C12N15/11 , C12N15/63 , C12Q1/68 , G01N33/50 , G01N33/569
CPC分类号： C12N7/00 , A61K39/00 , C07K14/005 , C07K16/1036 , C12N9/22 , C12N2740/13021 , C12N2740/13022 , C12Q1/6886 , C12Q1/70 , C12Q1/701 , C12Q2600/136
摘要： The present invention provides for isolated nucleic acid sequences encoding viruses; isolated polypeptides comprising amino acid sequences of the virus; vectors comprising the viral nucleic acid sequences; cells comprising the vectors; antibodies and antigen binding fragments thereof which have binding specificity for the virus; methods of detecting or screening for the virus (e.g., in an individual); methods of identifying agents that inhibit the virus; methods of inducing an immune response to the virus; methods of treating disease associated with the presence of XMRV in an individual (e.g., cancer such as prostate cancer); methods of detecting asymptomatic cancer (e.g., prostate cancer); methods of identifying an individual at risk for developing cancer (e.g., prostate cancer); and kits for detecting the virus.
摘要翻译：本发明提供了编码病毒的分离的核酸序列; 包含病毒的氨基酸序列的分离的多肽; 包含病毒核酸序列的载体; 包含载体的细胞; 对病毒具有结合特异性的抗体及其抗原结合片段; 检测或筛选病毒（例如在个体中）的方法; 鉴定抑制病毒的物质的方法; 诱导对病毒的免疫应答的方法; 治疗与个体中XMRV存在相关的疾病（例如癌症，例如前列腺癌）的方法; 检测无症状癌症（例如前列腺癌）的方法; 鉴定处于发展成癌症风险中的个体（例如前列腺癌）的方法; 和检测病毒的工具包。

3. 发明申请

WO2012135064A3 ATTENUATED STRAINS OF PLASMODIUM 审中-公开
标题翻译： PLASMODIUM的衰减菌株
公开(公告)号：WO2012135064A3
公开(公告)日：2013-02-14
申请号：PCT/US2012030443
申请日：2012-03-23
申请人： UNIV CALIFORNIA , DERISI JOSEPH L , YEH ELLEN
发明人： DERISI JOSEPH L , YEH ELLEN
IPC分类号： A61K31/215 , A61K31/496 , A61K31/65 , A61P7/00
CPC分类号： A61K31/665 , A61K31/165 , A61K31/496
摘要： The present disclosure relates to blood-stage malaria parasites. In particular, the present disclosure provides viable malarial parasites that lack an apicoplast as a consequence of conditions under which that are grown.
摘要翻译：本公开涉及血疟疾寄生虫。特别地，本公开提供了由于其生长的条件而导致缺乏天然淀粉的可行的疟疾寄生虫。

4. 发明申请

WO2010006296A2 NEW AVIAN BORNAVIRUS 审中-公开
标题翻译：新的AVIAN BORNAVIRUS
公开(公告)号：WO2010006296A2
公开(公告)日：2010-01-14
申请号：PCT/US2009/050300
申请日：2009-07-10
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , DERISI, Joseph , GANEM, Don , FISCHER, Kael , KISTLER, Amy , SKEWES-COX, Peter , SOBER, Katherine , CHIU, Charles , GRENINGER, Alex , KARLENE, Scott, B. , CLUBB, Susan , GANCZ, Ady , LUBLIN, Avishai
发明人： DERISI, Joseph , GANEM, Don , FISCHER, Kael , KISTLER, Amy , SKEWES-COX, Peter , SOBER, Katherine , CHIU, Charles , GRENINGER, Alex , KARLENE, Scott, B. , CLUBB, Susan , GANCZ, Ady , LUBLIN, Avishai
IPC分类号： C12N15/34 , C12N5/10 , C12N7/00 , C12Q1/68 , C07K16/08 , G01N33/569 , A61K39/12
CPC分类号： C12N7/00 , A61K39/00 , C07K14/005 , C07K16/10 , C12N2760/00022 , C12Q1/70 , G01N33/56983 , G01N2333/08
摘要： The present invention relates to the discovery of a new avian bornavirus as the causative agent for psittacine proventricular dilation disease, methods of detecting the bornavirus and diagnosing bornavirus infection, methods of treating or preventing bornavirus infection, and methods for identifying anti-bornaviral compounds.
摘要翻译：本发明涉及发现作为鹦鹉热心脏扩张疾病的病原体的新型禽源内病毒，检测内源性病毒和诊断内源性病毒感染的方法，治疗或预防内源性病毒感染的方法，以及方法用于鉴定抗内源性病毒化合物。

5. 发明授权

US4607612A Fireplace furnace 失效
标题翻译：壁炉炉
公开(公告)号：US4607612A
公开(公告)日：1986-08-26
申请号：US737274
申请日：1985-05-23
申请人： Joseph DeRisi
发明人： Joseph DeRisi
IPC分类号： F24B1/19 , F24B7/02 , F24B7/00
CPC分类号： F24B1/1902 , F24B7/025
摘要： A furnace insert (10) for an enclosed fireplace is disclosed. Furnace (10) includes an outer housing (11) and an inner housing (50) which define a firebox (11A). A plurality of tubular steel ducts (45-52), inclusive, are mounted within firebox (11A) and heat air as it rises through the ducts from inlets at the bottom and out of outlets at the top. Additional heat is recovered from the furnace and, in addition, an insulating effect is created which prevents damage to the fireplace walls by a heat exchange chamber (54) which is defined by a space between inner housing (11) and outer housing (50) which has an air inlet (54A) at the bottom and an air outlet (54A) at the top.
摘要翻译：公开了一种用于封闭壁炉的炉子插入件（10）。炉（10）包括限定火箱（11A）的外壳（11）和内壳（50）。多个管状钢管（45-52）（包括端部）安装在火箱（11A）中，并且当空气从底部的入口和顶部的出口排出时，加热空气通过管道。另外，从炉子回收额外的热量，此外还产生了绝热效果，其通过由内壳体（11）和外壳（50）之间的空间限定的热交换室（54）来防止对壁炉壁的损坏，其在底部具有空气入口（54A），在顶部具有空气出口（54A）。

6. 发明申请

WO2012135064A2 ATTENUATED STRAINS OF PLASMODIUM 审中-公开
标题翻译： PLASMODIUM的衰减菌株
公开(公告)号：WO2012135064A2
公开(公告)日：2012-10-04
申请号：PCT/US2012/030443
申请日：2012-03-23
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , DERISI, Joseph, L. , YEH, Ellen
发明人： DERISI, Joseph, L. , YEH, Ellen
IPC分类号： A61K31/215 , A61K31/65 , A61K31/496 , A61P7/00
CPC分类号： A61K31/665 , A61K31/165 , A61K31/496 , Y02A50/411
摘要： The present disclosure relates to blood-stage malaria parasites. In particular, the present disclosure provides viable malarial parasites that lack an apicoplast as a consequence of conditions under which that are grown.
摘要翻译：本公开涉及血疟疾寄生虫。特别地，本公开提供了由于其生长的条件而导致缺乏天然淀粉的可行的疟疾寄生虫。

7. 发明申请

WO2010006296A3 NEW AVIAN BORNAVIRUS 审中-公开
标题翻译：新AVIAN BORNAVIRUS
公开(公告)号：WO2010006296A3
公开(公告)日：2010-03-04
申请号：PCT/US2009050300
申请日：2009-07-10
申请人： UNIV CALIFORNIA , DERISI JOSEPH , GANEM DON , FISCHER KAEL , KISTLER AMY , SKEWES-COX PETER , SOBER KATHERINE , CHIU CHARLES , GRENINGER ALEX , KARLENE SCOTT B , CLUBB SUSAN , GANCZ ADY , LUBLIN AVISHAI
发明人： DERISI JOSEPH , GANEM DON , FISCHER KAEL , KISTLER AMY , SKEWES-COX PETER , SOBER KATHERINE , CHIU CHARLES , GRENINGER ALEX , KARLENE SCOTT B , CLUBB SUSAN , GANCZ ADY , LUBLIN AVISHAI
IPC分类号： C12N7/00 , A61K39/12 , C07K14/08 , C07K16/10 , C12Q1/70
CPC分类号： C12N7/00 , A61K39/00 , C07K14/005 , C07K16/10 , C12N2760/00022 , C12Q1/70 , G01N33/56983 , G01N2333/08
摘要： The present invention relates to the discovery of a new avian bornavirus as the causative agent for psittacine proventricular dilation disease, methods of detecting the bornavirus and diagnosing bornavirus infection, methods of treating or preventing bornavirus infection, and methods for identifying anti-bornaviral compounds.
摘要翻译：本发明涉及一种新的鸟类脱发病毒作为鹦鹉热室扩张疾病的病原体的发现，检测恶病毒和诊断恶病毒感染的方法，治疗或预防斑驳病毒感染的方法，以及用于鉴定抗体的方法。

8. 发明申请

WO2006110589A2 GAMMARETROVIRUS ASSOCIATED WITH CANCER 审中-公开
标题翻译：与癌症相关的巨噬细胞瘤
公开(公告)号：WO2006110589A2
公开(公告)日：2006-10-19
申请号：PCT/US2006013167
申请日：2006-04-07
申请人： CLEVELAND CLINIC FOUNDATION , UNIV CALIFORNIA , SILVERMAN ROBERT , KLEIN ERIC A , DERISI JOSEPH , GANEM DON , CASEY GRAHAM
发明人： SILVERMAN ROBERT , KLEIN ERIC A , DERISI JOSEPH , GANEM DON , CASEY GRAHAM
CPC分类号： C12N7/00 , A61K39/00 , C07K14/005 , C07K16/1036 , C12N9/22 , C12N2740/13021 , C12N2740/13022 , C12Q1/6886 , C12Q1/70 , C12Q1/701 , C12Q2600/136
摘要： The present invention provides for isolated nucleic acid sequences encoding viruses; isolated polypeptides comprising amino acid sequences of the virus; vectors comprising the viral nucleic acid sequences; cells comprising the vectors; antibodies and antigen binding fragments thereof which have binding specificity for the virus; methods of detecting or screening for the virus (e.g., in an individual); methods of identifying agents that inhibit the virus; methods of inducing an immune response to the virus; methods of treating disease associated with the presence of XMRV in an individual (e.g., cancer such as prostate cancer); methods of detecting asymptomatic cancer (e.g., prostate cancer); methods of identifying an individual at risk for developing cancer (e.g., prostate cancer); and kits for detecting the virus.
摘要翻译：本发明提供了编码病毒的分离的核酸序列; 包含病毒的氨基酸序列的分离的多肽; 包含病毒核酸序列的载体; 包含载体的细胞; 对病毒具有结合特异性的抗体及其抗原结合片段; 检测或筛选病毒的方法（例如，在个体中）; 识别抑制病毒的药剂的方法; 诱导对病毒的免疫应答的方法; 治疗与个体（例如癌症如前列腺癌）中XMRV存在相关的疾病的方法; 检测无症状癌症的方法（例如前列腺癌）; 识别患有癌症风险的个体（例如前列腺癌）的方法; 和用于检测病毒的工具包。

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