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1. 发明申请

US20110111392A1 INTEGRATED ENHANCED CHEMILUMINESCENCE BIOSENSORS 审中-公开
标题翻译：集成增强型荧光生物传感器
公开(公告)号：US20110111392A1
公开(公告)日：2011-05-12
申请号：US12988797
申请日：2008-04-21
申请人： Tao Pan , Zhenhong Sun , Wendy Wang , Xuanbin Liu
发明人： Tao Pan , Zhenhong Sun , Wendy Wang , Xuanbin Liu
IPC分类号： C12Q1/70 , G01N21/00 , C12Q1/00 , C12Q1/66 , C12Q1/28 , C12Q1/02 , C12M1/34 , G01N33/00 , G01N30/02 , G01N27/447
CPC分类号： G01N21/76 , G01N27/44726 , Y10T436/143333
摘要： A method and apparatus for determining the concentration of an analyte in a sample is provided. This method involves combining enhanced chemiluminescence with microchip capillary electrophoresis or microchip liquid chromatography.
摘要翻译：提供了用于确定样品中分析物浓度的方法和装置。该方法涉及将增强的化学发光与微芯片毛细管电泳或微芯片液相色谱相结合。

2. 发明授权

US08017327B2 Single nucleotide polymorphism genotyping detection via the real-time invader assay microarray platform 有权
标题翻译：通过实时入侵检测微阵列平台检测单核苷酸多态性基因型
公开(公告)号：US08017327B2
公开(公告)日：2011-09-13
申请号：US12257026
申请日：2008-10-23
申请人： Wendy Wang , Zhenhong Sun , Tao Pan , Xuanbin Liu
发明人： Wendy Wang , Zhenhong Sun , Tao Pan , Xuanbin Liu
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6827 , C12Q2561/109 , C12Q2565/101 , C12Q2565/1015 , C12Q2565/501
摘要： A method and apparatus for real-time, simultaneous, quantitative measurement for detecting a single nucleotide polymorphism in a target nucleic acid is provided. This method involves combining a polymerase chain reaction (PCR) technique with invader assay technique.
摘要翻译：提供了用于检测靶核酸中单核苷酸多态性的实时，同步，定量测量的方法和装置。该方法涉及将聚合酶链反应（PCR）技术与侵入物测定技术相结合。

3. 发明申请

US20130130937A1 SAMPLE HOLDER FOR MICROARRAY READER BASED ON EVANESCENT WAVE BIOSENSOR 有权
标题翻译：基于EVANESCENT WAVE生物传感器的微型读取器样品座
公开(公告)号：US20130130937A1
公开(公告)日：2013-05-23
申请号：US13697453
申请日：2010-05-20
申请人： Zhenhong Sun , Xuanbin Liu , Tao Pan
发明人： Zhenhong Sun , Xuanbin Liu , Tao Pan
IPC分类号： C12Q1/68
CPC分类号： G01N21/64 , C12Q1/686 , G01N21/6452 , G01N21/648
摘要： A microarray reader (500) includes a light source (501) which emits light and beam shaping elements (502) positioned near the light source (501) to direct the light. The microarray reader (500) further includes a microarray (504) that is at least formed of an optical substrate (505) and a reaction chamber (506) in contact with the optical substrate (505). A buffer solution (507) is encapsulated by the optical substrate (505) and the reaction chamber (506) and a holder (508) aligns the microarray (504) relative to the light source (501) such that when light hits the buffer solution (507) molecules in the buffer solution (507) are excited to emit fluorescent light. A temperature control component (509) is thermally engaged with the holder (508) such that the temperature control component (509) adjusts the temperature of the buffer solution (507). The microarray reader (500) further includes a sensor (510) that receives the fluorescent light emitted by the excited molecules in the buffer solution (507) to generate a signal. The microarray reader (500) provides a simple and low-cost solution to overcome the drawback of improper alignment of the microarray (504) on the temperature control component (509).
摘要翻译：微阵列读取器（500）包括发射光的光源（501）和位于光源（501）附近的引导光的光束成形元件（502）。微阵列读取器（500）还包括微阵列（504），其至少由与光学基板（505）接触的光学基板（505）和反应室（506）形成。缓冲溶液（507）由光学基底（505）和反应室（506）封装，并且保持器（508）相对于光源（501）对准微阵列（504），使得当光照射缓冲溶液缓冲溶液（507）中的（507）分子被激发以发射荧光。温度控制部件（509）与保持器（508）热接合，使得温度控制部件（509）调节缓冲溶液（507）的温度。微阵列读取器（500）还包括传感器（510），其接收由缓冲溶液（507）中的激发分子发射的荧光以产生信号。微阵列读取器（500）提供了简单且低成本的解决方案，以克服微阵列（504）在温度控制部件（509）上的不正确对准的缺点。

4. 发明申请

US20130040295A1 METHOD TO INCREASE DETECTION EFFICIENCY OF REAL TIME PCR MICROARRAY BY QUARTZ MATERIAL 有权
标题翻译：通过石墨材料提高实时荧光定量PCR检测效率的方法
公开(公告)号：US20130040295A1
公开(公告)日：2013-02-14
申请号：US13522938
申请日：2010-01-20
申请人： Zhenhong Sun , Tao Pan , Xuanbin Liu
发明人： Zhenhong Sun , Tao Pan , Xuanbin Liu
IPC分类号： C12M1/34 , G01N21/64
CPC分类号： B01L3/5027 , B01L3/502707 , B01L7/52 , B01L2200/0689 , B01L2200/12 , B01L2300/0636 , B01L2300/0816
摘要： A reactor for the quantitative analysis of target nucleic acids using an evanescent wave detection technique and a method for the quantitative analysis of target nucleic acids are provided. The reactor includes a substrate with a cavity, a buffer layer arranged over the substrate, a quartz cover plate arranged over the buffer layer, and inlet and outlet ports. The reactor is thermally and chemically stable for PCR processing and suitable for an evanescent wave detection technique.
摘要翻译：提供了使用ev逝波检测技术定量分析靶核酸的反应器和用于定量分析靶核酸的方法。反应器包括具有空腔的衬底，布置在衬底上的缓冲层，布置在缓冲层上的石英盖板以及入口和出口。反应器对于PCR处理是热和化学稳定的并且适用于ev逝波检测技术。

5. 发明授权

US09539571B2 Method to increase detection efficiency of real time PCR microarray by quartz material 有权
标题翻译：通过石英材料提高实时PCR微阵列检测效率的方法
公开(公告)号：US09539571B2
公开(公告)日：2017-01-10
申请号：US13522938
申请日：2010-01-20
申请人： Zhenhong Sun , Tao Pan , Xuanbin Liu
发明人： Zhenhong Sun , Tao Pan , Xuanbin Liu
IPC分类号： C12Q1/68 , B01L3/00 , B01L7/00
CPC分类号： B01L3/5027 , B01L3/502707 , B01L7/52 , B01L2200/0689 , B01L2200/12 , B01L2300/0636 , B01L2300/0816
摘要： A reactor for the quantitative analysis of target nucleic acids using an evanescent wave detection technique and a method for the quantitative analysis of target nucleic acids are provided. The reactor includes a substrate with a cavity, a buffer layer arranged over the substrate, a quartz cover plate arranged over the buffer layer, and inlet and outlet ports. The reactor is thermally and chemically stable for PCR processing and suitable for an evanescent wave detection technique.
摘要翻译：提供了使用ev逝波检测技术定量分析靶核酸的反应器和用于定量分析靶核酸的方法。反应器包括具有空腔的衬底，布置在衬底上的缓冲层，布置在缓冲层上的石英盖板以及入口和出口。反应器对于PCR处理是热和化学稳定的并且适用于ev逝波检测技术。

6. 发明授权

US08809810B2 Microarray reader based on evanescent wave detection 有权
标题翻译：基于ev逝波检测的微阵列阅读器
公开(公告)号：US08809810B2
公开(公告)日：2014-08-19
申请号：US13697453
申请日：2010-05-20
申请人： Xuanbin Liu , Tao Pan , Zhenhong Sun
发明人： Xuanbin Liu , Tao Pan , Zhenhong Sun
IPC分类号： G01N21/64
CPC分类号： G01N21/64 , C12Q1/686 , G01N21/6452 , G01N21/648
摘要： The disclosure relates to a microarray reader that includes a light source which emits light and beam shaping elements positioned near the light source to direct the light. The microarray reader further includes a microarray that is at least formed of an optical substrate and a reaction chamber in contact with the optical substrate. A buffer solution is encapsulated by the optical substrate and the reaction chamber and a holder aligns the microarray relative to the light source such that when light hits the buffer solution molecules in the buffer solution are excited to emit fluorescent light. A temperature control component is thermally engaged with the holder such that the temperature control component adjusts the temperature of the buffer solution. The microarray reader further includes a sensor that receives the fluorescent light emitted by the excited molecules in the buffer solution to generate a signal.
摘要翻译：本发明涉及一种微阵列读取器，其包括发射光的光源和位于光源附近的光束成形元件以引导光。微阵列读取器还包括至少由光学基底和与光学基底接触的反应室形成的微阵列。缓冲溶液被光学基底和反应室封装，并且保持器将微阵列相对于光源对准，使得当光照射缓冲溶液时，激发缓冲溶液中的分子发射荧光。温度控制部件与保持器热接合，使得温度控制部件调节缓冲溶液的温度。微阵列读取器还包括传感器，其接收由缓冲溶液中激发的分子发射的荧光以产生信号。

7. 发明授权

US08637302B2 Method for single nucleotide polymorphism and mutation detection using real time polymerase chain reaction microarray 有权
标题翻译：使用实时聚合酶链反应微阵列的单核苷酸多态性和突变检测方法
公开(公告)号：US08637302B2
公开(公告)日：2014-01-28
申请号：US13253806
申请日：2011-10-05
申请人： Zhenhong Sun , Tao Pan , Wendy Wang , Hang Liao
发明人： Zhenhong Sun , Tao Pan , Wendy Wang , Hang Liao
IPC分类号： C12M1/34 , C12M1/00
CPC分类号： G01N21/6428 , B01L7/52 , C12Q1/686 , C12Q1/689 , C12Q2565/629 , C12Q2565/501 , C12Q2527/15 , C12Q2527/107
摘要： A method and apparatus for real-time, simultaneous, qualitative measurement of one or more single nucleotide polymorphisms in one or more target nucleic acids is provided. This method involves combining a polymerase chain reaction (PCR) technique with an evanescent wave technique.
摘要翻译：提供了用于在一个或多个靶核酸中实时，同时，定性测量一个或多个单核苷酸多态性的方法和装置。该方法包括将聚合酶链反应（PCR）技术与ev逝波技术相结合。

8. 发明授权

US09480982B2 Reactor for the quantitative analysis of nucleic acids 有权
标题翻译：用于核酸定量分析的反应器
公开(公告)号：US09480982B2
公开(公告)日：2016-11-01
申请号：US12810151
申请日：2007-12-24
申请人： Zhenhong Sun , Wendy Wang , Hang Liao
发明人： Zhenhong Sun , Wendy Wang , Hang Liao
IPC分类号： C12Q1/68 , B01L3/00 , B01L7/00
CPC分类号： B01L3/508 , A61F9/045 , B01L3/5027 , B01L3/502715 , B01L3/50851 , B01L7/52 , B01L2200/027 , B01L2200/0689 , B01L2300/0636 , B01L2300/0822 , G02C7/16 , G02C11/12
摘要： A reactor for the quantitative analysis of target nucleic acids using an evanescent wave detection technique and a method of use thereof is provided. The reactor includes a substrate with a cavity, a buffer layer arranged over the substrate; a cover plate arranged over the buffer layer, and inlet and outlet ports. The reactor is thermally and chemically stable for PCR processing and suitable for an evanescent wave detection technique.
摘要翻译：提供了一种使用ev逝波检测技术定量分析靶核酸的反应器及其使用方法。反应器包括具有空腔的衬底，布置在衬底上的缓冲层; 布置在缓冲层上的盖板，以及入口和出口。反应器对于PCR处理是热和化学稳定的并且适用于ev逝波检测技术。

9. 发明授权

US09005931B2 Programmable oligonucleotide micro array 有权
标题翻译：可编程寡核苷酸微阵列
公开(公告)号：US09005931B2
公开(公告)日：2015-04-14
申请号：US12810078
申请日：2007-12-24
申请人： Zhenhong Sun , Wendy Wang , Hang Liao
发明人： Zhenhong Sun , Wendy Wang , Hang Liao
IPC分类号： C12P19/34 , C12Q1/68 , B01L7/00
CPC分类号： C12Q1/6837 , B01L7/52 , C12Q1/686 , Y02A50/57 , C12Q2565/628 , C12Q2561/113 , C12Q2537/143 , C12Q2527/107
摘要： A programmable probe design of DNA micro array and detection methodology is provided. DNA probes, which are complemented with the target DNA, are designed and classified into groups according to optimum hybridization temperature. The probes are arrayed by the group and immobilized on the substrate surface of the DNA micro array. The control system, imaging system and temperature control system are programmed to cooperate with each other during the detection process. This design increases the detection capabilities of the parallel-analysis system.
摘要翻译：提供了DNA微阵列和检测方法的可编程探针设计。根据最适杂交温度，设计与靶DNA互补的DNA探针。探针由组排列并固定在DNA微阵列的底物表面上。控制系统，成像系统和温度控制系统被编程为在检测过程中相互配合。该设计增加了并行分析系统的检测能力。

10. 发明授权

US09657337B2 Reaction buffer for microarray 有权
公开(公告)号：US09657337B2
公开(公告)日：2017-05-23
申请号：US12520987
申请日：2006-12-29
申请人： Leon Xu , Zhenhong Sun
发明人： Leon Xu , Zhenhong Sun
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： C12Q1/6837 , C12Q1/686 , C12Q2527/125 , C12Q2531/113 , C12Q2565/501
摘要： Embodiments of the present invention relate to a buffer composition for an integrated nucleic acid amplification and hybridization reaction. The buffer comprise about 50-200 mM of a salt, about 10-30 mM Tris-HCl, about 2-10M Water soluble magnesium salt, about 0.05-1.5% surfactant, about 0.05-0.15 mg/ml stabilizing protein about 50-300 nM of one or more primers, about 20-150 uM of one or more dNTPs, about 5-15% glycerine, about 0.5-1.5% formamide and at least about 5 unit/ml polymerase.

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