专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20060292158A1 Method for the treatment of cancer using a novel pharmaceutical composition containing at least one dolastatin 10 derivative 审中-公开
标题翻译：使用含有至少一种多拉司他汀10衍生物的新型药物组合物治疗癌症的方法
公开(公告)号：US20060292158A1
公开(公告)日：2006-12-28
申请号：US11297716
申请日：2005-12-08
申请人： Yuko Aoki , Masanori Miwa , Fumie Sawamura , Hiromi Tanimura , Toshikazu Yamazaki
发明人： Yuko Aoki , Masanori Miwa , Fumie Sawamura , Hiromi Tanimura , Toshikazu Yamazaki
IPC分类号： A61K38/06 , A61K39/395 , A61K31/675 , A61K33/24 , A61K31/7072
CPC分类号： A61K31/7068 , A61K31/282 , A61K31/40 , A61K31/4745 , A61K33/24 , A61K39/39558 , A61K45/06 , A61K2300/00
摘要： The present invention is directed to a method for the treatment of cancer via the administration of a pharmaceutical composition, comprising at least one compound of formula (I) or a pharmaceutically acceptable salt of compound (I), in combination with capecitabine, trastuzumab, pertuzumab, cisplatin or irinotecan, or a pharmaceutically acceptable salt thereof, for simultaneous, sequential or separated administration in the treatment of cancer.
摘要翻译：本发明涉及通过给药药物组合物治疗癌症的方法，所述药物组合物包含至少一种式（I）化合物或化合物（I）的药学上可接受的盐与卡培他滨，曲妥单抗，依托单抗，顺铂或伊立替康或其药学上可接受的盐，用于在治疗癌症中同时，顺序或分离给药。

2. 发明授权

US08273014B2 Endoscopic fluid control apparatus 有权
标题翻译：内窥镜液体控制装置
公开(公告)号：US08273014B2
公开(公告)日：2012-09-25
申请号：US12883294
申请日：2010-09-16
申请人： Takanori Ushijima , Toshikazu Yamazaki
发明人： Takanori Ushijima , Toshikazu Yamazaki
IPC分类号： A61B1/12 , A61B1/00
CPC分类号： A61B1/015 , G02B23/2476
摘要： An endoscopic fluid control apparatus includes a cylinder which is attachable to an attachment part attached to an endoscope, and includes a first channel which transfers fluid to an insertion channel of the endoscope, a piston which is set on the cylinder and includes a valve part movable relative to the cylinder between a position where the first channel is opened relative to the insertion channel and a position where the first channel is closed relative to the insertion channel, a connection port part for connecting a fluid tube, and a second channel which transfers the fluid from the connection port part to the insertion channel, an elastic member which holds the piston to be movable relative to the cylinder between the position where the first channel is closed and the position where the first channel is opened, a first engagement part which engages the piston and the elastic member with each other so as not to rotate about an axis of movement of the piston, and a second engagement part which engages the cylinder and the elastic member with each other so as not to rotate about an axis of movement of the cylinder.The piston includes the valve part, a connection port part, and the second channel.
摘要翻译：一种内窥镜液体控制装置，其具有可连接到内窥镜的安装部的气缸，具有将流体输送到内窥镜的插入通道的第一通道，设置在气缸上的活塞，相对于所述气缸相对于所述第一通道相对于所述插入通道打开的位置和所述第一通道相对于所述插入通道关闭的位置，用于连接流体管的连接端口部分和用于连接所述第二通道的第二通道，流体从所述连接口部分到所述插入通道;弹性构件，其将所述活塞相对于所述气缸保持在所述第一通道关闭的位置与所述第一通道打开的位置之间可移动;第一接合部，其接合所述活塞和所述弹性构件彼此不相对于所述活塞的运动轴线旋转，以及第二接合体 t部分，其使气缸和弹性构件彼此接合，以便不围绕气缸的运动轴线旋转。活塞包括阀部分，连接端口部分和第二通道。

3. 发明授权

US08362236B2 Macrocyclic compound 失效
标题翻译：大环化合物
公开(公告)号：US08362236B2
公开(公告)日：2013-01-29
申请号：US12529222
申请日：2008-02-29
申请人： Nobuo Shimma , Takuo Tsukuda , Hiroshi Koyano , Atsushi Suda , Tadakatsu Hayase , Kihito Hada , Ken-Ichi Kawasaki , Susumu Komiyama , Naomi Ono , Toshikazu Yamazaki , Ryoichi Saitoh , Masami Kohchi , Kiyoshi Hasegawa
发明人： Nobuo Shimma , Takuo Tsukuda , Hiroshi Koyano , Atsushi Suda , Tadakatsu Hayase , Kihito Hada , Ken-Ichi Kawasaki , Susumu Komiyama , Naomi Ono , Toshikazu Yamazaki , Ryoichi Saitoh , Masami Kohchi , Kiyoshi Hasegawa
IPC分类号： C07D497/08 , C07D513/08 , C07D513/20 , A61K31/529 , A61K31/53 , A61K31/5377 , A61P35/00
CPC分类号： C07D497/08 , C07D513/08 , C07D513/18 , C07D513/20
摘要： The present invention provides a novel class of compounds that have the activity of inhibiting HSP90 enzyme and are useful as anti-cancer agents or such, and compounds that are useful as synthetic intermediates thereof. Specifically, the present invention provides compounds represented by the following formula (1), and pharmaceutically acceptable salts thereof: wherein X, R1, R2, R3, R4, R5, R6, R7, L1, L2, and L3 are as defined in the specification.
摘要翻译：本发明提供具有抑制HSP90酶的活性的新型化合物，可用作抗癌剂等，以及可用作其合成中间体的化合物。具体而言，本发明提供下述式（1）表示的化合物及其药学上可接受的盐：其中X，R1，R2，R3，R4，R5，R6，R7，L1，L2和L3如规范。

4. 发明申请

US20100056510A1 Macrocyclic Compound 失效
标题翻译：大环化合物
公开(公告)号：US20100056510A1
公开(公告)日：2010-03-04
申请号：US12529222
申请日：2008-02-29
申请人： Nobuo Shimma , Takuo Tsukuda , Hiroshi Koyano , Atsushi Suda , Tadakatsu Hayase , Kihito Hada , Ken-ichi Kawasaki , Susumu Komiyama , Naomi Ono , Toshikazu Yamazaki , Ryoichi Saitoh , Masami Kohchi , Kiyoshi Hasegawa
发明人： Nobuo Shimma , Takuo Tsukuda , Hiroshi Koyano , Atsushi Suda , Tadakatsu Hayase , Kihito Hada , Ken-ichi Kawasaki , Susumu Komiyama , Naomi Ono , Toshikazu Yamazaki , Ryoichi Saitoh , Masami Kohchi , Kiyoshi Hasegawa
IPC分类号： A61K31/519 , C07D513/04 , A61P35/00 , A61K31/5377
CPC分类号： C07D497/08 , C07D513/08 , C07D513/18 , C07D513/20
摘要： The present invention provides a novel class of compounds that have the activity of inhibiting HSP90 enzyme and are useful as anti-cancer agents or such, and compounds that are useful as synthetic intermediates thereof. Specifically, the present invention provides compounds represented by the following formula (1), and pharmaceutically acceptable salts thereof: wherein X, R1, R2, R3, R4, R5, R6, R7, L1, L2, and L3 are as defined in the specification.
摘要翻译：本发明提供具有抑制HSP90酶的活性的新型化合物，可用作抗癌剂等，以及可用作其合成中间体的化合物。具体而言，本发明提供下述式（1）表示的化合物及其药学上可接受的盐：其中X，R1，R2，R3，R4，R5，R6，R7，L1，L2和L3如规范。

5. 发明授权

US06300353B1 Azoles for treatment of fungal infections 有权
标题翻译：唑类治疗真菌感染
公开(公告)号：US06300353B1
公开(公告)日：2001-10-09
申请号：US09263027
申请日：1999-03-05
申请人： Tadakatsu Hayase , Shigeyasu Ichihara , Yoshiaki Isshiki , Pingli Liu , Jun Ohwada , Toshiya Sakai , Nobuo Shimma , Masao Tsukazaki , Isao Umeda , Toshikazu Yamazaki
发明人： Tadakatsu Hayase , Shigeyasu Ichihara , Yoshiaki Isshiki , Pingli Liu , Jun Ohwada , Toshiya Sakai , Nobuo Shimma , Masao Tsukazaki , Isao Umeda , Toshikazu Yamazaki
IPC分类号： C07D41706
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08
摘要： Azole derivatives of the formula I wherein R14, R15 are each independently hydrogen or fluorine, T is a group of the formula: wherein R9 is pyrrolidinyl or a group A—NH—B—, A is hydrogen or straight-chain or branched C1-C5 alkyl; B is straight-chain or branched C1-C4 alkylene, —CH2—CONH—CH2 or —CH2CH2CH2—CH(NH2); and X− is a pharmaceutically acceptable anion; and pharmaceutically acceptable salts of said compounds, and hydrates and solvates of the compounds of formula I and the salts thereof can be used in the production of medicaments for treating fungal infections and mycoses.
摘要翻译：式I其中R 14，R 15各自独立地为氢或氟的唑衍生物，T为下式的基团：其中R 9为吡咯烷基或A-NH-B-A基团，A为氢或直链或支链C 1 -C 5烷基; B是直链或支链C1-C4亚烷基，-CH2-CONH-CH2或-CH2CH2CH2-CH（NH2）; 和X-是药学上可接受的阴离子;所述化合物的药学上可接受的盐，以及式I化合物及其盐的水合物和溶剂合物可用于生产用于治疗真菌感染和真菌病的药物。

6. 发明授权

US08858427B2 Endoscope 有权
标题翻译：内窥镜
公开(公告)号：US08858427B2
公开(公告)日：2014-10-14
申请号：US13314422
申请日：2011-12-08
申请人： Toshikazu Yamazaki
发明人： Toshikazu Yamazaki
IPC分类号： A61B1/04 , A61B1/005 , G02B23/24 , A61B1/05 , A61B1/00
CPC分类号： A61B1/0052 , A61B1/00066 , A61B1/05 , G02B23/2476
摘要： An endoscope includes: an insertion portion configured to be inserted into a subject; an image pickup section configured to pick up an image of inside of the subject; an operation portion configured to be connected to the insertion portion; a grasping portion configured to be able to be grasped by an operator, the grasping portion being connected to the operation portion and provided such that an axis in a longitudinal direction is substantially perpendicular to a central axis of the insertion portion; a protruding portion provided on a surface on the insertion portion side of the grasping portion, the protruding portion protruding so as to form an acute angle with respect to the central axis of the insertion portion, on the insertion portion side; and a switch portion provided on the protruding portion and disposed at an angle which makes a right angle with respect to the acute angle.
摘要翻译：内窥镜包括：被配置为插入到被检体内的插入部; 图像拾取部，被配置为拾取被检体内部的图像; 被配置为连接到所述插入部的操作部; 所述把持部构造成能够被操作者抓握，所述把持部连接到所述操作部，并且设置成使得沿长度方向的轴线基本上垂直于所述插入部的中心轴线; 所述突出部设置在所述把持部的所述插入部侧的表面上，所述突出部在所述插入部侧侧突出以相对于所述插入部的中心轴线形成锐角; 以及开关部，其设置在所述突出部上并且以相对于所述锐角成直角的角度设置。

7. 发明授权

US08193351B2 HSP90 inhibitor 失效
标题翻译： HSP90抑制剂
公开(公告)号：US08193351B2
公开(公告)日：2012-06-05
申请号：US12302149
申请日：2007-05-25
申请人： Takuo Tsukuda , Ken-Ichi Kawasaki , Susumu Komiyama , Yoshiaki Isshiki , Yasuhiko Shiratori , Kiyoshi Hasegawa , Takaaki Fukami , Takaaki Miura , Naomi Ono , Toshikazu Yamazaki , Young-Jun Na , Dong-Oh Yoon , Sung-Jin Kim
发明人： Takuo Tsukuda , Ken-Ichi Kawasaki , Susumu Komiyama , Yoshiaki Isshiki , Yasuhiko Shiratori , Kiyoshi Hasegawa , Takaaki Fukami , Takaaki Miura , Naomi Ono , Toshikazu Yamazaki , Young-Jun Na , Dong-Oh Yoon , Sung-Jin Kim
IPC分类号： C07D239/47 , C07D251/42 , A61K31/506 , A61K31/53 , A61P35/00
CPC分类号： C07D251/16 , C07D239/47 , C07D239/48 , C07D401/12 , C07D403/10 , C07D403/12 , C07D405/04 , C07D405/14 , C07D409/04 , C07D413/14 , C07D417/12 , C07D417/14
摘要： Compounds represented by formula (1) shown below, pharmaceutically acceptable salts thereof, and pharmaceutical compositions comprising such compounds are provided.
摘要翻译：提供了由下式（1）表示的化合物及其药学上可接受的盐，以及包含这些化合物的药物组合物。

8. 发明申请

US20090247524A1 HSP90 Inhibitor 失效
标题翻译： HSP90抑制剂
公开(公告)号：US20090247524A1
公开(公告)日：2009-10-01
申请号：US12302149
申请日：2007-05-25
申请人： Takuo Tsukuda , Ken-ichi Kawasaki , Susumu Komiyama , Yoshiaki Isshiki , Yasuhiko Shiratori , Kiyoshi Hasegawa , Takaaki Fukami , Takaaki Miura , Naomi Ono , Toshikazu Yamazaki , Young-Jun Na , Dong-Oh Yoon , Sung-Jin Kim
发明人： Takuo Tsukuda , Ken-ichi Kawasaki , Susumu Komiyama , Yoshiaki Isshiki , Yasuhiko Shiratori , Kiyoshi Hasegawa , Takaaki Fukami , Takaaki Miura , Naomi Ono , Toshikazu Yamazaki , Young-Jun Na , Dong-Oh Yoon , Sung-Jin Kim
IPC分类号： A61K31/5377 , C07D251/16 , A61K31/53 , C07D311/78 , C07D239/02 , A61K31/505 , C07D413/02 , A61P35/00
CPC分类号： C07D251/16 , C07D239/47 , C07D239/48 , C07D401/12 , C07D403/10 , C07D403/12 , C07D405/04 , C07D405/14 , C07D409/04 , C07D413/14 , C07D417/12 , C07D417/14
摘要： Compounds represented by formula (1) shown below, pharmaceutically acceptable salts thereof, and pharmaceutical compositions comprising such compounds are provided.
摘要翻译：提供了由下式（1）表示的化合物及其药学上可接受的盐，以及包含这些化合物的药物组合物。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式