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1. 发明申请

WO03017917A2 USE OF MICROBIOLOGY NON-VIRAL SUBSTANCES FOR TREATING ACNE 审中-公开
标题翻译：分子生物学生产的非病毒制剂治疗痤疮的治疗
公开(公告)号：WO03017917A2
公开(公告)日：2003-03-06
申请号：PCT/EP0209452
申请日：2002-08-23
申请人： ZOUBOULIS CHRISTOS C , RINA TECHNOLOGIEN GMBH
发明人： ZOUBOULIS CHRISTOS C
IPC分类号： A61K38/00 , A61P17/10 , C12N15/113 , A61K
CPC分类号： C12N15/1137 , A61K38/00 , C12N15/1138 , C12N2310/315 , C12N2310/321 , C12Y103/99005 , C12N2310/3521
摘要： The invention relates to the use of at least one microbiologically produced non-viral substance (anti-sense-oligonucleotides, ribozymes, stabilised ribozymes, aptamers, reverse-image aptamers, chimeric RNA/DNA oligonucleotides, naked plasmid DNA, liposmally encapsulated DNA), especially anti-sense oligonucleotides with specificity for a nucleic acid-target sequence of the gene which codes steroid hormone-receptors and/or steroid hormone-metabolised enzymes, especially for the androgen receptor and/or 5 alpha reductase, in the treatment of acne and acneic dermatoses including acne rosacea. Special anti-sense oligonucleotides and degenerated sequences of said oligonucleotides are preferably selected and introduced into the target cells by liposome-mediated transfection, especially human sebocytes and/or keratinocytes. A specific inhibition of the androgen-induced, specially testerone induced stimulation of the proliferation sebocytes or keratinocytes by the above mentioned anti-sense oligonucleotides was noted and evaluated in said target cells. The inventive effects were proven, for example, by virtue of sebocyte-cell line SZ95 and primary keratinocytes of the skin.
摘要翻译：它是利用至少一种分子生物学制备的非病毒活性成分的（反义寡核苷酸，核酶，稳定的核酶，适体，Spiegelaptamere，嵌合RNA / DNA寡核苷酸，裸质粒DNA，脂质体包裹的DNA），尤其是反义寡核苷酸具有特异性负责类固醇激素受体和/或类固醇激素代谢酶的基因的为雄激素受体和/或5编码α还原酶，用于治疗痤疮和痤疮皮肤病包括，红斑痤疮的核酸靶序列，特别是描述。为了这个目的，优选地特异性反义寡核苷酸和简并序列从这些被选择并优选被引入通过脂质体介导的转染到靶细胞，特别是人类皮脂细胞和/或角质形成细胞。在这些靶细胞，雄激素诱导的，特别是通过所描述的反义寡核苷酸或角质形成细胞增殖皮脂细胞的睾酮诱导的刺激的特异性抑制指出并进行评价。本发明的反应已经通过例子参照细胞系SZ95皮脂腺细胞和皮肤的原代角化细胞的方法证明。

2. 发明专利

DE10141443A1 未知
公开(公告)号：DE10141443A1
公开(公告)日：2003-03-13
申请号：DE10141443
申请日：2001-08-23
申请人： ZOUBOULIS CHRISTOS C , RINA TECHNOLOGIEN GMBH
发明人： ZOUBOULIS CHRISTOS C
IPC分类号： A61K38/00 , A61P17/10 , C12N15/113 , A61K48/00
摘要： The invention relates to the use of at least one microbiologically produced non-viral substance (anti-sense-oligonucleotides, ribozymes, stabilised ribozymes, aptamers, reverse-image aptamers, chimeric RNA/DNA oligonucleotides, naked plasmid DNA, liposmally encapsulated DNA), especially anti-sense oligonucleotides with specificity for a nucleic acid-target sequence of the gene which codes steroid hormone-receptors and/or steroid hormone-metabolised enzymes, especially for the androgen receptor and/or 5 alpha reductase, in the treatment of acne and acneic dermatoses including acne rosacea. Special anti-sense oligonucleotides and degenerated sequences of said oligonucleotides are preferably selected and introduced into the target cells by liposome-mediated transfection, especially human sebocytes and/or keratinocytes. A specific inhibition of the androgen-induced, specially testerone induced stimulation of the proliferation sebocytes or keratinocytes by the above mentioned anti-sense oligonucleotides was noted and evaluated in said target cells. The inventive effects were proven, for example, by virtue of sebocyte-cell line SZ95 and primary keratinocytes of the skin.

3. 发明申请

WO2014068092A3 METHOD FOR DETERMINING AGE INDEPENDENTLY OF SEX 审中-公开
标题翻译：独立测定老化的方法
公开(公告)号：WO2014068092A3
公开(公告)日：2014-06-26
申请号：PCT/EP2013072878
申请日：2013-11-01
申请人： MAKRANTONAKI EUGENIA , ZOUBOULIS CHRISTOS C
发明人： MAKRANTONAKI EUGENIA , ZOUBOULIS CHRISTOS C , ADJAYE JAMES
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6876 , C12Q2600/124 , C12Q2600/158 , C12Q2600/16 , G01N33/6881
摘要： The invention relates to a method for determining the aging condition of a subject. The method makes it possible to make conclusions about the age of a subject and conditions of the subject associated with the age - including independently of the sex - on the basis of certain nucleic acids or proteins and the expression level thereof. The invention further relates to a group of genes, the expression level of which depends on the aging condition of the particular subject - including independently of the sex. The invention further relates to the determination of the expression level of the genes and the use of the corresponding expression levels to determine aging conditions. The invention further relates to devices, in particular arrays and chips, that can be used to determine the aging condition of a subject.
摘要翻译：本发明涉及用于确定对象老化状态的方法。该方法允许从特定的核酸或蛋白质和有关主体的年龄和老年人相关的国家他们的表达水平的结论开始 - 画 - 即使是不分性别的。本发明还涉及一组基因，其表达水平取决于各个受试者的衰老状态，而不管性别如何。此外，本发明涉及确定基因的表达水平和使用相应的表达水平来测定老化条件。本发明还涉及可用于确定对象老化状态的装置，特别是阵列和芯片。

5. 发明专利

DE10211555A1 未知
公开(公告)号：DE10211555A1
公开(公告)日：2003-10-02
申请号：DE10211555
申请日：2002-03-15
申请人： IMTM INST FUER MEDIZINTECHNOLO , ANSORGE SIEGFRIED , GOLLNICK HARALD , NEUBERT KLAUS , ZOUBOULIS CHRISTOS C
发明人： ANSORGE SIEGFRIED , NEUBERT KLAUS , FAUST JUERGEN , REINHOLD DIRK , GOLLNICK HARALD , ZOUBOULIS CHRISTOS C , LENDECKEL UWE , VETTER ROBERT
IPC分类号： C12N9/99 , A61K31/195 , A61K31/40 , A61K31/426 , A61K31/4453 , A61K38/55 , A61K45/00 , A61P17/00 , A61P17/08 , A61P17/10 , A61P17/14 , A61P35/00 , A61P43/00 , A61K38/05
摘要： The invention relates to a process for the-inhibition of the DNA synthesis necessary for the proliferation of human sebaceous cells (sebocytes) by the isolated or joint effect of inhibitors of alanyl aminopeptidase (APN) and dipetidyl peptidase IV (DP IV) expressed by these cells. The DNA synthesis (proliferation) of human sebaceous cells is inhibited by the administration of the inhibitors of APN and/or of DP IV depending on the dose. Our invention shows that, for a therapy and for a prevention of dermatological diseases with sebaceous hyperproliferation and modified conditions of differentiation, the application of inhibitors of the above-mentioned enzymes and of corresponding pharmaceutical preparations and dosage forms thereof is suitable.

6. 发明专利

DE102012110469A1 Verfahren zur geschlechtsunabhängigen Bestimmung von Alterung 未知
公开(公告)号：DE102012110469A1
公开(公告)日：2014-05-08
申请号：DE102012110469
申请日：2012-11-01
申请人： MAKRANTONAKI EUGENIA , ZOUBOULIS CHRISTOS C
发明人： MAKRANTONAKI EUGENIA , ZOUBOULIS CHRISTOS C , ADJAYE JAMES
IPC分类号： C12Q1/68
摘要： Die vorliegende Erfindung bezieht sich auf ein Verfahren zur Bestimmung des Alterungszustandes eines Subjekts. Das Verfahren erlaubt es, ausgehend von bestimmten Nukleinsäuren oder Proteinen und deren Expressionslevel Rückschlüsse auf das Alter und mit dem Alter verbundene Zustände eines Subjektes – auch unabhängig vom Geschlecht – zu ziehen. Die vorliegende Erfindung betrifft außerdem eine Gruppe von Genen, deren Expressionslevel vom Alterungszustand des jeweiligen Subjekts – auch unabhängig vom Geschlecht – abhängt. Darüber hinaus betrifft die Erfindung die Bestimmung des Expressionslevels der Gene sowie die Benutzung der entsprechenden Expressionslevel zur Bestimmung von Alterungszuständen. Diese Erfindung betrifft auch Vorrichtungen, insbesondere Arrays und Chips, die zur Bestimmung des Alterungszustandes eines Subjekts eingesetzt werden können

7. 发明专利

AU2003214105B2 Use of enzyme inhibitors with aminopeptidase N and/or dipeptidylpeptidase IV activities and pharmaceutical preparations produced therefrom for the therapy and prevention of dermatological diseases with seborrhoeic hyperproliferation and altered differentiation states 未知
公开(公告)号：AU2003214105B2
公开(公告)日：2008-11-13
申请号：AU2003214105
申请日：2003-03-07
申请人： ANSORGE SIEGFRIED , GOLLNICK HARALD , IMTM GMBH , NEUBERT KLAUS , ZOUBOULIS CHRISTOS C
发明人： NEUBERT KLAUS , VETTER ROBERT , ANSORGE SIEGFRIED , REINHOLD DIRK , ZOUBOULIS CHRISTOS C , LENDECKEL UWE , GOLLNICK HARALD , FAUST JURGEN
IPC分类号： C12N9/99 , A61K31/195 , A61K31/40 , A61K31/426 , A61K31/4453 , A61K38/55 , A61K45/00 , A61P17/00 , A61P17/08 , A61P17/10 , A61P17/14 , A61P35/00 , A61P43/00
摘要： The invention relates to a process for the-inhibition of the DNA synthesis necessary for the proliferation of human sebaceous cells (sebocytes) by the isolated or joint effect of inhibitors of alanyl aminopeptidase (APN) and dipetidyl peptidase IV (DP IV) expressed by these cells. The DNA synthesis (proliferation) of human sebaceous cells is inhibited by the administration of the inhibitors of APN and/or of DP IV depending on the dose. Our invention shows that, for a therapy and for a prevention of dermatological diseases with sebaceous hyperproliferation and modified conditions of differentiation, the application of inhibitors of the above-mentioned enzymes and of corresponding pharmaceutical preparations and dosage forms thereof is suitable.

8. 发明专利

EA008745B1 ПРИМЕНЕНИЕ ИНГИБИТОРОВ ФЕРМЕНТОВ С АКТИВНОСТЬЮ АМИНОПЕПТИДАЗЫ N И/ИЛИ ДИПЕПТИДИЛПЕПТИДАЗЫ IV И ФАРМАЦЕВТИЧЕСКИЕ КОМПОЗИЦИИ НА ИХ ОСНОВЕ ДЛЯ ЛЕЧЕНИЯ И ПРОФИЛАКТИКИ ДЕРМАТОЛОГИЧЕСКИХ ЗАБОЛЕВАНИЙ С СЕБОЦИТАРНОЙ ГИПЕРПРОЛИФЕРАЦИЕЙ И ИЗМЕНЕННЫМИ ДИФФЕРЕНЦИРОВАННЫМИ СОСТОЯНИЯМИ 未知
公开(公告)号：EA008745B1
公开(公告)日：2007-08-31
申请号：EA200401212
申请日：2003-03-07
申请人： IMTM GMBH , ANSORGE SIEGFRIED , GOLLNICK HARALD , NEUBERT KLAUS , ZOUBOULIS CHRISTOS C
发明人： ANSORGE SIEGFRIED , GOLLNICK HARALD , NEUBERT KLAUS , ZOUBOULIS CHRISTOS C , FAUST JURGEN , LENDECKEL UWE , REINHOLD DIRK , VETTER ROBERT
IPC分类号： A61K38/05 , C12N9/99 , A61K31/195 , A61K31/40 , A61K31/426 , A61K31/4453 , A61K38/55 , A61K45/00 , A61P17/00 , A61P17/08 , A61P17/10 , A61P17/14 , A61P35/00 , A61P43/00
摘要： ИзобретениекасаетсяспособаподавлениясинтезаДНКсебоцитовчеловека, необходимогодляпролиферации, посредствомотдельногоилисовместногодействияингибитороваланиламинопептидазы (APN) идипептидилпептидазы IV (DP IV), экспрессированныхв этихклетках. СинтезДНК (пролиферация) себоцитовчеловекаподавляетсяпутемвведенияингибиторов APN или/и DP IV взависимостиотдозы. Данноеизобретениепредлагаетдлялеченияи профилактикидерматологическихзаболеванийс себоцитарнойпролиферациейи измененнымидифференцированнымисостояниямиприменениеингибитороввышеназванныхферментовилисоответствующихкомпозицийи препаративныхготовыхформнаихоснове.

9. 发明专利

AU2003214105A1 USE OF ENZYME INHIBITORS WITH AMINOPEPTIDASE N AND/OR DIPEPTIDYLPEPTIDASE IV ACTIVITIES AND PHARMACEUTICAL PREPARATIONS PRODUCED THEREFROM FOR THE THERAPY AND PREVENTION OF DERMATOLOGICAL DISEASES WITH SEBORRHOEIC HYPERPROLIFERATION AND ALTERED DIFFERENTIATION STATES 未知
公开(公告)号：AU2003214105A1
公开(公告)日：2003-09-29
申请号：AU2003214105
申请日：2003-03-07
申请人： IMTM INST FUR MEDIZINTECHNOLOG , ANSORGE SIEGFRIED , GOLLNICK HARALD , NEUBERT KLAUS , ZOUBOULIS CHRISTOS C
发明人： ANSORGE SIEGFRIED , GOLLNICK HARALD , NEUBERT KLAUS , ZOUBOULIS CHRISTOS C , FAUST JURGEN , LENDECKEL UWE , REINHOLD DIRK , VETTER ROBERT
IPC分类号： C12N9/99 , A61K31/195 , A61K31/40 , A61K31/426 , A61K31/4453 , A61K38/55 , A61K45/00 , A61P17/00 , A61P17/08 , A61P17/10 , A61P17/14 , A61P35/00 , A61P43/00 , A61K38/05
摘要： The invention relates to a process for the-inhibition of the DNA synthesis necessary for the proliferation of human sebaceous cells (sebocytes) by the isolated or joint effect of inhibitors of alanyl aminopeptidase (APN) and dipetidyl peptidase IV (DP IV) expressed by these cells. The DNA synthesis (proliferation) of human sebaceous cells is inhibited by the administration of the inhibitors of APN and/or of DP IV depending on the dose. Our invention shows that, for a therapy and for a prevention of dermatological diseases with sebaceous hyperproliferation and modified conditions of differentiation, the application of inhibitors of the above-mentioned enzymes and of corresponding pharmaceutical preparations and dosage forms thereof is suitable.

10. 发明专利

CA2445634C ACNE TREATMENT COMPRISING LIPOXYGENASE INHIBITORS 未知
公开(公告)号：CA2445634C
公开(公告)日：2013-02-12
申请号：CA2445634
申请日：2002-04-29
申请人： ZOUBOULIS CHRISTOS C
发明人： ZOUBOULIS CHRISTOS C
IPC分类号： A61K31/381 , C07D333/58 , A61K8/49 , A61K31/07 , A61K31/203 , A61K31/56 , A61K45/00 , A61K45/06 , A61P17/00 , A61P17/10 , A61P43/00 , A61Q19/02 , C07J63/00
摘要： The invention relates to the use of lipoxygenase inhibitors such as zileuton, for treating acne, particularly inflammatory acne. The inventive lipoxygenase inhibitor can be used alone or in combination with other lipoxygenase inhibitors or anti-acne active agents in a pharmaceutically suitable composition, particularly through oral and/or local-topic application.

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