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1. 发明专利

IL290060D0 Saponin derivatives with improved therapeutic window 未知
公开(公告)号：IL290060D0
公开(公告)日：2022-03-01
申请号：IL29006022
申请日：2022-01-23
申请人： SAPREME TECH BV , CHARITE – UNIV BERLIN , RUBEN POSTEL , GUY HERMANS , HENDRIK FUCHS
发明人： RUBEN POSTEL , GUY HERMANS , HENDRIK FUCHS
IPC分类号： C07H15/256 , C07J63/00
摘要： The invention relates to a saponin derivative based on a saponin comprising a triterpene aglycone and a first saccharide chain and/or a second saccharide chain, and comprising: an aglycone core structure comprising an aldehyde group which has been derivatised; and/or the first saccharide chain wherein the first saccharide chain comprises a carboxyl group, which has been derivatised; and/or the second saccharide chain wherein the second saccharide chain comprises at least one acetoxy group which has been derivatised. The invention also relates to a first pharmaceutical composition comprising the saponin derivative of the invention. In addition, the invention relates to a pharmaceutical combination comprising the first pharmaceutical composition of the invention and a second pharmaceutical composition comprising any one or more of an antibody-toxin conjugate, a receptor-ligand – toxin conjugate, an antibody-drug conjugate, a receptor-ligand – drug conjugate, an antibody-oligonucleotide conjugate or a receptor-ligand – oligonucleotide conjugate. The invention also relates to the first pharmaceutical composition or the pharmaceutical combination of the invention, for use as a medicament, or use in the treatment or prophylaxis of a cancer, an infectious disease, viral infection, hypercholesterolemia, primary hyperoxaluria, haemophilia A, haemophilia B, alpha-1 antitrypsin related liver disease, acute hepatic porphyria, transthyretin-mediated amyloidosis, or an auto-immune disease. Furthermore, the invention relates to an in vitro or ex vivo method for transferring a molecule from outside a cell to inside said cell, comprising contacting said cell with the molecule and with a saponin derivative of the invention.

2. 发明授权

US08907065B2 Polypeptides that modulate the interaction between cells of the immune system 有权
标题翻译：调节免疫系统细胞之间相互作用的多肽
公开(公告)号：US08907065B2
公开(公告)日：2014-12-09
申请号：US12448260
申请日：2007-12-17
申请人： Guy Hermans , Peter Verheesen , Edward Dolk , Hendricus Renerus Jacobus Mattheus Hoogenboom , Michael John Scott Saunders , Johannes Joseph Wilhelmus De Haard , Renee de Bruin
发明人： Guy Hermans , Peter Verheesen , Edward Dolk , Hendricus Renerus Jacobus Mattheus Hoogenboom , Michael John Scott Saunders , Johannes Joseph Wilhelmus De Haard , Renee de Bruin
IPC分类号： C07K16/28 , A61K39/395
CPC分类号： C07K16/2818 , A61K47/643 , C07K14/76 , C07K16/2803 , C07K16/2827 , C07K2317/22 , C07K2317/24 , C07K2317/31 , C07K2317/35 , C07K2317/565 , C07K2317/567 , C07K2317/569 , C07K2317/76 , C07K2317/92 , C07K2317/94 , C07K2319/31
摘要： The present invention relates to amino acid sequences that block the interaction between (a target on) an antigen presenting cell (APC) and (a target on) a T-cell. More particularly, the present invention relates to amino acid sequences that are directed against (as defined herein) a target on an APC (also referred to herein as “APC target”) or a target on a T-cell (also referred to herein as “T-cell target”). The invention further relates to compounds or constructs, and in particular proteins and polypeptides, that comprise or essentially consist of one or more such amino acid sequences.
摘要翻译：本发明涉及阻断抗原呈递细胞（APC）上的靶标（APC）和（T细胞上的靶标）之间的相互作用的氨基酸序列。更具体地，本发明涉及针对（如本文所定义）APC上的靶（本文中也称为“APC靶”）或T细胞上的靶（本文也称为“靶”）的氨基酸序列 “T细胞靶”）。本发明还涉及包含或基本上由一个或多个这样的氨基酸序列组成的化合物或构建体，特别是蛋白质和多肽。

3. 发明申请

US20100028341A1 AMINO ACID SEQUENCES THAT MODULATE THE INTERACTION BETWEEN CELLS OF THE IMMUNE SYSTEM 有权
标题翻译：调节免疫系统细胞之间的相互作用的氨基酸序列
公开(公告)号：US20100028341A1
公开(公告)日：2010-02-04
申请号：US12448260
申请日：2007-12-17
申请人： Guy Hermans , Peter Verheesen , Edward Dolk , Hendricus Renerus Jacobus Mattheus Hoogenboom , Michael John Scott Saunders , Johannes Joseph Wilhelmus De Haard , Renee de Bruin
发明人： Guy Hermans , Peter Verheesen , Edward Dolk , Hendricus Renerus Jacobus Mattheus Hoogenboom , Michael John Scott Saunders , Johannes Joseph Wilhelmus De Haard , Renee de Bruin
IPC分类号： A61K39/395 , C07K16/28 , C12N15/11 , C12N15/00 , C12N5/10 , C12P21/02
CPC分类号： C07K16/2818 , A61K47/643 , C07K14/76 , C07K16/2803 , C07K16/2827 , C07K2317/22 , C07K2317/24 , C07K2317/31 , C07K2317/35 , C07K2317/565 , C07K2317/567 , C07K2317/569 , C07K2317/76 , C07K2317/92 , C07K2317/94 , C07K2319/31
摘要： The present invention relates to amino acid sequences that block the interaction between (a target on) an antigen presenting cell (APC) and (a target on) a T-cell. More particularly, the present invention relates to amino acid sequences that are directed against (as defined herein) a target on an APC (also referred to herein as “APC target”) or a target on a T-cell (also referred to herein as “T-cell target”). The invention further relates to compounds or constructs, and in particular proteins and polypeptides, that comprise or essentially consist of one or more such amino acid sequences
摘要翻译：本发明涉及阻断抗原呈递细胞（APC）上的靶标（APC）和（T细胞上的靶标）之间的相互作用的氨基酸序列。更具体地，本发明涉及针对（如本文所定义）APC上的靶（本文中也称为“APC靶”）或T细胞上的靶（本文也称为“靶”）的氨基酸序列 “T细胞靶”）。本发明还涉及包含或基本上由一个或多个这样的氨基酸序列组成的化合物或构建体，特别是蛋白质和多肽

4. 发明申请

US20110189203A1 IMMUNOGLOBULIN CONSTRUCTS 审中-公开
标题翻译：免疫球蛋白构建体
公开(公告)号：US20110189203A1
公开(公告)日：2011-08-04
申请号：US12745023
申请日：2008-11-27
申请人： Guy Hermans , Hilde Adi Pierrette Revets , Michael John Scott Saunders
发明人： Guy Hermans , Hilde Adi Pierrette Revets , Michael John Scott Saunders
IPC分类号： A61K39/395 , C07K16/18 , C07K16/24 , C07K16/28 , C07H21/04 , C12P21/06 , C12N5/16 , A61P35/00
CPC分类号： C07K16/2863 , A61K39/3955 , A61K2039/505 , C07K16/3007 , C07K16/32 , C07K16/468 , C07K2317/22 , C07K2317/31 , C07K2317/32 , C07K2317/52 , C07K2317/565 , C07K2317/567 , C07K2317/569 , C07K2317/64 , C07K2317/76 , C07K2317/94 , C07K2319/00
摘要： The present invention relates to protein and polypeptide constructs that comprise single variable domains that are linked to an Fc portion. The immunoglobulin constructs comprise two polypeptide chains in which each polypeptide chain comprises two or more single variable domains that are linked, usually via a suitable hinge region or linker, to one or more constant domains that, together, form an Fc portion. The invention also relates to polypeptide chains that form part of such constructs and/or that can be used to form such constructs. The invention further relates to nucleotide sequences and nucleic acids that encode or can be used to express such constructs or polypeptide chains; to methods for producing such constructs and polypeptides chains; to compositions (and in particular pharmaceutical compositions) that comprise such constructs or polypeptide chains; and to uses of such constructs, polypeptide chains or compositions.
摘要翻译：本发明涉及包含与Fc部分连接的单个可变结构域的蛋白质和多肽构建体。免疫球蛋白构建体包含两条多肽链，其中每个多肽链包含两个或更多个单可变结构域，其通常通过合适的铰链区或接头连接到一个或多个恒定区，一起形成Fc部分。本发明还涉及形成这种构建体的一部分的多肽链和/或可用于形成此类构建体的多肽链。本发明还涉及编码或可用于表达此类构建体或多肽链的核苷酸序列和核酸; 涉及产生这种构建体和多肽链的方法; 包括这样的构建体或多肽链的组合物（特别是药物组合物）; 以及这种构建体，多肽链或组合物的用途。

5. 发明申请

US20090297535A1 Amino Acid Sequences Directed Against Il-6 And Polypetides Comprising The Same For The Treatment Of Diseases And Disorders Associated With Il-6 Mediated Signalling 审中-公开
标题翻译：与Il-6介导信号相关的疾病和疾病治疗的II-6和Polypetides指导的氨基酸序列
公开(公告)号：US20090297535A1
公开(公告)日：2009-12-03
申请号：US12225045
申请日：2007-03-13
申请人： Joost Alexander Kolkman , Guy Hermans , Hendricus Renerus Jacobus Matteus Hoogenboom
发明人： Joost Alexander Kolkman , Guy Hermans , Hendricus Renerus Jacobus Matteus Hoogenboom
IPC分类号： A61K39/395 , C07K16/24 , C07H21/04 , C12N5/10 , C12P21/02 , A61P19/10 , A61P35/02 , A61P11/06 , A61P19/02
CPC分类号： C07K16/248 , C07K2317/22 , C07K2317/24 , C07K2317/569 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to amino acid sequences that are directed against interleukin-6 (IL-6), as well as to compounds or constructs, and in particular proteins and polypeptides that comprise or essentially consist of one or more such amino acid sequences. The invention also relates to nucleic acids encoding such amino acid sequences and polypeptides to methods for preparing such amino acid sequences and polypeptides; to host cells expressing or capable of expressing such amino acid sequences or polypeptides; to compositions, and in particular to pharmaceutical compositions, that comprise such amino acid sequences, polypeptides, nucleic acids and/or host cells; and to uses of such amino acid sequences, polypeptides, nucleic acids, host cells and/or compositions, in particular for prophylactic, therapeutic or diagnostic purposes.
摘要翻译：本发明涉及针对白细胞介素-6（IL-6）以及包含或基本上由一个或多个这样的氨基酸序列组成的化合物或构建体，特别是蛋白质和多肽的氨基酸序列。本发明还涉及将这种氨基酸序列和多肽编码到制备这种氨基酸序列和多肽的方法中的核酸; 宿主表达或能够表达这种氨基酸序列或多肽的细胞; 包括这样的氨基酸序列，多肽，核酸和/或宿主细胞的组合物，特别是药物组合物; 以及这些氨基酸序列，多肽，核酸，宿主细胞和/或组合物的用途，特别是用于预防，治疗或诊断目的。

6. 发明申请

US20060211088A1 Method for generating variable domain sequences of heavy chain antibodies 审中-公开
公开(公告)号：US20060211088A1
公开(公告)日：2006-09-21
申请号：US11375679
申请日：2006-03-13
申请人： Guy Hermans , Johannes De Haard
发明人： Guy Hermans , Johannes De Haard
IPC分类号： C07H21/04 , C12P21/06 , C07K16/18 , C12N5/06
CPC分类号： C07K16/241 , C07K16/00 , C07K16/2818 , C07K16/2839 , C07K16/2863 , C07K2317/22 , C07K2317/569 , C07K2317/76
摘要： The present invention relates to a method for generating or cloning a nucleic acid or nucleotide sequence that encodes a heavy chain antibody or an antigen-binding fragment thereof, wherein said heavy chain antibody or antigen-binding fragment is directed against a specific antigen, said method comprising the steps of providing a sample or population of cells from a Camelid immunized with said antigen, isolating from said sample or population said at least one cell that expresses or is capable of expressing a heavy chain antibody directed against said antigen, and obtaining from said at least one cell a nucleic acid or nucleotide sequence that encodes a heavy chain antibody directed against antigen or that encodes an antigen-binding fragment thereof directed against said antigen.

7. 发明申请

US20180009888A9 TECHNIQUES FOR PREDICTING, DETECTING AND REDUCING ASPECIFIC PROTEIN INTERFERENCE IN ASSAYS INVOLVING IMMUNOGLOBULIN SINGLE VARIABLE DOMAINS 审中-公开
公开(公告)号：US20180009888A9
公开(公告)日：2018-01-11
申请号：US14128681
申请日：2012-06-25
申请人： Judith Baumeister , Marie-Paule Lucienne Armanda Bouche , Carlo Boutton , Marie-Ange Buyse , Veerle Snoeck , Stephanie Staelens , Bruno Dombrecht , Peter Schotte , Cedric Jozef Neotere Ververken , Gerald Beste , Guy Hermans , Soren Steffensen , Alexander Szyroki , Tinneke Denayer
发明人： Judith Baumeister , Marie-Paule Lucienne Armanda Bouche , Carlo Boutton , Marie-Ange Buyse , Veerle Snoeck , Stephanie Staelens , Bruno Dombrecht , Peter Schotte , Cedric Jozef Neotere Ververken , Gerald Beste , Guy Hermans , Soren Steffensen , Alexander Szyroki , Tinneke Denayer
IPC分类号： C07K16/28 , C07K16/42 , C07K16/00 , G01N33/68
CPC分类号： C07K16/28 , C07K16/00 , C07K16/4283 , C07K2317/22 , C07K2317/569 , C07K2317/94 , C07K2319/30 , G01N33/6854
摘要： This invention provides, and in certain specific but non-limiting aspects relates to: assays that can be used to predict whether a given ISV will be subject to protein interference as described herein and/or give rise to an (aspecific) signal in such an assay (such as for example in an ADA immunoassay). Such predictive assays could for example be used to test whether a given ISV could have a tendency to give rise to such protein interference and/or such a signal; to select ISV's that are not or less prone to such protein interference or to giving such a signal; as an assay or test that can be used to test whether certain modification(s) to an ISV will (fully or partially) reduce its tendency to give rise to such interference or such a signal; and/or as an assay or test that can be used to guide modification or improvement of an ISV so as to reduce its tendency to give rise to such protein interference or signal; —methods for modifying and/or improving ISV's to as to remove or reduce their tendency to give rise to such protein interference or such a signal; —modifications that can be introduced into an ISV that remove or reduce its tendency to give rise to such protein interference or such a signal; ISV's that have been specifically selected (for example, using the assay(s) described herein) to have no or low(er)/reduced tendency to give rise to such protein interference or such a signal; modified and/or improved ISV's that have no or a low(er)/reduced tendency to give rise to such protein interference or such a signal.

8. 发明授权

US08703135B2 Biological materials related to c-Met 有权
标题翻译：与c-Met相关的生物材料
公开(公告)号：US08703135B2
公开(公告)日：2014-04-22
申请号：US13435567
申请日：2012-03-30
申请人： Gerald Beste , Guy Hermans , Soren Steffensen , Alexander Szyroki , Cedric Jozef Neotere Ververken , Tinneke Denayer
发明人： Gerald Beste , Guy Hermans , Soren Steffensen , Alexander Szyroki , Cedric Jozef Neotere Ververken , Tinneke Denayer
IPC分类号： A61K39/395 , C12P21/08 , C07K16/18 , C07K16/28
CPC分类号： C07K16/2863 , A61K2039/505 , C07K16/18 , C07K2317/22 , C07K2317/34 , C07K2317/565 , C07K2317/567 , C07K2317/569 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C12Q1/6876 , G01N33/53
摘要： The present invention relates to biological materials related to c-Met possibly in combination with VEGF and/or EGFR, and more in particular to polypeptides, nucleic acids encoding such polypeptides; to methods for preparing such polypeptides; to host cells expressing or capable of expressing such polypeptides; to compositions and in particular to pharmaceutical compositions that comprise such polypeptides, for prophylactic, therapeutic or diagnostic purposes. Methods and kits for assessing the responsiveness of a patient to c-Met therapy are also described and provided.
摘要翻译：本发明涉及与可能与VEGF和/或EGFR组合的c-Met相关的生物学材料，更具体地涉及编码这些多肽的多肽，核酸; 制备这种多肽的方法; 以宿主表达或能够表达这种多肽的细胞; 组合物，特别是涉及用于预防，治疗或诊断目的的包含这种多肽的药物组合物。还描述和提供了用于评估患者对c-Met治疗的反应性的方法和试剂盒。

9. 发明申请

US20120244164A1 BIOLOGICAL MATERIALS RELATED TO C-MET 有权
标题翻译：与C-MET相关的生物材料
公开(公告)号：US20120244164A1
公开(公告)日：2012-09-27
申请号：US13435567
申请日：2012-03-30
申请人： Gerald Beste , Guy Hermans , Soren Steffensen , Alexander Szyroki , Cedric Jozef Neotere Ververken , Tinneke Denayer
发明人： Gerald Beste , Guy Hermans , Soren Steffensen , Alexander Szyroki , Cedric Jozef Neotere Ververken , Tinneke Denayer
IPC分类号： A61K39/395 , C40B30/04 , A61P35/00 , C07K16/18 , C12N15/13 , C12P21/02 , G01N21/76
CPC分类号： C07K16/2863 , A61K2039/505 , C07K16/18 , C07K2317/22 , C07K2317/34 , C07K2317/565 , C07K2317/567 , C07K2317/569 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C12Q1/6876 , G01N33/53
摘要： The present invention relates to biological materials related to c-Met possibly in combination with VEGF and/or EGFR, and more in particular to polypeptides, nucleic acids encoding such polypeptides; to methods for preparing such polypeptides; to host cells expressing or capable of expressing such polypeptides; to compositions and in particular to pharmaceutical compositions that comprise such polypeptides, for prophylactic, therapeutic or diagnostic purposes. Methods and kits for assessing the responsiveness of a patient to c-Met therapy are also described and provided.
摘要翻译：本发明涉及与可能与VEGF和/或EGFR组合的c-Met相关的生物学材料，更具体地涉及编码这些多肽的多肽，核酸; 制备这种多肽的方法; 以宿主表达或能够表达这种多肽的细胞; 组合物，特别是涉及用于预防，治疗或诊断目的的包含这种多肽的药物组合物。还描述和提供了用于评估患者对c-Met治疗的反应性的方法和试剂盒。

10. 发明申请

US20110059101A9 Amino Acid Sequences Directed Against Il-6 And Polypetides Comprising The Same For The Treatment Of Diseases And Disorders Associated With Il-6 Mediated Signalling 审中-公开
标题翻译：与Il-6介导信号相关的疾病和疾病治疗的II-6和Polypetides指导的氨基酸序列
公开(公告)号：US20110059101A9
公开(公告)日：2011-03-10
申请号：US12225045
申请日：2007-03-13
申请人： Joost Alexander Kolkman , Guy Hermans , Hendricus Renerus Jacobus Matteus Hoogenboom
发明人： Joost Alexander Kolkman , Guy Hermans , Hendricus Renerus Jacobus Matteus Hoogenboom
IPC分类号： A61K39/395 , C07K16/24 , C07H21/04 , C12N5/10 , C12P21/02 , A61P19/10 , A61P35/02 , A61P11/06 , A61P19/02
CPC分类号： C07K16/248 , C07K2317/22 , C07K2317/24 , C07K2317/569 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to amino acid sequences that are directed against interleukin-6 (IL-6), as well as to compounds or constructs, and in particular proteins and polypeptides that comprise or essentially consist of one or more such amino acid sequences. The invention also relates to nucleic acids encoding such amino acid sequences and polypeptides to methods for preparing such amino acid sequences and polypeptides; to host cells expressing or capable of expressing such amino acid sequences or polypeptides; to compositions, and in particular to pharmaceutical compositions, that comprise such amino acid sequences, polypeptides, nucleic acids and/or host cells; and to uses of such amino acid sequences, polypeptides, nucleic acids, host cells and/or compositions, in particular for prophylactic, therapeutic or diagnostic purposes.
摘要翻译：本发明涉及针对白细胞介素-6（IL-6）以及包含或基本上由一个或多个这样的氨基酸序列组成的化合物或构建体，特别是蛋白质和多肽的氨基酸序列。本发明还涉及将这种氨基酸序列和多肽编码到制备这种氨基酸序列和多肽的方法中的核酸; 宿主表达或能够表达这种氨基酸序列或多肽的细胞; 包括这样的氨基酸序列，多肽，核酸和/或宿主细胞的组合物，特别是药物组合物; 以及这些氨基酸序列，多肽，核酸，宿主细胞和/或组合物的用途，特别是用于预防，治疗或诊断目的。

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