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1. 发明申请

US20130330346A1 Chemokine receptor binding polypeptides 有权
标题翻译：趋化因子受体结合多肽
公开(公告)号：US20130330346A1
公开(公告)日：2013-12-12
申请号：US13886530
申请日：2013-05-03
申请人： Zarin Brown , Michelle Bradley , Steven John Charlton , Gino Anselmus Van Heeke , Karen Cromie , Bruno Dombrecht , Soren Steffensen , Judith Baumeister , Marie-Paule Bouche , Carlo Boutton , Marie-Ange Buyse , Veerle Snoeck , Stephanie Staelens
发明人： Zarin Brown , Michelle Bradley , Steven John Charlton , Gino Anselmus Van Heeke , Karen Cromie , Bruno Dombrecht , Soren Steffensen , Judith Baumeister , Marie-Paule Bouche , Carlo Boutton , Marie-Ange Buyse , Veerle Snoeck , Stephanie Staelens
IPC分类号： C07K16/46
CPC分类号： C07K16/2866 , A61K2039/505 , C07K16/468 , C07K2317/22 , C07K2317/31 , C07K2317/34 , C07K2317/35 , C07K2317/569 , C07K2317/76 , C07K2317/92 , C07K2317/94 , C07K2319/31
摘要： The present invention relates to polypeptides directed against or specifically binding to chemokine receptor CXCR2 and in particular to polypeptides capable of modulating signal transduction from CXCR2. The invention also relates to nucleic acids, vectors and host cells capable of expressing the polypeptides of the invention, pharmaceutical compositions comprising the polypeptides and uses of said polypeptides and compositions for treatment of diseases involving aberrant functioning of CXCR2.
摘要翻译：本发明涉及针对或特异性结合趋化因子受体CXCR2的多肽，特别涉及能够调节CXCR2信号转导的多肽。本发明还涉及能够表达本发明多肽的核酸，载体和宿主细胞，包含多肽的药物组合物以及用于治疗涉及CXCR2异常功能的疾病的所述多肽和组合物的用途。

2. 发明申请

US20180009888A9 TECHNIQUES FOR PREDICTING, DETECTING AND REDUCING ASPECIFIC PROTEIN INTERFERENCE IN ASSAYS INVOLVING IMMUNOGLOBULIN SINGLE VARIABLE DOMAINS 审中-公开
公开(公告)号：US20180009888A9
公开(公告)日：2018-01-11
申请号：US14128681
申请日：2012-06-25
申请人： Judith Baumeister , Marie-Paule Lucienne Armanda Bouche , Carlo Boutton , Marie-Ange Buyse , Veerle Snoeck , Stephanie Staelens , Bruno Dombrecht , Peter Schotte , Cedric Jozef Neotere Ververken , Gerald Beste , Guy Hermans , Soren Steffensen , Alexander Szyroki , Tinneke Denayer
发明人： Judith Baumeister , Marie-Paule Lucienne Armanda Bouche , Carlo Boutton , Marie-Ange Buyse , Veerle Snoeck , Stephanie Staelens , Bruno Dombrecht , Peter Schotte , Cedric Jozef Neotere Ververken , Gerald Beste , Guy Hermans , Soren Steffensen , Alexander Szyroki , Tinneke Denayer
IPC分类号： C07K16/28 , C07K16/42 , C07K16/00 , G01N33/68
CPC分类号： C07K16/28 , C07K16/00 , C07K16/4283 , C07K2317/22 , C07K2317/569 , C07K2317/94 , C07K2319/30 , G01N33/6854
摘要： This invention provides, and in certain specific but non-limiting aspects relates to: assays that can be used to predict whether a given ISV will be subject to protein interference as described herein and/or give rise to an (aspecific) signal in such an assay (such as for example in an ADA immunoassay). Such predictive assays could for example be used to test whether a given ISV could have a tendency to give rise to such protein interference and/or such a signal; to select ISV's that are not or less prone to such protein interference or to giving such a signal; as an assay or test that can be used to test whether certain modification(s) to an ISV will (fully or partially) reduce its tendency to give rise to such interference or such a signal; and/or as an assay or test that can be used to guide modification or improvement of an ISV so as to reduce its tendency to give rise to such protein interference or signal; —methods for modifying and/or improving ISV's to as to remove or reduce their tendency to give rise to such protein interference or such a signal; —modifications that can be introduced into an ISV that remove or reduce its tendency to give rise to such protein interference or such a signal; ISV's that have been specifically selected (for example, using the assay(s) described herein) to have no or low(er)/reduced tendency to give rise to such protein interference or such a signal; modified and/or improved ISV's that have no or a low(er)/reduced tendency to give rise to such protein interference or such a signal.

3. 发明申请

US20140199295A1 TECHNIQUES FOR PREDICTING, DETECTING AND REDUCING ASPECIFIC PROTEIN INTERFERENCE IN ASSAYS INVOLVING IMMUNOGLOBULIN SINGLE VARIABLE DOMAINS 审中-公开
标题翻译：涉及免疫球蛋白单个可变区域的测定中预测，检测和降低相关蛋白质干扰的技术
公开(公告)号：US20140199295A1
公开(公告)日：2014-07-17
申请号：US14128681
申请日：2012-06-25
申请人： Judith Baumeister , Marie-Paule Lucienne Armanda Bouche , Carlo Boutton , Marie-Ange Buyse , Veerle Snoeck , Stephanie Staelens
发明人： Judith Baumeister , Marie-Paule Lucienne Armanda Bouche , Carlo Boutton , Marie-Ange Buyse , Veerle Snoeck , Stephanie Staelens
IPC分类号： C07K16/00
CPC分类号： C07K16/28 , C07K16/00 , C07K16/4283 , C07K2317/22 , C07K2317/569 , C07K2317/94 , C07K2319/30 , G01N33/6854
摘要： This invention provides, and in certain specific but non-limiting aspects relates to: assays that can be used to predict whether a given ISV will be subject to protein interference as described herein and/or give rise to an (aspecific) signal in such an assay (such as for example in an ADA immunoassay). Such predictive assays could for example be used to test whether a given ISV could have a tendency to give rise to such protein interference and/or such a signal; to select ISV's that are not or less prone to such protein interference or to giving such a signal; as an assay or test that can be used to test whether certain modification(s) to an ISV will (fully or partially) reduce its tendency to give rise to such interference or such a signal; and/or as an assay or test that can be used to guide modification or improvement of an ISV so as to reduce its tendency to give rise to such protein interference or signal; —methods for modifying and/or improving ISV's to as to remove or reduce their tendency to give rise to such protein interference or such a signal; —modifications that can be introduced into an ISV that remove or reduce its tendency to give rise to such protein interference or such a signal; ISV's that have been specifically selected (for example, using the assay(s) described herein) to have no or low(er)/reduced tendency to give rise to such protein interference or such a signal; modified and/or improved ISV's that have no or a low(er)/reduced tendency to give rise to such protein interference or such a signal.
摘要翻译：本发明提供并且在某些特定但非限制性方面涉及：可用于预测给定ISV是否将如本文所述受到蛋白质干扰和/或产生（特异性）信号的测定法测定（例如在ADA免疫测定中）。这样的预测测定可以例如用于测试给定的ISV是否可能具有引起这种蛋白质干扰和/或这种信号的倾向; 选择不是或不太容易发生蛋白质干扰的ISV或给出这样的信号; 作为可用于测试对ISV的某些修改（完全或部分）是否降低其引起这种干扰或这种信号的趋势的测定或测试; 和/或作为可用于指导ISV的修饰或改进的测定或测试，以便减少引起这种蛋白质干扰或信号的趋势; - 用于修饰和/或改善ISV的方法以消除或减少其引起这种蛋白质干扰或这种信号的倾向; - 可以引入到ISV中的改变，其去除或减少其引起这种蛋白质干扰或这种信号的趋势; 已经特别选择的ISV（例如，使用本文所述的测定）具有没有或低（呃）/降低的趋势导致这种蛋白质干扰或这种信号; 修饰和/或改进的ISV，其没有或低（呃）/降低的趋势引起这种蛋白质干扰或这种信号。

4. 发明申请

US20170137520A1 PD1/CTLA4 BINDERS 审中-公开
公开(公告)号：US20170137520A1
公开(公告)日：2017-05-18
申请号：US15353867
申请日：2016-11-17
申请人： Juha Punnonen , Edward Bowman , Maribel Beaumont , Marie-Ange Buyse , Carlo Boutton , Bruno Dombrecht , Bjorn Victor , David Vlerick
发明人： Juha Punnonen , Edward Bowman , Maribel Beaumont , Marie-Ange Buyse , Carlo Boutton , Bruno Dombrecht , Bjorn Victor , David Vlerick
IPC分类号： C07K16/28 , A61K39/395
CPC分类号： C07K16/2818 , A61K39/3955 , A61K39/39558 , A61K2039/505 , A61K2039/507 , A61K2039/54 , A61K2039/545 , C07K16/18 , C07K2317/22 , C07K2317/24 , C07K2317/31 , C07K2317/33 , C07K2317/34 , C07K2317/565 , C07K2317/569 , C07K2317/62 , C07K2317/76 , C07K2317/92 , Y02A50/403
摘要： The present invention provides multispecific molecules, e.g., comprising more than one ISVD or Nanobody, that bind to PD1 and CTLA4. These molecules have been engineered so as to reduce the incidence of binding by pre-existing antibodies in the bodies of a subject administered such a molecule. Methods for increasing immune response, treating cancer and/or treating an infectious disease with such molecules are provided.

5. 发明申请

US20170137521A1 CTLA4 BINDERS 审中-公开
公开(公告)号：US20170137521A1
公开(公告)日：2017-05-18
申请号：US15353886
申请日：2016-11-17
申请人： Juha Punnonen , Maribel Beaumont , Marie-Ange Buyse , Carlo Boutton , Bruno Dombrecht , Bjorn Victor
发明人： Juha Punnonen , Maribel Beaumont , Marie-Ange Buyse , Carlo Boutton , Bruno Dombrecht , Bjorn Victor
IPC分类号： C07K16/28 , A61K39/395 , C07K14/765
CPC分类号： C07K16/2818 , A61K39/3955 , A61K39/39558 , A61K2039/505 , A61K2039/54 , A61K2039/545 , C07K14/765 , C07K16/18 , C07K2317/22 , C07K2317/24 , C07K2317/31 , C07K2317/32 , C07K2317/33 , C07K2317/34 , C07K2317/35 , C07K2317/565 , C07K2317/569 , C07K2317/62 , C07K2317/76 , C07K2317/92 , C07K2319/31
摘要： The present invention provides molecules, such as ISVDs and Nanobodies, that bind to CTLA4 or human serum albumin. These molecules have been engineered so as to reduce the incidence of binding by pre-existing antibodies in the bodies of a subject administered such a molecule. Methods for increasing immune response, treating cancer and/or treating an infectious disease with such molecules are provided.

6. 发明申请

US20170137517A1 PD1 and/or LAG3 BINDERS 审中-公开
公开(公告)号：US20170137517A1
公开(公告)日：2017-05-18
申请号：US15353919
申请日：2016-11-17
申请人： Edward Bowman , Maribel Beaumont , Marie-Ange Buyse , Carlo Boutton , Bruno Dombrecht , David Vlerick
发明人： Edward Bowman , Maribel Beaumont , Marie-Ange Buyse , Carlo Boutton , Bruno Dombrecht , David Vlerick
IPC分类号： C07K16/28 , A61K45/06 , C07K16/46 , A61K39/395
CPC分类号： C07K16/2803 , A61K39/3955 , A61K45/06 , C07K16/18 , C07K16/2818 , C07K16/468 , C07K2317/22 , C07K2317/24 , C07K2317/31 , C07K2317/33 , C07K2317/34 , C07K2317/565 , C07K2317/569 , C07K2317/62 , C07K2317/76 , C07K2317/92
摘要： The present invention provides molecules, such as ISVDs and Nanobodies, that bind to PD1 and LAG3 and, optionally to human serum albumin. These molecules have been engineered so as to reduce the incidence of binding by pre-existing antibodies in the bodies of a subject administered such a molecule. Methods for increasing immune response, treating cancer and/or treating an infectious disease with such molecules are provided.

7. 发明授权

US08217140B2 Peptides capable of binding to serum proteins and compounds, constructs and polypeptides comprising the same 失效
标题翻译：能够结合血清蛋白和化合物的肽，构建体和包含其的多肽
公开(公告)号：US08217140B2
公开(公告)日：2012-07-10
申请号：US12424986
申请日：2009-04-16
申请人： Hilde Adi Pierrette Revets , Carlo Boutton , Stephanie Staelens , Peter Verheesen
发明人： Hilde Adi Pierrette Revets , Carlo Boutton , Stephanie Staelens , Peter Verheesen
IPC分类号： C07K2/10 , C07K4/10
CPC分类号： C07K16/32 , C07K14/765 , C07K16/36 , C07K2317/22 , C07K2317/565 , C07K2317/569 , C07K2319/31
摘要： The present invention relates to amino acid sequences that are capable of binding to serum proteins; to compounds, proteins, polypeptides, fusion proteins or constructs comprising or essentially consisting of such amino acid sequences; to nucleic acids that encode such amino acid sequences, compounds, proteins, polypeptides, fusion proteins or constructs; to compositions, and in particular pharmaceutical compositions, that comprise such amino acid sequences, compounds, proteins, polypeptides, fusion proteins or constructs; and to uses of such amino acid sequences, compounds, proteins, polypeptides, fusion proteins or constructs.
摘要翻译：本发明涉及能够结合血清蛋白质的氨基酸序列; 化合物，蛋白质，多肽，融合蛋白或包含或基本上由此类氨基酸序列组成的构建体; 编码这种氨基酸序列的核酸，化合物，蛋白质，多肽，融合蛋白或构建体; 包括这样的氨基酸序列，化合物，蛋白质，多肽，融合蛋白或构建体的组合物，特别是药物组合物; 以及这些氨基酸序列，化合物，蛋白质，多肽，融合蛋白或构建体的使用。

8. 发明申请

US20110243954A1 PEPTIDES CAPABLE OF BINDING TO SERUM PROTEINS AND COMPOUNDS, CONSTRUCTS AND POLYPEPTIDES COMPRISING THE SAME 审中-公开
标题翻译：能够与血清蛋白和化合物结合的蛋白质，构建物和包含其的多肽
公开(公告)号：US20110243954A1
公开(公告)日：2011-10-06
申请号：US13018047
申请日：2011-01-31
申请人： Hilde Adi Pierrette Revets , Carlo Boutton , Stephanie Staelens , Peter Verheesen
发明人： Hilde Adi Pierrette Revets , Carlo Boutton , Stephanie Staelens , Peter Verheesen
IPC分类号： A61K39/395 , C07K16/18 , A61P43/00
CPC分类号： C07K14/765 , A61K2039/505 , C07K16/18 , C07K16/2866 , C07K16/32 , C07K16/36 , C07K2317/22 , C07K2317/31 , C07K2317/33 , C07K2317/34 , C07K2317/565 , C07K2317/569 , C07K2317/76 , C07K2317/90 , C07K2317/92 , C07K2317/94 , C07K2319/31
摘要： Provided are pharmaceutical compositions, preparations or formulations including a compounds or constructs that include at least one amino acid sequence that is directed against serum albumin and at least one therapeutic moiety. The pharmaceutical compositions, preparations or formulations are preparations or formulations that are suitable for and/or intended for, e.g., pulmonary administration. Methods for use of the pharmaceutical compositions, preparations or formulations also are provided.
摘要翻译：提供的药物组合物，制剂或制剂包括包含至少一个针对血清白蛋白和至少一个治疗部分的氨基酸序列的化合物或构建体。药物组合物，制剂或制剂是适合于和/或用于例如肺部给药的制剂或制剂。还提供了使用药物组合物，制剂或制剂的方法。

9. 发明申请

US20090281277A1 PEPTIDES CAPABLE OF BINDING TO SERUM PROTEINS AND COMPOUNDS, CONSTRUCTS AND POLYPEPTIDES COMPRISING THE SAME 失效
标题翻译：能够与血清蛋白和化合物结合的蛋白质，构建物和包含其的多肽
公开(公告)号：US20090281277A1
公开(公告)日：2009-11-12
申请号：US12424986
申请日：2009-04-16
申请人： Hilde Adi Pierrette Revets , Carlo Boutton , Stephanie Staelens , Peter Verheesen
发明人： Hilde Adi Pierrette Revets , Carlo Boutton , Stephanie Staelens , Peter Verheesen
IPC分类号： C07K14/00 , C07K7/08 , C07K16/00
CPC分类号： C07K16/32 , C07K14/765 , C07K16/36 , C07K2317/22 , C07K2317/565 , C07K2317/569 , C07K2319/31
摘要： The present invention relates to amino acid sequences that are capable of binding to serum proteins; to compounds, proteins, polypeptides, fusion proteins or constructs comprising or essentially consisting of such amino acid sequences; to nucleic acids that encode such amino acid sequences, compounds, proteins, polypeptides, fusion proteins or constructs; to compositions, and in particular pharmaceutical compositions, that comprise such amino acid sequences, compounds, proteins, polypeptides, fusion proteins or constructs; and to uses of such amino acid sequences, compounds, proteins, polypeptides, fusion proteins or constructs.
摘要翻译：本发明涉及能够结合血清蛋白质的氨基酸序列; 化合物，蛋白质，多肽，融合蛋白或包含或基本上由此类氨基酸序列组成的构建体; 编码这种氨基酸序列的核酸，化合物，蛋白质，多肽，融合蛋白或构建体; 包括这样的氨基酸序列，化合物，蛋白质，多肽，融合蛋白或构建体的组合物，特别是药物组合物; 以及这些氨基酸序列，化合物，蛋白质，多肽，融合蛋白或构建体的使用。

10. 发明申请

US20120253008A1 PEPTIDES CAPABLE OF BINDING TO SERUM PROTEINS AND COMPOUNDS, CONSTRUCTS AND POLYPEPTIDES COMPRISING THE SAME 审中-公开
标题翻译：能够与血清蛋白和化合物结合的蛋白质，构建物和包含其的多肽
公开(公告)号：US20120253008A1
公开(公告)日：2012-10-04
申请号：US13495120
申请日：2012-06-13
申请人： Hilde Adi Pierrette Revets , Carlo Boutton , Stephanie Staelens , Peter Verheesen
发明人： Hilde Adi Pierrette Revets , Carlo Boutton , Stephanie Staelens , Peter Verheesen
IPC分类号： C07K7/08 , C07K14/00
CPC分类号： C07K16/32 , C07K14/765 , C07K16/36 , C07K2317/22 , C07K2317/565 , C07K2317/569 , C07K2319/31
摘要： The present invention relates to amino acid sequences that are capable of binding to serum proteins; to compounds, proteins, polypeptides, fusion proteins or constructs comprising or essentially consisting of such amino acid sequences; to nucleic acids that encode such amino acid sequences, compounds, proteins, polypeptides, fusion proteins or constructs; to compositions, and in particular pharmaceutical compositions, that comprise such amino acid sequences, compounds, proteins, polypeptides, fusion proteins or constructs; and to uses of such amino acid sequences, compounds, proteins, polypeptides, fusion proteins or constructs.
摘要翻译：本发明涉及能够结合血清蛋白质的氨基酸序列; 化合物，蛋白质，多肽，融合蛋白或包含或基本上由此类氨基酸序列组成的构建体; 编码这种氨基酸序列的核酸，化合物，蛋白质，多肽，融合蛋白或构建体; 包括这样的氨基酸序列，化合物，蛋白质，多肽，融合蛋白或构建体的组合物，特别是药物组合物; 以及这些氨基酸序列，化合物，蛋白质，多肽，融合蛋白或构建体的使用。

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