专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20070031332A1 Angiogenic agents from plant extracts, gallic acid, and derivatives 有权
标题翻译：来自植物提取物，没食子酸和衍生物的血管生成剂
公开(公告)号：US20070031332A1
公开(公告)日：2007-02-08
申请号：US10559091
申请日：2004-05-27
申请人： Frank Greenway , Zhijun Liu , Eugene Woltering
发明人： Frank Greenway , Zhijun Liu , Eugene Woltering
IPC分类号： A61K51/00 , A61K38/21 , A61K38/18 , A61K31/7024 , A61K31/454 , A61M36/14
CPC分类号： A61K31/192 , A61K31/454 , A61K31/7024 , A61K36/40 , A61K36/44 , A61K36/708 , A61K36/73
摘要： An extract of Chinese blackberry (Rubus suavissimus) has been found to inhibit angiogenesis, and two active fractions isolated. Gallic acid was shown to be one of the active anti-angiogenic compounds by an in vitro human angiogenesis model. Aqueous extracts from other plants either known or found to have gallic acid were also found to have anti-angiogenic activity. Various derivatives of gallic acid were found to inhibit angiogenesis. The extract from Chinese blackberry also slowed the growth of a pancreatic tumor and of corneal neovascularization in rats. Extracts from pomegranate were shown to inhibit angiogenesis in fat tissue. Extracts from Rubus spp, and other plants with gallic acid, and gallic acid and its derivatives will be useful for treating various diseases associated with neovascularization, including diabetic retinopathy, psoriasis, tumors, obesity, cancer, rheumatoid arthritis, etc.
摘要翻译：已经发现中国黑莓（Rubus suavissimus）的提取物抑制血管生成，并分离出两种活性级分。没食子酸通过体外人血管生成模型显示为活性抗血管生成化合物之一。已知或发现有没食子酸的其他植物的水提取物也被发现具有抗血管生成活性。发现没食子酸的各种衍生物抑制血管生成。中国黑莓的提取物也减缓了大鼠胰腺肿瘤和角膜新血管形成的发生。石榴提取物显示抑制脂肪组织中的血管发生。来自红豆杉和其他具有没食子酸的植物和没食子酸及其衍生物的提取物可用于治疗与新生血管形成相关的各种疾病，包括糖尿病性视网膜病变，牛皮癣，肿瘤，肥胖症，癌症，类风湿性关节炎等。

2. 发明授权

US09604543B2 Apparatus and method for automatic ground fault location determination in high resistance grounded motor drive system 有权
公开(公告)号：US09604543B2
公开(公告)日：2017-03-28
申请号：US14296502
申请日：2014-06-05
申请人： Jiangang Hu , Lixiang Wei , Zhijun Liu , Jeffrey D. McGuire
发明人： Jiangang Hu , Lixiang Wei , Zhijun Liu , Jeffrey D. McGuire
IPC分类号： G01R31/02 , G01R31/08 , H02H3/16 , B60L3/00 , H02H1/00 , H02P29/032 , H02P29/024 , H02M1/32 , G01R31/40
CPC分类号： B60L3/0069 , G01R31/025 , G01R31/08 , G01R31/086 , G01R31/40 , H02H1/0092 , H02H3/16 , H02M1/32 , H02P29/0241 , H02P29/032 , Y02T10/642
摘要： Methods an apparatus are presented for identifying ground fault locations in multi-drive systems in which individual drives perform self-diagnosis for detected faults based on an identified fault signal frequency while the system drives continue operation, and a ground fault location system identifies suspected drives and individually confirms or exonerates individual drives by selective command speed adjustment while the drives remain operational within system tolerance ranges.

3. 发明授权

US09091742B2 Fault identification techniques for high resistance grounded systems 有权
标题翻译：高电阻接地系统的故障识别技术
公开(公告)号：US09091742B2
公开(公告)日：2015-07-28
申请号：US13400537
申请日：2012-02-20
申请人： Lixiang Wei , Zhijun Liu
发明人： Lixiang Wei , Zhijun Liu
IPC分类号： G01R31/00 , G01R31/42 , G01R31/02
CPC分类号： G01R31/42 , G01R31/025
摘要： The present techniques include methods and systems for detecting a high resistive ground fault condition in an HRG system. Embodiments include systems and methods of measuring drive voltages and detecting voltage changes in the drive once the drive is in operation, particularly for drives operating at relatively low voltages and frequencies. In some embodiments, an integrator is utilized to detect peaks in the measured voltage changes. Relatively small ground currents are also measured to determine HRG faults. Moreover, in some embodiments, the detection of an HRG fault for one of several motor drives provide indication for the particular motor drive in fault.
摘要翻译：本技术包括用于检测HRG系统中的高电阻接地故障状况的方法和系统。实施例包括测量驱动电压并检测驱动器运行中的电压变化的系统和方法，特别是对于在较低电压和频率下工作的驱动器。在一些实施例中，使用积分器来检测所测量的电压变化中的峰值。还测量相对较小的接地电流以确定HRG故障。此外，在一些实施例中，几个电动机驱动器之一的HRG故障的检测为故障中的特定电机驱动器提供指示。

4. 发明授权

US07805597B2 Parallel link reset in link based system 有权
标题翻译：基于链路的系统并行链路复位
公开(公告)号：US07805597B2
公开(公告)日：2010-09-28
申请号：US11731064
申请日：2007-03-30
申请人： Xiaohua Cai , Yufu Li , Zhijun Liu , Geng Tian
发明人： Xiaohua Cai , Yufu Li , Zhijun Liu , Geng Tian
IPC分类号： G06F9/00 , G06F9/24 , G06F15/177
CPC分类号： G06F15/16
摘要： A link based system including a plurality of processors is reset when transitioning from a slower speed to a higher speed mode during a booting process. One processor may coordinate the simultaneous establishment of link resetting of a plurality of other processors. In one embodiment, the processors may operate beginning with the farthest processor to reset their local links. Each processor sets its local links and if it determines, based on the speed of the link that the link has already been reset, it moves on to the next link.
摘要翻译：包括多个处理器的基于链路的系统在引导过程期间从较慢速度转换到较高速度模式时被复位。一个处理器可以协调同时建立多个其他处理器的链路重置。在一个实施例中，处理器可以从最远的处理器开始操作以重置其本地链路。每个处理器设置其本地链路，并且如果它根据链路已经被重置的链路的速度来确定它移动到下一个链路。

5. 发明授权

US09066959B2 Ficus extracts having angiogenesis inhibiting activity and methods of isolating and using the same 有权
标题翻译：具有血管发生抑制活性的榕提取物及其分离和使用方法
公开(公告)号：US09066959B2
公开(公告)日：2015-06-30
申请号：US13058957
申请日：2009-08-14
申请人： Zhijun Liu , Eugene A. Woltering
发明人： Zhijun Liu , Eugene A. Woltering
IPC分类号： A61P35/00 , A61P17/06 , A61P19/02 , A61P41/00 , C12Q1/02 , A61K9/12 , A61P3/04 , A61P1/00 , A61P9/12 , A61P37/00 , A61P31/10 , A61P27/02 , A61K36/00 , A61K36/60
CPC分类号： A61K36/60
摘要： The present invention is directed to methods for extracting and isolating extracts having angiogenesis inhibiting activity from a latex-containing portion of a Ficus variant, pharmaceutical and nutraceutical compositions comprising the extracts, methods of administering the extracts to treat angiogenesis-dependent diseases and to reduce or inhibit neovessel growth in a subject in need thereof, and the use of the extracts in the manufacture of a composition for reducing or inhibiting neovessel growth.
摘要翻译：本发明涉及从榕属变体的含胶乳部分提取和分离具有血管生成抑制活性的提取物的方法，包含提取物的药物和营养组合物，施用提取物以治疗血管发生依赖性疾病的方法和减少或抑制有需要的受试者的新生血管生长，以及在制备用于减少或抑制新生血管生长的组合物中使用提取物。

6. 发明申请

US20120329738A1 Water Soluble Drug-Solubilizer Powders and Their Uses 审中-公开
标题翻译：水溶性药物溶剂粉及其用途
公开(公告)号：US20120329738A1
公开(公告)日：2012-12-27
申请号：US13501496
申请日：2010-10-15
申请人： Zhijun Liu
发明人： Zhijun Liu
IPC分类号： A61K47/26 , A61K31/337 , A61K31/7048 , A61K31/704
CPC分类号： A61K9/19
摘要： Enhanced methods have been discovered, using either sonication or homogenization followed by increased temperature and pressure, to solubilize compounds using diterpene glycosides and to produce a powder form of the compound-solubilizer complex than can be reconstituted in water. Without the diterpene glycoside, the compounds were insoluble or sparingly soluble in water, including some fat-insoluble vitamins. Water solutions of these compounds were made using a diterpene glycoside solubilizer, for example, rubusoside. The compound-solubilizer complex was then dehydrated to a stable powder that could then be reconstituted with water. A reconstituted drug-solubilizer complex (curcumin-rubusoside) was shown to be effective on reconstitution. In addition, the diterpene glycoside, rubusoside, was shown to be an inhibitor of permeability glycoprotein (P-gp), and will thus increase gastrointestinal absorption of certain drugs administered with rubusoside.
摘要翻译：已经发现了增强的方法，使用超声处理或均化，随后升高温度和压力，以使用二萜糖苷溶解化合物，并产生比在水中重构的化合物增溶复合物的粉末形式。没有二萜糖苷，这些化合物不溶或微溶于水，包括一些脂肪不溶性维生素。这些化合物的水溶液是使用二萜糖苷增溶剂例如鲁氏皂苷制成的。然后将化合物增溶剂络合物脱水成稳定的粉末，然后可以用水重构。重组的药物增溶复合物（姜黄素 - 罗红糖苷）被证明对重建有效。此外，二萜糖苷（Rubusoside）显示为渗透性糖蛋白（P-gp）的抑制剂，因此会增加某些用鲁莽药物施用的药物的胃肠道吸收。

7. 发明授权

US08334000B2 Anti-angiogenic extracts from pomegranate 有权
标题翻译：来自石榴的抗血管生成提取物
公开(公告)号：US08334000B2
公开(公告)日：2012-12-18
申请号：US12718148
申请日：2010-03-22
申请人： Frank L. Greenway , Zhijun Liu , Eugene A. Woltering
发明人： Frank L. Greenway , Zhijun Liu , Eugene A. Woltering
IPC分类号： A61K36/00 , A61K51/00 , A61K39/395 , A61K38/21
CPC分类号： A61K31/192 , A61K31/454 , A61K31/7024 , A61K36/40 , A61K36/44 , A61K36/708 , A61K36/73
摘要： An extract of Chinese blackberry (Rubus suavissimus) has been found to inhibit angiogenesis, and two active fractions isolated. Gallic acid was shown to be one of the active anti-angiogenic compounds by an in vitro human angiogenesis model. Aqueous extracts from other plants either known or found to have gallic acid were also found to have anti-angiogenic activity. Various derivatives of gallic acid were found to inhibit angiogenesis. The extract from Chinese blackberry also slowed the growth of a pancreatic tumor and of corneal neovascularization in rats. Extracts from pomegranate were shown to inhibit angiogenesis in fat tissue. Extracts from Rubus spp, and other plants with gallic acid, and gallic acid and its derivatives will be useful for treating various diseases associated with neovascularization, including diabetic retinopathy, psoriasis, tumors, obesity, cancer, rheumatoid arthritis, etc.
摘要翻译：已经发现中国黑莓（Rubus suavissimus）的提取物抑制血管生成，并分离出两种活性级分。没食子酸通过体外人血管生成模型显示为活性抗血管生成化合物之一。已知或发现有没食子酸的其他植物的水提取物也被发现具有抗血管生成活性。发现没食子酸的各种衍生物抑制血管生成。中国黑莓的提取物也减缓了大鼠胰腺肿瘤和角膜新血管形成的发生。石榴提取物显示抑制脂肪组织中的血管发生。来自红豆杉和其他具有没食子酸的植物和没食子酸及其衍生物的提取物可用于治疗与新生血管形成相关的各种疾病，包括糖尿病性视网膜病变，牛皮癣，肿瘤，肥胖症，癌症，类风湿性关节炎等。

8. 发明授权

US08233258B2 DC bus clamp circuit to prevent over voltage failure of adjustable speed drives 有权
标题翻译：直流母线钳位电路可防止变频器过电压故障
公开(公告)号：US08233258B2
公开(公告)日：2012-07-31
申请号：US12354109
申请日：2009-01-15
申请人： Lixiang Wei , Zhijun Liu , Gary L. Skibinski
发明人： Lixiang Wei , Zhijun Liu , Gary L. Skibinski
IPC分类号： H02H3/22
CPC分类号： H02P29/02 , H02M1/32 , H02P27/06
摘要： The present invention relates to a protective circuit to provide over voltage protection for an ASD. The protective circuit provides the benefits of fewer components with lower power ratings than existing protective circuits. The protective circuit may be incorporated directly in the ASD for continuous protection or mounted externally and connected to the ASD under operating conditions that require the circuit. This flexibility for mounting the protective circuit allows the capacitor of the protective circuit to be sized either in relation to capacitive elements on the DC bus within the ASD or according to external capacitance observed at the output of the ASD. In addition, the circuit is only operative during an overvoltage condition allowing for power ratings lower than would be required for continuous operation.
摘要翻译：本发明涉及一种为ASD提供过电压保护的保护电路。保护电路具有较少的额定功率比现有保护电路更少的元件的优点。保护电路可以直接并入ASD，用于连续保护或外部安装，并在需要电路的工作条件下连接到ASD。安装保护电路的这种灵活性允许保护电路的电容器的尺寸与ASD内的DC总线上的电容元件或ASD的输出端所观察到的外部电容相匹配。此外，该电路仅在过压状态下工作，允许额定电压低于连续工作所需的额定功率。

9. 发明申请

US20110033525A1 Diterpene Glycosides as Natural Solubilizers 审中-公开
标题翻译：二萜糖苷作为天然增溶剂
公开(公告)号：US20110033525A1
公开(公告)日：2011-02-10
申请号：US12937055
申请日：2009-04-13
申请人： Zhijun Liu
发明人： Zhijun Liu
IPC分类号： A61K9/127 , A61K47/26 , A61K31/337 , A61K31/4375 , A61K31/165 , A61K31/192 , A61K31/7048 , A61K31/12 , A61K31/355 , A61K31/05 , A61K31/122 , A61K31/343 , A61K31/436 , A61K38/13 , A61K31/366 , A61K31/352 , A61K35/60 , A61K31/496 , A61K31/415 , B82Y5/00
CPC分类号： A61K31/122 , A61K9/08 , A61K31/165 , A61K31/337 , A61K31/7048 , A61K47/26
摘要： Several diterpene glycosides (e.g., rubusoside, rebaudioside, steviol monoside and stevioside) were discovered to enhance the solubility of a number of pharmaceutically and medicinally important compounds, including but not limited to, paclitaxel, camptothecin, curcumin, tanshinone HA, capsaicin, cyclosporine, erythromycin, nystatin, itraconazole, and celecoxib. The use of the diterpene glycoside rubusoside increased solubility in all tested compounds. The diterpene glycosides are a naturally occurring class of water solubility-enhancing compounds that are non-toxic and that will be useful as new complexing agents or excipients in the pharmaceutical, agricultural (e.g., solubilizing pesticides), cosmetic and food industries. Aqueous solutions by using rubusoside to increase the solubility of otherwise insoluble drugs will have several new routes of administration. In addition, aqueous solutions of therapeutic compounds with rubusoside were shown to retain the known pharmacological activity of the compounds.
摘要翻译：发现了几种二萜糖苷（例如，罗红糖苷，莱鲍迪苷，甜菊苷和甜菊苷）以增强许多药物和药物上重要的化合物的溶解度，包括但不限于紫杉醇，喜树碱，姜黄素，丹参酮HA，辣椒素，环孢菌素，红霉素，制霉菌素，伊曲康唑和塞来昔布。使用二萜糖苷罗红苷增加了所有测试化合物的溶解度。二萜糖苷是天然存在的水溶性增强化合物，其是无毒的并且可用作药物，农业（例如增溶农药），化妆品和食品工业中的新的络合剂或赋形剂。通过使用罗红糖苷增加其它不溶性药物的溶解度的水溶液将具有几种新的施用途径。此外，显示具有罗红糖苷的治疗化合物的水溶液保留了化合物的已知药理活性。

10. 发明申请

US20100177452A1 DC BUS CLAMP CIRCUIT TO PREVENT OVER VOLTAGE FAILURE OF ADJUSTABLE SPEED DRIVES 有权
标题翻译： DC BUS钳位电路，以防止可调节速度驱动器的电压故障
公开(公告)号：US20100177452A1
公开(公告)日：2010-07-15
申请号：US12354109
申请日：2009-01-15
申请人： Lixiang Wei , Zhijun Liu , Gary L. Skibinski
发明人： Lixiang Wei , Zhijun Liu , Gary L. Skibinski
IPC分类号： H02H9/04
CPC分类号： H02P29/02 , H02M1/32 , H02P27/06
摘要： The present invention relates to a protective circuit to provide over voltage protection for an ASD. The protective circuit provides the benefits of fewer components with lower power ratings than existing protective circuits. The protective circuit may be incorporated directly in the ASD for continuous protection or mounted externally and connected to the ASD under operating conditions that require the circuit. This flexibility for mounting the protective circuit allows the capacitor of the protective circuit to be sized either in relation to capacitive elements on the DC bus within the ASD or according to external capacitance observed at the output of the ASD. In addition, the circuit is only operative during an overvoltage condition allowing for power ratings lower than would be required for continuous operation.
摘要翻译：本发明涉及一种为ASD提供过电压保护的保护电路。保护电路具有较少的额定功率比现有保护电路更少的元件的优点。保护电路可以直接并入ASD，用于连续保护或外部安装，并在需要电路的工作条件下连接到ASD。安装保护电路的这种灵活性允许保护电路的电容器的尺寸与ASD内的DC总线上的电容元件或ASD的输出端所观察到的外部电容相匹配。此外，该电路仅在过压状态下工作，允许额定电压低于连续工作所需的额定功率。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式