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1. 发明申请

US20090269386A1 COMPOSITE IMPLANTS FOR PROMOTING BONE REGENERATION AND AUGMENTATION AND METHODS FOR THEIR PREPARATION AND USE 审中-公开
标题翻译：用于促进骨髓再生和补充的复合植入物及其制备和使用方法
公开(公告)号：US20090269386A1
公开(公告)日：2009-10-29
申请号：US12432830
申请日：2009-04-30
申请人： YUVAL ZUBERY , ARIE GOLDLUST , THOMAS BAYER , ERAN NIR
发明人： YUVAL ZUBERY , ARIE GOLDLUST , THOMAS BAYER , ERAN NIR
IPC分类号： A61K9/00 , A61P19/00
CPC分类号： A61L27/56 , A61L27/48 , C08L89/06
摘要： Collagen based matrices cross-linked by a reducing sugar(s) are used for preparing composite matrices, implants and scaffolds. The composite matrices may have at least two layers including reducing sugar cross-linked collagen matrices of different densities. The composite matrices may be used in bone regeneration and/or augmentation applications. Scaffolds including glycated and/or reducing sugar cross-linked collagen exhibit improved support for cell proliferation and/or growth and/or differentiation. The denser collagen matrix of the composite matrices may have a dual effect initially functioning as a cell barrier and later functioning as an ossification supporting layer. The composite matrices, implants and scaffolds may be prepared using different collagen types and collagen mixtures and by cross-linking the collagen(s) using a reducing sugar or a mixture of reducing sugars. The composite matrices, implants and scaffolds may include additives and/or living cells.
摘要翻译：用还原糖交联的基于胶原的基质用于制备复合基质，植入物和支架。复合基质可以具有至少两层，包括不同密度的还原糖交联的胶原基质。复合基质可用于骨再生和/或增强应用。包括糖基化和/或还原糖交联胶原的支架显示改善的对细胞增殖和/或生长和/或分化的支持。复合基质的更密集的胶原基质可能具有起初作为细胞屏障起作用的双重作用，并且此后作为骨化支持层起作用。复合基质，植入物和支架可以使用不同的胶原类型和胶原混合物和使用还原糖或还原糖的混合物交联胶原来制备。复合基质，植入物和支架可以包括添加剂和/或活细胞。

2. 发明授权

US5801017A Production of recombinant factor Xa inhibitor of leech Hirudo medicinalis 失效
标题翻译：水蛭药材重组因子Xa抑制剂的生产
公开(公告)号：US5801017A
公开(公告)日：1998-09-01
申请号：US226264
申请日：1994-04-08
申请人： Moshe M. Werber , Elisha P. Zeelon , Avigdor Levanon , Rachel Guy , Arie Goldlust , Meir Rigbi , Amos Panet , Meir Fischer
发明人： Moshe M. Werber , Elisha P. Zeelon , Avigdor Levanon , Rachel Guy , Arie Goldlust , Meir Rigbi , Amos Panet , Meir Fischer
IPC分类号： C12N15/09 , A61K38/00 , A61K38/45 , A61K38/46 , A61P7/02 , A61P31/12 , A61P43/00 , C07K1/16 , C07K14/815 , C07K16/38 , C12N1/21 , C12N9/99 , C12N15/15 , C12P21/02 , C12P21/08 , C12R1/19 , C12N15/63
CPC分类号： C07K14/815 , C07K16/38 , A61K38/00
摘要： The present invention provides a recombinant polypeptide having the amino acid sequence X-tyr.sup.26 -gly.sup.110 where tyr.sup.26 -gly.sup.110 is identical to the sequence shown in FIG. 10, and wherein X is methionine or absent and wherein asn.sup.72 may be substituted by pro. The invention further provides a method of producing the polypeptide which comprises transforming a host cell with an expression plasmid encoding the polypeptide, culturing the transformed host cell so that the cell produces the polypeptide encoded by the plasmid, and a method of recovering the polypeptide so produced.
摘要翻译：本发明提供具有氨基酸序列X-tyr26-gly110的重组多肽，其中tyr26-gly110与图1所示的序列相同。 10，并且其中X是甲硫氨酸或不存在，并且其中asn72可以被亲代替。本发明还提供了一种生产多肽的方法，其包括用编码多肽的表达质粒转化宿主细胞，培养转化的宿主细胞，使得细胞产生由质粒编码的多肽，以及回收如此产生的多肽的方法。

3. 发明申请

US20090269385A1 COMPOSITE IMPLANTS FOR PROMOTING BONE REGENERATION AND AUGMENTATION AND METHODS FOR THEIR PREPARATION AND USE 审中-公开
公开(公告)号：US20090269385A1
公开(公告)日：2009-10-29
申请号：US12432826
申请日：2009-04-30
申请人： Yuval ZUBERY , Arie GOLDLUST , Thomas BAYER , Eran NIR
发明人： Yuval ZUBERY , Arie GOLDLUST , Thomas BAYER , Eran NIR
IPC分类号： A61F2/00 , A61K38/18 , A61K38/00 , A61K31/726 , A61K31/727 , A61K33/42 , A61K31/7088 , A61K31/722 , A61K35/00 , A61K35/32 , A61K35/30
CPC分类号： A61L27/56 , A61L27/48 , C08L89/06
摘要： Collagen based matrices cross-linked by a reducing sugar(s) are used for preparing composite matrices, implants and scaffolds. The composite matrices may have at least two layers including reducing sugar cross-linked collagen matrices of different densities. The composite matrices may be used in bone regeneration and/or augmentation applications. Scaffolds including glycated and/or reducing sugar cross-linked collagen exhibit improved support for cell proliferation and/or growth and/or differentiation. The denser collagen matrix of the composite matrices may have a dual effect initially functioning as a cell barrier and later functioning as an ossification supporting layer. The composite matrices, implants and scaffolds may be prepared using different collagen types and collagen mixtures and by cross-linking the collagen(s) using a reducing sugar or a mixture of reducing sugars. The composite matrices, implants and scaffolds may include additives and/or living cells.

4. 发明申请

US20080026032A1 COMPOSITE IMPLANTS FOR PROMOTING BONE REGENERATION AND AUGMENTATION AND METHODS FOR THEIR PREPARATION AND USE 审中-公开
标题翻译：用于促进骨髓再生和补充的复合植入物及其制备和使用方法
公开(公告)号：US20080026032A1
公开(公告)日：2008-01-31
申请号：US11829111
申请日：2007-07-27
申请人： Yuval ZUBERY , Arie Goldlust , Thomas Bayer , Eran Nir
发明人： Yuval ZUBERY , Arie Goldlust , Thomas Bayer , Eran Nir
IPC分类号： A61F2/00 , A61K38/00 , A61P19/00
CPC分类号： A61L27/56 , A61L27/48 , C08L89/06
摘要： Collagen based matrices cross-linked by a reducing sugar(s) are used for preparing composite matrices, implants and scaffolds. The composite matrices may have at least two layers including reducing sugar cross-linked collagen matrices of different densities. The composite matrices may be used in bone regeneration and/or augmentation applications. Scaffolds including glycated and/or reducing sugar cross-linked collagen exhibit improved support for cell proliferation and/or growth and/or differentiation. The denser collagen matrix of the composite matrices may have a dual effect initially functioning as a cell barrier and later functioning as an ossification supporting layer. The composite matrices, implants and scaffolds may be prepared using different collagen types and collagen mixtures and by cross-linking the collagen(s) using a reducing sugar or a mixture of reducing sugars. The composite matrices, implants and scaffolds may include additives and/or living cells.
摘要翻译：用还原糖交联的基于胶原的基质用于制备复合基质，植入物和支架。复合基质可以具有至少两层，包括不同密度的还原糖交联的胶原基质。复合基质可用于骨再生和/或增强应用。包括糖基化和/或还原糖交联胶原的支架显示改善的对细胞增殖和/或生长和/或分化的支持。复合基质的更密集的胶原基质可能具有起初作为细胞屏障起作用的双重作用，并且此后作为骨化支持层起作用。复合基质，植入物和支架可以使用不同的胶原类型和胶原混合物和使用还原糖或还原糖的混合物交联胶原来制备。复合基质，植入物和支架可以包括添加剂和/或活细胞。

5. 发明申请

US20090269387A1 COMPOSITE IMPLANTS FOR PROMOTING BONE REGENERATION AND AUGMENTATION AND METHODS FOR THEIR PREPARATION AND USE 审中-公开
公开(公告)号：US20090269387A1
公开(公告)日：2009-10-29
申请号：US12432833
申请日：2009-04-30
申请人： Yuval Zubery , Arie Goldlust , Thomas Bayer , Eran Nir
发明人： Yuval Zubery , Arie Goldlust , Thomas Bayer , Eran Nir
IPC分类号： A61F2/00 , A61K35/00 , A61K35/32 , A61K35/30 , A61P19/00
CPC分类号： A61L27/56 , A61L27/48 , C08L89/06
摘要： Collagen based matrices cross-linked by a reducing sugar(s) are used for preparing composite matrices, implants and scaffolds. The composite matrices may have at least two layers including reducing sugar cross-linked collagen matrices of different densities. The composite matrices may be used in bone regeneration and/or augmentation applications. Scaffolds including glycated and/or reducing sugar cross-linked collagen exhibit improved support for cell proliferation and/or growth and/or differentiation. The denser collagen matrix of the composite matrices may have a dual effect initially functioning as a cell barrier and later functioning as an ossification supporting layer. The composite matrices, implants and scaffolds may be prepared using different collagen types and collagen mixtures and by cross-linking the collagen(s) using a reducing sugar or a mixture of reducing sugars. The composite matrices, implants and scaffolds may include additives and/or living cells.

6. 发明申请

US20070053987A1 Cross-linked polysacharide and protein matrices and methods for their preparation 审中-公开
标题翻译：交联多糖和蛋白质基质及其制备方法
公开(公告)号：US20070053987A1
公开(公告)日：2007-03-08
申请号：US11513345
申请日：2006-08-31
申请人： Thomas Bayer , Arie Goldlust
发明人： Thomas Bayer , Arie Goldlust
IPC分类号： A61K48/00 , A61K38/22 , A61K38/18 , A61K38/14 , C07H5/06 , C08B37/00 , A61K9/14
CPC分类号： A61K38/39 , A61K9/146 , A61K47/61 , A61L27/20 , C07H5/06 , C08B37/003 , C08B37/0063 , C08B37/0072 , C08B37/0075 , C08B37/0081 , C08H1/00 , C08H1/06
摘要： Methods for preparing cross-linked polysaccharide matrices by cross-linking one or more amino group containing polysaccharides or amino-functionalized polysaccharides with reducing sugars and/or reducing sugar derivatives. The resulting matrices may include polysaccharide matrices and composite cross-linked matrices including polysaccharides cross-linked with proteins and/or polypeptides. Additives and/or cells may also be included in or embedded within the matrices. Various different solvent systems and reducing sugar cross-linkers for performing the cross-linking are described. The resulting matrices exhibit various different physical, chemical and biological properties.
摘要翻译：通过用还原糖和/或还原糖衍生物交联一个或多个含氨基的多糖或氨基官能化多糖来制备交联多糖基质的方法。所得到的基质可以包括多糖基质和包含与蛋白质和/或多肽交联的多糖的复合交联基质。添加剂和/或细胞也可以包括在基质中或嵌入在基质中。描述了用于进行交联的各种不同的溶剂体系和还原糖交联剂。所得到的基质表现出各种不同的物理，化学和生物学特性。

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