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1. 发明申请

WO2006051088A3 DEVICES FOR CARRYING OUT AND DIAGNOSING MICROARRAY EXPERIMENTS 审中-公开
标题翻译：微型阵列实验装置的实施和分析
公开(公告)号：WO2006051088A3
公开(公告)日：2006-08-03
申请号：PCT/EP2005055871
申请日：2005-11-09
申请人： CLONDIAG CHIP TECH GMBH , ERMANTRAUT EUGEN , SCHULZ TORSTEN , WOESTEMEYER ANKE
发明人： ERMANTRAUT EUGEN , SCHULZ TORSTEN , WOESTEMEYER ANKE
IPC分类号： B01L3/00 , B01J19/00 , C12Q1/68 , G01N1/00
CPC分类号： B01J19/0046 , B01J2219/00315 , B01J2219/00662 , B01J2219/00702 , B01J2219/0072 , B01J2219/00722 , B01L3/5085 , G01N35/00029 , G01N35/028 , G01N2035/00158
摘要： The invention relates to devices for carrying out parallel microarray experiments for detecting specific interactions between probe and target molecules in a microtiter plate and to methods for producing said devices. The invention also relates the use of such devices in a method for the qualitative and/or quantitative detection of specific interactions between probe and target molecules.
摘要翻译：本发明涉及用于平行实施微阵列实验以检测微量滴定板中探针和靶分子之间的特异性相互作用的装置以及制造这种装置的方法。此外，本发明涉及这样的装置在用于对探针和靶分子之间的特异性相互作用进行定性和/或定量检测的方法中的用途。

2. 发明申请

WO2004087951A2 DEVICE FOR THE MULTIPLICATION AND DETECTION OF NUCLEIC ACIDS 审中-公开
标题翻译：装置用于生殖和对于核酸的检测
公开(公告)号：WO2004087951A2
公开(公告)日：2004-10-14
申请号：PCT/EP2004003532
申请日：2004-04-02
申请人： CLONDIAG CHIP TECH GMBH , BICKEL RALF , ELLINGER THOMAS , ERMANTRAUT EUGEN , KAISER THOMAS , SCHULZ TORSTEN , ULLRICH THOMAS
发明人： BICKEL RALF , ELLINGER THOMAS , ERMANTRAUT EUGEN , KAISER THOMAS , SCHULZ TORSTEN , ULLRICH THOMAS
IPC分类号： B01L3/00 , B01L7/00 , G01N21/47 , G01N21/59 , C12Q1/68
CPC分类号： B01L7/52 , B01L3/5027 , B01L2200/147 , B01L2300/0636 , B01L2300/0654 , B01L2300/0877 , G01N21/4738 , G01N21/59
摘要： The invention relates to a device for the multiplication and detection of nucleic acids, comprising a temperature controller and/or regulation unit, a reaction chamber, containing a substrate with a detection surface on which a substance library is immobilised and an optical system, by means of which the temporal process of formation of deposit on the detection surface may be detected. The temperature in the reaction chamber may be controlled and/or regulated by means of the temperature controller and/or regulation unit. The invention further relates to a method for the amplification and qualitative and quantitative detection of nucleic acids in a sample, comprising the following steps: a) introduction of the sample into a reaction chamber, formed by a capillary gap between a chamber support and a microarray, whereby the microarray comprises a substrate with nucleic acid probes arranged on array elements thereon, b) amplification of the nucleic acid for detection in the reaction chamber, by means of a cyclical amplification reaction, c) detection of a hybridisation between the nucleic acid for detection and the nucleic acid probes immobilised on the substrate without removal from the reaction chamber of molecules which are not hybridized with the nucleic acids immobilised on the substrate.
摘要翻译：本发明涉及一种用于再现的装置和用于检测的核酸，包括温度控制和/或调节单元; 包含具有检测表面在其上的物质库是一个irrmobilisiert载体，其中在所述反应室中的温度通过温度控制和调节单元和/或调节控制的反应室; 和光学系统与沉淀的时间进程是在检测区域中检测到。本发明还涉及一种用于扩增和核酸的定性和定量检测样品中，包括以下步骤的方法：（a）将所述样品引入反应室中，这是由腔室支撑件和微阵列，其特征在于之间的毛细间隙形成所述微阵列包含用irrmobilisierten上的核酸探针阵列元件的衬底; （B）通过循环扩增反应的扩增方法在反应室中的核酸; （C）检测irrmobilisierten而不分子在基板上的核酸和核酸探针之间的杂交，从该反应室，与所述核酸在基板上irrmobilisierten未杂交去除。

3. 发明申请

WO03004699A3 METHOD FOR IDENTIFYING NUCLEIC ACID MOLECULES AMPLIFIED IN A POLYMERASE CHAIN REACTION 审中-公开
标题翻译：方法用于检测在聚合酶链式反应扩增的核酸分子
公开(公告)号：WO03004699A3
公开(公告)日：2003-04-24
申请号：PCT/EP0207539
申请日：2002-07-05
申请人： CLONDIAG CHIP TECH GMBH , SCHULZ TORSTEN , ERMANTRAUT EUGEN , POSER SIEGFRIED , KAISER THOMAS , MOEBIUS KLAUS-PETER , ULLRICH THOMAS , ADELHELM KARIN
发明人： SCHULZ TORSTEN , ERMANTRAUT EUGEN , POSER SIEGFRIED , KAISER THOMAS , MOEBIUS KLAUS-PETER , ULLRICH THOMAS , ADELHELM KARIN
IPC分类号： G01N33/483 , C12M1/00 , C12N15/09 , C12Q1/68 , B01J19/00
CPC分类号： C12Q1/6851 , C12Q2563/173
摘要： Die Erfindung betrifft eine Vorrichtung sowie ein Verfahren zum qualitativen und/oder quantitativen Nachweis von in einer Polymerase-Kettenreaktion amplifizierten Nukleinsäuremolekülen.
摘要翻译：本发明涉及一种装置和方法，用于定性和/或核酸分子定量识别并在聚合酶链反应扩增。

4. 发明申请

WO0202810A3 METHOD FOR QUALITATIVE AND/OR QUANTITATIVE DETECTING OF MOLECULAR INTERACTIONS ON PROBE ARRAYS 审中-公开
标题翻译：用于定性和/或定量检测探针阵列上分子相互作用的方法
公开(公告)号：WO0202810A3
公开(公告)日：2002-09-19
申请号：PCT/EP0107575
申请日：2001-07-02
申请人： CLONDIAG CHIP TECH GMBH , BICKEL RALF , EHRICHT RALF , ELLINGER THOMAS , ERMANTRAUT EUGEN , KAISER THOMAS , SCHULZ TORSTEN , WAGNER GERD
发明人： BICKEL RALF , EHRICHT RALF , ELLINGER THOMAS , ERMANTRAUT EUGEN , KAISER THOMAS , SCHULZ TORSTEN , WAGNER GERD
IPC分类号： G01N33/53 , C12M1/00 , C12Q1/68 , G01N21/47 , G01N29/06 , G01N33/566 , G01N37/00
CPC分类号： C12Q1/6837
摘要： The invention relates to a method for qualitatively and/or quantitatively detecting certain molecular targets using probe arrays. The inventive detection method comprises a reaction which delivers a product with a particular solubility product, this solubility product causing the precipitation or the formation of a precipitate of the product on an array element of the probe array on which an interaction has taken place between the probe and the target.
摘要翻译：本发明涉及用于通过探针阵列定性和/或定量检测某些分子靶标的装置和方法，其中在本发明方法中通过提供具有某种溶解度产物的反应的检测，所述溶解度产物是沉淀将产品沉淀在探针阵列的阵列元素上，探针和目标之间发生相互作用，产生结果。

5. 发明申请

WO2007051863A3 METHOD AND DEVICE FOR THE DETECTION OF MOLECULAR INTERACTIONS 审中-公开
标题翻译：用于检测分子相互作用的方法和装置
公开(公告)号：WO2007051863A3
公开(公告)日：2007-06-28
申请号：PCT/EP2006068155
申请日：2006-11-06
申请人： CLONDIAG CHIP TECH GMBH , ERMANTRAUT EUGEN , BICKEL RALF , SCHULZ TORSTEN , ULLRICH THOMAS
发明人： ERMANTRAUT EUGEN , BICKEL RALF , SCHULZ TORSTEN , ULLRICH THOMAS
IPC分类号： C12Q1/68 , B01L3/00
CPC分类号： C12Q1/6837 , B01F11/0045 , B01L3/5027 , B01L3/502746 , B01L7/52 , B01L7/525 , B01L2200/027 , B01L2300/044 , B01L2300/0636 , B01L2300/0654 , B01L2300/0816 , B01L2300/0819 , B01L2300/0864 , B01L2300/0877 , B01L2300/1827 , B01L2300/1838 , B01L2400/0481 , G01N21/6452 , G01N21/6458
摘要： The present invention relates to devices and methods for the detection of analytes. In particular, the invention relates to methods for the qualitative and/or quantitative detection of analytes, comprising a microarray on a substrate, onto which probe molecules are immobilized on array elements, said microarray being disposed on a first surface of the device; and a detection chamber formed between the first surface including the microarray disposed thereon and a second surface, wherein the distance between the microarray and the second surface is variable, and wherein the second surface has a displacement structure.
摘要翻译：本发明涉及用于检测分析物的装置和方法。特别地，本发明涉及用于定性和/或定量检测分析物的方法，其包括在基底上的微阵列，探针分子固定在阵列元件上，所述微阵列设置在装置的第一表面上; 以及形成在包括设置在其上的微阵列的第一表面和第二表面之间的检测室，其中微阵列和第二表面之间的距离是可变的，并且其中第二表面具有位移结构。

6. 发明申请

WO2005108604A3 DEVICE AND METHOD FOR DETECTING MOLECULAR INTERACTIONS 审中-公开
标题翻译：设备和检测方法的分子间的相互作用
公开(公告)号：WO2005108604A3
公开(公告)日：2006-04-13
申请号：PCT/EP2005004923
申请日：2005-05-06
申请人： CLONDIAG CHIP TECH GMBH , DWORRAK ALEXANDRA , ELLINGER THOMAS , ERMANTRAUT EUGEN , SCHULZ TORSTEN , ULLRICH THOMAS , KAISER THOMAS
发明人： DWORRAK ALEXANDRA , ELLINGER THOMAS , ERMANTRAUT EUGEN , SCHULZ TORSTEN , ULLRICH THOMAS , KAISER THOMAS
IPC分类号： G01N21/03 , B01L3/00 , B01L7/00 , C12Q1/68 , G01N21/64 , G01N33/50
CPC分类号： B01L3/502738 , B01L3/50851 , B01L7/52 , B01L7/525 , B01L2300/0636 , B01L2300/0654 , B01L2300/0816 , B01L2300/0819 , B01L2300/0864 , B01L2300/0877 , B01L2300/1827 , B01L2300/1838 , B01L2400/0481 , G01N21/6428 , G01N21/6452 , G01N2201/024
摘要： The invention relates to devices and methods for detecting specific interactions between probe and target molecules. The invention especially relates to a device for the qualitative and/or quantitative detection of molecular interactions between probe and target molecules, which comprises a) a microarray comprising a substrate on which probe molecules are immobilized on array elements, said microarray being located on a first surface of the device; and b) a reaction chamber that is defined between the first area with the microarray disposed thereon and a second surface, the distance between the microarray and the second surface being modifiable.
摘要翻译：本发明涉及一种装置和方法用于检测探针和目标分子之间的特异性相互作用的。特别地，本发明涉及一种用于探测和目标分子之间的分子相互作用的定性和/或定量检测的装置，其包括：（a）具有一个基片的微阵列在其上的阵列元件的探针分子被固定，其中，在第一表面上的微阵列该装置被设置; 及（b）其与微阵列中的第一面之间所形成的反应室设置在其上和第二表面，其中所述Mikroarrayund第二表面修改的之间的距离。

7. 发明申请

WO2005071108A3 METHOD FOR GENO- AND PATHOTYPING PSEUDOMONAS AERUGINOSA 审中-公开
标题翻译：方法和铜绿假单胞菌的GENO pathotyping
公开(公告)号：WO2005071108A3
公开(公告)日：2005-11-24
申请号：PCT/EP2005000751
申请日：2005-01-26
申请人： CLONDIAG CHIP TECH GMBH , WAGNER GERD , WIEHLMANN LUTZ , TUEMMLER BURKHARD
发明人： WAGNER GERD , WIEHLMANN LUTZ , TUEMMLER BURKHARD
IPC分类号： C12Q1/68
CPC分类号： C12Q1/689 , C12Q2600/16
摘要： The invention relates to a method for geno- and pathotyping Pseudomonas aeruginosa-type bacteria by means of hybridisation assays on a biochip or an micro matrix. Specific oligonucleotide probes usable for a detection method and biochips provided therewith are also disclosed.
摘要翻译：本发明涉及一种通过在生物芯片上或微阵列杂交分析手段的种类绿脓杆菌的细菌的基因型和pathotyping的方法。具体发明寡核苷酸探针可以用来作为检测方法的一部分，并且与这样的寡核苷酸探针的关注生物芯片。

8. 发明申请

WO2006056466A3 METHOD FOR SPECIFICALLY LOCATED SYNTHESIS OF BIOPOLYMERS ON SOLID CARRIERS 审中-公开
标题翻译：在固体支持物上特定位点合成生物聚合物的方法
公开(公告)号：WO2006056466A3
公开(公告)日：2006-08-03
申请号：PCT/EP2005012648
申请日：2005-11-25
申请人： CLONDIAG CHIP TECH GMBH , ELLINGER THOMAS , ERMANTRAUT EUGEN , HOLZHEY NANCY , PLENZ FRANK , SCHULZ TORSTEN , TUCHSCHEERER JENS , WEICHERDING DANIEL
发明人： ELLINGER THOMAS , ERMANTRAUT EUGEN , HOLZHEY NANCY , PLENZ FRANK , SCHULZ TORSTEN , TUCHSCHEERER JENS , WEICHERDING DANIEL
IPC分类号： B01J19/00 , C40B40/06 , C40B50/14
CPC分类号： B82Y30/00 , B01J19/0046 , B01J2219/0043 , B01J2219/00659 , B01J2219/00662 , B01J2219/00675 , B01J2219/00722 , B01J2219/00725 , C40B40/06 , C40B40/10 , C40B50/14 , C40B60/14
摘要： The invention relates to a method for specifically located synthesis of biopolymers such as nucleic acids or peptides and the respective derivatives thereof on solid carriers, wherein local discrimination of synthesis is carried out particularly with the aid of masks, directing aqueous activation reagents for the cleavage of protective groups to predetermined areas on the carrier.
摘要翻译：本发明涉及一种用于生物聚合物的位点特异性的合成方法，如核酸或肽和在固体载体上，其中所述合成的本地鉴别特别是通过使用掩模的情况下进行其各自的衍生物，例如，使得所述水性活化试剂用于除去保护基团，以预定区域在载体上。

9. 发明申请

WO2004046378A2 MICROARRAY-BASED METHOD FOR AMPLIFYING AND DETECTING NUCLEIC ACIDS DURING A CONTINUOUS PROCESS 审中-公开
标题翻译：基于微阵列的连续方法中核酸的扩增和检测
公开(公告)号：WO2004046378A2
公开(公告)日：2004-06-03
申请号：PCT/EP0312905
申请日：2003-11-18
申请人： CLONDIAG CHIP TECH GMBH , ERMANTRAUT EUGEN , BICKEL RALF , ELLINGER THOMAS , WAGENHAUS ANNETTE
发明人： ERMANTRAUT EUGEN , BICKEL RALF , ELLINGER THOMAS , WAGENHAUS ANNETTE
IPC分类号： C12P19/34 , C12Q1/68
CPC分类号： C12Q1/6837 , C12Q1/6844 , C12Q2537/163 , C12Q2537/161 , C12Q2527/101 , C12Q2561/113
摘要： The invention concerns methods, in the context of slide-based evaluation, for efficiently amplifying and detecting nucleic acids during a continuous process. The invention mainly concerns methods which consists in performing a polymerase chain reaction occurs, whereto a competitor element is added at the beginning of the reaction. The invention also concerns methods which consist in an hybridization in the presence of a molecule which, proximate to the hybridizing sequences, is bound to one of the hybridizing nucleic acid molecules.
摘要翻译：本发明涉及能够在连续过程中有效扩增核酸及其检测的方法，作为基于芯片的评估的一部分。本发明特别涉及进行PCR的方法，最初加入竞争者。本发明的另一个目的是其中杂交在杂交序列附近与杂交核酸分子之一结合的分子存在下进行的方法。

10. 发明申请

WO03031063A3 DEVICE FOR HOLDING A SUBSTANCE LIBRARY CARRIER 审中-公开
标题翻译：用于安装物质库支持的装置
公开(公告)号：WO03031063A3
公开(公告)日：2003-09-12
申请号：PCT/EP0211313
申请日：2002-10-09
申请人： CLONDIAG CHIP TECH GMBH , SCHULZ TORSTEN , ERMANTRAUT EUGEN , ULLRICH THOMAS , ELLINGER THOMAS , FISCHER JOACHIM , KAISER THOMAS , MOEBIUS KLAUS-PETER , POSER SIEGFRIED , TUCHSCHEERER JENS , ZEIREN MARTIN
发明人： SCHULZ TORSTEN , ERMANTRAUT EUGEN , ULLRICH THOMAS , ELLINGER THOMAS , FISCHER JOACHIM , KAISER THOMAS , MOEBIUS KLAUS-PETER , POSER SIEGFRIED , TUCHSCHEERER JENS , ZEIREN MARTIN
IPC分类号： G01N33/53 , B01J19/00 , B01L3/00 , B01L7/00 , C12M1/00 , C12N15/09 , C12Q1/68 , G01N33/566 , G01N37/00
CPC分类号： B01L7/52 , B01J2219/00527 , B01J2219/00531 , B01J2219/00596 , B01J2219/00605 , B01J2219/00659 , B01J2219/00722 , B01J2219/00725 , B01L3/502715 , B01L2200/025 , B01L2200/027 , B01L2200/10 , B01L2200/141 , B01L2200/147 , B01L2300/044 , B01L2300/0636 , B01L2300/0877 , B01L2300/1805
摘要： The invention relates to a modularly structured device for holding substance library carriers and the use of said device for qualitative and quantitative detection of given molecular target molecules. The invention more particularly relates to a device (1) for holding a substance library carrier, which is characterized in that two holder elements that can be fixed to one another (101 and 102) form a layer composite consisting of: (i) a cover element (200) that has a detection surface with a substance library (201) on its lower surface and that is optically transparent at least in the area of the detection surface; (ii) an intermediate sealing element (300) having an enclosed groove and (iii) an optically transparent bottom element in the area of the detection surface of the cover element (400), whereby an optically transparent chamber area is obtained.
摘要翻译：本发明涉及一种用于容纳物质库载体的模块化装置及其用于定性和定量检测某些分子靶分子的用途。特别地，本发明涉及一种装置（1），用于保持一个物质文库的载体，其特征在于，两个可固定到彼此保持元件（101和102）的层的复合由在其下侧（I）的盖元件（200）的，检测表面与一种物质库（201），并且是光学透明的，至少在检测表面的面积，（ⅱ）密封并且具有中间元件（300）和一个封闭的凹口（iii）至少在盖部件底部构件的检测面的面积的光学透明（400）形式，由此光学地通过腔室空间出现。

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