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1. 发明专利

JP2013014583A Novel polypeptide containing methionine sulfoxide 有权
标题翻译：含有甲硫氨酸的新型多肽
公开(公告)号：JP2013014583A
公开(公告)日：2013-01-24
申请号：JP2012130321
申请日：2012-06-08
申请人： Anges Mg Inc , アンジェスMg株式会社
发明人： TOMIOKA HIDEKI , TENMAN AKIKO , TAMURA NAO
IPC分类号： C07K7/08 , A61K38/00 , A61P9/00 , A61P9/10 , A61P17/02 , A61P31/04 , C07K14/00
摘要： PROBLEM TO BE SOLVED: To provide a novel polypeptide having excellent angiogenesis-inducing activity and antibacterial activity, and an angiogenesis inducing agent containing the novel polypeptide.SOLUTION: The polypeptide is composed of a specific amino acid sequence. The polypeptide is effective in prevention/amelioration/treatment of diseases such as burns, decubitus, wounds, skin ulcers, leg ulcers, diabetic ulcers, and ulcers caused by occlusive arterial diseases, arteriosclerosis obliterans and the like. The polypeptide is also effective as antibacterial agent in prevention/amelioration/treatment of diseases such as burns, decubitus, wounds, skin ulcers, leg ulcers, and diabetic ulcers.
摘要翻译：待解决的问题：提供具有优异的血管发生诱导活性和抗菌活性的新型多肽，以及含有该新型多肽的血管发生诱导剂。解决方案：多肽由特定氨基酸序列组成。该多肽在预防/改善/治疗诸如烧伤，褥疮，伤口，皮肤溃疡，腿部溃疡，糖尿病性溃疡和由闭塞性动脉疾病引起的溃疡，闭塞性动脉硬化等疾病中是有效的。该多肽在预防/改善/治疗诸如烧伤，褥疮，伤口，皮肤溃疡，腿部溃疡和糖尿病性溃疡等疾病中也是有效的抗菌剂。版权所有（C）2013，JPO＆INPIT

2. 发明专利

JP2010090103A NEW OLIGONUCLEOTIDE DERIVATIVE AND NF-κB DECOY COMPOSED OF THE SAME 有权
标题翻译：新的寡核苷酸衍生物和NF-κB复合物
公开(公告)号：JP2010090103A
公开(公告)日：2010-04-22
申请号：JP2009030915
申请日：2009-02-13
申请人： Anges Mg Inc , Gene Design Inc , アンジェスMg株式会社 , 株式会社ジーンデザイン
发明人： YOSHINO MASAFUMI , YUYAMA KAZUHIKO , UENO NOBUHIRO , KONO HIROKAZU , GENBAN GAKUSEN
IPC分类号： A61K31/7125 , A61P1/04 , A61P9/00 , A61P9/10 , A61P11/00 , A61P11/06 , A61P13/00 , A61P13/02 , A61P13/12 , A61P17/00 , A61P17/02 , A61P17/06 , A61P19/02 , A61P29/00 , A61P35/04 , A61P37/02 , A61P37/08 , C12N15/09
摘要： PROBLEM TO BE SOLVED: To provide a new oligonucleotide derivative which has a higher bonding affinity with an NF-κB than the known NF-κB decoys, when used as an NF-κB decoy, an NF-κB decoy composed of the derivative and a drug containing the derivative as an effective ingredient.
SOLUTION: A hairpin type double-stranded oligonucleotide in which an oligonucleotide having a specific base sequence and its complementary chain are bonded with a specific linker exhibits a higher NF-κB bonding affinity than the known NF-κB decoys.
COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：待解决的问题：为了提供与已知NF-κB诱饵相比具有比NF-κB更高的结合亲和力的新的寡核苷酸衍生物，当用作NF-κB诱饵时，由以下组成的NF-κB诱饵衍生物和含有该衍生物作为有效成分的药物。解决方案：其中具有特异性碱基序列及其互补链的寡核苷酸与特异性接头结合的发夹型双链寡核苷酸表现出比已知NF-κB诱饵更高的NF-κB结合亲和力。版权所有（C）2010，JPO＆INPIT

3. 发明专利

JP2005336081A Reexpression inhibitor against nr2b-nmda receptor 审中-公开
标题翻译：抑制NR2B-NMDA受体的抑制剂
公开(公告)号：JP2005336081A
公开(公告)日：2005-12-08
申请号：JP2004155679
申请日：2004-05-26
申请人： Anges Mg Inc , National Institute Of Advanced Industrial & Technology , アンジェスMg株式会社 , 独立行政法人産業技術総合研究所
发明人： KIYOSUE KAZUYUKI , MORISHITA RYUICHI
IPC分类号： A61K48/00 , A61K31/7125 , A61P25/00 , A61P25/02 , A61P25/04 , A61P43/00
摘要： PROBLEM TO BE SOLVED: To provide a technique for controlling expression of an NR2B-NMDA receptor and to provide a prophylactic and therapeutic agent for pain, an inhibitor against fixation of memories related to psychic traumata and an inhibitor against neurocyte death.
SOLUTION: The reexpression inhibitor against the NR2B-NMDA receptor, the prophylactic and therapeutic agent for pain, the inhibitor against fixation of memories related to psychic trauma and the inhibitor against neurocyte death comprise an NF-κB decoy as an effective ingredient.
COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：要解决的问题：提供一种控制NR2B-NMDA受体表达的技术，并提供一种用于疼痛的预防和治疗剂，一种抑制与心理创伤有关的记忆的抑制剂和一种抑制神经细胞死亡的抑制剂。解决方案：针对NR2B-NMDA受体的再表达抑制剂，疼痛的预防和治疗剂，与心理创伤相关记忆的固定抑制剂和针对神经细胞死亡的抑制剂的抑制剂包括NF-κB诱饵作为有效成分。版权所有（C）2006，JPO＆NCIPI

4. 发明专利

JP2004358234A Needleless syringe with a plurality of nozzle holes 审中-公开
公开(公告)号：JP2004358234A
公开(公告)日：2004-12-24
申请号：JP2004139364
申请日：2004-05-10
申请人： Anges Mg Inc , Ryuichi Morishita , Shimadzu Corp , アンジェスMg株式会社 , 株式会社島津製作所 , 竜一森下
发明人： MORISHITA RYUICHI , TOMITA NARUYA , KUNUGIZA YASUO , TANIYAMA YOSHIAKI , KOIKE HIROMI , UDAGAWA HARUHIDE , KIMURA TATSUO
IPC分类号： C12N15/09 , A61K31/7088 , A61K35/74 , A61K38/00 , A61K38/22 , A61K38/27 , A61K38/43 , A61K38/55 , A61K48/00 , A61M5/30 , A61P9/00 , A61P9/10 , A61P19/02 , A61P19/08 , A61P29/00 , A61P35/04 , A61P37/06 , A61P37/08
CPC分类号： A61M5/30 , A61M5/19
摘要： PROBLEM TO BE SOLVED: To provide a needleless syringe for jet-injecting various kinds of medical solutions from a plurality of nozzle holes to uniformly inject them into the whole treated part. SOLUTION: The needleless syringe comprises a medical solution chamber 22 for storing the medical solution L, formed with the plurality of nozzle holes 94 and provided with a plurality of pistons 93 corresponding to the plurality of nozzle holes 94 respectively, and a syringe body 12 provided with a pressing mechanism 32 for pressing the pistons 93 toward the nozzle holes 94 to inject the medical solution L from the nozzle holes 94. COPYRIGHT: (C)2005,JPO&NCIPI

5. 发明专利

JP2003095988A MEDICAMENT CONTAINING HGF GENE 审中-公开
公开(公告)号：JP2003095988A
公开(公告)日：2003-04-03
申请号：JP2002261616
申请日：2002-09-06
申请人： ANGES MG INC
发明人： MORISHITA RYUICHI , OGIWARA TOSHIO , NAKAMURA TOSHIICHI , TOMITA TETSUYA , OCHI TAKAHIRO
IPC分类号： A61K9/127 , A61K35/76 , A61K48/00 , A61P9/00 , A61P19/00
摘要： PROBLEM TO BE SOLVED: To provide a medicament containing HGF (hepatocyte growth factor) gene. SOLUTION: This medicament, which contains the HGF gene, has the sustainability of therapeutic effect compared to the case with administration of HGF itself and can also be made to act in a locally selective manner, therefore enabling the side effects of the HGF to be reduced.

6. 发明专利

JP2013166726A Wound dressing material made of film or sheet containing mixture of polypeptide with high antibacterial activity and polysaccharide not inhibiting the antibacterial activity 有权
标题翻译：含有高抗细菌活性的多肽和多糖的混合物的薄膜或薄片的封闭材料不妨碍抗生素活性
公开(公告)号：JP2013166726A
公开(公告)日：2013-08-29
申请号：JP2012031409
申请日：2012-02-16
申请人： Morishita Jintan Co Ltd , 森下仁丹株式会社 , Anges Mg Inc , アンジェスMg株式会社
发明人： ONO TORU , OKAMACHI RYUHEI , TOMIOKA HIDEKI , TAMURA NAO , TENMAN AKIKO
IPC分类号： A61K38/00 , A61K9/70 , A61K47/36 , A61L15/16 , A61P17/00 , A61P31/02 , A61P31/04 , C07K14/00
摘要： PROBLEM TO BE SOLVED: To provide a wound dressing material made of a film or sheet containing a mixture of polypeptide with high antibacterial activity and polysaccharide not inhibiting the antibacterial activity.SOLUTION: This wound dressing material is made of a film or sheet containing a mixture of polypeptide with high antibacterial activity represented by sequence No.1 to sequence No.11 and polysaccharide not inhibiting the antibacterial activity. There is provided the wound dressing material containing the mixture of polypeptide with high antibacterial activity and polysaccharide not inhibiting the antibacterial activity.
摘要翻译：要解决的问题：提供由含有高抗菌活性的多肽混合物的膜或片制成的伤口敷料材料和不抑制抗菌活性的多糖。解决方案：该伤口敷料材料由含有混合物的膜或片制成具有高抗菌活性的多肽，其序列号为No.1〜11，多糖不抑制抗菌活性。提供了包含具有高抗菌活性的多肽混合物和不抑制抗菌活性的多糖的伤口敷料材料。

7. 发明专利

JP2010130900A NOVEL CYCLIC STAPLE-TYPE OLIGONUCLEOTIDE, AND NF-κB DECOY COMPRISING THE SAME 审中-公开
标题翻译：新型循环阶型寡聚核苷酸和包含其的NF-κB
公开(公告)号：JP2010130900A
公开(公告)日：2010-06-17
申请号：JP2007078316
申请日：2007-03-26
申请人： Anges Mg Inc , アンジェスMg株式会社
发明人： NAKAJIMA TOSHIHIRO , TENMAN AKIKO , SUZUKI NANAHO
IPC分类号： C12N15/09 , A61K31/713 , A61P1/04 , A61P9/00 , A61P9/10 , A61P11/00 , A61P11/06 , A61P13/02 , A61P13/12 , A61P17/00 , A61P17/02 , A61P17/06 , A61P19/00 , A61P19/02 , A61P29/00 , A61P35/00 , A61P35/04 , A61P37/00 , A61P37/08 , A61P41/00 , A61P43/00
CPC分类号： C12N15/115 , C12N2310/13 , C12N2310/16 , C12N2310/53
摘要： PROBLEM TO BE SOLVED: To provide a novel oligonucleotide which has a higher binding ability to NF-κB than that of a conventional oligonucleotide decoy to NF-κB and is useful as NF-κB decoy, and to provide a medicinal use thereof. SOLUTION: The oligonucleotide is a cyclic staple-type oligodeoxynucleotide composed of a stem structure and two loop structures attached to both termini of the stem structure, wherein the stem structure comprises a double-strand composed of two chains, and each of the two chains comprises a consensus sequence and a 5'-addition sequence and a 3'-addition sequence each having a specific nucleotide sequence and attached to both termini of the consensus sequence. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：提供与NF-κB的常规寡核苷酸诱饵相比具有更高的NF-κB结合能力的新型寡核苷酸，并且可用作NF-κB诱饵，并提供其药物用途。解决方案：寡核苷酸是由茎结构和连接到茎结构的两个末端的两个环结构组成的环状主链型寡脱氧核苷酸，其中茎结构包含由两条链组成的双链，并且每个两条链包含共有序列和5'加成序列和3'加成序列，每个序列具有特异性核苷酸序列并连接在共有序列的两个末端。版权所有（C）2010，JPO＆INPIT

8. 发明专利

JP2008056611A Pharmaceutical preparation 有权
标题翻译：药物制剂
公开(公告)号：JP2008056611A
公开(公告)日：2008-03-13
申请号：JP2006235153
申请日：2006-08-31
申请人： Anges Mg Inc , Hosokawa Funtai Gijutsu Kenkyusho:Kk , アンジェスMg株式会社 , 株式会社ホソカワ粉体技術研究所
发明人： TSUKADA TAKESUKE , TSUJIMOTO HIROYUKI , SAKAGUCHI MAKOTO
IPC分类号： A61K48/00 , A61K9/14 , A61K31/7088 , A61K47/34 , A61K47/36 , A61P17/00 , A61P37/08 , C12N15/09
CPC分类号： A61K31/7088 , A61K9/5153 , A61K48/00
摘要： PROBLEM TO BE SOLVED: To provide an easy to prepare pharmaceutical preparation with a high safety, effectively delivering NFκB decoy to the core of the skin in a region with high barrier potentials, and excellent in immediate effectivity.
SOLUTION: The pharmaceutical preparation is obtained by preparing nano sized particles (nanosphere) of a biocompatible polymer, and supporting a NFκB decoy which binds with the NFκB and suppresses activation, on the surface of the nano particles. The pharmaceutical preparation delivers the NFκB decoy to the disease region by the penetration of the nano particles to inside of cells, and releases the NFκB decoy from the surface of the nano particles and effectively and position specifically introduces to the disease region.
COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：要解决的问题：为了提供易于制备具有高安全性的药物制剂，在具有高势垒电位的区域中有效地将NFκB诱饵输送到皮肤的核心，并且具有优异的即时有效性。解决方案：药物制剂通过制备生物相容性聚合物的纳米尺寸颗粒（纳米球）并且在纳米颗粒的表面上支持与NFκB结合并抑制活化的NFκB诱饵获得。药物制剂通过将纳米颗粒渗透到细胞内部将NFκB诱饵递送到疾病区域，并从纳米颗粒的表面释放NFκB诱饵，并且有效地将位置特异性引入疾病区域。版权所有（C）2008，JPO＆INPIT

9. 发明专利

JP2006111591A Preparation for target-specifically delivering nucleic acid medicine inside cell 审中-公开
标题翻译：目标特异性递送核酸内科细胞的准备
公开(公告)号：JP2006111591A
公开(公告)日：2006-04-27
申请号：JP2004302250
申请日：2004-10-15
申请人： Anges Mg Inc , アンジェスMg株式会社
发明人： HATTORI YOSHIYUKI , YONETANI YOSHIE , WAKI ATSUO , SAKAGUCHI MAKOTO
IPC分类号： A61K48/00 , A61K31/7088 , A61K47/28 , A61K47/34 , A61P17/00 , A61P17/06 , A61P29/00 , A61P35/00
摘要： PROBLEM TO BE SOLVED: To provide a preparation for the target-specific delivery of a nucleic acid medicine inside a cell, especially a stable nano-particle preparation containing a nucleic acid medicine. SOLUTION: The stabilized preparation for the target-specific delivery of the nucleic acid medicine inside the cell contains the nucleic acid medicine such as a gene or its analog contained in a composition composed of [3β-N-(N',N'-dimethylaminoethane)carbamoyl]cholesterol (DC-Chol), a polyoxyethylene sorbitan mono-oleate 80 (commercial name; Tween 80) and a folic acid-polyethylene glycol-distearoylphosphatidyl ethanolamine (folate-PEG-DSPE). The medicine is not a liposome containing water therein by a lipid double membrane but a nano-particle free from water therein. COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：待解决的问题：提供细胞内核酸药物靶向特异性递送的制剂，特别是含有核酸药物的稳定的纳米粒子制剂。解决方案：用于靶细胞靶向特异性递送细胞内的核酸药物的稳定制剂含有由[3β-N-（N'，N 聚氧乙烯脱水山梨糖醇单油酸酯80（商品名;吐温80）和叶酸 - 聚乙二醇 - 二硬脂酰磷脂酰乙醇胺（叶酸-PEG-DSPE）。药物不是通过脂质双膜而是其中没有水的纳米粒子的含脂质体的脂质体。版权所有（C）2006，JPO＆NCIPI

10. 发明专利

JP2003128559A THERAPEUTIC AND PROPHYLACTIC AGENT FOR DISEASE CAUSED BY NF-kappaB 审中-公开
公开(公告)号：JP2003128559A
公开(公告)日：2003-05-08
申请号：JP2002263431
申请日：2002-09-09
申请人： ANGES MG INC , MORISHITA RYUICHI , OGIWARA TOSHIO
发明人： MORISHITA RYUICHI , OGIWARA TOSHIO , SUGIMOTO SATOKO , MAEDA KAZUHIRO , KAWAMURA IKUO , CHIBA TOSHIYUKI
IPC分类号： C12N15/09 , A61K31/713 , A61K48/00 , A61P1/16 , A61P9/04 , A61P9/10 , A61P13/12 , A61P19/02 , A61P25/28 , A61P29/00 , A61P35/00 , A61P35/04 , A61P37/00
摘要： PROBLEM TO BE SOLVED: To carry out therapy and prophylaxis of diseases caused by a transcriptional regulatory factor NF-κB, e.g. ischemic diseases, inflammatory diseases, autoimmune diseases, cancer metastatis and invasion, and cachexia. SOLUTION: A decoy of a binding site of the NF-κB to a nucleic acid specifically antagonizing the binding site of the NF-κB to the nucleic acid is administered to thereby inhibit the expression of a gene activated by the NF-κB. As a result, therapy and prophylaxis of diseases caused by the NF-κB, e.g. the ischemic diseases, inflammatory diseases, autoimmune diseases, cancer metastatis and invasion and cachexia are carried out.

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