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1. 发明授权

US06818247B1 Ethylene vinyl alcohol-dimethyl acetamide composition and a method of coating a stent 有权
标题翻译：乙烯乙烯醇 - 二甲基乙酰胺组合物和涂布支架的方法
公开(公告)号：US06818247B1
公开(公告)日：2004-11-16
申请号：US09844522
申请日：2001-04-27
申请人： Yung-Ming Chen , Syed F. A. Hossainy , Deborra Sanders Millare , Wouter E. Roorda , Ashok A. Shah
发明人： Yung-Ming Chen , Syed F. A. Hossainy , Deborra Sanders Millare , Wouter E. Roorda , Ashok A. Shah
IPC分类号： B05D140
CPC分类号： A61L31/16 , A61L27/34 , A61L27/54 , A61L29/085 , A61L29/16 , A61L31/10 , A61L2300/416 , A61L2300/606 , A61L2420/02 , C08L29/04
摘要： A composition comprising an ethylene vinyl alcohol copolymer and a dimethyl acetamide solvent is provided for forming a coating on prostheses such as stents. The composition can include an active agent or therapeutic substance. Methods are also provided for coating the stents.
摘要翻译：提供包含乙烯乙烯醇共聚物和二甲基乙酰胺溶剂的组合物，用于在诸如支架的假体上形成涂层。组合物可以包括活性剂或治疗物质。还提供了用于涂覆支架的方法。

2. 发明授权

US07651695B2 Medicated stents for the treatment of vascular disease 失效
标题翻译：用于治疗血管疾病的药物支架
公开(公告)号：US07651695B2
公开(公告)日：2010-01-26
申请号：US09860384
申请日：2001-05-18
申请人： Wouter E. Roorda , Vinayak D. Bhat , Steven L. Mouw , Syed F. A. Hossainy , Steven Z. Wu , Deborra Sanders Millare
发明人： Wouter E. Roorda , Vinayak D. Bhat , Steven L. Mouw , Syed F. A. Hossainy , Steven Z. Wu , Deborra Sanders Millare
IPC分类号： A61F2/00 , A61F2/06
CPC分类号： A61L31/16 , A61L31/10 , A61L2300/416 , A61L2300/606 , C08L29/04
摘要： The invention provides bioactive compositions and methods of delivery for ameliorating a vascular diseased state, particularly for the management of stenosis or restenosis following a vascular trauma or disease.
摘要翻译：本发明提供用于改善血管疾病状态的生物活性组合物和递送方法，特别是用于在血管创伤或疾病之后管理狭窄或再狭窄。

3. 发明授权

US07247313B2 Polyacrylates coatings for implantable medical devices 有权
标题翻译：用于可植入医疗器械的聚丙烯酸酯涂层
公开(公告)号：US07247313B2
公开(公告)日：2007-07-24
申请号：US10176504
申请日：2002-06-21
申请人： Wouter E. Roorda , Ni Ding , Stephen D. Pacetti , Eugene T. Michal , Ashok A. Shah , Syed F. A. Hossainy
发明人： Wouter E. Roorda , Ni Ding , Stephen D. Pacetti , Eugene T. Michal , Ashok A. Shah , Syed F. A. Hossainy
IPC分类号： A61F2/02 , A61K9/00
CPC分类号： A61L31/16 , A61L31/10 , A61L2300/416 , A61L2300/602 , A61L2300/606 , A61L2300/608 , A61L2420/08 , C08L33/10 , C08L33/06
摘要： A coating for a medical device, particularly for a drug eluting stent, is described. The coating can include a polyacrylate, a blend of polyacrylates, or a blend of the polyacrylate with other polymers, for example, poly(ethylene-co-vinyl alcohol).
摘要翻译：描述了用于医疗装置的涂层，特别是用于药物洗脱支架的涂层。涂层可以包括聚丙烯酸酯，聚丙烯酸酯的共混物或聚丙烯酸酯与其它聚合物的共混物，例如聚（乙烯 - 共 - 乙烯醇）。

4. 发明授权

US07175873B1 Rate limiting barriers for implantable devices and methods for fabrication thereof 有权
标题翻译：用于可植入装置的速率限制障碍及其制造方法
公开(公告)号：US07175873B1
公开(公告)日：2007-02-13
申请号：US10198898
申请日：2002-07-18
申请人： Wouter E. Roorda , Syed F. A. Hossainy , Ni Ding , Fuh-Wei Tang , Stephen D. Pacetti
发明人： Wouter E. Roorda , Syed F. A. Hossainy , Ni Ding , Fuh-Wei Tang , Stephen D. Pacetti
IPC分类号： A61L33/10
CPC分类号： A61L31/16 , A61L31/10 , A61L2300/416 , A61L2300/608 , A61L2420/02 , A61L2420/08 , C08L29/04
摘要： A method of coating an implantable medical device, such as a stent, is disclosed. The method includes applying a formulation on a first polymer layer containing a therapeutic substance to form a second layer. The formulation can contain a highly hydrophobic polymer or a solvent which is a poor solvent for the drug or the polymer of the first layer. The formulation can have a low surface tension value or a high Weber number value.
摘要翻译：公开了一种涂覆可植入医疗装置（例如支架）的方法。该方法包括在含有治疗物质的第一聚合物层上施用制剂以形成第二层。制剂可以含有高度疏水性的聚合物或作为第一层药物或聚合物的不良溶剂的溶剂。制剂可以具有低表面张力值或高Weber数值。

5. 发明授权

US07622146B2 Rate limiting barriers for implantable devices and methods for fabrication thereof 有权
标题翻译：用于可植入装置的速率限制障碍及其制造方法
公开(公告)号：US07622146B2
公开(公告)日：2009-11-24
申请号：US11592632
申请日：2006-11-02
申请人： Wouter E. Roorda , Syed F. A. Hossainy , Ni Ding , Fuh-Wei Tang , Stephen D. Pacetti
发明人： Wouter E. Roorda , Syed F. A. Hossainy , Ni Ding , Fuh-Wei Tang , Stephen D. Pacetti
IPC分类号： A61L33/00 , A61M25/00 , A61F2/06
CPC分类号： A61L31/10 , A61L31/16 , A61L2300/416 , A61L2420/02 , A61L2420/08
摘要： A method of coating an implantable medical device, such as a stent, is disclosed. The method includes applying a formulation on a first polymer layer containing a therapeutic substance to form a second layer. The formulation can contain a highly hydrophobic polymer or a solvent which is a poor solvent for the drug or the polymer of the first layer. The formulation can have a low surface tension value or a high Weber number value.
摘要翻译：公开了一种涂覆可植入医疗装置（例如支架）的方法。该方法包括在含有治疗物质的第一聚合物层上施用制剂以形成第二层。制剂可以含有高度疏水性的聚合物或作为第一层的药物或聚合物的不良溶剂的溶剂。制剂可以具有低表面张力值或高Weber数值。

6. 发明授权

US07955615B2 Polycationic peptide coatings and methods of coating implantable medical devices 有权
公开(公告)号：US07955615B2
公开(公告)日：2011-06-07
申请号：US11212376
申请日：2005-08-26
申请人： Stephen D. Pacetti , Eugene T. Michal , Syed F. A. Hossainy , Ni Ding , Wouter E. Roorda
发明人： Stephen D. Pacetti , Eugene T. Michal , Syed F. A. Hossainy , Ni Ding , Wouter E. Roorda
IPC分类号： A61F2/04
CPC分类号： A61K31/727 , A61K31/728 , A61K31/737 , A61L31/10 , C08L89/00
摘要： Coatings for medical devices which include polycationic peptides such as L-arginine and methods for fabricating the coatings are disclosed.

7. 发明授权

US07875286B2 Polycationic peptide coatings and methods of coating implantable medical devices 有权
标题翻译：聚阳离子肽涂层和涂覆可植入医疗器械的方法
公开(公告)号：US07875286B2
公开(公告)日：2011-01-25
申请号：US11213290
申请日：2005-08-26
申请人： Stephen D. Pacetti , Eugene T. Michal , Syed F. A. Hossainy , Ni Ding , Wouter E. Roorda
发明人： Stephen D. Pacetti , Eugene T. Michal , Syed F. A. Hossainy , Ni Ding , Wouter E. Roorda
IPC分类号： A61F2/02
CPC分类号： A61K31/727 , A61K31/728 , A61K31/737 , A61L31/10 , C08L89/00
摘要： Coatings for medical devices which include polycationic peptides such as L-arginine and methods for fabricating the coatings are disclosed.
摘要翻译：公开了包括聚阳离子肽如L-精氨酸的医疗器械用涂层和制造涂层的方法。

8. 发明授权

US07803406B2 Polycationic peptide coatings and methods of coating implantable medical devices 有权
标题翻译：聚阳离子肽涂层和涂覆可植入医疗器械的方法
公开(公告)号：US07803406B2
公开(公告)日：2010-09-28
申请号：US11213288
申请日：2005-08-26
申请人： Stephen D. Pacetti , Eugene T. Michal , Syed F. A. Hossainy , Ni Ding , Wouter E. Roorda
发明人： Stephen D. Pacetti , Eugene T. Michal , Syed F. A. Hossainy , Ni Ding , Wouter E. Roorda
IPC分类号： A61K9/50
CPC分类号： A61K31/727 , A61K31/728 , A61K31/737 , A61L31/10 , C08L89/00
摘要： Methods of forming coatings comprising a polycationic peptide for medical devices are disclosed. Also disclosed is a coating comprising a polycationic peptide.
摘要翻译：公开了形成包含用于医疗装置的聚阳离子肽的涂层的方法。还公开了包含聚阳离子肽的涂层。

9. 发明授权

US08852220B2 Thrombus penetrating devices, systems, and methods 有权
标题翻译：血栓穿透装置，系统和方法
公开(公告)号：US08852220B2
公开(公告)日：2014-10-07
申请号：US13227071
申请日：2011-09-07
申请人： Wouter E. Roorda , Aaron M. Fortson
发明人： Wouter E. Roorda , Aaron M. Fortson
IPC分类号： A61B17/22 , A61B17/3207 , A61B18/04 , A61B17/00
CPC分类号： A61B17/320725 , A61B18/04 , A61B2017/00867 , A61B2017/22094
摘要： A device for penetrating occlusive material in a body lumen is provided that may include an outer tube, an intermediate tube, and an inner tube. At least a portion of the intermediate tube may be moveably disposed within the outer tube. At least a portion of the inner tube may be moveably disposed within the intermediate tube. A first dynamic member may be operably connected to the intermediate tube and the inner tube. The first dynamic member may be configured to penetrate the occlusive material and to anchor the first dynamic member within the occlusive material. A second dynamic member may be operably connected to the outer tube and the intermediate tube. The second dynamic member may be configured to penetrate the occlusive material and to anchor the second dynamic member within the occlusive material and to support movement of the first dynamic member.
摘要翻译：提供一种用于穿透体腔内的封闭材料的装置，其可以包括外管，中间管和内管。中间管的至少一部分可以可移动地设置在外管内。内管的至少一部分可以可移动地设置在中间管内。第一动态构件可以可操作地连接到中间管和内管。第一动态构件可以构造成穿透封闭材料并将第一动态构件锚定在封闭材料内。第二动态构件可以可操作地连接到外管和中间管。第二动态构件可以构造成穿透封闭材料并将第二动态构件锚定在封闭材料内并且支撑第一动态构件的移动。

10. 发明申请

US20140074124A1 NEEDLE HARVESTING DEVICES, SYSTEMS AND METHODS 有权
标题翻译：针刺收集装置，系统和方法
公开(公告)号：US20140074124A1
公开(公告)日：2014-03-13
申请号：US13610602
申请日：2012-09-11
申请人： Laveille Kao Voss , Stephanie Henze , Kristopher M. Konawalik , Leah M. Davis , Wouter E. Roorda
发明人： Laveille Kao Voss , Stephanie Henze , Kristopher M. Konawalik , Leah M. Davis , Wouter E. Roorda
IPC分类号： A61B17/06 , A61B17/04
CPC分类号： A61B17/06161 , A61B17/0057 , A61B17/0469 , A61B17/0491 , A61B17/06061 , A61B17/062 , A61B50/3001 , A61B50/362 , A61B2017/00663 , A61B2017/047 , A61B2017/0472 , A61B2017/06142 , A61B2050/364 , A61B2090/0807 , A61M5/3278 , A61M2005/3284
摘要： A needle removal device is provided for removing needles from suturing devices and/or systems. In an embodiment, the needle removal device may be intended for use with a suturing device having one or more needle lumens. The needle removal device may include a first member having a first plurality of needle receptacles extending therethrough. The first needle receptacles may be configured and positioned to correspond to one or more of the one or more needle lumens of the suturing device. The needle removal device may also include a second member having a second plurality of needle receptacles extending therethrough. At least one of the first member or the second member may be moveable between a first position, wherein the first needle receptacles and the second needle receptacles are substantially aligned, and a second position, wherein the first needle receptacles and the second needle receptacles substantially unaligned.
摘要翻译：提供针去除装置用于从缝合装置和/或系统中去除针。在一个实施例中，针去除装置可以用于具有一个或多个针管的缝合装置。针去除装置可以包括具有延伸穿过其中的第一多个针插座的第一构件。可以将第一针插槽配置和定位成对应于缝合装置的一个或多个针管腔中的一个或多个。针去除装置还可以包括具有延伸穿过其中的第二多个针插座的第二构件。第一构件或第二构件中的至少一个可以在第一位置和第二位置之间移动，第一位置和第二针座基本上对准，其中第一针座和第二针座基本上对准，其中第一针座和第二针座基本上不对齐。

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