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1. 发明授权

US08058005B2 Method for single nucleotide polymorphism and mutation detection using real time polymerase chain reaction microarray 有权
标题翻译：使用实时聚合酶链反应微阵列的单核苷酸多态性和突变检测方法
公开(公告)号：US08058005B2
公开(公告)日：2011-11-15
申请号：US12256979
申请日：2008-10-23
申请人： Zhen Hong Sun , Tao Pan , Wendy Wang , Hang Liao
发明人： Zhen Hong Sun , Tao Pan , Wendy Wang , Hang Liao
IPC分类号： C12Q1/68
CPC分类号： G01N21/6428 , B01L7/52 , C12Q1/686 , C12Q1/689 , C12Q2565/629 , C12Q2565/501 , C12Q2527/15 , C12Q2527/107
摘要： A method and apparatus for real-time, simultaneous, qualitative measurement of one or more single nucleotide polymorphisms in one or more target nucleic acids is provided. This method involves combining a polymerase chain reaction (PCR) technique with an evanescent wave technique.
摘要翻译：提供了用于在一个或多个靶核酸中实时，同时，定性测量一个或多个单核苷酸多态性的方法和装置。该方法包括将聚合酶链反应（PCR）技术与ev逝波技术相结合。

2. 发明申请

US20120088294A1 METHOD FOR SINGLE NUCLEOTIDE POLYMORPHISM AND MUTATION DETECTION USING REAL TIME POLYMERASE CHAIN REACTION MICROARRAY 有权
标题翻译：使用实时聚合酶链反应微阵列的单核多聚体和突变检测方法
公开(公告)号：US20120088294A1
公开(公告)日：2012-04-12
申请号：US13253806
申请日：2011-10-05
申请人： Zhen Hong Sun , Tao Pan , Wendy Wang , Hang Liao
发明人： Zhen Hong Sun , Tao Pan , Wendy Wang , Hang Liao
IPC分类号： C12M1/34
CPC分类号： G01N21/6428 , B01L7/52 , C12Q1/686 , C12Q1/689 , C12Q2565/629 , C12Q2565/501 , C12Q2527/15 , C12Q2527/107
摘要： A method and apparatus for real-time, simultaneous, qualitative measurement of one or more single nucleotide polymorphisms in one or more target nucleic acids is provided. This method involves combining a polymerase chain reaction (PCR) technique with an evanescent wave technique.
摘要翻译：提供了用于在一个或多个靶核酸中实时，同时，定性测量一个或多个单核苷酸多态性的方法和装置。该方法包括将聚合酶链反应（PCR）技术与ev逝波技术相结合。

3. 发明授权

US08105844B2 Apparatus and method of using porous material for antigen separation, identification, and quantification with electrophoresis techniques 有权
标题翻译：使用多孔材料进行抗原分离，鉴定和电泳技术定量的装置和方法
公开(公告)号：US08105844B2
公开(公告)日：2012-01-31
申请号：US12123714
申请日：2008-05-20
申请人： Zhen Hong Sun , Tao Pan , Wendy Wang , Xuanbin Liu
发明人： Zhen Hong Sun , Tao Pan , Wendy Wang , Xuanbin Liu
IPC分类号： G01N33/563
CPC分类号： B01D57/02 , G01N33/582
摘要： An apparatus includes a porous membrane for retaining antigens from a sample as the sample passes through the membrane. The apparatus also includes a first binding region within the membrane. The first binding region includes antibodies associated with a first antigen of interest. At least some of the antigens retained in the membrane are brought into contact with the first binding region by applying an electrophoresis field across the membrane. The porous membrane could also include an electrophoresis buffer. A presence of the first antigen of interest could be detected by exposing the first binding region to a chemiluminescent reagent, and a quantity of the first antigen of interest could be determined by performing a chemiluminescent assay on the binding region.
摘要翻译：一种装置包括当样品通过膜时用于保留来自样品的抗原的多孔膜。该装置还包括膜内的第一结合区域。第一结合区包括与感兴趣的第一抗原相关的抗体。通过在膜上施加电泳场，保留在膜中的至少一些抗原与第一结合区接触。多孔膜还可以包括电泳缓冲液。可以通过将第一结合区域暴露于化学发光试剂来检测感兴趣的第一抗原的存在，并且可以通过在结合区域上进行化学发光测定来确定一定数量的目的第一抗原。

4. 发明申请

US20090288953A1 APPARATUS AND METHOD OF USING POROUS MATERIAL FOR ANTIGEN SEPARATION, IDENTIFICATION, AND QUANTIFICATION WITH ELECTROPHORESIS TECHNIQUES 有权
标题翻译：使用多孔材料进行抗电离技术的装置和方法进行抗分离，鉴定和定量
公开(公告)号：US20090288953A1
公开(公告)日：2009-11-26
申请号：US12123714
申请日：2008-05-20
申请人： Zhen Hong Sun , Tao Pan , Wendy Wang , Xuanbin Liu
发明人： Zhen Hong Sun , Tao Pan , Wendy Wang , Xuanbin Liu
IPC分类号： B01D57/02
CPC分类号： B01D57/02 , G01N33/582
摘要： An apparatus includes a porous membrane for retaining antigens from a sample as the sample passes through the membrane. The apparatus also includes a first binding region within the membrane. The first binding region includes antibodies associated with a first antigen of interest. At least some of the antigens retained in the membrane are brought into contact with the first binding region by applying an electrophoresis field across the membrane. The porous membrane could also include an electrophoresis buffer. A presence of the first antigen of interest could be detected by exposing the first binding region to a chemiluminescent reagent, and a quantity of the first antigen of interest could be determined by performing a chemiluminescent assay on the binding region.
摘要翻译：一种装置包括当样品通过膜时用于保留来自样品的抗原的多孔膜。该装置还包括膜内的第一结合区域。第一结合区包括与感兴趣的第一抗原相关的抗体。通过在膜上施加电泳场，保留在膜中的至少一些抗原与第一结合区接触。多孔膜还可以包括电泳缓冲液。可以通过将第一结合区域暴露于化学发光试剂来检测感兴趣的第一抗原的存在，并且可以通过在结合区域上进行化学发光测定来确定一定数量的目的第一抗原。

5. 发明申请

US20090088338A1 MULTI-CHANNEL MICROARRAY APPARATUS AND METHODS 审中-公开
标题翻译：多通道微型计算机和方法
公开(公告)号：US20090088338A1
公开(公告)日：2009-04-02
申请号：US12325913
申请日：2008-12-01
申请人： Xuanbin Liu , Zhen Hong Sun , Wendy Wang , Tao Pan
发明人： Xuanbin Liu , Zhen Hong Sun , Wendy Wang , Tao Pan
IPC分类号： C40B30/04 , C40B60/12
CPC分类号： G01N21/6452 , G01N21/648
摘要： A multi-channel microarray reader has a light source carried by a first supporting stage, a second supporting stage having a plurality of reaction assembly receiving positions, each position to receive a reaction assembly, wherein each reaction assembly includes a reaction chamber and an optical substrate to support a microarray chip, and wherein the reaction chamber and the optical substrate encapsulate a buffer solution. The reader also includes an imaging sensor positioned to detect fluorescence emitted from a single microarray chip and a motion control module to position at least one of the first and second supporting stages to cause a selected microarray chip to receive energy emitted from the light source and to position the imaging sensor to receive fluorescence from that microarray chip.
摘要翻译：多通道微阵列读取器具有由第一支撑台承载的光源，具有多个反应组件接收位置的第二支撑台，每个位置接收反应组件，其中每个反应组件包括反应室和光学基板以支持微阵列芯片，并且其中所述反应室和所述光学基板封装缓冲溶液。读取器还包括成像传感器，其定位成检测从单个微阵列芯片发射的荧光和运动控制模块以定位第一和第二支持级中的至少一个，以使选定的微阵列芯片接收从光源发射的能量，将成像传感器定位成从该微阵列芯片接收荧光。

6. 发明授权

US08637302B2 Method for single nucleotide polymorphism and mutation detection using real time polymerase chain reaction microarray 有权
标题翻译：使用实时聚合酶链反应微阵列的单核苷酸多态性和突变检测方法
公开(公告)号：US08637302B2
公开(公告)日：2014-01-28
申请号：US13253806
申请日：2011-10-05
申请人： Zhenhong Sun , Tao Pan , Wendy Wang , Hang Liao
发明人： Zhenhong Sun , Tao Pan , Wendy Wang , Hang Liao
IPC分类号： C12M1/34 , C12M1/00
CPC分类号： G01N21/6428 , B01L7/52 , C12Q1/686 , C12Q1/689 , C12Q2565/629 , C12Q2565/501 , C12Q2527/15 , C12Q2527/107
摘要： A method and apparatus for real-time, simultaneous, qualitative measurement of one or more single nucleotide polymorphisms in one or more target nucleic acids is provided. This method involves combining a polymerase chain reaction (PCR) technique with an evanescent wave technique.
摘要翻译：提供了用于在一个或多个靶核酸中实时，同时，定性测量一个或多个单核苷酸多态性的方法和装置。该方法包括将聚合酶链反应（PCR）技术与ev逝波技术相结合。

7. 发明申请

US20110091916A1 LUCIFERIN-LUCIFERASE BASED MICRODEVICE FOR BIOSENSING 审中-公开
标题翻译： LUCIFERIN-LUCIFERASE基于微生物鉴定的MICRODEVICE
公开(公告)号：US20110091916A1
公开(公告)日：2011-04-21
申请号：US12988402
申请日：2008-04-21
申请人： Tao Pan , Zhenghong Sun , Wendy Wang , Xuanbin Liu
发明人： Tao Pan , Zhenghong Sun , Wendy Wang , Xuanbin Liu
IPC分类号： C12Q1/66 , C12M1/34
CPC分类号： G01N21/763
摘要： A method and apparatus for determining the concentration of one or more microbes in a sample is provided. This method involves filtering a sample through a filter inside a sample tube to retain the one or more microbes on the filter. The resulting filtrate, which contains or produces adenosine triphosphate, is passed through the sample tube and enters the reporter region. In the reporter region, the adenosine triphosphate in the filtrate comes in contact with a transparent porous matrix, which includes a luciferin-luciferase complex. The adenosine triphosphate interacts with the luciferin-luciferase complex to provide light response, which is measured by a detector. The light response is compared with a calibration curve to determine the total concentration of one or more microbes in a sample.
摘要翻译：提供了用于确定样品中一种或多种微生物浓度的方法和装置。该方法包括通过样品管内的过滤器过滤样品以将一种或多种微生物保留在过滤器上。将含有或产生三磷酸腺苷的所得滤液通过样品管并进入报道区。在报道区域中，滤液中的三磷酸腺苷与透明的多孔基质接触，该基质包括荧光素 - 荧光素酶复合物。三磷酸腺苷与荧光素 - 萤光素酶复合物相互作用以提供光响应，其由检测器测量。将光响应与校准曲线进行比较，以确定样品中一种或多种微生物的总浓度。

8. 发明授权

US08017327B2 Single nucleotide polymorphism genotyping detection via the real-time invader assay microarray platform 有权
标题翻译：通过实时入侵检测微阵列平台检测单核苷酸多态性基因型
公开(公告)号：US08017327B2
公开(公告)日：2011-09-13
申请号：US12257026
申请日：2008-10-23
申请人： Wendy Wang , Zhenhong Sun , Tao Pan , Xuanbin Liu
发明人： Wendy Wang , Zhenhong Sun , Tao Pan , Xuanbin Liu
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6827 , C12Q2561/109 , C12Q2565/101 , C12Q2565/1015 , C12Q2565/501
摘要： A method and apparatus for real-time, simultaneous, quantitative measurement for detecting a single nucleotide polymorphism in a target nucleic acid is provided. This method involves combining a polymerase chain reaction (PCR) technique with invader assay technique.
摘要翻译：提供了用于检测靶核酸中单核苷酸多态性的实时，同步，定量测量的方法和装置。该方法涉及将聚合酶链反应（PCR）技术与侵入物测定技术相结合。

9. 发明申请

US20110111392A1 INTEGRATED ENHANCED CHEMILUMINESCENCE BIOSENSORS 审中-公开
标题翻译：集成增强型荧光生物传感器
公开(公告)号：US20110111392A1
公开(公告)日：2011-05-12
申请号：US12988797
申请日：2008-04-21
申请人： Tao Pan , Zhenhong Sun , Wendy Wang , Xuanbin Liu
发明人： Tao Pan , Zhenhong Sun , Wendy Wang , Xuanbin Liu
IPC分类号： C12Q1/70 , G01N21/00 , C12Q1/00 , C12Q1/66 , C12Q1/28 , C12Q1/02 , C12M1/34 , G01N33/00 , G01N30/02 , G01N27/447
CPC分类号： G01N21/76 , G01N27/44726 , Y10T436/143333
摘要： A method and apparatus for determining the concentration of an analyte in a sample is provided. This method involves combining enhanced chemiluminescence with microchip capillary electrophoresis or microchip liquid chromatography.
摘要翻译：提供了用于确定样品中分析物浓度的方法和装置。该方法涉及将增强的化学发光与微芯片毛细管电泳或微芯片液相色谱相结合。

10. 发明授权

US09539571B2 Method to increase detection efficiency of real time PCR microarray by quartz material 有权
标题翻译：通过石英材料提高实时PCR微阵列检测效率的方法
公开(公告)号：US09539571B2
公开(公告)日：2017-01-10
申请号：US13522938
申请日：2010-01-20
申请人： Zhenhong Sun , Tao Pan , Xuanbin Liu
发明人： Zhenhong Sun , Tao Pan , Xuanbin Liu
IPC分类号： C12Q1/68 , B01L3/00 , B01L7/00
CPC分类号： B01L3/5027 , B01L3/502707 , B01L7/52 , B01L2200/0689 , B01L2200/12 , B01L2300/0636 , B01L2300/0816
摘要： A reactor for the quantitative analysis of target nucleic acids using an evanescent wave detection technique and a method for the quantitative analysis of target nucleic acids are provided. The reactor includes a substrate with a cavity, a buffer layer arranged over the substrate, a quartz cover plate arranged over the buffer layer, and inlet and outlet ports. The reactor is thermally and chemically stable for PCR processing and suitable for an evanescent wave detection technique.
摘要翻译：提供了使用ev逝波检测技术定量分析靶核酸的反应器和用于定量分析靶核酸的方法。反应器包括具有空腔的衬底，布置在衬底上的缓冲层，布置在缓冲层上的石英盖板以及入口和出口。反应器对于PCR处理是热和化学稳定的并且适用于ev逝波检测技术。

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