专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明专利

JP2002179561A SOLUTION-BASED TRANSDERMAL DRUG DELIVERY SYSTEM 审中-公开
公开(公告)号：JP2002179561A
公开(公告)日：2002-06-26
申请号：JP2001328616
申请日：2001-10-26
申请人： BIOCHEMICS INC
发明人： MASIZ JOHN J , CARTER STEPHEN G
IPC分类号： A61K9/70 , A61K31/4523 , A61K31/4535 , A61K47/46 , A61P29/00 , A61P43/00
摘要： PROBLEM TO BE SOLVED: To provide a method for enabling efficient delivery of a broad range of an active drug ingredient. SOLUTION: This efficient transdermal drug delivery system for delivering the active ingredient to the bloodstream of a living body is provided. The system comprises the use of a vasodilator, the active ingredient, a permeation enhancer for the active ingredient, etc. The components of the mixture are combined in a manner that dissolves the components into a solution. Thereby, the need for a polymeric binding agent is eliminated and the total molecular weight of the mixture is diminished to improve the penetration and delivery of the active drug molecules.

2. 发明申请

WO2009152372A1 CONTROL OF BLOOD VESSEL PHYSIOLOGY TO TREAT SKIN DISORDERS 审中-公开
标题翻译：控制血管生理学治疗皮肤病
公开(公告)号：WO2009152372A1
公开(公告)日：2009-12-17
申请号：PCT/US2009/047098
申请日：2009-06-11
申请人： BIOCHEMICS, INC. , CARTER, Stephen, G. , MASIZ, John, J. , STEPHENS, Laura , ZHU, Zhen , PATEL, Kanu , DONABEDIAN, David, H.
发明人： CARTER, Stephen, G. , MASIZ, John, J. , STEPHENS, Laura , ZHU, Zhen , PATEL, Kanu , DONABEDIAN, David, H.
IPC分类号： A61K31/198 , A61K31/455 , A61K41/00 , A61P17/00
CPC分类号： A61K41/0028 , A61K9/0014 , A61K31/137 , A61K31/17 , A61K31/198 , A61K31/295 , A61K31/401 , A61K31/4164 , A61K31/4166 , A61K31/425 , A61K31/455 , A61K31/522 , A61K36/14 , A61K36/16 , A61K36/185 , A61K36/28 , A61K36/53 , A61K36/62 , A61K36/734 , A61K36/752 , A61K36/88 , A61K36/886 , A61K36/8969 , A61K36/9068 , A61M37/00 , A61N5/062 , A61N7/00
摘要： In a method for treating an affected skin region of a patient having a skin disorder, a vasodilation composition is applied to an affected skin region of a patient, the affected skin region exhibiting a skin disorder characterized by at least one abnormal blood vessel, and the affected skin region is then treated so as to non-invasively disrupt tissue architecture, e.g., by inducing ischemia, of the at least one abnormal blood vessel. A vasoconstriction composition can then be applied to the skin region to cause vasoconstriction of the at least one blood vessel in order to promote healing.
摘要翻译：在用于治疗患有皮肤病的患者的受影响的皮肤区域的方法中，将血管舒张组合物施用于患者的受影响的皮肤区域，所述受影响的皮肤区域呈现以至少一种异常血管为特征的皮肤病，然后治疗受影响的皮肤区域，以便非侵入性地破坏至少一个异常血管的组织结构，例如通过诱导缺血。然后可以将血管收缩组合物施用于皮肤区域以引起至少一个血管的血管收缩以促进愈合。

3. 发明专利

MX349176B SUMINISTRO TRANSDERMICO DE FARMACO EMPLEANDO UN OSMOLITO Y UN AGENTE VASOACTIVO. 未知
公开(公告)号：MX349176B
公开(公告)日：2017-07-14
申请号：MX2010004169
申请日：2009-09-22
申请人： BIOCHEMICS INC
发明人： CARTER STEPHEN G , ZHU ZHEN , PATEL KANU , MASIZ JOHN J
IPC分类号： A61K9/70 , A61K9/00 , A61K31/455 , A61K47/22 , A61K47/26
摘要： La presente invención se refiere a una formulación y un método para el suministro de sustancias bioactivas cuando son aplicadas a, o dentro de, la piel u otra región exterior de mamífero, por ejemplo un paciente, incluye un agente vasoactivo, un osmolito, y un ingrediente activo; la formulación es suficientemente higroscópica para crear una condición de hipertonicidad cuando es absorbida por la piel; cuando se aplica la formulación a la piel, se puede suministrar el agente vasoactivo a la dermis para hacer contacto con la vasculatura de un paciente.

4. 发明专利

CA2727710C CONTROL OF BLOOD VESSEL PHYSIOLOGY TO TREAT SKIN DISORDERS 未知
公开(公告)号：CA2727710C
公开(公告)日：2016-11-01
申请号：CA2727710
申请日：2009-06-11
申请人： BIOCHEMICS INC
发明人： CARTER STEPHEN G , MASIZ JOHN J , STEPHENS LAURA , ZHU ZHEN , PATEL KANU , DONABEDIAN DAVID H
IPC分类号： A61K31/198 , A61B18/20 , A61K31/295 , A61K31/4174 , A61K31/455 , A61P17/00
摘要： In a method for treating an affected skin region of a patient having a skin disorder, a vasodilation composition is applied to an affected skin region of a patient, the affected skin region exhibiting a skin disorder characterized by at least one ab-normal blood vessel, and the affected skin region is then treated so as to non-invasively disrupt tissue architecture, e.g., by induc-ing ischemia, of the at least one abnormal blood vessel. A vasoconstriction composition can then be applied to the skin region to cause vasoconstriction of the at least one blood vessel in order to promote healing.

5. 发明专利

AU2009291755A1 Ibuprofen for topical administration 未知
公开(公告)号：AU2009291755A1
公开(公告)日：2010-03-18
申请号：AU2009291755
申请日：2009-09-10
申请人： BIOCHEMICS INC
发明人： CARTER STEPHEN G , ZHU ZHEN , PATEL KANU , KOZWICH DIANE
IPC分类号： A61K47/32

6. 发明专利

CA2569285A1 METHODS OF DEVICE-ASSISTED DRUG DELIVERY 未知
公开(公告)号：CA2569285A1
公开(公告)日：2006-03-30
申请号：CA2569285
申请日：2005-09-20
申请人： BIOCHEMICS INC
发明人： PATEL KANU , CARTER STEPHEN G , ZHU ZHEN
IPC分类号： A61F13/00

7. 发明专利

CA2570782A1 PERIPHERALLY-ACTING VASODILATORS 未知
公开(公告)号：CA2570782A1
公开(公告)日：2006-01-26
申请号：CA2570782
申请日：2004-10-26
申请人： BIOCHEMICS INC
发明人： PATEL KANU , CARTER STEPHEN G , ZHU ZHEN
IPC分类号： A61K31/455 , A61K31/198
摘要： A system for the delivery of chemical vasodilators into the skin for the purpose of increasing the blood flow in a tissue that exhibits compromised circulation. The designated purpose of this increased blood flow is to transiently reverse or inhibit or prevent the onset of an associated medical affliction that may in part or in whole, be either the consequence of that medical condition or participating in the clinical symptoms and etiology of that medical condition. The process and the effect of the topical delivery of a chemical vasodilator has been previously demonstrated for other medical and pharmaceutical applications, however the specific use of this class of drug molecules for the focused effect of improving blood flow to the skin and surrounding tissue with the goal of improving the metabolic health of the tissue and to possibly affect the symptoms of a medical condition is the specific aim of this patent.

8. 发明专利

CA2512059A1 TRANSDERMAL DRUG DELIVERY FORMULATIONS WITH OPTIMAL AMOUNTS OF VASODILATORS THEREIN 未知
公开(公告)号：CA2512059A1
公开(公告)日：2006-01-16
申请号：CA2512059
申请日：2005-07-12
申请人： BIOCHEMICS INC
发明人： CARTER STEPHEN G , ZHU ZHEN , PATEL KANU
IPC分类号： A61K31/192 , A61K9/70 , A61K47/22
摘要： Topical drug delivery formulations with optical amounts of vasodilator. Vasodilator chemicals applied topically dilate the blood vessels in the skin tissue, which have been shown to facilitate or inhibit systemic or skin tissue deposition of drug substances. The level of stimulation and/or inhibition has been found to be dependent on the concentration and the identity of the specific vasodilator chemical(s) used as well as the drug molecule(s) to be delivered. This work teaches the need to consider specific formulation requirements when dealing with vasodilator chemicals for the creation of successful delivery vehicles in the transdermal drug delivery system. These requirements for very low concentrations of vasodilators were an unexpected and a surprise finding, in contrast to the concentrations of the vasodilators typically used to elicit an increase in skin blood flow.

9. 发明申请

WO2014144712A1 TOPICAL FORMULATIONS AND METHODS FOR DRUG DELIVERY 审中-公开
标题翻译：用于药物递送的主题制剂和方法
公开(公告)号：WO2014144712A1
公开(公告)日：2014-09-18
申请号：PCT/US2014/029240
申请日：2014-03-14
申请人： BIOCHEMICS, INC.
发明人： CARTER, Stephen, G. , ZHU, Zhen , VARADI, Gyula
IPC分类号： A61K9/00
CPC分类号： A61K31/198 , A61K9/0004 , A61K9/0014 , A61K31/047 , A61K31/05 , A61K31/192 , A61K31/195 , A61K31/4174 , A61K31/455 , A61K31/675 , A61K45/06 , A61K2300/00
摘要： Disclosed are topical formulations for delivery of an active ingredient to a patient. The formulation comprises components including: an active ingredient; a vasoactive agent; and a chelator, wherein the components are selected so that none of the other components is sequestered by the chelator. In some embodiments, the formulation comprises an osmolarity that is greater than about 345 milliOsmoles/liter (345 mOsM). In some embodiments, the formulation further comprises an osmolyte, wherein the osmolyte does not include an ion with a valency higher than monovalency. In some embodiments, the osmolyte in the formulation comprises an osmolarity that is greater than about 290 milliOsmoles/liter (290 mOsM). Also disclosed are methods for using the formulations, and components thereof, kits comprising the components of the formulation, and methods for manufacturing a medicament comprising components of the formulations.
摘要翻译：公开了用于将活性成分递送至患者的局部制剂。制剂包含组分，包括：活性成分; 血管活性剂和螯合剂，其中选择组分使得其它组分都不被螯合剂螯合。在一些实施方案中，制剂包含大于约345毫摩尔/升（345mOsM）的渗透压浓度。在一些实施方案中，制剂还包含渗透剂，其中渗透剂不包括具有高于单价的化合价的离子。在一些实施方案中，制剂中的渗透液包含大于约290毫摩尔/升（290mOsM）的渗透压浓度。还公开了使用制剂及其组分的方法，其包含制剂组分的试剂盒，以及制备包含制剂组分的药物的方法。

10. 发明申请

WO2010034019A4 TRANSDERMAL DRUG DELIVERY USING AN OSMOLYTE AND VASOACTIVE AGENT 审中-公开
标题翻译：使用渗透剂和血管活性剂的透皮药物递送
公开(公告)号：WO2010034019A4
公开(公告)日：2010-05-20
申请号：PCT/US2009057916
申请日：2009-09-22
申请人： BIOCHEMICS INC , CARTER STEPHEN G , ZHU ZHEN , PATEL KANU , MASIZ JOHN J
发明人： CARTER STEPHEN G , ZHU ZHEN , PATEL KANU , MASIZ JOHN J
IPC分类号： A61K9/70 , A61K47/02
CPC分类号： A61K31/192 , A61F2013/00906 , A61K9/0014 , A61K9/06 , A61K31/05 , A61K31/19 , A61K31/415 , A61K31/426 , A61K31/427 , A61K31/455 , A61K45/06 , A61K47/02 , A61K47/22 , A61K47/26 , A61K2300/00
摘要： A formulation and method for delivery of bioactive substances when applied to, or within, the skin or other exterior region of a mammal, for example, a patient, includes a vasoactive agent; an osmolyte; and an active ingredient. The formulation is sufficiently hygroscopic so as to create a condition of hypertonicity when absorbed by the skin. When the formulation is applied to the skin, the vasoactive agent can be delivered to the dermis so as to contact the vasculature of a patient.
摘要翻译：当施用于哺乳动物（例如患者）的皮肤或其他外部区域时或其内部时，用于递送生物活性物质的制剂和方法包括血管活性剂; 渗透剂; 和一种活性成分。该制剂具有足够的吸湿性，从而当被皮肤吸收时产生高张度状态。当制剂应用于皮肤时，血管活性剂可被递送至真皮以接触患者的脉管系统。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式