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1. 发明授权

US06017496A Matrices with memories and uses thereof 失效
公开(公告)号：US06017496A
公开(公告)日：2000-01-25
申请号：US709435
申请日：1996-09-06
申请人： Michael P. Nova , Zahra Parandoosh , Andrew E. Senyei , Xiao-Yi Xiao , Gary S. David , Yozo Satoda , Chanfeng Zhao , Hanan Potash
发明人： Michael P. Nova , Zahra Parandoosh , Andrew E. Senyei , Xiao-Yi Xiao , Gary S. David , Yozo Satoda , Chanfeng Zhao , Hanan Potash
IPC分类号： B01J19/00 , B01L3/00 , C07B61/00 , C07H21/00 , C07K1/00 , C07K1/04 , C40B40/06 , C40B40/10 , C40B60/14 , C40B70/00 , G01N15/14 , G01N35/00 , G11C13/02 , G01N15/06 , G01N33/48 , G01N35/02 , G01N35/04
CPC分类号： G11C13/0019 , B01J19/0046 , B01L3/50825 , B01L3/5453 , B82Y10/00 , C07H21/00 , C07K1/00 , C07K1/04 , C07K1/047 , G01N35/00732 , G01N35/00871 , G11C13/0014 , B01J2219/00283 , B01J2219/00295 , B01J2219/00299 , B01J2219/00308 , B01J2219/00333 , B01J2219/00344 , B01J2219/00461 , B01J2219/00463 , B01J2219/005 , B01J2219/00502 , B01J2219/0054 , B01J2219/00542 , B01J2219/00547 , B01J2219/00549 , B01J2219/00551 , B01J2219/00554 , B01J2219/0056 , B01J2219/00563 , B01J2219/00567 , B01J2219/00569 , B01J2219/00585 , B01J2219/0059 , B01J2219/00592 , B01J2219/00596 , B01J2219/00689 , B01J2219/00695 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , B01L2300/022 , B01L2300/0609 , C40B40/06 , C40B40/10 , C40B60/14 , C40B70/00 , G01N2015/149 , G01N2035/00782 , G01N2333/9121 , G01N2500/00 , G11C13/025
摘要： Combinations, called matrices with memories, of matrix materials that are encoded with an optically readable code are provided. The matrix materials are those that are used in as supports in solid phase chemical and biochemical syntheses, immunoassays and hybridization reactions. The matrix materials may additionally include fluophors or other luminescent moieties to produce luminescing matrices with memories. The memories include electronic and optical storage media and also include optical memories, such as bar codes and other machine-readable codes. By virtue of this combination, molecules and biological particles, such as phage and viral particles and cells, that are in proximity or in physical contact with the matrix combination can be labeled by programming the memory with identifying information and can be identified by retrieving the stored information. Combinations of matrix materials, memories, and linked molecules and biological materials are also provided. The combinations have a multiplicity of applications, including combinatorial chemistry, isolation and purification of target macromolecules, capture and detection of macromolecules for analytical purposes, selective removal of contaminants, enzymatic catalysis, cell sorting, drug delivery, chemical modification and other uses. Methods for tagging molecules, biological particles and matrix support materials, immunoassays, receptor binding assays, scintillation proximity assays, non-radioactive proximity assays, and other methods are also provided.

2. 发明授权

US5961923A Matrices with memories and uses thereof 失效
公开(公告)号：US5961923A
公开(公告)日：1999-10-05
申请号：US723423
申请日：1996-09-30
申请人： Michael P. Nova , Zahra Parandoosh , Andrew E. Senyei , Xiao-Yi Xiao , Gary S. David , Yozo Satoda , Chanfeng Zhao , Hanan Potash
发明人： Michael P. Nova , Zahra Parandoosh , Andrew E. Senyei , Xiao-Yi Xiao , Gary S. David , Yozo Satoda , Chanfeng Zhao , Hanan Potash
IPC分类号： B01J19/00 , B01L3/00 , C07B61/00 , C07H21/00 , C07K1/00 , C07K1/04 , C40B40/06 , C40B40/10 , C40B60/14 , C40B70/00 , G01N15/14 , G01N35/00 , G11C13/02 , G01N33/48 , G01N21/01 , G01N33/544 , G06G7/58
CPC分类号： G01N35/00732 , B01J19/0046 , B01L3/50825 , B01L3/5453 , B82Y10/00 , C07H21/00 , C07K1/00 , C07K1/047 , G01N35/00871 , G11C13/0014 , G11C13/0019 , G11C13/02 , B01J2219/00283 , B01J2219/00295 , B01J2219/00299 , B01J2219/00308 , B01J2219/00333 , B01J2219/00344 , B01J2219/00461 , B01J2219/00463 , B01J2219/005 , B01J2219/00502 , B01J2219/0054 , B01J2219/00542 , B01J2219/00547 , B01J2219/00549 , B01J2219/00551 , B01J2219/00554 , B01J2219/0056 , B01J2219/00563 , B01J2219/00567 , B01J2219/00569 , B01J2219/00585 , B01J2219/0059 , B01J2219/00592 , B01J2219/00596 , B01J2219/00689 , B01J2219/00695 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , B01L2300/0609 , C40B40/06 , C40B40/10 , C40B60/14 , C40B70/00 , G01N2015/149 , G01N2035/00782 , G01N2333/9121 , G01N2500/00 , G11C13/025
摘要： Combinations, called matrices with memories, of matrix materials that are encoded with an optically readable code are provided. The matrix materials are those that are used in as supports in solid phase chemical and biochemical syntheses, immunoassays and hybridization reactions. The matrix materials may additionally include fluophors or other luminescent moieties to produce luminescing matrices with memories. The memories include electronic and optical storage media and also include optical memories, such as bar codes and other machine-readable codes. By virtue of this combination, molecules and biological particles, such as phage and viral particles and cells, that are in proximity or in physical contact with the matrix combination can be labeled by programming the memory with identifying information and can be identified by retrieving the stored information. Combinations of matrix materials, memories, and linked molecules and biological materials are also provided. The combinations have a multiplicity of applications, including combinatorial chemistry, isolation and purification of target macromolecules, capture and detection of macromolecules for analytical purposes, selective removal of contaminants, enzymatic catalysis, cell sorting, drug delivery, chemical modification and other uses. Methods for tagging molecules, biological particles and matrix support materials, immunoassays, receptor binding assays, scintillation proximity assays, non-radioactive proximity assays, and other methods are also provided.

3. 发明授权

US06284459B1 Solid support matrices with memories and combinatorial libraries therefrom 失效
标题翻译：具有存储器和组合库的固体支持矩阵
公开(公告)号：US06284459B1
公开(公告)日：2001-09-04
申请号：US08711426
申请日：1996-09-05
申请人： Michael P. Nova , Andrew E. Senyei , Xiao-Yi Xiao , Chanfeng Zhao , Hanan Potash
发明人： Michael P. Nova , Andrew E. Senyei , Xiao-Yi Xiao , Chanfeng Zhao , Hanan Potash
IPC分类号： C12Q168
CPC分类号： G11C13/0019 , B01J19/0046 , B01J2219/00295 , B01J2219/00299 , B01J2219/00308 , B01J2219/00333 , B01J2219/00344 , B01J2219/00461 , B01J2219/00463 , B01J2219/005 , B01J2219/00502 , B01J2219/0054 , B01J2219/00542 , B01J2219/00547 , B01J2219/00549 , B01J2219/00551 , B01J2219/0056 , B01J2219/00563 , B01J2219/00567 , B01J2219/00569 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00689 , B01J2219/00695 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , B01L3/50825 , B01L3/5453 , B01L2300/022 , B01L2300/024 , B01L2300/0609 , B82Y10/00 , C07H21/00 , C07K1/00 , C07K1/04 , C07K1/047 , C40B40/06 , C40B40/10 , C40B60/14 , C40B70/00 , G01N35/00732 , G01N35/00871 , G01N2015/149 , G01N2035/00782 , G01N2333/9121 , G01N2500/00 , G11C13/0014 , G11C13/025
摘要： Combinations, called matrices with memories, of matrix materials that are encoded with an optically readable code are provided. The matrix materials are those that are used in as supports in solid phase chemical and biochemical syntheses, immunoassays and hybridization reactions. The matrix materials may additionally include fluophors or other luminescent moieties to produce luminescing matrices with memories. The memories include electronic and optical storage media and also include optical memories, such as bar codes and other machine-readable codes. By virtue of this combination, molecules and biological particles, such as phage and viral particles and cells, that are in proximity or in physical contact with the matrix combination can be labeled by programming the memory with identifying information and can be identified by retrieving the stored information. Combinations of matrix materials, memories, and linked molecules and biological materials are also provided. The combinations have a multiplicity of applications, including combinatorial chemistry, isolation and purification of target macromolecules, capture and detection of macromolecules for analytical purposes, selective removal of contaminants, enzymatic catalysis, cell sorting, drug delivery, chemical modification and other uses. Methods for tagging molecules, biological particles and matrix support materials, immunoassays, receptor binding assays, scintillation proximity assays, non-radioactive proximity assays, and other methods are also provided.
摘要翻译：提供了用光学可读代码编码的矩阵材料的组合，称为具有存储器的矩阵。基质材料是在固相化学和生物化学合成，免疫测定和杂交反应中用作载体的基质材料。基质材料还可以包括荧光体或其它发光部分以产生具有记忆的发光基质。存储器包括电子和光学存储介质，并且还包括诸如条形码和其他机器可读代码的光学存储器。通过这种组合，可以通过用识别信息对存储器进行编程来标记与基质组合接近或物理接触的分子和生物颗粒，例如噬菌体和病毒颗粒和细胞，并且可以通过检索存储的信息。还提供了基质材料，记忆和连接分子和生物材料的组合。这些组合具有多种应用，包括组合化学，目标大分子的分离和纯化，用于分析目的的大分子的捕获和检测，污染物的选择性去除，酶催化，细胞分选，药物递送，化学修饰和其它用途。还提供了用于标记分子，生物颗粒和基质支持材料的方法，免疫测定，受体结合测定，闪烁亲和测定，非放射性邻近测定和其它方法。

4. 发明授权

US06319668B1 Method for tagging and screening molecules 失效
标题翻译：标记和筛选分子的方法
公开(公告)号：US06319668B1
公开(公告)日：2001-11-20
申请号：US08669252
申请日：1996-06-24
申请人： Michael P. Nova , Hanan Potash , Xiao-Yi Xiao , Zahra Parandoosh , Gary S. David
发明人： Michael P. Nova , Hanan Potash , Xiao-Yi Xiao , Zahra Parandoosh , Gary S. David
IPC分类号： C12Q168
CPC分类号： G11C13/0019 , B01J19/0046 , B01J2219/00295 , B01J2219/00299 , B01J2219/00308 , B01J2219/00333 , B01J2219/00344 , B01J2219/00461 , B01J2219/00463 , B01J2219/005 , B01J2219/00502 , B01J2219/0054 , B01J2219/00542 , B01J2219/00547 , B01J2219/00549 , B01J2219/00551 , B01J2219/0056 , B01J2219/00563 , B01J2219/00567 , B01J2219/00569 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00689 , B01J2219/00695 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , B01L3/50825 , B01L3/5453 , B01L2300/022 , B01L2300/024 , B01L2300/0609 , B82Y10/00 , C07K1/00 , C07K1/04 , C07K1/047 , C40B40/06 , C40B40/10 , C40B60/14 , C40B70/00 , G01N35/00732 , G01N35/00871 , G01N2015/149 , G01N2035/00782 , G11C13/0014 , G11C13/025
摘要： Combinations, called matrices with memories, of matrix materials that are encoded with an optically readable code are provided. The matrix materials are those that are used in as supports in solid phase chemical and biochemical syntheses, immunoassays and hybridization reactions. The matrix materials may additionally include fluophors or other luminescent moieties to produce luminescing matrices with memories. The memories include electronic and optical storage media and also include optical memories, such as bar codes and other machine-readable codes. By virtue of this combination, molecules and biological particles, such as phage and viral particles and cells, that are in proximity or in physical contact with the matrix combination can be labeled by programming the memory with identifying information and can be identified by retrieving the stored information. Combinations of matrix materials, memories, and linked molecules and biological materials are also provided. The combinations have a multiplicity of applications, including combinatorial chemistry, isolation and purification of target macromolecules, capture and detection of macromolecules for analytical purposes, selective removal of contaminants, enzymatic catalysis, cell sorting, drug delivery, chemical modification and other uses. Methods for tagging molecules, biological particles and matrix support materials, immunoassays, receptor binding assays, scintillation proximity assays, non-radioactive proximity assays, and other methods are also provided.
摘要翻译：提供了用光学可读代码编码的矩阵材料的组合，称为具有存储器的矩阵。基质材料是在固相化学和生物化学合成，免疫测定和杂交反应中用作载体的基质材料。基质材料还可以包括荧光体或其它发光部分以产生具有记忆的发光基质。存储器包括电子和光学存储介质，并且还包括诸如条形码和其他机器可读代码的光学存储器。通过这种组合，可以通过用识别信息对存储器进行编程来标记与基质组合接近或物理接触的分子和生物颗粒，例如噬菌体和病毒颗粒和细胞，并且可以通过检索存储的信息。还提供了基质材料，记忆和连接分子和生物材料的组合。这些组合具有多种应用，包括组合化学，目标大分子的分离和纯化，用于分析目的的大分子的捕获和检测，污染物的选择性去除，酶催化，细胞分选，药物递送，化学修饰和其它用途。还提供了用于标记分子，生物颗粒和基质支持材料的方法，免疫测定，受体结合测定，闪烁亲和测定，非放射性邻近测定和其它方法。

5. 发明授权

US06329139B1 Automated sorting system for matrices with memory 失效
标题翻译：具有存储器的矩阵的自动排序系统
公开(公告)号：US06329139B1
公开(公告)日：2001-12-11
申请号：US08912998
申请日：1997-08-11
申请人： Michael P. Nova , John E. Lillig , Kanchana Sanjaya Gunesekera Karunaratne , William Ewing , Yozo Satoda , Hanan Potash
发明人： Michael P. Nova , John E. Lillig , Kanchana Sanjaya Gunesekera Karunaratne , William Ewing , Yozo Satoda , Hanan Potash
IPC分类号： C12Q168
CPC分类号： G11C13/0019 , B01J19/0046 , B01J2219/00283 , B01J2219/00295 , B01J2219/00299 , B01J2219/00308 , B01J2219/0031 , B01J2219/00313 , B01J2219/00319 , B01J2219/00333 , B01J2219/00344 , B01J2219/00454 , B01J2219/00461 , B01J2219/00463 , B01J2219/005 , B01J2219/00502 , B01J2219/0054 , B01J2219/00542 , B01J2219/00547 , B01J2219/00549 , B01J2219/00551 , B01J2219/00554 , B01J2219/0056 , B01J2219/00563 , B01J2219/00567 , B01J2219/00569 , B01J2219/00585 , B01J2219/0059 , B01J2219/00592 , B01J2219/00596 , B01J2219/00689 , B01J2219/00691 , B01J2219/00695 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , B01L3/50255 , B01L3/50825 , B01L3/5453 , B01L2300/022 , B01L2300/0609 , B01L2400/0655 , B82Y10/00 , C07H21/00 , C07K1/00 , C07K1/04 , C07K1/047 , C08J7/16 , C08J2327/12 , C40B40/06 , C40B40/10 , C40B50/14 , C40B60/14 , C40B70/00 , G01N33/542 , G01N33/54353 , G01N33/54393 , G01N35/00732 , G01N35/00871 , G01N2015/149 , G01N2035/00782 , G01N2333/9121 , G01N2500/00 , G11C13/0014 , G11C13/025 , G11C2213/81
摘要： Automated drug discovery protocols, or partially automated protocols, in which matrices with memories serve as the platform on which all manipulations are performed or serve as the repository of information that is transferred to other memories as the synthesized compounds are processed and screened. Also provided are automated drug discovery units for use in the protocols. The units provide a means for seamless data tracking and include instrumentation and vials with memories for information transfer to other memories in a unit. The units, which are provided herein, include some or all of the following: an automated or manual sorter, microvessels, which contain memories, an automated or semi-automated synthesizer, a microvessel washer/dryer, a manual or automated cleaver for removing compounds from the matrix with memory microvessels, and associated software. The memories may be any of any type, including electromagnetically encodable memories and optical memories, or combinations thereof. The memories may be pre-encoded or may be encodabie during, after or before processing. Also provided are manual and automated methods for sorting matrices with memories.
摘要翻译：自动药物发现协议或部分自动化协议，其中具有记忆的矩阵作为执行所有操作的平台，或者当作为合成化合物被处理和筛选时被传送到其他存储器的信息库。还提供了用于协议的自动化药物发现单元。这些单元为无缝数据跟踪提供了一种手段，其中包括仪器和样品瓶，用于将信息传输到单元中的其他存储器。这里提供的单元包括以下部分或全部：自动或手动分拣机，包含记忆的微血管，自动或半自动合成器，微血清洗涤器/干燥器，用于去除化合物的手动或自动切割器从具有记忆微血管的矩阵和相关联的软件。存储器可以是任何类型的存储器，包括电磁编码存储器和光存储器，或其组合。存储器可以被预编码，或者可以在处理期间，之后或之前编码。还提供了用于使用存储器排序矩阵的手动和自动化方法。

6. 发明授权

US6100026A Matrices with memories and uses thereof 失效
标题翻译：具有记忆和使用的矩阵
公开(公告)号：US6100026A
公开(公告)日：2000-08-08
申请号：US633410
申请日：1996-06-10
申请人： Michael P. Nova , Andrew E. Senyei , Hanan Potash
发明人： Michael P. Nova , Andrew E. Senyei , Hanan Potash
IPC分类号： B01J19/00 , B01L3/00 , C07K1/00 , C07K1/04 , C40B40/06 , C40B40/10 , C40B60/14 , C40B70/00 , G01N15/14 , G01N35/00 , G11C13/02 , C12Q1/68 , C12M1/00 , G01N15/06 , G01N33/53
CPC分类号： G11C13/0019 , B01J19/0046 , B01L3/5453 , B82Y10/00 , C07K1/00 , C07K1/04 , C07K1/047 , G01N35/00732 , G01N35/00871 , G11C13/0014 , B01J2219/00295 , B01J2219/00299 , B01J2219/00308 , B01J2219/00333 , B01J2219/00344 , B01J2219/00461 , B01J2219/00463 , B01J2219/005 , B01J2219/00502 , B01J2219/0054 , B01J2219/00542 , B01J2219/00547 , B01J2219/00549 , B01J2219/00551 , B01J2219/0056 , B01J2219/00563 , B01J2219/00567 , B01J2219/00569 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00689 , B01J2219/00695 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , B01L2300/022 , B01L2300/024 , B01L2300/0609 , C40B40/06 , C40B40/10 , C40B60/14 , C40B70/00 , G01N2015/149 , G01N2035/00782 , G11C13/025
摘要： Combinations, called matrices with memories, of matrix materials that are encoded with an optically readable code are provided. The matrix materials are those that are used in as supports in solid phase chemical and biochemical syntheses, immunoassays and hybridization reactions. The matrix materials may additionally include fluophors or other luminescent moieties to produce luminescing matrices with memories. The memories include electronic and optical storage media and also include optical memories, such as bar codes and other machine-readable codes. By virtue of this combination, molecules and biological particles, such as phage and viral particles and cells, that are in proximity or in physical contact with the matrix combination can be labeled by programming the memory with identifying information and can be identified by retrieving the stored information. Combinations of matrix materials, memories, and linked molecules and biological materials are also provided. The combinations have a multiplicity of applications, including combinatorial chemistry, isolation and purification of target macromolecules, capture and detection of macromolecules for analytical purposes, selective removal of contaminants, enzymatic catalysis, cell sorting, drug delivery, chemical modification and other uses. Methods for tagging molecules, biological particles and matrix support materials, immunoassays, receptor binding assays, scintillation proximity assays, non-radioactive proximity assays, and other methods are also provided.
摘要翻译：提供了用光学可读代码编码的矩阵材料的组合，称为具有存储器的矩阵。基质材料是在固相化学和生物化学合成，免疫测定和杂交反应中用作载体的基质材料。基质材料还可以包括荧光体或其它发光部分以产生具有记忆的发光基质。存储器包括电子和光学存储介质，并且还包括诸如条形码和其他机器可读代码的光学存储器。通过这种组合，可以通过用识别信息对存储器进行编程来标记与基质组合接近或物理接触的分子和生物颗粒，例如噬菌体和病毒颗粒和细胞，并且可以通过检索存储的信息。还提供了基质材料，记忆和连接分子和生物材料的组合。这些组合具有多种应用，包括组合化学，目标大分子的分离和纯化，用于分析目的的大分子的捕获和检测，污染物的选择性去除，酶催化，细胞分选，药物递送，化学修饰和其它用途。还提供了用于标记分子，生物颗粒和基质支持材料的方法，免疫测定，受体结合测定，闪烁亲和测定，非放射性邻近测定和其它方法。

7. 发明授权

US06340588B1 Matrices with memories 失效
标题翻译：有记忆的矩阵
公开(公告)号：US06340588B1
公开(公告)日：2002-01-22
申请号：US09051022
申请日：1998-09-22
申请人： Michael P. Nova , Hanan Potash
发明人： Michael P. Nova , Hanan Potash
IPC分类号： C12M134
CPC分类号： G11C13/0019 , B01J19/0046 , B01J2219/00283 , B01J2219/00295 , B01J2219/00299 , B01J2219/00308 , B01J2219/00333 , B01J2219/00344 , B01J2219/00461 , B01J2219/00463 , B01J2219/005 , B01J2219/00502 , B01J2219/0054 , B01J2219/00542 , B01J2219/00547 , B01J2219/00549 , B01J2219/00551 , B01J2219/00554 , B01J2219/0056 , B01J2219/00563 , B01J2219/00567 , B01J2219/00569 , B01J2219/00585 , B01J2219/0059 , B01J2219/00592 , B01J2219/00596 , B01J2219/00689 , B01J2219/00695 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , B01L3/5027 , B01L3/502761 , B01L3/50825 , B01L2300/0609 , B82Y10/00 , C07H21/00 , C07K1/00 , C07K1/04 , C07K1/047 , C40B40/06 , C40B40/10 , C40B60/14 , C40B70/00 , G01N35/00732 , G01N35/00871 , G01N2015/149 , G01N2035/00782 , G01N2333/9121 , G01N2500/00 , G11C13/0014 , G11C13/025
摘要： Combinations, called matrices with memories, of matrix materials that are encoded with an optically readable code are provided. The matrix materials are those that are used in as supports in solid phase chemical and biochemical syntheses, immunoassays and hybridization reactions. The matrix materials may additionally include fluophors or other luminescent moieties to produce luminescing matrices with memories. The memories include electronic and optical storage media and also include optical memories, such as bar codes and other machine-readable codes. By virtue of this combination, molecules and biological particles, such as phage and viral particles and cells, that are in proximity or in physical contact with the matrix combination can be labeled by programming the memory with identifying information and can be identified by retrieving the stored information. Combinations of matrix materials, memories, and linked molecules and biological materials are also provided. The combinations have a multiplicity of applications, including combinatorial chemistry, isolation and purification of target macromolecules, capture and detection of macromolecules for analytical purposes, selective removal of contaminants, enzymatic catalysis, cell sorting, sensors and drug delivery, chemical modification and other uses. Methods for tagging molecules, biological particles and matrix support materials, immunoassays, receptor binding assays, scintillation proximity assays, non-radioactive proximity assays, and other methods are also provided. Sensors containing a memory in combination with a matrix are also provided.
摘要翻译：提供了用光学可读代码编码的矩阵材料的组合，称为具有存储器的矩阵。基质材料是在固相化学和生物化学合成，免疫测定和杂交反应中用作载体的基质材料。基质材料还可以包括荧光体或其它发光部分以产生具有记忆的发光基质。存储器包括电子和光学存储介质，并且还包括诸如条形码和其他机器可读代码的光学存储器。通过这种组合，可以通过用识别信息对存储器进行编程来标记与基质组合接近或物理接触的分子和生物颗粒，例如噬菌体和病毒颗粒和细胞，并且可以通过检索存储的信息。还提供了基质材料，记忆和连接分子和生物材料的组合。这些组合具有多种应用，包括组合化学，目标大分子的分离和纯化，用于分析目的的大分子的捕获和检测，污染物的选择性去除，酶催化，细胞分选，传感器和药物递送，化学修饰和其它用途。还提供了用于标记分子，生物颗粒和基质支持材料的方法，免疫测定，受体结合测定，闪烁亲和测定，非放射性邻近测定和其它方法。还提供了包含与基质结合的记忆体的传感器。

8. 发明申请

US20170083449A1 PROCESSOR WITH LOGICAL MENTOR 审中-公开
公开(公告)号：US20170083449A1
公开(公告)日：2017-03-23
申请号：US14863041
申请日：2015-09-23
申请人： Hanan Potash
发明人： Hanan Potash
IPC分类号： G06F12/10
CPC分类号： G06F12/10 , G06F8/41 , G06F9/00 , G06F9/34 , G06F9/4488 , G06F2212/65
摘要： A computing device includes a memory structure storing one or more Variables; and a logical mentor. The logical mentor is assigned to at least one of the one or more Variables and performs addressing operations with respect to the Variables to which it is assigned. In an embodiment, a method of computing includes storing one or more Variables in the memory of a computing device, assigning a logical mentor to the Variables; and performing, by the logical mentor, addressing operations with respect to the Variables.

9. 发明授权

US4777615A Backplane structure for a computer superpositioning scalar and vector operations 失效
标题翻译：用于计算机的背板结构叠加标量和矢量操作
公开(公告)号：US4777615A
公开(公告)日：1988-10-11
申请号：US834942
申请日：1986-02-28
申请人： Hanan Potash
发明人： Hanan Potash
IPC分类号： G06F1/16 , G06F1/18 , G06F13/40 , H05K1/14 , H05K7/14
CPC分类号： H05K1/14 , G06F13/409 , H05K7/1445
摘要： A backplane structure for a computer includes first and second spaced apart backplane sections each having a series of spaced, vertical connector assemblies for receiving edge connectors of a series of parallel spaced apart circuit boards in a vertical orientation. Spaced bus lines run horizontally across each backplane section for interconnecting appropriate pins of the respective circuit board connectors. One of the backplane sections receives circuit boards of the memory section of a computer, and the other section receives the computer functional unit boards. A third backplane section extends between the first and second sections and has a series of spaced horizontal connector assemblies for receiving connector edges of a series of circuit boards in a horizontal orientation. At least some of the horizontal connector assemblies receive circuit boards of the buffer section of a computer. Each horizontal buffer board connector assembly is connected at each end to a respective selected portion of the bus lines of the first and second backplane sections, respectively, so a connected buffer board can act as a bridge between these sections.
摘要翻译：用于计算机的背板结构包括第一和第二间隔开的背板部分，每个底板部分具有一系列间隔开的垂直连接器组件，用于在垂直方向上接收一系列平行隔开的电路板的边缘连接器。间距的总线横跨每个背板部分水平运行，用于互连相应电路板连接器的相应引脚。背板部分之一接收计算机的存储器部分的电路板，另一部分接收计算机功能单元板。第三背板部分在第一和第二部分之间延伸并且具有一系列间隔开的水平连接器组件，用于在水平方向上接收一系列电路板的连接器边缘。至少一些水平连接器组件接收计算机的缓冲部分的电路板。每个水平缓冲板连接器组件在每一端分别连接到第一和第二背板部分的总线的相应选定部分，因此连接的缓冲板可以用作这些部分之间的桥梁。

10. 发明授权

US4538241A Address translation buffer 失效
标题翻译：地址转换缓冲区
公开(公告)号：US4538241A
公开(公告)日：1985-08-27
申请号：US513660
申请日：1983-07-14
申请人： Burton L. Levin , Andrew E. Phelps , Hanan Potash
发明人： Burton L. Levin , Andrew E. Phelps , Hanan Potash
IPC分类号： G06F12/10 , G06F13/00
CPC分类号： G06F12/1027
摘要： An apparatus is disclosed that translates virtual memory addresses into physical memory addresses. In particular, this apparatus comprises a plurality of rows of content addressable memory cells, a corresponding plurality of random access memory cells and another corresponding plurality of control circuits. The content addressable memory cells store the virtual memory addresses and the random access memory cells store the physical memory addresses. The control circuits are coupled to both the content addressable and the random access memory cells and are disposed for controlling the operation of the apparatus.
摘要翻译：公开了将虚拟存储器地址转换为物理存储器地址的装置。特别地，该装置包括多行内容可寻址存储单元，相应的多个随机存取存储单元和另一对应的多个控制电路。内容可寻址存储器单元存储虚拟存储器地址，并且随机存取存储器单元存储物理存储器地址。控制电路耦合到内容可寻址存储单元和随机存取存储单元两者，并被设置用于控制设备的操作。

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