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1. 发明申请

US20070248957A1 Encoded solid supports for biological processing and assays using same 失效
标题翻译：用于生物处理的编码固体支持物和使用其的测定法
公开(公告)号：US20070248957A1
公开(公告)日：2007-10-25
申请号：US11011452
申请日：2004-12-14
申请人： Michael Nova , Andrew Senyei , Zahra Parandoosh , Gary David , Xiao-Yi Xiao
发明人： Michael Nova , Andrew Senyei , Zahra Parandoosh , Gary David , Xiao-Yi Xiao
IPC分类号： C12Q1/68 , G01N33/53 , G06F19/00 , C12M3/00
CPC分类号： C40B30/04 , B01J19/0046 , B01J2219/00295 , B01J2219/00299 , B01J2219/00308 , B01J2219/00333 , B01J2219/00344 , B01J2219/00461 , B01J2219/00463 , B01J2219/005 , B01J2219/00502 , B01J2219/0054 , B01J2219/00542 , B01J2219/00547 , B01J2219/00549 , B01J2219/00551 , B01J2219/0056 , B01J2219/00563 , B01J2219/00567 , B01J2219/00569 , B01J2219/00585 , B01J2219/0059 , B01J2219/00592 , B01J2219/00596 , B01J2219/00689 , B01J2219/00695 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , B01L3/5027 , B01L3/502707 , B01L2300/0609 , B82Y10/00 , C07K1/00 , C07K1/04 , C07K1/047 , C40B40/06 , C40B40/10 , C40B60/08 , C40B60/14 , C40B70/00 , G01N35/00732 , G01N35/00871 , G01N2015/149 , G01N2035/00782 , G11C13/0014 , G11C13/0019 , G11C13/025
摘要： Combinations, called matrices with memories, of matrix materials with remotely addressable or remotely programmable recording devices that contain at least one data storage unit are provided. The matrix materials are those that are used in as supports in solid phase chemical and biochemical syntheses, immunoassays and hybridization reactions. The matrix materials may additionally include fluophors or other luminescent moieties to produce luminescing matrices with memories. The data storage units are non-volatile antifuse memories or volatile memories, such as EEPROMS, DRAMS or flash memory. By virtue of this combination, molecules and biological particles, such as phage and viral particles and cells, that are in proximity or in physical contact with the matrix combination can be labeled by programming the memory with identifying information and can be identified by retrieving the stored information. Combinations of matrix materials, memories, and linked molecules and biological materials are also provided. The combinations have a multiplicity of applications, including combinatorial chemistry, isolation and purification of target macromolecules, capture and detection of macromolecules for analytical purposes, selective removal of contaminants, enzymatic catalysis, cell sorting, drug delivery, chemical modification and other uses. Methods for electronically tagging molecules, biological particles and matrix support materials, immunoassays, receptor binding assays, scintillation proximity assays, non-radioactive proximity assays, and other methods are also provided.
摘要翻译：提供了具有包含至少一个数据存储单元的具有可远程寻址或远程可编程记录设备的矩阵材料的具有存储器的组合。基质材料是在固相化学和生物化学合成，免疫测定和杂交反应中用作载体的基质材料。基质材料还可以包括荧光体或其它发光部分以产生具有记忆的发光基质。数据存储单元是非易失性反熔丝存储器或易失性存储器，例如EEPROMS，DRAMS或闪存。通过这种组合，可以通过用识别信息对存储器进行编程来标记与基质组合接近或物理接触的分子和生物颗粒，例如噬菌体和病毒颗粒和细胞，并且可以通过检索存储的信息。还提供了基质材料，记忆和连接分子和生物材料的组合。这些组合具有多种应用，包括组合化学，目标大分子的分离和纯化，用于分析目的的大分子的捕获和检测，污染物的选择性去除，酶催化，细胞分选，药物递送，化学修饰和其它用途。还提供了用于电子标记分子，生物颗粒和基质支持材料的方法，免疫测定，受体结合测定，闪烁亲近测定，非放射性邻近测定和其它方法。

2. 发明授权

US07935659B2 Multiplexed assays using encoded solid supports 失效
标题翻译：使用编码的固体支持物的多重测定
公开(公告)号：US07935659B2
公开(公告)日：2011-05-03
申请号：US11011452
申请日：2004-12-14
申请人： Michael P. Nova , Andrew E. Senyei , Zahra Parandoosh , Gary S. David , Xiao-Yi Xiao
发明人： Michael P. Nova , Andrew E. Senyei , Zahra Parandoosh , Gary S. David , Xiao-Yi Xiao
IPC分类号： C40B50/16 , C40B50/18
CPC分类号： C40B30/04 , B01J19/0046 , B01J2219/00295 , B01J2219/00299 , B01J2219/00308 , B01J2219/00333 , B01J2219/00344 , B01J2219/00461 , B01J2219/00463 , B01J2219/005 , B01J2219/00502 , B01J2219/0054 , B01J2219/00542 , B01J2219/00547 , B01J2219/00549 , B01J2219/00551 , B01J2219/0056 , B01J2219/00563 , B01J2219/00567 , B01J2219/00569 , B01J2219/00585 , B01J2219/0059 , B01J2219/00592 , B01J2219/00596 , B01J2219/00689 , B01J2219/00695 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , B01L3/5027 , B01L3/502707 , B01L2300/0609 , B82Y10/00 , C07K1/00 , C07K1/04 , C07K1/047 , C40B40/06 , C40B40/10 , C40B60/08 , C40B60/14 , C40B70/00 , G01N35/00732 , G01N35/00871 , G01N2015/149 , G01N2035/00782 , G11C13/0014 , G11C13/0019 , G11C13/025
摘要： Combinations, called matrices with memories, of matrix materials with remotely addressable or remotely programmable recording devices that contain at least one data storage unit are provided. The matrix materials are those that are used in as supports in solid phase chemical and biochemical syntheses, immunoassays and hybridization reactions. The matrix materials may additionally include fluophors or other luminescent moieties to produce luminescing matrices with memories. The data storage units are non-volatile antifuse memories or volatile memories, such as EEPROMS, DRAMS or flash memory. By virtue of this combination, molecules and biological particles, such as phage and viral particles and cells, that are in proximity or in physical contact with the matrix combination can be labeled by programming the memory with identifying information and can be identified by retrieving the stored information. Combinations of matrix materials, memories, and linked molecules and biological materials are also provided. The combinations have a multiplicity of applications, including combinatorial chemistry, isolation and purification of target macromolecules, capture and detection of macromolecules for analytical purposes, selective removal of contaminants, enzymatic catalysis, cell sorting, drug delivery, chemical modification and other uses. Methods for electronically tagging molecules, biological particles and matrix support materials, immunoassays, receptor binding assays, scintillation proximity assays, non-radioactive proximity assays, and other methods are also provided.
摘要翻译：提供了具有包含至少一个数据存储单元的具有可远程寻址或远程可编程记录设备的矩阵材料的具有存储器的组合。基质材料是在固相化学和生物化学合成，免疫测定和杂交反应中用作载体的基质材料。基质材料还可以包括荧光体或其它发光部分以产生具有记忆的发光基质。数据存储单元是非易失性反熔丝存储器或易失性存储器，例如EEPROMS，DRAMS或闪存。通过这种组合，可以通过用识别信息对存储器进行编程来标记与基质组合接近或物理接触的分子和生物颗粒，例如噬菌体和病毒颗粒和细胞，并且可以通过检索存储的信息。还提供了基质材料，记忆和连接分子和生物材料的组合。这些组合具有多种应用，包括组合化学，目标大分子的分离和纯化，用于分析目的的大分子的捕获和检测，污染物的选择性去除，酶催化，细胞分选，药物递送，化学修饰和其它用途。还提供了用于电子标记分子，生物颗粒和基质支持材料的方法，免疫测定，受体结合测定，闪烁亲近测定，非放射性邻近测定和其它方法。

3. 发明授权

US6025129A Remotely programmable matrices with memories and uses thereof 失效
标题翻译：具有存储器及其用途的远程可编程矩阵
公开(公告)号：US6025129A
公开(公告)日：2000-02-15
申请号：US567746
申请日：1995-12-05
申请人： Michael P. Nova , Andrew E. Senyei , Zahra Parandoosh , Gary S. David
发明人： Michael P. Nova , Andrew E. Senyei , Zahra Parandoosh , Gary S. David
IPC分类号： B01J19/00 , B01L3/00 , C07K1/00 , C07K1/04 , C40B40/06 , C40B40/10 , C40B60/14 , C40B70/00 , G01N15/14 , G01N35/00 , G11C13/02 , C12Q1/68 , C07H21/04 , C12P19/34 , G01N33/53
CPC分类号： G11C13/0014 , B01J19/0046 , B82Y10/00 , C07K1/00 , C07K1/04 , C07K1/047 , G01N35/00732 , G01N35/00871 , G11C13/0019 , B01J2219/00295 , B01J2219/00299 , B01J2219/00308 , B01J2219/00333 , B01J2219/00344 , B01J2219/00461 , B01J2219/00463 , B01J2219/005 , B01J2219/00502 , B01J2219/0054 , B01J2219/00542 , B01J2219/00547 , B01J2219/00549 , B01J2219/00551 , B01J2219/0056 , B01J2219/00563 , B01J2219/00567 , B01J2219/00569 , B01J2219/00585 , B01J2219/0059 , B01J2219/00592 , B01J2219/00596 , B01J2219/00689 , B01J2219/00695 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , B01L2300/0609 , C40B40/06 , C40B40/10 , C40B60/14 , C40B70/00 , G01N2015/149 , G01N2035/00782 , G11C13/025
摘要： Combinations, called matrices with memories, of matrix materials with remotely addressable or remotely programmable recording devices that contain at least one data storage unit are provided. The matrix materials are those that are used in as supports in solid phase chemical and biochemical syntheses, immunoassays and hybridization reactions. The matrix materials may additionally include fluophors or other luminescent moieties to produce luminescing matrices with memories. The data storage units are non-volatile antifuse memories or volatile memories, such as EEPROMS, DRAMS or flash memory. By virtue of this combination, molecules and biological particles, such as phage and viral particles and cells, that are in proximity or in physical contact with the matrix combination can be labeled by programming the memory with identifying information and can be identified by retrieving the stored information. Combinations of matrix materials, memories, and linked molecules and biological materials are also provided. The combinations have a multiplicity of applications, including combinatorial chemistry, isolation and purification of target macromolecules, capture and detection of macromolecules for analytical purposes, selective removal of contaminants, enzymatic catalysis, cell sorting, drug delivery, chemical modification and other uses. Methods for electronically tagging molecules, biological particles and matrix support materials, immunoassays, receptor binding assays, scintillation proximity assays, non-radioactive proximity assays, and other methods are also provided.
摘要翻译：提供了具有包含至少一个数据存储单元的具有可远程寻址或远程可编程记录设备的矩阵材料的具有存储器的组合。基质材料是在固相化学和生物化学合成，免疫测定和杂交反应中用作载体的基质材料。基质材料还可以包括荧光体或其它发光部分以产生具有记忆的发光基质。数据存储单元是非易失性反熔丝存储器或易失性存储器，例如EEPROMS，DRAMS或闪存。通过这种组合，可以通过用识别信息对存储器进行编程来标记与基质组合接近或物理接触的分子和生物颗粒，例如噬菌体和病毒颗粒和细胞，并且可以通过检索存储的信息。还提供了基质材料，记忆和连接分子和生物材料的组合。这些组合具有多种应用，包括组合化学，目标大分子的分离和纯化，用于分析目的的大分子的捕获和检测，污染物的选择性去除，酶催化，细胞分选，药物递送，化学修饰和其它用途。还提供了用于电子标记分子，生物颗粒和基质支持材料的方法，免疫测定，受体结合测定，闪烁亲近测定，非放射性邻近测定和其它方法。

4. 发明授权

US5972639A Fluorescence-based assays for measuring cell proliferation 失效
标题翻译：用于测量细胞增殖的基于荧光的测定
公开(公告)号：US5972639A
公开(公告)日：1999-10-26
申请号：US901229
申请日：1997-07-24
申请人： Zahra Parandoosh
发明人： Zahra Parandoosh
IPC分类号： C12Q1/42 , C12Q1/02
CPC分类号： C12Q1/42 , C12Q2334/00
摘要： A method is for determining the number of cells in cell culture is provided. In practicing the method, the cells are lysed and incubated at about 18.degree. C. to 25.degree. C. at acid pH with a benzothiazole substrate for a sufficient time to generate detectable fluorescence that is proportional to cell number, and then measuring fluorescence. The method is highly sensitive and can detect small differences or changes in cell number. Thus, the method can be used in drug screening assays. An automated high throughput screening assay for identifying compounds that modulate angiogenesis using the method is also provided.
摘要翻译：一种用于确定提供细胞培养物中的细胞数量的方法。在实施该方法时，将细胞裂解并在酸性pH下用苯并噻唑底物在约18℃至25℃温育足够的时间以产生与细胞数成正比的可检测的荧光，然后测量荧光。该方法高度敏感，可以检测细胞数量的小差异或变化。因此，该方法可用于药物筛选测定。还提供了用于鉴定使用该方法调节血管发生的化合物的自动化高通量筛选测定法。

5. 发明授权

US08219327B2 Multiplexed assay using encoded solid support matrices 失效
标题翻译：使用编码固体支持基质的多重测定
公开(公告)号：US08219327B2
公开(公告)日：2012-07-10
申请号：US13099198
申请日：2011-05-02
申请人： Michael P. Nova , Andrew E. Senyei , Zahra Parandoosh , Gary S. David , Xiao-Yi Xiao
发明人： Michael P. Nova , Andrew E. Senyei , Zahra Parandoosh , Gary S. David , Xiao-Yi Xiao
IPC分类号： G01N33/48 , G01N33/50 , G01N31/00 , C12Q1/00
CPC分类号： C40B30/04 , B01J19/0046 , B01J2219/00295 , B01J2219/00299 , B01J2219/00308 , B01J2219/00333 , B01J2219/00344 , B01J2219/00461 , B01J2219/00463 , B01J2219/005 , B01J2219/00502 , B01J2219/0054 , B01J2219/00542 , B01J2219/00547 , B01J2219/00549 , B01J2219/00551 , B01J2219/0056 , B01J2219/00563 , B01J2219/00567 , B01J2219/00569 , B01J2219/00585 , B01J2219/0059 , B01J2219/00592 , B01J2219/00596 , B01J2219/00689 , B01J2219/00695 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , B01L3/5027 , B01L3/502707 , B01L2300/0609 , B82Y10/00 , C07K1/00 , C07K1/04 , C07K1/047 , C40B40/06 , C40B40/10 , C40B60/08 , C40B60/14 , C40B70/00 , G01N35/00732 , G01N35/00871 , G01N2015/149 , G01N2035/00782 , G11C13/0014 , G11C13/0019 , G11C13/025
摘要： In a multiplexed assay, each molecule of a plurality of molecules is attached to a support matrix with a substrate adapted for attachment and/or synthesis of molecules and an integrally-formed memory device with an optically-encoded identifier to uniquely identify the molecule attached to the substrate. The molecules are exposed to one or more processing conditions then placed within the path of an optical detector adapted to read the optically-encoded identifier and measure biochemical processes on each support matrix. The support matrices may besingulated to be read by the optical detector one at a time.
摘要翻译：在多重分析中，多个分子的每个分子连接到具有适于附着和/或合成分子的底物的支持基质和具有光学编码标识符的整体形成的存储器件，以唯一地识别附着于底物。分子暴露于一个或多个处理条件，然后放置在适于读取光学编码标识符并测量每个支撑矩阵上的生物化学过程的光学检测器的路径内。支撑矩阵可以一次一个地被光学检测器读取。

6. 发明申请

US20090226891A2 ENCODED SOLID SUPPORTS FOR BIOLOGICAL PROCESSING AND ASSAYS USING SAME 失效
标题翻译：用于生物加工的编码固体支持和使用相同的测定
公开(公告)号：US20090226891A2
公开(公告)日：2009-09-10
申请号：US11011452
申请日：2004-12-14
申请人： Michael Nova , Andrew Senyei , Zahra Parandoosh , Gary David , Xiao-Yi Xiao
发明人： Michael Nova , Andrew Senyei , Zahra Parandoosh , Gary David , Xiao-Yi Xiao
IPC分类号： C12Q1/68 , G01N33/53 , G06F19/00 , C12M3/00
CPC分类号： C40B30/04 , B01J19/0046 , B01J2219/00295 , B01J2219/00299 , B01J2219/00308 , B01J2219/00333 , B01J2219/00344 , B01J2219/00461 , B01J2219/00463 , B01J2219/005 , B01J2219/00502 , B01J2219/0054 , B01J2219/00542 , B01J2219/00547 , B01J2219/00549 , B01J2219/00551 , B01J2219/0056 , B01J2219/00563 , B01J2219/00567 , B01J2219/00569 , B01J2219/00585 , B01J2219/0059 , B01J2219/00592 , B01J2219/00596 , B01J2219/00689 , B01J2219/00695 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , B01L3/5027 , B01L3/502707 , B01L2300/0609 , B82Y10/00 , C07K1/00 , C07K1/04 , C07K1/047 , C40B40/06 , C40B40/10 , C40B60/08 , C40B60/14 , C40B70/00 , G01N35/00732 , G01N35/00871 , G01N2015/149 , G01N2035/00782 , G11C13/0014 , G11C13/0019 , G11C13/025
摘要： Combinations, called matrices with memories, of matrix materials with remotely addressable or remotely programmable recording devices that contain at least one data storage unit are provided. The matrix materials are those that are used in as supports in solid phase chemical and biochemical syntheses, immunoassays and hybridization reactions. The matrix materials may additionally include fluophors or other luminescent moieties to produce luminescing matrices with memories. The data storage units are non-volatile antifuse memories or volatile memories, such as EEPROMS, DRAMS or flash memory. By virtue of this combination, molecules and biological particles, such as phage and viral particles and cells, that are in proximity or in physical contact with the matrix combination can be labeled by programming the memory with identifying information and can be identified by retrieving the stored information. Combinations of matrix materials, memories, and linked molecules and biological materials are also provided. The combinations have a multiplicity of applications, including combinatorial chemistry, isolation and purification of target macromolecules, capture and detection of macromolecules for analytical purposes, selective removal of contaminants, enzymatic catalysis, cell sorting, drug delivery, chemical modification and other uses. Methods for electronically tagging molecules, biological particles and matrix support materials, immunoassays, receptor binding assays, scintillation proximity assays, non-radioactive proximity assays, and other methods are also provided.
摘要翻译：提供了具有包含至少一个数据存储单元的具有可远程寻址或远程可编程记录设备的矩阵材料的具有存储器的组合。基质材料是在固相化学和生物化学合成，免疫测定和杂交反应中用作载体的基质材料。基质材料还可以包括荧光体或其它发光部分以产生具有记忆的发光基质。数据存储单元是非易失性反熔丝存储器或易失性存储器，例如EEPROMS，DRAMS或闪存。通过这种组合，可以通过用识别信息对存储器进行编程来标记与基质组合接近或物理接触的分子和生物颗粒，例如噬菌体和病毒颗粒和细胞，并且可以通过检索存储的信息。还提供了基质材料，记忆和连接分子和生物材料的组合。这些组合具有多种应用，包括组合化学，目标大分子的分离和纯化，用于分析目的的大分子的捕获和检测，污染物的选择性去除，酶催化，细胞分选，药物递送，化学修饰和其它用途。还提供了用于电子标记分子，生物颗粒和基质支持材料的方法，免疫测定，受体结合测定，闪烁亲近测定，非放射性邻近测定和其它方法。

7. 发明授权

US06319668B1 Method for tagging and screening molecules 失效
标题翻译：标记和筛选分子的方法
公开(公告)号：US06319668B1
公开(公告)日：2001-11-20
申请号：US08669252
申请日：1996-06-24
申请人： Michael P. Nova , Hanan Potash , Xiao-Yi Xiao , Zahra Parandoosh , Gary S. David
发明人： Michael P. Nova , Hanan Potash , Xiao-Yi Xiao , Zahra Parandoosh , Gary S. David
IPC分类号： C12Q168
CPC分类号： G11C13/0019 , B01J19/0046 , B01J2219/00295 , B01J2219/00299 , B01J2219/00308 , B01J2219/00333 , B01J2219/00344 , B01J2219/00461 , B01J2219/00463 , B01J2219/005 , B01J2219/00502 , B01J2219/0054 , B01J2219/00542 , B01J2219/00547 , B01J2219/00549 , B01J2219/00551 , B01J2219/0056 , B01J2219/00563 , B01J2219/00567 , B01J2219/00569 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00689 , B01J2219/00695 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , B01L3/50825 , B01L3/5453 , B01L2300/022 , B01L2300/024 , B01L2300/0609 , B82Y10/00 , C07K1/00 , C07K1/04 , C07K1/047 , C40B40/06 , C40B40/10 , C40B60/14 , C40B70/00 , G01N35/00732 , G01N35/00871 , G01N2015/149 , G01N2035/00782 , G11C13/0014 , G11C13/025
摘要： Combinations, called matrices with memories, of matrix materials that are encoded with an optically readable code are provided. The matrix materials are those that are used in as supports in solid phase chemical and biochemical syntheses, immunoassays and hybridization reactions. The matrix materials may additionally include fluophors or other luminescent moieties to produce luminescing matrices with memories. The memories include electronic and optical storage media and also include optical memories, such as bar codes and other machine-readable codes. By virtue of this combination, molecules and biological particles, such as phage and viral particles and cells, that are in proximity or in physical contact with the matrix combination can be labeled by programming the memory with identifying information and can be identified by retrieving the stored information. Combinations of matrix materials, memories, and linked molecules and biological materials are also provided. The combinations have a multiplicity of applications, including combinatorial chemistry, isolation and purification of target macromolecules, capture and detection of macromolecules for analytical purposes, selective removal of contaminants, enzymatic catalysis, cell sorting, drug delivery, chemical modification and other uses. Methods for tagging molecules, biological particles and matrix support materials, immunoassays, receptor binding assays, scintillation proximity assays, non-radioactive proximity assays, and other methods are also provided.
摘要翻译：提供了用光学可读代码编码的矩阵材料的组合，称为具有存储器的矩阵。基质材料是在固相化学和生物化学合成，免疫测定和杂交反应中用作载体的基质材料。基质材料还可以包括荧光体或其它发光部分以产生具有记忆的发光基质。存储器包括电子和光学存储介质，并且还包括诸如条形码和其他机器可读代码的光学存储器。通过这种组合，可以通过用识别信息对存储器进行编程来标记与基质组合接近或物理接触的分子和生物颗粒，例如噬菌体和病毒颗粒和细胞，并且可以通过检索存储的信息。还提供了基质材料，记忆和连接分子和生物材料的组合。这些组合具有多种应用，包括组合化学，目标大分子的分离和纯化，用于分析目的的大分子的捕获和检测，污染物的选择性去除，酶催化，细胞分选，药物递送，化学修饰和其它用途。还提供了用于标记分子，生物颗粒和基质支持材料的方法，免疫测定，受体结合测定，闪烁亲和测定，非放射性邻近测定和其它方法。

8. 发明授权

US06306975B1 Radiation-grafted solid supports for chemical synthesis 失效
标题翻译：用于化学合成的辐射接枝固体载体
公开(公告)号：US06306975B1
公开(公告)日：2001-10-23
申请号：US09010951
申请日：1998-01-22
申请人： Chanfeng Zhao , John E. Lillig , Robert Neeper , Gordon W. Hudson , Anthony W. Czarnik , Zahra Parandoosh , Gary S. David , Xiao-Yi Xiao
发明人： Chanfeng Zhao , John E. Lillig , Robert Neeper , Gordon W. Hudson , Anthony W. Czarnik , Zahra Parandoosh , Gary S. David , Xiao-Yi Xiao
IPC分类号： C08F25900
CPC分类号： G01N33/54393 , B01J19/0046 , B01J2219/00283 , B01J2219/00295 , B01J2219/00299 , B01J2219/00308 , B01J2219/0031 , B01J2219/00313 , B01J2219/00319 , B01J2219/00344 , B01J2219/00454 , B01J2219/00461 , B01J2219/00463 , B01J2219/005 , B01J2219/00542 , B01J2219/00547 , B01J2219/00567 , B01J2219/00585 , B01J2219/0059 , B01J2219/00592 , B01J2219/00596 , B01J2219/00689 , B01J2219/00691 , B01J2219/00695 , B01L2300/0609 , B82Y10/00 , C07K1/047 , C08J7/16 , C08J2327/12 , C40B50/14 , C40B60/14 , C40B70/00 , G01N33/542 , G01N33/54353 , G01N2015/149 , G11C13/0014 , G11C13/0019 , G11C13/025 , G11C2213/81
摘要： Methods for irradiation induced graft polymerization of a monomers, such as styrenes, onto fluoropolymers are provided. The methods, which involve either the use of acids, preferably mineral acids, or creating a rough surface on the fluoropolymer, provide higher levels of grafting of the copolymer than grafting in the absence of the acid or of the rough surface on the fluoropolymer. Also provided are grafted copolymers produced by the methods. Methods for increasing the performance of solid phase assays, such as scintillation proximity assays, are also provided.
摘要翻译：提供了将单体（如苯乙烯）接枝聚合到含氟聚合物上的辐射诱导方法。涉及使用酸，优选无机酸，或在含氟聚合物上形成粗糙表面的方法提供了比在氟聚合物上不存在酸或粗糙表面时接枝更高水平的共聚物接枝。还提供了通过该方法制备的接枝共聚物。还提供了用于增加固相测定的性能的方法，例如闪烁亲近测定法。

9. 发明授权

US06017496A Matrices with memories and uses thereof 失效
公开(公告)号：US06017496A
公开(公告)日：2000-01-25
申请号：US709435
申请日：1996-09-06
申请人： Michael P. Nova , Zahra Parandoosh , Andrew E. Senyei , Xiao-Yi Xiao , Gary S. David , Yozo Satoda , Chanfeng Zhao , Hanan Potash
发明人： Michael P. Nova , Zahra Parandoosh , Andrew E. Senyei , Xiao-Yi Xiao , Gary S. David , Yozo Satoda , Chanfeng Zhao , Hanan Potash
IPC分类号： B01J19/00 , B01L3/00 , C07B61/00 , C07H21/00 , C07K1/00 , C07K1/04 , C40B40/06 , C40B40/10 , C40B60/14 , C40B70/00 , G01N15/14 , G01N35/00 , G11C13/02 , G01N15/06 , G01N33/48 , G01N35/02 , G01N35/04
CPC分类号： G11C13/0019 , B01J19/0046 , B01L3/50825 , B01L3/5453 , B82Y10/00 , C07H21/00 , C07K1/00 , C07K1/04 , C07K1/047 , G01N35/00732 , G01N35/00871 , G11C13/0014 , B01J2219/00283 , B01J2219/00295 , B01J2219/00299 , B01J2219/00308 , B01J2219/00333 , B01J2219/00344 , B01J2219/00461 , B01J2219/00463 , B01J2219/005 , B01J2219/00502 , B01J2219/0054 , B01J2219/00542 , B01J2219/00547 , B01J2219/00549 , B01J2219/00551 , B01J2219/00554 , B01J2219/0056 , B01J2219/00563 , B01J2219/00567 , B01J2219/00569 , B01J2219/00585 , B01J2219/0059 , B01J2219/00592 , B01J2219/00596 , B01J2219/00689 , B01J2219/00695 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , B01L2300/022 , B01L2300/0609 , C40B40/06 , C40B40/10 , C40B60/14 , C40B70/00 , G01N2015/149 , G01N2035/00782 , G01N2333/9121 , G01N2500/00 , G11C13/025
摘要： Combinations, called matrices with memories, of matrix materials that are encoded with an optically readable code are provided. The matrix materials are those that are used in as supports in solid phase chemical and biochemical syntheses, immunoassays and hybridization reactions. The matrix materials may additionally include fluophors or other luminescent moieties to produce luminescing matrices with memories. The memories include electronic and optical storage media and also include optical memories, such as bar codes and other machine-readable codes. By virtue of this combination, molecules and biological particles, such as phage and viral particles and cells, that are in proximity or in physical contact with the matrix combination can be labeled by programming the memory with identifying information and can be identified by retrieving the stored information. Combinations of matrix materials, memories, and linked molecules and biological materials are also provided. The combinations have a multiplicity of applications, including combinatorial chemistry, isolation and purification of target macromolecules, capture and detection of macromolecules for analytical purposes, selective removal of contaminants, enzymatic catalysis, cell sorting, drug delivery, chemical modification and other uses. Methods for tagging molecules, biological particles and matrix support materials, immunoassays, receptor binding assays, scintillation proximity assays, non-radioactive proximity assays, and other methods are also provided.

10. 发明申请

US20120238466A1 Multiplexed Assay Using Encoded Solid Support Matrices 审中-公开
标题翻译：使用编码固体支持矩阵的复用测定
公开(公告)号：US20120238466A1
公开(公告)日：2012-09-20
申请号：US13478689
申请日：2012-05-23
申请人： Michael P. Nova , Andrew E. Senyei , Zahra Parandoosh , Gary S. David , Xiao-Yi Xiao
发明人： Michael P. Nova , Andrew E. Senyei , Zahra Parandoosh , Gary S. David , Xiao-Yi Xiao
IPC分类号： C40B30/04
CPC分类号： C40B30/04 , B01J19/0046 , B01J2219/00295 , B01J2219/00299 , B01J2219/00308 , B01J2219/00333 , B01J2219/00344 , B01J2219/00461 , B01J2219/00463 , B01J2219/005 , B01J2219/00502 , B01J2219/0054 , B01J2219/00542 , B01J2219/00547 , B01J2219/00549 , B01J2219/00551 , B01J2219/0056 , B01J2219/00563 , B01J2219/00567 , B01J2219/00569 , B01J2219/00585 , B01J2219/0059 , B01J2219/00592 , B01J2219/00596 , B01J2219/00689 , B01J2219/00695 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , B01L3/5027 , B01L3/502707 , B01L2300/0609 , B82Y10/00 , C07K1/00 , C07K1/04 , C07K1/047 , C40B40/06 , C40B40/10 , C40B60/08 , C40B60/14 , C40B70/00 , G01N35/00732 , G01N35/00871 , G01N2015/149 , G01N2035/00782 , G11C13/0014 , G11C13/0019 , G11C13/025
摘要： In a multiplexed assay, each molecule of a plurality of molecules is attached to a support matrix with a substrate adapted for attachment and/or synthesis of molecules and an integrally-formed memory device with an optically-encoded identifier to uniquely identify the molecule attached to the substrate. The molecules are exposed to one or more processing conditions then placed within the path of an optical detector adapted to read the optically-encoded identifier and measure biochemical processes on each support matrix. The support matrices may be singulated to be read by the optical detector one at a time.
摘要翻译：在多重分析中，多个分子的每个分子连接到具有适于附着和/或合成分子的底物的支持基质和具有光学编码标识符的整体形成的存储器件，以唯一地识别附着于底物。分子暴露于一个或多个处理条件，然后放置在适于读取光学编码标识符并测量每个支撑矩阵上的生物化学过程的光学检测器的路径内。支持矩阵可以一次被光学检测器单独读取。

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