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1. 发明申请

US20090269387A1 COMPOSITE IMPLANTS FOR PROMOTING BONE REGENERATION AND AUGMENTATION AND METHODS FOR THEIR PREPARATION AND USE 审中-公开
公开(公告)号：US20090269387A1
公开(公告)日：2009-10-29
申请号：US12432833
申请日：2009-04-30
申请人： Yuval Zubery , Arie Goldlust , Thomas Bayer , Eran Nir
发明人： Yuval Zubery , Arie Goldlust , Thomas Bayer , Eran Nir
IPC分类号： A61F2/00 , A61K35/00 , A61K35/32 , A61K35/30 , A61P19/00
CPC分类号： A61L27/56 , A61L27/48 , C08L89/06
摘要： Collagen based matrices cross-linked by a reducing sugar(s) are used for preparing composite matrices, implants and scaffolds. The composite matrices may have at least two layers including reducing sugar cross-linked collagen matrices of different densities. The composite matrices may be used in bone regeneration and/or augmentation applications. Scaffolds including glycated and/or reducing sugar cross-linked collagen exhibit improved support for cell proliferation and/or growth and/or differentiation. The denser collagen matrix of the composite matrices may have a dual effect initially functioning as a cell barrier and later functioning as an ossification supporting layer. The composite matrices, implants and scaffolds may be prepared using different collagen types and collagen mixtures and by cross-linking the collagen(s) using a reducing sugar or a mixture of reducing sugars. The composite matrices, implants and scaffolds may include additives and/or living cells.

2. 发明申请

US20080026032A1 COMPOSITE IMPLANTS FOR PROMOTING BONE REGENERATION AND AUGMENTATION AND METHODS FOR THEIR PREPARATION AND USE 审中-公开
标题翻译：用于促进骨髓再生和补充的复合植入物及其制备和使用方法
公开(公告)号：US20080026032A1
公开(公告)日：2008-01-31
申请号：US11829111
申请日：2007-07-27
申请人： Yuval ZUBERY , Arie Goldlust , Thomas Bayer , Eran Nir
发明人： Yuval ZUBERY , Arie Goldlust , Thomas Bayer , Eran Nir
IPC分类号： A61F2/00 , A61K38/00 , A61P19/00
CPC分类号： A61L27/56 , A61L27/48 , C08L89/06
摘要： Collagen based matrices cross-linked by a reducing sugar(s) are used for preparing composite matrices, implants and scaffolds. The composite matrices may have at least two layers including reducing sugar cross-linked collagen matrices of different densities. The composite matrices may be used in bone regeneration and/or augmentation applications. Scaffolds including glycated and/or reducing sugar cross-linked collagen exhibit improved support for cell proliferation and/or growth and/or differentiation. The denser collagen matrix of the composite matrices may have a dual effect initially functioning as a cell barrier and later functioning as an ossification supporting layer. The composite matrices, implants and scaffolds may be prepared using different collagen types and collagen mixtures and by cross-linking the collagen(s) using a reducing sugar or a mixture of reducing sugars. The composite matrices, implants and scaffolds may include additives and/or living cells.
摘要翻译：用还原糖交联的基于胶原的基质用于制备复合基质，植入物和支架。复合基质可以具有至少两层，包括不同密度的还原糖交联的胶原基质。复合基质可用于骨再生和/或增强应用。包括糖基化和/或还原糖交联胶原的支架显示改善的对细胞增殖和/或生长和/或分化的支持。复合基质的更密集的胶原基质可能具有起初作为细胞屏障起作用的双重作用，并且此后作为骨化支持层起作用。复合基质，植入物和支架可以使用不同的胶原类型和胶原混合物和使用还原糖或还原糖的混合物交联胶原来制备。复合基质，植入物和支架可以包括添加剂和/或活细胞。

3. 发明申请

US20070053987A1 Cross-linked polysacharide and protein matrices and methods for their preparation 审中-公开
标题翻译：交联多糖和蛋白质基质及其制备方法
公开(公告)号：US20070053987A1
公开(公告)日：2007-03-08
申请号：US11513345
申请日：2006-08-31
申请人： Thomas Bayer , Arie Goldlust
发明人： Thomas Bayer , Arie Goldlust
IPC分类号： A61K48/00 , A61K38/22 , A61K38/18 , A61K38/14 , C07H5/06 , C08B37/00 , A61K9/14
CPC分类号： A61K38/39 , A61K9/146 , A61K47/61 , A61L27/20 , C07H5/06 , C08B37/003 , C08B37/0063 , C08B37/0072 , C08B37/0075 , C08B37/0081 , C08H1/00 , C08H1/06
摘要： Methods for preparing cross-linked polysaccharide matrices by cross-linking one or more amino group containing polysaccharides or amino-functionalized polysaccharides with reducing sugars and/or reducing sugar derivatives. The resulting matrices may include polysaccharide matrices and composite cross-linked matrices including polysaccharides cross-linked with proteins and/or polypeptides. Additives and/or cells may also be included in or embedded within the matrices. Various different solvent systems and reducing sugar cross-linkers for performing the cross-linking are described. The resulting matrices exhibit various different physical, chemical and biological properties.
摘要翻译：通过用还原糖和/或还原糖衍生物交联一个或多个含氨基的多糖或氨基官能化多糖来制备交联多糖基质的方法。所得到的基质可以包括多糖基质和包含与蛋白质和/或多肽交联的多糖的复合交联基质。添加剂和/或细胞也可以包括在基质中或嵌入在基质中。描述了用于进行交联的各种不同的溶剂体系和还原糖交联剂。所得到的基质表现出各种不同的物理，化学和生物学特性。

4. 发明授权

US08961544B2 Dry composition wound dressings and adhesives comprising gelatin and transglutaminase in a cross-linked matrix 有权
标题翻译：干组合伤口敷料和包含明胶和转谷氨酰胺酶在交联基质中的粘合剂
公开(公告)号：US08961544B2
公开(公告)日：2015-02-24
申请号：US13813814
申请日：2011-08-05
申请人： Chagai Komlos , Guy Tomer , Maria Ziv , Orahn Preiss-Bloom , Thomas Bayer
发明人： Chagai Komlos , Guy Tomer , Maria Ziv , Orahn Preiss-Bloom , Thomas Bayer
IPC分类号： A61B17/08
CPC分类号： A61F2/0063 , A61L15/325 , A61L15/38 , A61L15/425 , A61L31/045 , A61L31/047 , A61L31/14
摘要： Patches comprising dry gelatin compositions.
摘要翻译：贴剂包括干明胶组合物。

5. 发明申请

US20130295095A1 MONOCLONAL ANTIBODIES TARGETING AMYLOID BETA OLIGOMERS 有权
标题翻译：单克隆抗体靶向AMYLOID BETA寡聚体
公开(公告)号：US20130295095A1
公开(公告)日：2013-11-07
申请号：US13701758
申请日：2011-06-03
申请人： Thomas Bayer , Oliver Wirths , Henrik Martens , Christian Erck
发明人： Thomas Bayer , Oliver Wirths , Henrik Martens , Christian Erck
IPC分类号： C07K16/18
CPC分类号： C07K16/18 , A61K2039/505 , C07K2317/32 , C07K2317/33 , C07K2317/76
摘要： The invention relates to binding molecules capable of specifically recognizing soluble oligomers of N-terminal truncated Aβ starting with pyroglutamate (AβρE), pharmaceutical compositions comprising same, and their respective therapeutic uses. Particularly, the invention relates to an antibody molecule capable of specifically recognizing Aβ oligomers, wherein said antibody binds and/or detects an epitope as bound and/or detected by antibody PG3-38 9D5H6 as deposited under DSM AC-C3056. Further, the invention provides a method of inhibiting the formation or the seeding effect of said AβρE oligomers, and a method for identifying agents useful in the treatment and/or prevention of an amyloid-related disorder as well as methods of diagnosing a subject suspected of suffering from a disease associated with amyloidogenesis and/or amyloid plaque formation and to methods of monitoring the efficacy of a treatment of a disease associated with amyloidogenesis and/or amyloid-plaque formation characterized by the presence of Aβ oligomers in a subject.
摘要翻译：本发明涉及能够特异性识别由焦谷氨酸（AbetarhoE）开始的N-末端截短的Abeta的可溶性低聚物，包含其的药物组合物及其各自的治疗用途的结合分子。特别地，本发明涉及能够特异性识别Aβ寡聚体的抗体分子，其中所述抗体结合和/或检测由DSM AC-C3056沉积的抗体PG3-38 9D5H6结合和/或检测的表位。此外，本发明提供抑制所述AbetarhoE寡聚体的形成或播种作用的方法，以及用于鉴定可用于治疗和/或预防淀粉样蛋白相关病症的药剂的方法以及诊断疑似患者的方法患有与淀粉样变性和/或淀粉样蛋白斑形成相关的疾病，以及监测治疗与淀粉样变性和/或淀粉样蛋白斑形成有关的疾病的功效的方法，其特征在于受试者中存在Aβ寡聚体。

6. 发明授权

US08220363B2 Bevel gear transmission 有权
标题翻译：锥齿轮传动
公开(公告)号：US08220363B2
公开(公告)日：2012-07-17
申请号：US12950675
申请日：2010-11-19
申请人： Thomas Bayer , Karl-Georg Melber , Michael Engelbreit , Thomas Wilhelm
发明人： Thomas Bayer , Karl-Georg Melber , Michael Engelbreit , Thomas Wilhelm
IPC分类号： F16H57/02
CPC分类号： F16H57/033 , F16H1/14 , F16H1/28 , F16H57/025 , F16H2057/0335 , Y10T74/19074 , Y10T74/19642 , Y10T74/2186
摘要： A conical gear drive comprising an input element that interacts with a truncated conical gear via which an output element can be driven. A number of different output elements or variably selectable output elements should be able to be connected to the truncated conical gear drive.
摘要翻译：一种锥形齿轮传动装置，其包括与能够驱动输出元件的截锥形齿轮相互作用的输入元件。多个不同的输出元件或可变选择的输出元件应该能够连接到截锥形齿轮传动。

7. 发明申请

US20100089163A1 METHOD FOR OPTIMALLY OPERATING TRANSMISSIONS 有权
标题翻译：最佳运行方式
公开(公告)号：US20100089163A1
公开(公告)日：2010-04-15
申请号：US12595277
申请日：2008-04-02
申请人： Michael Engelbreit , Thomas Bayer
发明人： Michael Engelbreit , Thomas Bayer
IPC分类号： G01M13/02
CPC分类号： G01M13/021
摘要： A method for optimally operating mechanically loaded, moved, particularly rotating components, such as gearboxes, wherein in the operating stage damage accumulation is used to evaluate the influence of a collective load on the lifespan of the loaded rotating components, the moving components (1) being divided into a plurality of segments (5-10) for determining individual collective loads (6; 18).
摘要翻译：用于最佳地操作机械负载的，移动的，特别是旋转的部件（例如齿轮箱）的方法，其中在操作阶段损伤积累用于评估集合载荷对所加载的旋转部件的寿命的影响，移动部件（1）被分成多个段（5-10），用于确定各个集体负荷（6; 18）。

8. 发明申请

US20090320630A1 Linear drive, in particular a rack and pinion drive 审中-公开
标题翻译：线性驱动，特别是齿条齿轮传动
公开(公告)号：US20090320630A1
公开(公告)日：2009-12-31
申请号：US10588747
申请日：2004-11-23
申请人： Thomas Bayer , Frank Michel
发明人： Thomas Bayer , Frank Michel
IPC分类号： F16H55/28
CPC分类号： F16H55/28 , B23Q5/385 , B23Q5/56 , F16H2057/123 , Y10T74/19623
摘要： The invention relates to a linear drive, in particular a rack and pinion drive, comprising at least one motor element (2) which is mounted on or in a retaining element (1.1, 1.2). The motor element (2) drives, directly or indirectly, a pinion (4), optionally, via an integrated drive (3), said pinion co-operating with a linear guide (5). According to the invention, the retaining element (1.1, 1.2) can be displaced by at least one actuator (12.1 to 12.3) in relation to a receiving element (6).
摘要翻译：本发明涉及线性驱动器，特别是齿条和小齿轮驱动器，其包括安装在保持元件（1.1,1.2）上或其中的至少一个马达元件（2）。马达元件（2）直接或间接地驱动小齿轮（4），可选地通过集成驱动器（3）驱动，所述小齿轮与直线导轨（5）配合。根据本发明，保持元件（1.1,1.2）可以相对于接收元件（6）由至少一个致动器（12.1至12.3）移位。

9. 发明授权

US07563918B2 Solid and crystalline ibandronate sodium and processes for preparation thereof 有权
标题翻译：固体和结晶伊班膦酸钠及其制备方法
公开(公告)号：US07563918B2
公开(公告)日：2009-07-21
申请号：US11644568
申请日：2006-12-22
申请人： Revital Lifshitz-Liron , Thomas Bayer , Judith Aronhime , Michael Pinchasov
发明人： Revital Lifshitz-Liron , Thomas Bayer , Judith Aronhime , Michael Pinchasov
IPC分类号： C07C229/00
CPC分类号： C07F9/3873
摘要： The present invention relates to solid amorphous and crystalline forms of ibandronate sodium.
摘要翻译：本发明涉及伊班膦酸钠的固体无定形和结晶形式。

10. 发明申请

US20090114818A1 Particle-Optical Component 有权
标题翻译：粒子光学部件
公开(公告)号：US20090114818A1
公开(公告)日：2009-05-07
申请号：US11991546
申请日：2006-09-06
申请人： Antonio Casares , Rainer Knippelmeyer , Thomas Kemen , Thomas Bayer , Georg Fritz , Johann Greschner , Samuel Kalt
发明人： Antonio Casares , Rainer Knippelmeyer , Thomas Kemen , Thomas Bayer , Georg Fritz , Johann Greschner , Samuel Kalt
IPC分类号： G01N23/00
CPC分类号： H01J37/04 , H01J37/045 , H01J37/09 , H01J37/145 , H01J37/147 , H01J37/244 , H01J37/3177 , H01J2237/0435 , H01J2237/0453 , H01J2237/04922 , H01J2237/04924 , H01J2237/04926 , H01J2237/15 , H01J2237/2446 , H01J2237/2448 , H01J2237/2561 , H01J2237/2817 , H01J2237/31774
摘要： The present invention relates to a particle-optical component comprising a first multi-aperture plate, and a second multi-aperture plate forming a gap between them; wherein a plurality of apertures of the first multi-aperture plate is arranged such that each aperture of the plurality of apertures of the first multi-aperture plate is aligned with a corresponding aperture of a plurality of apertures of the second multi-aperture plate; and wherein the gap has a first width at a first location and a second width at a second location and wherein the second width is by at least 5% greater than the first width. In addition, the present invention pertains to charged particle systems and arrangements comprising such components and methods of manufacturing multi aperture plates having a curved surface.
摘要翻译：本发明涉及一种包括第一多孔板和在其间形成间隙的第二多孔板的颗粒光学部件; 其中所述第一多孔板的多个孔被布置成使得所述第一多孔板的所述多个孔中的每个孔与所述第二多孔板的多个孔的对应孔对齐; 并且其中所述间隙在第一位置处具有第一宽度，在第二位置处具有第二宽度，并且其中所述第二宽度比所述第一宽度大至少5％。此外，本发明涉及包含这些部件的带电粒子系统和布置以及制造具有弯曲表面的多孔板的方法。

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