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1. 发明授权

US06495604B1 Cycloalkene derivatives, process for producing the same, and use 有权
标题翻译：环烯烃衍生物，生产方法和使用
公开(公告)号：US06495604B1
公开(公告)日：2002-12-17
申请号：US09622392
申请日：2000-08-14
申请人： Yuzo Ichimori , Masayuki Ii , Katsumi Itoh , Tomoyuki Kitazaki , Junji Yamada
发明人： Yuzo Ichimori , Masayuki Ii , Katsumi Itoh , Tomoyuki Kitazaki , Junji Yamada
IPC分类号： A61K3118
CPC分类号： C07D249/08 , C07C311/14 , C07C2601/10 , C07C2601/16 , C07C2601/18 , C07D249/06 , C07D257/04 , C07D275/06
摘要： The present invention provides a compound represented by the formula: wherein R represents an aliphatic hydrocarbon group optionally having substituents, an aromatic hydrocarbon group optionally having substituents, a heterocyclic group optionally having substituents, a group represented by the formula: OR1 (wherein R1 represents a hydrogen atom or an aliphatic hydrocarbon group optionally having substituents) or a group represented by the formula: wherein R1b represents a hydrogen atom or an aliphatic hydrocarbon group optionally having substituents, R1c is, same with or different from R1b, a hydrogen atom or an aliphatic hydrocarbon group optionally having substituents, R0 represents a hydrogen atom or an aliphatic hydrocarbon group, or R and R0 represents a bond with each other, Ar represents an aromatic hydrocarbon group optionally having substituents, and n is an integer of 1 to 4, or a salt thereof, which is a agent for preventing or treating diseases such as cardiac disease, autoimmune disease, septick shock, etc.
摘要翻译：本发明提供由下式表示的化合物：其中R表示任选具有取代基的脂族烃基，任选具有取代基的芳族烃基，任选具有取代基的杂环基，由式OR1表示的基团（其中R1表示氢原子或任选具有取代基的脂族烃基）或由下式表示的基团：其中R 1b表示氢原子或任选具有取代基的脂族烃基，R 1c与R 1b相同或不同，为氢原子或脂族任选具有取代基的烃基，R 0表示氢原子或脂族烃基，或R和R 0表示彼此的键，Ar表示任选具有取代基的芳香族烃基，n表示1〜4的整数，或者其盐，其是用于预防或治疗诸如心脏病的疾病的药剂麻疹，败血性休克等

2. 发明授权

US06407129B1 Azole compounds, their production and their use 失效
标题翻译：唑类化合物，其生产及其用途
公开(公告)号：US06407129B1
公开(公告)日：2002-06-18
申请号：US09381479
申请日：1999-09-20
申请人： Katsumi Itoh , Tomoyuki Kitazaki , Kenji Okonogi
发明人： Katsumi Itoh , Tomoyuki Kitazaki , Kenji Okonogi
IPC分类号： A61K3141
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08
摘要： A quaternized nitrogen-containing imidazol-1-yl or 1,2,4-triazol-1-yl compound wherein one of the nitrogen atoms constituting an azole ring is quaternized with a substituent capable of being eliminated in vivo and the substituent can be eliminated in vivo to be converted into an antifungal azole compound, has an improved solubility in water, can advantageously be applied to injection, has an improved internal absorption and can be expected to have a good effect for the treatment or prevention of disease.
摘要翻译：构成唑环的氮原子之一的季铵化的含氮咪唑-1-基或1,2,4-三唑-1-基化合物被能够在体内消除的取代基季铵化，并且可以消除取代基在体内被转化为抗真菌唑化合物，在水中的溶解度提高，可有利地应用于注射，具有改善的内部吸收，并且可以预期对于治疗或预防疾病具有良好的效果。

3. 发明申请

US20110184034A1 Severe sepsis preventive therapeutic agent 审中-公开
标题翻译：严重脓毒症预防治疗剂
公开(公告)号：US20110184034A1
公开(公告)日：2011-07-28
申请号：US13064526
申请日：2011-03-30
申请人： Masayuki Ii , Yuji Iizawa , Tomoyuki Kitazaki , Kazuki Kubo
发明人： Masayuki Ii , Yuji Iizawa , Tomoyuki Kitazaki , Kazuki Kubo
IPC分类号： A61K31/18 , A61K31/4192 , A61K31/41 , A61K31/428 , C07C311/21 , C07D249/06 , C07D257/04 , C07D275/03 , A61P31/00
CPC分类号： A61K31/4192 , A61K31/00 , A61K31/215 , A61K31/223 , A61K31/245 , A61K31/27 , A61K31/277 , A61K31/41 , A61K31/4196 , A61K31/428 , Y02A50/411
摘要： The present invention provides an agent for the prophylaxis or treatment of severe sepsis, which contains a compound represented by the formula (I): or, the formula (II): or a salt thereof or a prodrug thereof, a TLR signal inhibitor containing a non-peptide compound and an agent for the prophylaxis or treatment of organ dysfunction and the like, which contains a TLR signal inhibitory substance.
摘要翻译：本发明提供一种预防或治疗严重败血症的药剂，其含有式（I）表示的化合物或式（II）：或其盐或其前药，含有非肽化合物和用于预防或治疗器官功能障碍等的试剂，其含有TLR信号抑制物质。

4. 发明申请

US20060058288A1 Severe sepsis preventive therapeutic agent 审中-公开
标题翻译：严重脓毒症预防治疗剂
公开(公告)号：US20060058288A1
公开(公告)日：2006-03-16
申请号：US10510596
申请日：2003-04-07
申请人： Masayuki II , Yuji Iizawa , Tomoyuki Kitazaki , Kazuki Kubo
发明人： Masayuki II , Yuji Iizawa , Tomoyuki Kitazaki , Kazuki Kubo
IPC分类号： A61K31/54 , A61K31/18
CPC分类号： A61K31/4192 , A61K31/00 , A61K31/215 , A61K31/223 , A61K31/245 , A61K31/27 , A61K31/277 , A61K31/41 , A61K31/4196 , A61K31/428 , Y02A50/411
摘要： The present invention provides an agent for the prophylaxis or treatment of severe sepsis, which contains a compound represented by the formula (I): or, the formula (II): , or a salt thereof or a prodrug thereof, a TLR signal inhibitor containing a non-peptide compound and an agent for the prophylaxis or treatment of organ dysfunction and the like, which contains a TLR signal inhibitory substance.
摘要翻译：本发明提供一种预防或治疗严重败血症的药剂，其含有式（I）表示的化合物：

5. 发明申请

US20090209585A1 CYCLOALKENE DERIVATIVES, PROCESS FOR PRODUCTION OF THE DERIVATIVES, AND USE OF THE SAME 审中-公开
标题翻译：环己酮衍生物，生产衍生物的方法及其用途
公开(公告)号：US20090209585A1
公开(公告)日：2009-08-20
申请号：US12309080
申请日：2007-07-06
申请人： Takashi Ichikawa , Tomoyuki Kitazaki , Norikazu Tamura
发明人： Takashi Ichikawa , Tomoyuki Kitazaki , Norikazu Tamura
IPC分类号： A61K31/24 , C07C311/21 , C07D207/16 , C07D211/34 , A61K31/265 , A61K31/4015 , A61K31/445 , A61K31/27 , A61P9/00 , A61P37/00 , A61P25/00
CPC分类号： C07C311/14 , C07C2601/14 , C07C2601/16 , C07D207/16 , C07D211/34
摘要： The present invention relates to a cycloalkene derivative represented by the formula (I): wherein each symbol is as defined in the specification, a pharmaceutical agent containing the derivative, and a production method thereof. The cycloalkene derivative of the present invention has high solubility in water and is suitable for use as an injection.
摘要翻译：本发明涉及由式（I）表示的环烯烃衍生物及其制备方法：其中各符号如说明书中所定义，含有该衍生物的药剂及其制备方法。本发明的环烯衍生物在水中的溶解度高，适合用作注射剂。

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