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1. 发明授权

US06677331B2 Carbapenem derivatives 失效
标题翻译：卡巴培南衍生物
公开(公告)号：US06677331B2
公开(公告)日：2004-01-13
申请号：US10217670
申请日：2002-08-14
申请人： Yuko Kano , Toshiro Sasaki , Yumiko Sambongi , Kiyoshi Tanabe , Yoshihisa Akiyama , Hideo Kitagawa , Takahisa Maruyama , Hiromasa Takizawa , Takashi Ando , Kazuhiro Aihara , Kunio Atsumi , Katsuyoshi Iwamatsu , Takashi Ida
发明人： Yuko Kano , Toshiro Sasaki , Yumiko Sambongi , Kiyoshi Tanabe , Yoshihisa Akiyama , Hideo Kitagawa , Takahisa Maruyama , Hiromasa Takizawa , Takashi Ando , Kazuhiro Aihara , Kunio Atsumi , Katsuyoshi Iwamatsu , Takashi Ida
IPC分类号： C07D51906
CPC分类号： C07D477/14
摘要： Disclosed is a novel carbapenem derivative having a substituted imidazo[5,1-b]thiazole group at the 2-position on the carbapenem ring have high anti microbial activities against &bgr;-lactamase producing bacteria, MRSA, resistant-Pseudomonas aeruginosa, PRSP, enterococci, and influenza, and high stabilities to DHP-1. According to the present invention, there is provided a compound represented by the formula (I), or a pharmacologically acceptable salt thereof or an ester at the 3-position on the carbapenem ring thereof:
摘要翻译：公开了一种在碳青霉烯环上位置具有取代的咪唑并[5,1-b]噻唑基的新型碳青霉烯衍生物对β-内酰胺酶生产细菌，MRSA，耐药铜绿假单胞菌，PRSP，肠球菌具有高抗微生物活性，流感，以及DHP-1的高稳定性。根据本发明，提供由式（I）表示的化合物或其药理学上可接受的盐或其碳青霉烯环的3-位上的酯：

2. 发明授权

US06458780B1 Carbapenem derivatives 失效
标题翻译：卡巴培南衍生物
公开(公告)号：US06458780B1
公开(公告)日：2002-10-01
申请号：US09744583
申请日：2001-01-26
申请人： Yuko Kano , Toshiro Sasaki , Yumiko Sambongi , Kiyoshi Tanabe , Yoshihisa Akiyama , Hideo Kitagawa , Takahisa Maruyama , Hiromasa Takizawa , Takashi Ando , Kazuhiro Aihara , Kunio Atsumi , Katsuyoshi Iwamatsu , Takashi Ida
发明人： Yuko Kano , Toshiro Sasaki , Yumiko Sambongi , Kiyoshi Tanabe , Yoshihisa Akiyama , Hideo Kitagawa , Takahisa Maruyama , Hiromasa Takizawa , Takashi Ando , Kazuhiro Aihara , Kunio Atsumi , Katsuyoshi Iwamatsu , Takashi Ida
IPC分类号： A61L31429
CPC分类号： C07D477/14
摘要： Disclosed is a novel carbapenem derivative having a substituted imidazo[5,1-b]thiazole group at the 2-position on the carbapenem ring have high anti-microbial activities against &bgr;-lactamase producing bacteria, MRSA, resistant-Pseudomonas aeruginosa, PRSP, enterococci, and influenza, and high stabilities to DHP-1. According to the present invention, there is provided a compound represented by the formula (I), or a pharmacologically acceptable salt thereof or an ester at the 3-position on the carbapenem ring thereof:
摘要翻译：公开了一种在碳青霉烯环上2-位具有取代的咪唑并[5,1-b]噻唑基的新型碳青霉烯衍生物对β-内酰胺酶生产细菌，MRSA，耐药铜绿假单胞菌，PRSP，肠球菌和流感，以及DHP-1的高度稳定性。根据本发明，提供由式（I）表示的化合物或其药理学上可接受的盐或其碳青霉烯环的3-位上的酯：

3. 发明授权

US08261031B2 Device and method to manage migration volume selection 有权
标题翻译：管理迁移量选择的设备和方法
公开(公告)号：US08261031B2
公开(公告)日：2012-09-04
申请号：US11968253
申请日：2008-01-02
申请人： Kiyoshi Tanabe , Takaki Kuroda
发明人： Kiyoshi Tanabe , Takaki Kuroda
IPC分类号： G06F12/16
CPC分类号： G06F3/0647 , G06F3/0605 , G06F3/067 , G06F2206/1008
摘要： A management device and management method capable of improving usability of a storage system is proposed. The management device and the management method for managing data migration between volumes in a storage system in which normal volumes to which fixed storage areas are allocated in advance and virtual volumes to which storage areas are dynamically allocated according to use status coexist as types of volumes for reading and writing data is arranged so that information regarding each volume is collected, and based on the collected information, at least a total logical capacity that is a summation of logical capacities determined in advance for the respective volume is separately displayed for normal volumes and virtual volumes.
摘要翻译：提出了一种能够提高存储系统的可用性的管理装置和管理方法。用于管理存储系统中的卷之间的数据迁移的管理装置和管理方法，其中预先分配固定存储区域的正常卷和根据使用状态动态分配存储区域的虚拟卷共存为卷的类型读取和写入数据被布置成使得关于每个卷的信息被收集，并且基于收集的信息，对于正常的卷和虚拟的，分别显示作为对于各个卷预先确定的逻辑容量的总和的总逻辑容量的总和逻辑容量卷。

4. 发明申请

US20070255922A1 Storage resource management system, method, and computer 失效
标题翻译：存储资源管理系统，方法和计算机
公开(公告)号：US20070255922A1
公开(公告)日：2007-11-01
申请号：US11480372
申请日：2006-07-05
申请人： Naotsugu Toume , Nobuo Beniyama , Kiyoshi Tanabe
发明人： Naotsugu Toume , Nobuo Beniyama , Kiyoshi Tanabe
IPC分类号： G06F12/00
CPC分类号： G06F3/0632 , G06F3/0604 , G06F3/0605 , G06F3/0631 , G06F3/067
摘要： A storage resource management system includes a storage apparatus having one or more pieces of volumes and a management computer. The management computer holds volume characteristic information and use field sort volume information. The management computer executes a single use field portion allocating sequence for allocating the use fields to volumes having volume characteristics suitable for a single use field from volume characteristics described in the use field sort volume information, and also, executes a plural use fields common portion allocating sequence for allocating volumes having volume characteristics suitable for the plural use fields to any use field. Since the sequences are executed by the management computer, such a use field sort volume allocation information is formed which has described that one use field in maximum is allocated to the volume, namely one use field is allocated thereto, or none of these use fields is allocated to the volume.
摘要翻译：存储资源管理系统包括具有一个或多个卷的存储装置和管理计算机。管理计算机保存体积特征信息并使用字段排序量信息。管理计算机执行单个使用场部分分配序列，用于将使用场分配给具有适合于使用场排序卷信息中描述的卷特性的单个使用场的体积特征的体积，并且还执行多个使用场共同部分分配将具有适于多个使用场的体积特征的体积分配给任何使用场的顺序。由于这些序列是由管理计算机执行的，因此形成了这样的使用场分类卷分配信息，其描述了将最大的一个使用字段分配给该卷，即分配一个使用字段，或者这些使用字段不是分配到卷。

5. 发明授权

US06949383B2 Mutagenesis method 失效
标题翻译：诱变法
公开(公告)号：US06949383B2
公开(公告)日：2005-09-27
申请号：US09600027
申请日：1999-11-11
申请人： Kiyoshi Tanabe , Mitsuru Furusawa
发明人： Kiyoshi Tanabe , Mitsuru Furusawa
IPC分类号： C12N1/21 , C12N15/01 , C12N15/10 , C12N1/20
CPC分类号： C12N15/102 , C12N15/01
摘要： This application provides a method for mutagenesis of a gene, which comprises introducing much more point mutations into one strand of double-stranded genomic DNA of cell or organism individual than into another strand. In accordance with such a method, it is now possible to efficiently and effectively construct various useful mutants of microorganisms, cells or organism individuals. It is also now possible by analyzing the mutating conditions of the gene to clarify the mechanism of drug resistance, to estimate the occurrence of a novel insensible microorganism or to develop a drug therefor, to analyze the mutation of an oncogene and the mechanisms of cancer metastasis and increase in malignancy, to develop a therapeutic method using these mechanisms, etc.
摘要翻译：该应用提供了一种诱变基因的方法，其包括将多点突变引入单个细胞或生物体的双链基因组DNA的一条链中而不是另一条链。根据这种方法，现在可以有效地和有效地构建微生物，细胞或生物个体的各种有用的突变体。现在也可以通过分析基因的突变条件来阐明耐药机制，估计新颖的不敏感微生物的发生或开发药物，分析癌基因的突变和癌转移的机制并增加恶性肿瘤，开发使用这些机制的治疗方法等。

6. 发明授权

US5100922A Method for producing a molded product of integral-skin polyurethane foam 失效
标题翻译：生产聚氨酯泡沫塑料的成型产品的方法
公开(公告)号：US5100922A
公开(公告)日：1992-03-31
申请号：US538099
申请日：1990-06-13
申请人： Hiroshi Wada , Kiyoshi Kaiden , Tadashi Shimada , Kiyoshi Tanabe , Shoji Hayashida
发明人： Hiroshi Wada , Kiyoshi Kaiden , Tadashi Shimada , Kiyoshi Tanabe , Shoji Hayashida
IPC分类号： C08G18/48 , C08G18/66 , C08J9/34
CPC分类号： C08J9/34 , C08G18/4837 , C08G18/667 , C08G2101/0033 , C08G2120/00 , C08J2375/04
摘要： A method for producing a molded product of integral-skin polyurethane foam, which comprises reacting and curing (1) a high molecular weight polyol comprising, as the main component, a polyoxyalkylene polyol having, as the main constituent, oxyalkylene groups of at least 3 carbon atoms and oxyethylene groups at its molecular terminals with the overall oxyethylene group content being not higher than 15% by weight and having a hydroxyl value of not higher than 80, (2) a crosslinking agent containing a compound having an aromatic nucleus and at least two active hydrogen-containing groups selected from the group consisting of hydroxyl groups, primary amino groups and secondary amino groups, and (3) a polyisocyanate, in a mold in the presence of a catalyst and a hydrogen atom-containing halogenated hydrocarbon foaming agent.

7. 发明授权

US08661210B2 Data migration management device and method 失效
标题翻译：数据迁移管理装置及方法
公开(公告)号：US08661210B2
公开(公告)日：2014-02-25
申请号：US13589252
申请日：2012-08-20
申请人： Kiyoshi Tanabe , Takaki Kuroda
发明人： Kiyoshi Tanabe , Takaki Kuroda
IPC分类号： G06F12/16
CPC分类号： G06F3/0647 , G06F3/0605 , G06F3/067 , G06F2206/1008
摘要： A management device and management method capable of improving usability of a storage system is proposed. The management device and the management method for managing data migration between volumes in a storage system in which normal volumes to which fixed storage areas are allocated in advance and virtual volumes to which storage areas are dynamically allocated according to use status coexist as types of volumes for reading and writing data is arranged so that information regarding each volume is collected, and based on the collected information, at least a total logical capacity that is a summation of logical capacities determined in advance for the respective volume is separately displayed for normal volumes and virtual volumes.
摘要翻译：提出了一种能够提高存储系统的可用性的管理装置和管理方法。用于管理存储系统中的卷之间的数据迁移的管理装置和管理方法，其中预先分配固定存储区域的正常卷和根据使用状态动态分配存储区域的虚拟卷共存为卷的类型读取和写入数据被布置成使得关于每个卷的信息被收集，并且基于收集的信息，对于正常的卷和虚拟的，分别显示作为对于各个卷预先确定的逻辑容量的总和的总逻辑容量的总和逻辑容量卷。

8. 发明申请

US20080270720A1 MANAGEMENT DEVICE AND MANAGEMENT METHOD 有权
标题翻译：管理设备和管理方法
公开(公告)号：US20080270720A1
公开(公告)日：2008-10-30
申请号：US11968253
申请日：2008-01-02
申请人： Kiyoshi Tanabe , Takaki Kuroda
发明人： Kiyoshi Tanabe , Takaki Kuroda
IPC分类号： G06F12/02 , G06F12/16
CPC分类号： G06F3/0647 , G06F3/0605 , G06F3/067 , G06F2206/1008
摘要： A management device and management method capable of improving usability of a storage system is proposed. The management device and the management method for managing data migration between volumes in a storage system in which normal volumes to which fixed storage areas are allocated in advance and virtual volumes to which storage areas are dynamically allocated according to use status coexist as types of volumes for reading and writing data is arranged so that information regarding each volume is collected, and based on the collected information, at least a total logical capacity that is a summation of logical capacities determined in advance for the respective volume is separately displayed for normal volumes and virtual volumes.
摘要翻译：提出了一种能够提高存储系统的可用性的管理装置和管理方法。用于管理存储系统中的卷之间的数据迁移的管理装置和管理方法，其中预先分配固定存储区域的正常卷和根据使用状态动态分配存储区域的虚拟卷共存为卷的类型读取和写入数据被布置成使得关于每个卷的信息被收集，并且基于收集的信息，对于正常的卷和虚拟的，分别显示作为对于各个卷预先确定的逻辑容量的总和的总逻辑容量的总和逻辑容量卷。

9. 发明授权

US6077840A Tetrahydrobenzindolone derivatives 有权
标题翻译：四氢苯并吲哚酮衍生物
公开(公告)号：US6077840A
公开(公告)日：2000-06-20
申请号：US331294
申请日：1999-06-18
申请人： Kenichi Kurihara , Rie Shinei , Yasushi Kurata , Yuji Tabata , Kiyoshi Tanabe , Tsuneo Okonogi
发明人： Kenichi Kurihara , Rie Shinei , Yasushi Kurata , Yuji Tabata , Kiyoshi Tanabe , Tsuneo Okonogi
IPC分类号： C07D209/60 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D521/00 , A61K31/535 , A61K31/40 , A61K31/44 , A61K31/50 , C07D233/02
CPC分类号： C07D231/12 , C07D209/60 , C07D233/56 , C07D249/08 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12
摘要： Compounds represented by the following formula (I) or pharmaceutically acceptable salts thereof and a process for producing the same are disclosed. The compounds have progesterone receptor binding inhibitory activity and, hence, can be used as therapeutic and prophylactic agents for progesterone-related diseases. Specifically, they are useful as carcinostatic agents for breast cancer and ovarian cancer, therapeutic agents for hysteromyoma, endometriosis, meningioma, and myeloma, abortifacients, oral contraceptive pills, and therapeutic and prophylactic agents for osteoporosis and climacteric disturbance. ##STR1## wherein R.sup.1 represents alkyl or aralkyl; R.sup.2 represents a hydrogen atom, alkylcarbonyl, cycloalkylcarbonyl, aromatic acyl, heteroaromatic acyl, saturated heterocyclic acyl, alkyl, alkenyl, aralkyl, carbamoyl, alkylcarbamoyl, aromatic carbamoyl, aralkylcarbamoyl, alkylaminocarbonyl, cycloalkylcarbamoyl, alkoxycarbonyl, aryloxycarbonyl, heteroaromatic thiocarbonyl, saturated heterocyclic thiocarbonyl, or alkyl-thiocarbamoyl: and R.sup.3 represents a hydrogen atom, a hydroxyl group, alkyloxy, alkylcarbonyloxy, alkylthio, or arylthio.
摘要翻译： PCT No.PCT / JP97 / 04683 Sec。 371日期：1999年6月18日 102（e）1999年6月18日PCT 1997年12月18日PCT公布。第WO98 / 27059号公报日期：1998年6月25日公开了由下式（I）表示的化合物或其药学上可接受的盐及其制备方法。所述化合物具有孕酮受体结合抑制活性，因此可用作孕酮相关疾病的治疗和预防剂。具体地说，它们可用作乳腺癌和卵巢癌的制癌剂，子宫肌瘤，子宫内膜异位症，脑膜瘤和骨髓瘤的治疗剂，流产者，口服避孕药以及用于骨质疏松和更年期障碍的治疗和预防剂。其中R1表示烷基或芳烷基; R 2表示氢原子，烷基羰基，环烷基羰基，芳香族酰基，杂芳基酰基，饱和杂环酰基，烷基，烯基，芳烷基，氨基甲酰基，烷基氨基甲酰基，芳香族氨基甲酰基，芳烷基氨基甲酰基，烷基氨基羰基，环烷基氨基甲酰基，烷氧基羰基，芳氧基羰基，杂芳硫基羰基，饱和杂环硫代羰基，或烷基 - 硫代氨基甲酰基：和R3表示氢原子，羟基，烷氧基，烷基羰氧基，烷硫基或芳硫基。

10. 发明授权

US07447863B2 Storage resource management system, method, and computer for dividing volumes based on priority, necessary capacity and volume characteristics 失效
标题翻译：存储资源管理系统，方法和计算机，用于根据优先级，必要容量和卷特性分割卷
公开(公告)号：US07447863B2
公开(公告)日：2008-11-04
申请号：US11480372
申请日：2006-07-05
申请人： Naotsugu Toume , Nobuo Beniyama , Kiyoshi Tanabe
发明人： Naotsugu Toume , Nobuo Beniyama , Kiyoshi Tanabe
IPC分类号： G06F12/00 , G06F13/00
CPC分类号： G06F3/0632 , G06F3/0604 , G06F3/0605 , G06F3/0631 , G06F3/067
摘要： A storage resource management system includes a storage apparatus having one or more pieces of volumes and a management computer. The management computer holds volume characteristic information and use field sort volume information. The management computer executes a single use field portion allocating sequence for allocating the use fields to volumes having volume characteristics suitable for a single use field from volume characteristics described in the use field sort volume information, and also, executes a plural use fields common portion allocating sequence for allocating volumes having volume characteristics suitable for the plural use fields to any use field. Since the sequences are executed by the management computer, such a use field sort volume allocation information is formed which has described that one use field in maximum is allocated to the volume, namely one use field is allocated thereto, or none of these use fields is allocated to the volume.
摘要翻译：存储资源管理系统包括具有一个或多个卷的存储装置和管理计算机。管理计算机保存体积特征信息并使用字段排序量信息。管理计算机执行单个使用场部分分配序列，用于将使用场分配给具有适合于使用场排序卷信息中描述的卷特性的单个使用场的体积特征的体积，并且还执行多个使用场共同部分分配将具有适于多个使用场的体积特征的体积分配给任何使用场的顺序。由于这些序列是由管理计算机执行的，因此形成了这样的使用场分类卷分配信息，其描述了将最大的一个使用字段分配给该卷，即分配一个使用字段，或者这些使用字段不是分配到卷。

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