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1. 发明申请

WO2012151736A1 MARKER CONSISTING OF PLASMA MICRORNA AND NEW METHOD FOR DIAGNOSIS OF HEPATOCELLULAR CARCINOMA 审中-公开
标题翻译：血浆微血管标记标记及肝细胞癌诊断新方法
公开(公告)号：WO2012151736A1
公开(公告)日：2012-11-15
申请号：PCT/CN2011/073774
申请日：2011-05-06
申请人： ZHONGSHAN HOSPITAL FUDAN UNIVERSITY , FAN, Jia , ZHOU, Jian , DAI, Zhi , YU, Lei , HU, Jie , WANG, Zheng
发明人： FAN, Jia , ZHOU, Jian , DAI, Zhi , YU, Lei , HU, Jie , WANG, Zheng
IPC分类号： C12Q1/68 , G01N33/48 , C12N15/113
CPC分类号： C12Q1/6886 , C12Q2600/16 , C12Q2600/178
摘要： The present invention relates to a marker for diagnosing hepatocellular carcinoma consisting of plasma microRNA, a kit containing the same, and a new method thereof. The marker for diagnosing hepatocellular carcinoma consists of a plurality of nucleic acid molecules, each nucleic acid molecule encoding at least one microRNA sequence, preferably consists of nucleic acid molecules encoding hsa-miR-122, hsa-miR-192, hsa-miR-21, hsa-miR-223, hsa-miR-26a, hsa-miR-27a, hsa-miR-801 and hsa-miR-1228. The kit can be used for diagnosing hepatocellular carcinoma, especially early hepatocellular carcinoma, and also for discriminating plasma of at least one hepatocellular carcinoma patient from that of at least one healthy individual, at least one chronic hepatitis B patient, or at least one cirrhosis patient.
摘要翻译：本发明涉及用于诊断由血浆微小RNA组成的肝细胞癌的标记物，含有该微血管小RNA的试剂盒及其新方法。用于诊断肝细胞癌的标记物由多个核酸分子组成，每个核酸分子编码至少一个microRNA序列，优选由编码hsa-miR-122，hsa-miR-192，hsa-miR-21的核酸分子组成，hsa-miR-223，hsa-miR-26a，hsa-miR-27a，hsa-miR-801和hsa-miR-1228。该试剂盒可用于诊断肝细胞癌，特别是早期肝细胞癌，并且还用于区分至少一种肝细胞癌患者的血浆与至少一个健康个体，至少一种慢性乙型肝炎患者或至少一种肝硬化患者的血浆。

2. 发明公开

EP2596136A1 MARKER CONSISTING OF PLASMA MICRORNA AND NEW METHOD FOR DIAGNOSIS OF HEPATOCELLULAR CARCINOMA 有权
标题翻译：血浆微RNA标记与肝细胞癌的诊断新方法
公开(公告)号：EP2596136A1
公开(公告)日：2013-05-29
申请号：EP11865138.9
申请日：2011-05-06
申请人： Zhongshan Hospital Fudan University
发明人： FAN, Jia , ZHOU, Jian , DAI, Zhi , YU, Lei , HU, Jie , WANG, Zheng
IPC分类号： C12Q1/68 , G01N33/48 , C12N15/113
CPC分类号： C12Q1/6886 , C12Q2600/16 , C12Q2600/178
摘要： The present invention relates to a kit for diagnosing hepatocellular carcinoma consisting of plasma microRNA, a kit containing the same, and a new method therefor. The marker for diagnosing hepatocellular carcinoma consists of a plurality of nucleic acid molecules, each nucleic acid molecule encoding at least one microRNA sequence, preferably consists of nucleic acid molecules encoding hsa-miR-122, hsa-miR-192, hsa-miR-21, hsa-miR-223, hsa-miR-26a, hsa-miR-27a, hsa-miR-801 and hsa-miR-1228. The kit can be used for diagnosing hepatocellular carcinoma, especially early hepatocellular carcinoma, and also for discriminating plasma of at least one hepatocellular carcinoma patient from that of at east one healthy individual, at east one chronic hepatitis B patient, or at east one cirrhosis patient.

3. 发明授权

EP2596136B1 MARKER CONSISTING OF PLASMA MICRORNA AND NEW METHOD FOR DIAGNOSIS OF HEPATOCELLULAR CARCINOMA 有权
标题翻译：血浆微RNA标记与肝细胞癌的诊断新方法
公开(公告)号：EP2596136B1
公开(公告)日：2014-07-16
申请号：EP11865138.9
申请日：2011-05-06
申请人： Zhongshan Hospital Fudan University
发明人： FAN, Jia , ZHOU, Jian , DAI, Zhi , YU, Lei , HU, Jie , WANG, Zheng
IPC分类号： C12Q1/68 , G01N33/48 , C12N15/113
CPC分类号： C12Q1/6886 , C12Q2600/16 , C12Q2600/178

4. 发明申请

WO2010062688A2 DOSAGE FORM FOR INSERTION INTO THE MOUTH 审中-公开
标题翻译：用于插入入口的剂型
公开(公告)号：WO2010062688A2
公开(公告)日：2010-06-03
申请号：PCT/US2009/062776
申请日：2009-10-30
申请人： NAL PHARMACEUTICALS LTD. , RYOO, Je, Phil , CHU, Chun, Kwong , WANG, Zheng
发明人： RYOO, Je, Phil , CHU, Chun, Kwong , WANG, Zheng
IPC分类号： A61K9/20 , A61K9/00 , A61K47/26 , A61K47/32 , A61K31/404 , A61K31/403
CPC分类号： A61K9/7015 , A61K9/0056 , A61K9/006 , A61K9/0095 , A61K9/2018 , A61K9/2027 , A61K9/7007 , A61K31/00 , A61K31/192 , A61K31/196 , A61K31/4045 , A61K31/4196 , A61K31/421 , A61K31/422 , A61K31/4439 , A61K31/445 , A61K31/4468 , A61K31/465 , A61K31/495 , A61K31/55 , A61K31/78 , A61K38/05 , A61K38/06 , A61K47/26 , A61K47/32 , A61K47/36 , A61K47/38 , A61K2300/00
摘要： Oral dosage forms as a biodegradable, water soluble film for delivering pharmaceutically active agents, particularly anti-migraine agents to patients through insertion into the mouth of patient and methods for administering pharmaceutically active agents to patients by insertion into the mouth to provide selective uptake of said agents through the mucosa and thus avoiding the gastrointestinal tract.
摘要翻译：口服剂型作为可生物降解的水溶性薄膜，用于通过插入到患者口中向患者输送药物活性剂，特别是抗偏头痛药物，以及通过插入到口腔中向患者施用药物活性剂以提供选择性吸收所述药剂通过粘膜，从而避免胃肠道。

5. 发明申请

WO2008148111A1 INTER-DOMAIN COMMUNICATION 审中-公开
标题翻译：互联网通信
公开(公告)号：WO2008148111A1
公开(公告)日：2008-12-04
申请号：PCT/US2008/064919
申请日：2008-05-27
申请人： GOOGLE INC. , APPLETON, Benjamin Charles , MESCHKAT, Steffen , TRAN, Thai , SAH, Adam , WANG, Zheng , SCHUCK, Adam Paul , MACGILL, James Robert
发明人： APPLETON, Benjamin Charles , MESCHKAT, Steffen , TRAN, Thai , SAH, Adam , WANG, Zheng , SCHUCK, Adam Paul , MACGILL, James Robert
IPC分类号： G06Q50/00
CPC分类号： G06Q30/02 , H04L67/28
摘要： A computer-implemented method for performing inter-domain communication in a web browser includes receiving first data from a first domain at a router associated with one or more domains other than the first domain, identifying at the router the one or more domains for receiving data associated with the received data, and transmitting second data associated with the received data to the one or more domains.
摘要翻译：用于在web浏览器中执行域间通信的计算机实现的方法包括从与第一域以外的一个或多个域相关联的路由器处接收来自第一域的第一数据，在路由器处标识用于接收数据的一个或多个域与所接收的数据相关联，以及将与所接收的数据相关联的第二数据发送到所述一个或多个域。

6. 发明申请

WO2008005096A2 DETECTION OF NITRO-AND NITRATE-CONTAINING COMPOUNDS 审中-公开
标题翻译：含有硝酸和硝酸的化合物的检测
公开(公告)号：WO2008005096A2
公开(公告)日：2008-01-10
申请号：PCT/US2007/010583
申请日：2007-05-01
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , TROGLER, William, C. , SANCHEZ, Jason , TOAL, Sarah , WANG, Zheng , DUGAN, Regina, E.
发明人： TROGLER, William, C. , SANCHEZ, Jason , TOAL, Sarah , WANG, Zheng , DUGAN, Regina, E.
CPC分类号： G01N21/6428 , G01N21/77 , G01N2021/7786 , Y10T436/17 , Y10T436/173076 , Y10T436/173845
摘要： A method of the invention is a method of detecting nitramines and nitrate esters believed to be present on a sampling substrate. In the method, a sampling substrate is exposed to a first reagent that is formulated to react with nitramine- and nitrate ester-type explosives to release nitrite. The sampling substrate is then exposed to a second reagent that contains an acid to react with the nitrite and a diaminoaromatic. present in either the first or second reagent, to form a triazole that will luminesce. Another method of the invention combines this process for nitramine- and nitrate ester-based explosives detection with a technique to detect nitroaromatic-based explosives using luminescent polymers, for a three-step process for the detection of explosives in these three classes.
摘要翻译：本发明的方法是检测被认为存在于采样基质上的硝胺和硝酸酯的方法。在该方法中，将采样衬底暴露于配制成与硝胺和硝酸酯型炸药反应以释放亚硝酸盐的第一试剂。然后将采样衬底暴露于含有酸的第二试剂，以与亚硝酸盐和二氨基芳族化合物反应。存在于第一或第二试剂中，以形成将发光的三唑。本发明的另一种方法将用硝酸和硝酸酯类爆炸物检测的方法与使用发光聚合物检测基于硝基芳族化合物的爆炸物的技术结合，用于在这三类中检测爆炸物的三步法。

7. 发明申请

WO2007002264A3 BIOMARKER FOR OVARIAN CANCER: CTAP3-RELATED PROTEINS 审中-公开
公开(公告)号：WO2007002264A3
公开(公告)日：2007-01-04
申请号：PCT/US2006/024269
申请日：2006-06-21
申请人： THE JOHNS HOPKINS UNIVERSITY , CIPHERGEN BIOSYSTEMS, INC. , ZHANG, Zhen , CHAN, Daniel, W. , FUNG, Eric, Thomas , WANG, Zheng , ZHANG, Fujun
发明人： ZHANG, Zhen , CHAN, Daniel, W. , FUNG, Eric, Thomas , WANG, Zheng , ZHANG, Fujun
IPC分类号： G01N33/50 , G01N33/574
摘要： The present invention provides a protein-based biomarker that is useful in qualifying ovarian cancer status in a patient. In particular, the biomarker of this invention is useful to classify a subject sample as ovarian cancer or non-ovarian cancer. The biomarker can be detected by SELDI mass spectrometry.

8. 发明申请

WO2006060329A3 ADVANCED CURRENT CONTROL METHOD AND APPARATUS FOR A MOTOR DRIVE SYSTEM 审中-公开
公开(公告)号：WO2006060329A3
公开(公告)日：2006-06-08
申请号：PCT/US2005/042972
申请日：2005-11-29
申请人： HONEYWELL INTERNATIONAL INC. , MA, Jack , WANG, Zheng , ZHOU, George
发明人： MA, Jack , WANG, Zheng , ZHOU, George
IPC分类号： H02P23/00 , H02P27/00
摘要： An apparatus controls a power converter (115) of an AC motor drive system (100), the power converter (115) outputting multi-phase AC current to an AC motor (110). The apparatus comprises: a state selecting unit (160); and an advanced controller (300). The state selecting unit selects an operation mode, from among a plurality of operation modes, for the AC motor (110) based on system real-time operating conditions, the plurality of operation modes including a normal mode, a power interruption mode, a fault protection mode, and a powerup/down dynamic mode. The system operating conditions include DC voltage available to the power converter (115), motor load condition, and motor speed command. The advanced controller (300) controls multi-phase AC current output from the power converter (115) to the motor (110) in accordance with the operation mode selected by the state selecting unit (160). The advanced controller (300) generates a current control reference value that is based on the selected operation mode to achieve current control under various operating conditions of the motor drive system (100).

9. 发明申请

WO2006052997A1 APPARATUS AND METHODS FOR NON-REGENERATIVE AND REGENERATIVE HOT GAS DESULFURIZATION 审中-公开
标题翻译：非再生和再生热气脱硫装置及方法
公开(公告)号：WO2006052997A1
公开(公告)日：2006-05-18
申请号：PCT/US2005/040488
申请日：2005-11-08
申请人： TRUSTEES OF TUFTS COLLEGE , STEPHANOPOULOS, Maria, F. , WANG, Zheng , SAKBODIN, Mann
发明人： STEPHANOPOULOS, Maria, F. , WANG, Zheng , SAKBODIN, Mann
IPC分类号： B01D53/02 , B01D53/52
CPC分类号： H01M8/0675 , B01D53/52 , B01D53/96 , B01D2251/202 , B01D2251/204 , B01D2257/30 , B01D2259/4009 , B01J20/0207 , B01J20/0237 , B01J20/06 , B01J20/3433 , B01J20/3458 , C10K1/22 , C10K1/28 , C10K1/32 , C10L3/10
摘要： Disclosed is a doped cerium oxide sorbent that can effectively and regenerably remove H 2 S in the temperature range of about 500 °C to about 1000 °C. Regenerable sorbents (e.g., ZnO, La 2 O 3 , CeO 2 ) and methods of using them are disclosed that allow cyclic desulfurization from about 300-500 °C, 350-450 °C, and at about 400 °C. In one embodiment, the present invention relates to a method of desulfurizing fuel gas comprising passing the fuel gas through the sorbent at a space velocity wherein the sulfur compounds are adsorbed substantially on the surface of the sorbent; and regenerating the sorbent by passing a regenerating gas through the sorbent, wherein substantially all of the sulfur compounds are desorbed from the sorbent surface. In a further embodiment, the method of desulfurizing fuel gas further comprises repeating the aforementioned steps while the fuel processor is in operation. In another embodiment, the step of passing the fuel gas may be preceded by reducing the sorbent by passing a reducing gas through the sorbent. In another embodiment, the sorbent may be fully sulfided, i.e., sulfided on its surface and bulk (internally).
摘要翻译：公开了一种掺杂的氧化铈吸附剂，其可以在约500℃至约1000℃的温度范围内有效地和可再生地除去H 2 S。公开了可再生吸附剂（例如ZnO，La 2 O 3，CeO 2）及其使用方法，其允许循环脱硫约300 -500℃，350-450℃和约400℃。在一个实施方案中，本发明涉及一种使燃料气体脱硫的方法，包括使燃料气体以空间速度通过吸附剂，其中硫化合物基本上吸附在吸附剂的表面上; 以及通过使再生气体通过吸附剂来再生吸附剂，其中基本上所有的硫化合物都从吸附剂表面脱附。在另一个实施例中，燃料气体脱硫的方法还包括在燃料处理器运行时重复上述步骤。在另一个实施方案中，通过燃料气体的步骤之前可以通过使还原气体通过吸附剂来还原吸附剂。在另一个实施方案中，吸附剂可以完全硫化，即在其表面上硫化并且体积（内部）。

10. 发明申请

WO2006034318A1 POWER CONVERTER CONTROLLING APPARATUS AND METHOD PROVIDING RIDE THROUGH CAPABILITY DURING POWER INTERRUPTION IN A MOTOR DRIVE SYSTEM 审中-公开
标题翻译：电动变频器控制装置和方法在电机驱动系统中断电时通过能力提供
公开(公告)号：WO2006034318A1
公开(公告)日：2006-03-30
申请号：PCT/US2005/033759
申请日：2005-09-21
申请人： HONEYWELL INTERNATIONAL INC. , MA, Jack, Daming , WANG, Zheng , ZHOU, George, You
发明人： MA, Jack, Daming , WANG, Zheng , ZHOU, George, You
IPC分类号： H02P3/18 , H02P6/06 , H02P6/08 , H02P6/24
CPC分类号： H02P6/24 , H02P6/08 , H02P23/0004 , H02P29/025
摘要： A method of controlling a power converter (20) of a motor drive system (10) controls the power converter (20) during a first operating mode by applying a current control scheme, which sets power converter commands to control torque current flowing from the power converter (20) to the motor (30) to achieve desired motor speed; and initiates a second operating mode when power supply to the power converter (20) is interrupted. The second operating mode includes controlling negative torque current between the power converter (20) and the motor (30) so that mechanical energy from the motor (30) charges an element (58) on a power supply side of the power converter (20). The first operating mode is resumed when the input power recovers. Torque current between the power converter (20) and the motor (30) is also controlled to limit a maximum transient DC bus voltage.
摘要翻译：控制电动机驱动系统（10）的功率转换器（20）的方法通过施加电流控制方案来控制功率转换器（20），该电流控制方案设置功率转换器命令以控制从功率转换器转换器（20）到电动机（30）以实现期望的电动机速度; 并且当电力转换器（20）的电源被中断时启动第二操作模式。第二操作模式包括控制功率转换器（20）和马达（30）之间的负转矩电流，使得来自马达（30）的机械能对功率转换器（20）的电源侧的元件（58）充电，。当输入功率恢复时，第一个操作模式恢复。功率转换器（20）和电动机（30）之间的转矩电流也被控制以限制最大瞬态直流母线电压。

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