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1. 发明申请

US20100189830A1 Sweet Gum Fruit Extract as a Therapeutic Agent 审中-公开
标题翻译：甜胶提取物作为治疗剂
公开(公告)号：US20100189830A1
公开(公告)日：2010-07-29
申请号：US12600751
申请日：2008-05-21
申请人： Zhijun Liu , Peiying Yang , Robert A. Newman
发明人： Zhijun Liu , Peiying Yang , Robert A. Newman
IPC分类号： A61K36/185 , A61P25/28 , A61P9/10 , A61P9/12 , A61P3/10 , A61P37/06
CPC分类号： A61K36/185 , A61K45/06
摘要： Sweet gum (Liquidambar styraciflua L., family Hamamelidaceae) fruit extract was discovered to possess potent activities against multiple targets of the PBK (phosphatidylinositide 3-kinase) pathway, especially the PI3K/Akt and mTOR pathways. At a very low concentration of 1.85 μg/ml (IC50), sweet gun extract showed the ability of simultaneously blocking the pathways of PI3K/Akt (upstream), mTOR (mammalian target of rapamycin) (downstream), as well as its downstream protein products S6K and S6. It was also able to block 5-HETE, a lipoxygenase product that contributes to inflammation and activation of PI3K/Akt. The sweet gum fruit extract was prepared with 50% methanol (47:1; raw to extract) and concentrated to an organic fraction (210:1 raw to extract) referred as LIS-100 via reverse-phase column chromatography using a bioassay directed fractionation approach. The extract is a new targeted therapeutic agent for numerous disorders known to be treated by mTOR inhibitors, including cancer, diabetes, obesity, and inflammation.
摘要翻译：发现甜口香糖（枫香香a，，家amel科）水果提取物具有针对PBK（磷脂酰肌醇3-激酶）途径的多个靶点，特别是PI3K / Akt和mTOR途径的有效活性。在1.85μg/ ml（IC 50）的非常低的浓度下，甜枪提取物显示同时阻断PI3K / Akt（上游），mTOR（雷帕霉素的哺乳动物靶标）（下游）以及其下游蛋白的途径的能力产品S6K和S6。它还能够阻断5-HETE，一种有助于PI3K / Akt的炎症和活化的脂氧合酶产物。用50％甲醇（47:1，未加萃取物）制备甜口香糖果提取物，并通过反相柱色谱法使用生物测定方向分馏法浓缩成称为LIS-100的有机级分（210:1原始提取物）方法提取物是已知用mTOR抑制剂治疗的许多病症的新靶向治疗剂，包括癌症，糖尿病，肥胖症和炎症。

2. 发明申请

US20150110862A1 Sweet Gum Fruit Extract as a Therapeutic Agent 审中-公开
标题翻译：甜胶提取物作为治疗剂
公开(公告)号：US20150110862A1
公开(公告)日：2015-04-23
申请号：US14590033
申请日：2015-01-06
申请人： Zhijun Liu , Peiying Yang , Robert A. Newman
发明人： Zhijun Liu , Peiying Yang , Robert A. Newman
IPC分类号： A61K36/185 , A61K45/06
CPC分类号： A61K36/185 , A61K45/06
摘要： Sweet gum (Liquidambar styraciflua L., family Hamamelidaceae) fruit extract was discovered to possess potent activities against multiple targets of the PI3K (phosphatidylinositide 3-kinase) pathway, especially the PI3K/Akt and mTOR pathways. At a very low concentration of 1.85 μg/ml (IC50), sweet gun extract showed the ability of simultaneously blocking the pathways of PI3K/Akt (upstream), mTOR (mammalian target of rapamycin) (downstream), as well as its downstream protein products S6K and S6. It was also able to block 5-HETE, a lipoxygenase product that contributes to inflammation and activation of PI3K/Akt. The sweet gum fruit extract was prepared with 50% methanol (47:1; raw to extract) and concentrated to an organic fraction (210:1 raw to extract) referred as LIS-100 via reverse-phase column chromatography using a bioassay directed fractionation approach. The extract is a new targeted therapeutic agent for numerous disorders known to be treated by mTOR inhibitors, including cancer, diabetes, obesity, and inflammation.
摘要翻译：发现甜口香糖（Liquidambar styraciflua L.，家amel科）水果提取物具有针对PI3K（磷脂酰肌醇3-激酶）途径的多个靶点的有效活性，特别是PI3K / Akt和mTOR途径。在1.85μg/ ml（IC 50）的非常低的浓度下，甜枪提取物显示同时阻断PI3K / Akt（上游），mTOR（雷帕霉素的哺乳动物靶标）（下游）以及其下游蛋白的途径的能力产品S6K和S6。它还能够阻断5-HETE，一种有助于PI3K / Akt的炎症和活化的脂氧合酶产物。用50％甲醇（47:1，未加萃取物）制备甜口香糖果提取物，并通过反相柱色谱法使用生物测定方向分馏法浓缩成称为LIS-100的有机级分（210:1原始提取物）方法提取物是已知用mTOR抑制剂治疗的许多病症的新靶向治疗剂，包括癌症，糖尿病，肥胖症和炎症。

3. 发明授权

US09072762B2 Natural composition to decrease effects of a high fat diet 有权
标题翻译：天然成分降低高脂肪饮食的作用
公开(公告)号：US09072762B2
公开(公告)日：2015-07-07
申请号：US13746630
申请日：2013-01-22
申请人： Zhijun Liu , Peiying Yang
发明人： Zhijun Liu , Peiying Yang
IPC分类号： A61K31/704 , A61K31/192 , A61K31/366
CPC分类号： A61K31/704 , A61K31/192 , A61K31/366 , A61K2300/00
摘要： The combination of gallic acid, ellagic acid, and rubusoside was shown to inhibit angiogenesis by inhibition of pro-angiogenic factors. These three compounds were shown to be absorbed from the intestine making the compounds orally bioavailable. The ratio of the three compounds in the composition was a weight ratio of approximately 1:1.7:17.0 of gallic acid, ellagic acid, and rubusoside, respectively, resulting in a composition with 5% w/w gallic acid, 9% w/w ellagic acid, and 86% w/w rubusoside. This combination was also shown to reduce weight gain, fat accumulation, and serum cholesterol in mammals fed a high fat diet. It also reduced serum triglycerides and tended to reduce blood glucose in mammals on both normal and high fat diets. This three-compound composition (“GER”) can be used to treat diseases associated with angiogenesis and to decrease effects of a high fat diet.
摘要翻译：没食子酸，鞣花酸和罗红糖苷的组合显示通过抑制促血管生成因子抑制血管生成。这三种化合物被显示为从肠中吸收，使化合物口服生物可利用。组合物中三种化合物的比例分别为没食子酸，鞣花酸和罗红糖苷的约1:1.7:17.0的重量比，得到具有5％w / w没食子酸的组成，9％w / w 鞣花酸和86％w / w的Rubusoside。这种组合也显示出降低饲喂高脂肪饮食的哺乳动物体重增加，脂肪积累和血清胆固醇。它还减少血清甘油三酯，并倾向于降低哺乳动物在正常和高脂肪饮食中的血糖。这种三重化合物（“GER”）可用于治疗与血管生成相关的疾病，并降低高脂肪饮食的作用。

4. 发明申请

US20140206634A1 Natural Composition to Decrease Effects of a High Fat Diet 审中-公开
标题翻译：天然成分降低高脂肪饮食的影响
公开(公告)号：US20140206634A1
公开(公告)日：2014-07-24
申请号：US13746630
申请日：2013-01-22
申请人： Zhijun Liu , Peiying Yang
发明人： Zhijun Liu , Peiying Yang
IPC分类号： A61K31/704 , A61K31/366 , A61K31/192
CPC分类号： A61K31/704 , A61K31/192 , A61K31/366 , A61K2300/00
摘要： The combination of gallic acid, ellagic acid, and rubusoside was shown to inhibit angiogenesis by inhibition of pro-angiogenic factors. These three compounds were shown to be absorbed from the intestine making the compounds orally bioavailable. The ratio of the three compounds in the composition was a weight ratio of approximately 1:1.7:17.0 of gallic acid, ellagic acid, and rubusoside, respectively, resulting in a composition with 5% w/w gallic acid, 9% w/w ellagic acid, and 86% w/w rubusoside. This combination was also shown to reduce weight gain, fat accumulation, and serum cholesterol in mammals fed a high fat diet. It also reduced serum triglycerides and tended to reduce blood glucose in mammals on both normal and high fat diets. This three-compound composition (“GER”) can be used to treat diseases associated with angiogenesis and to decrease effects of a high fat diet.
摘要翻译：没食子酸，鞣花酸和罗红糖苷的组合显示通过抑制促血管生成因子抑制血管生成。这三种化合物被显示为从肠中吸收，使化合物口服生物可利用。组合物中三种化合物的比例分别为没食子酸，鞣花酸和罗红糖苷的约1:1.7:17.0的重量比，得到具有5％w / w没食子酸的组成，9％w / w 鞣花酸和86％w / w的Rubusoside。这种组合也显示出降低饲喂高脂肪饮食的哺乳动物体重增加，脂肪积累和血清胆固醇。它还减少血清甘油三酯，并倾向于降低哺乳动物在正常和高脂肪饮食中的血糖。这种三重化合物（“GER”）可用于治疗与血管生成相关的疾病，并降低高脂肪饮食的作用。

5. 发明申请

US20110039796A1 Natural Composition for Anti-Angiogenesis and Anti-Obesity 审中-公开
标题翻译：抗血管生成和抗肥胖的天然成分
公开(公告)号：US20110039796A1
公开(公告)日：2011-02-17
申请号：US12761798
申请日：2010-04-16
申请人： Zhijun Liu , Peiying Yang
发明人： Zhijun Liu , Peiying Yang
IPC分类号： A61K31/704 , A61P35/00 , A61P3/04 , A61P3/00
CPC分类号： A61K45/06 , A61K31/192 , A61K31/366 , A61K31/704 , Y02A50/401 , A61K2300/00
摘要： The combination of gallic acid, ellagic acid, and rubusoside was shown to inhibit angiogenesis by inhibition of pro-angiogenic factors. These three compounds were shown to be absorbed from the intestine making the compounds orally bioavailable. The ratio of the three compounds in the composition was a weight ratio of approximately 1:1.7:17.0 of gallic acid, ellagic acid, and rubusoside, respectively, resulting in a composition with 5% w/w gallic acid, 9% w/w ellagic acid, and 86% w/w rubusoside. This combination was also shown to reduce weight gain, fat accumulation, and serum cholesterol in mammals fed a high fat diet. It also reduced serum triglycerides and tended to reduce blood glucose in mammals on both normal and high fat diets. This three-compound composition (“GER”) can be used to treat diseases associated with angiogenesis and to decrease effects of a high fat diet.
摘要翻译：没食子酸，鞣花酸和罗红糖苷的组合显示通过抑制促血管生成因子抑制血管生成。这三种化合物被显示为从肠中吸收，使化合物口服生物可利用。组合物中三种化合物的比例分别为没食子酸，鞣花酸和罗红糖苷的约1:1.7:17.0的重量比，得到具有5％w / w没食子酸的组成，9％w / w 鞣花酸和86％w / w的Rubusoside。这种组合也显示出降低饲喂高脂肪饮食的哺乳动物体重增加，脂肪积累和血清胆固醇。它还减少血清甘油三酯，并倾向于降低哺乳动物在正常和高脂肪饮食中的血糖。这种三重化合物（“GER”）可用于治疗与血管生成相关的疾病，并降低高脂肪饮食的作用。

6. 发明授权

US09604543B2 Apparatus and method for automatic ground fault location determination in high resistance grounded motor drive system 有权
公开(公告)号：US09604543B2
公开(公告)日：2017-03-28
申请号：US14296502
申请日：2014-06-05
申请人： Jiangang Hu , Lixiang Wei , Zhijun Liu , Jeffrey D. McGuire
发明人： Jiangang Hu , Lixiang Wei , Zhijun Liu , Jeffrey D. McGuire
IPC分类号： G01R31/02 , G01R31/08 , H02H3/16 , B60L3/00 , H02H1/00 , H02P29/032 , H02P29/024 , H02M1/32 , G01R31/40
CPC分类号： B60L3/0069 , G01R31/025 , G01R31/08 , G01R31/086 , G01R31/40 , H02H1/0092 , H02H3/16 , H02M1/32 , H02P29/0241 , H02P29/032 , Y02T10/642
摘要： Methods an apparatus are presented for identifying ground fault locations in multi-drive systems in which individual drives perform self-diagnosis for detected faults based on an identified fault signal frequency while the system drives continue operation, and a ground fault location system identifies suspected drives and individually confirms or exonerates individual drives by selective command speed adjustment while the drives remain operational within system tolerance ranges.

7. 发明授权

US09091742B2 Fault identification techniques for high resistance grounded systems 有权
标题翻译：高电阻接地系统的故障识别技术
公开(公告)号：US09091742B2
公开(公告)日：2015-07-28
申请号：US13400537
申请日：2012-02-20
申请人： Lixiang Wei , Zhijun Liu
发明人： Lixiang Wei , Zhijun Liu
IPC分类号： G01R31/00 , G01R31/42 , G01R31/02
CPC分类号： G01R31/42 , G01R31/025
摘要： The present techniques include methods and systems for detecting a high resistive ground fault condition in an HRG system. Embodiments include systems and methods of measuring drive voltages and detecting voltage changes in the drive once the drive is in operation, particularly for drives operating at relatively low voltages and frequencies. In some embodiments, an integrator is utilized to detect peaks in the measured voltage changes. Relatively small ground currents are also measured to determine HRG faults. Moreover, in some embodiments, the detection of an HRG fault for one of several motor drives provide indication for the particular motor drive in fault.
摘要翻译：本技术包括用于检测HRG系统中的高电阻接地故障状况的方法和系统。实施例包括测量驱动电压并检测驱动器运行中的电压变化的系统和方法，特别是对于在较低电压和频率下工作的驱动器。在一些实施例中，使用积分器来检测所测量的电压变化中的峰值。还测量相对较小的接地电流以确定HRG故障。此外，在一些实施例中，几个电动机驱动器之一的HRG故障的检测为故障中的特定电机驱动器提供指示。

8. 发明授权

US07805597B2 Parallel link reset in link based system 有权
标题翻译：基于链路的系统并行链路复位
公开(公告)号：US07805597B2
公开(公告)日：2010-09-28
申请号：US11731064
申请日：2007-03-30
申请人： Xiaohua Cai , Yufu Li , Zhijun Liu , Geng Tian
发明人： Xiaohua Cai , Yufu Li , Zhijun Liu , Geng Tian
IPC分类号： G06F9/00 , G06F9/24 , G06F15/177
CPC分类号： G06F15/16
摘要： A link based system including a plurality of processors is reset when transitioning from a slower speed to a higher speed mode during a booting process. One processor may coordinate the simultaneous establishment of link resetting of a plurality of other processors. In one embodiment, the processors may operate beginning with the farthest processor to reset their local links. Each processor sets its local links and if it determines, based on the speed of the link that the link has already been reset, it moves on to the next link.
摘要翻译：包括多个处理器的基于链路的系统在引导过程期间从较慢速度转换到较高速度模式时被复位。一个处理器可以协调同时建立多个其他处理器的链路重置。在一个实施例中，处理器可以从最远的处理器开始操作以重置其本地链路。每个处理器设置其本地链路，并且如果它根据链路已经被重置的链路的速度来确定它移动到下一个链路。

9. 发明申请

US20070031332A1 Angiogenic agents from plant extracts, gallic acid, and derivatives 有权
标题翻译：来自植物提取物，没食子酸和衍生物的血管生成剂
公开(公告)号：US20070031332A1
公开(公告)日：2007-02-08
申请号：US10559091
申请日：2004-05-27
申请人： Frank Greenway , Zhijun Liu , Eugene Woltering
发明人： Frank Greenway , Zhijun Liu , Eugene Woltering
IPC分类号： A61K51/00 , A61K38/21 , A61K38/18 , A61K31/7024 , A61K31/454 , A61M36/14
CPC分类号： A61K31/192 , A61K31/454 , A61K31/7024 , A61K36/40 , A61K36/44 , A61K36/708 , A61K36/73
摘要： An extract of Chinese blackberry (Rubus suavissimus) has been found to inhibit angiogenesis, and two active fractions isolated. Gallic acid was shown to be one of the active anti-angiogenic compounds by an in vitro human angiogenesis model. Aqueous extracts from other plants either known or found to have gallic acid were also found to have anti-angiogenic activity. Various derivatives of gallic acid were found to inhibit angiogenesis. The extract from Chinese blackberry also slowed the growth of a pancreatic tumor and of corneal neovascularization in rats. Extracts from pomegranate were shown to inhibit angiogenesis in fat tissue. Extracts from Rubus spp, and other plants with gallic acid, and gallic acid and its derivatives will be useful for treating various diseases associated with neovascularization, including diabetic retinopathy, psoriasis, tumors, obesity, cancer, rheumatoid arthritis, etc.
摘要翻译：已经发现中国黑莓（Rubus suavissimus）的提取物抑制血管生成，并分离出两种活性级分。没食子酸通过体外人血管生成模型显示为活性抗血管生成化合物之一。已知或发现有没食子酸的其他植物的水提取物也被发现具有抗血管生成活性。发现没食子酸的各种衍生物抑制血管生成。中国黑莓的提取物也减缓了大鼠胰腺肿瘤和角膜新血管形成的发生。石榴提取物显示抑制脂肪组织中的血管发生。来自红豆杉和其他具有没食子酸的植物和没食子酸及其衍生物的提取物可用于治疗与新生血管形成相关的各种疾病，包括糖尿病性视网膜病变，牛皮癣，肿瘤，肥胖症，癌症，类风湿性关节炎等。

10. 发明授权

US09066959B2 Ficus extracts having angiogenesis inhibiting activity and methods of isolating and using the same 有权
标题翻译：具有血管发生抑制活性的榕提取物及其分离和使用方法
公开(公告)号：US09066959B2
公开(公告)日：2015-06-30
申请号：US13058957
申请日：2009-08-14
申请人： Zhijun Liu , Eugene A. Woltering
发明人： Zhijun Liu , Eugene A. Woltering
IPC分类号： A61P35/00 , A61P17/06 , A61P19/02 , A61P41/00 , C12Q1/02 , A61K9/12 , A61P3/04 , A61P1/00 , A61P9/12 , A61P37/00 , A61P31/10 , A61P27/02 , A61K36/00 , A61K36/60
CPC分类号： A61K36/60
摘要： The present invention is directed to methods for extracting and isolating extracts having angiogenesis inhibiting activity from a latex-containing portion of a Ficus variant, pharmaceutical and nutraceutical compositions comprising the extracts, methods of administering the extracts to treat angiogenesis-dependent diseases and to reduce or inhibit neovessel growth in a subject in need thereof, and the use of the extracts in the manufacture of a composition for reducing or inhibiting neovessel growth.
摘要翻译：本发明涉及从榕属变体的含胶乳部分提取和分离具有血管生成抑制活性的提取物的方法，包含提取物的药物和营养组合物，施用提取物以治疗血管发生依赖性疾病的方法和减少或抑制有需要的受试者的新生血管生长，以及在制备用于减少或抑制新生血管生长的组合物中使用提取物。

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