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1. 发明专利

HRP931430B1 N-OXYCARBONYL SUBSTITUTED 5'-DEOXY-5-FLUOROCYTIDINES 未知
公开(公告)号：HRP931430B1
公开(公告)日：1999-08-31
申请号：HRP931430
申请日：1993-11-23
申请人： ISAO UMEDA
发明人： UMEDA ISAO
IPC分类号： A61K31/305 , A61K31/7042 , A61K31/70 , A61K31/7052 , A61K31/7064 , A61K31/7068 , A61P35/00 , C07D239/00 , C07H19/06 , C07H19/067
摘要： Compounds represented by the general formula (I), wherein R is a saturated or unsaturated, straight or branched hydrocarbon radical [wherein the number of carbon atoms in the longest straight chain of this hydrocarbon radical ranges from three to seven], or a radical of the formula -(CH2)n-Y [in which n is an integer from 0 to 4, when Y is a cyclohexyl radical, or n is an integer from 2 to 4, when Y is a lower alkoxy radical having 1 to 4 carbon atom(s) or a phenyl radical], and R is a hydrogen atom or a radical easily hydrolyzable under physiological conditions, as well as hydrates or solvates of the compounds of the general formula (I), can be utilized in the treatment of tumors, They can be prepared by reacting a compound of formula R -OCOCl with a N -unsubstituted 5'-deoxy-5-fluorocytidine of the above formula I, wherein R would stand for protecting groups, and if necessary removing the protecting groups.

2. 发明专利

HRP970479A2 N-BENZYLAZOLIUM DERIVATIVES 未知
公开(公告)号：HRP970479A2
公开(公告)日：1998-08-31
申请号：HRP970479
申请日：1997-09-08
申请人： ISAO UMEDA
发明人： UMEDA ISAO
IPC分类号： A01N43/647 , A61K20060101 , A61K31/395 , A61K31/41 , A61K31/415 , A61K31/425 , A61K31/44 , A61K31/495 , C07D20060101 , C07D233/64 , C07D249/08 , C07D401/10 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/06 , C07D405/14 , C07D417/00 , C07D417/10 , C07D417/14 , C07F20060101

3. 发明专利

JP2010049289A Stringed instrument 有权
标题翻译：弦乐器
公开(公告)号：JP2010049289A
公开(公告)日：2010-03-04
申请号：JP2009275174
申请日：2009-12-03
申请人： Isao Umeda , 勲梅田
发明人： UMEDA ISAO
IPC分类号： G10D3/02 , G10D1/02 , G10D1/06 , G10D1/08
CPC分类号： G10D3/02
摘要： PROBLEM TO BE SOLVED: To provide a stringed instrument that can improve its sound characteristic by vibrating a specific region of a table.
SOLUTION: A guitar 1 has a body 8 provided with the table 2 and the like, wherein the table 2 is attached with a breath bar 3 having a laterally bridged connection portions 16 in longitudinal shapes arranged in parallel along an inner surface 15 of the table 2, a pair of cone connection legs 17a and 17b curved to intersect a longitudinal direction from both edges of each of the laterally bridged connection portions 16, and a bridge connection leg 18 arranged along a projection direction of the cone connection leg 17a and the like from a central portion of the laterally bridged connection portions 16. Further, a pair of concave portions 21a cut in concave shapes are formed in the table 2 and the cone connection leg 17a and the like of the breath bar 3 are connected with a thin plate-like cone portion 4 stuck on the concave portion 21a and the like.
COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：提供一种弦乐器，其可以通过振动桌子的特定区域来改善其声音特性。吉他1具有设置有工作台2等的主体8，其中工作台2安装有具有沿着内表面15并排布置的纵向形状的横向桥接连接部分16的呼吸杆3 在一对锥形连接腿部17a和17b中，一对锥形连接腿部17a和17b弯曲以沿着每个横向桥接的连接部分16的两个边缘的纵向相交，以及桥接连接腿部18，其沿着锥形连接腿部17a的突出方向布置等等。另外，在桌子2中形成一对凹陷形状的凹部21a，并且呼吸条3的锥形连接腿17a等与粘贴在凹部21a上的薄板状锥部4等。版权所有（C）2010，JPO＆INPIT

4. 发明授权

US08399024B2 Water-insoluble medicine 失效
标题翻译：水不溶性药
公开(公告)号：US08399024B2
公开(公告)日：2013-03-19
申请号：US12879413
申请日：2010-09-10
申请人： Hiroyuki Kato , Isao Umeda , Kazuo Watanabe , Kazuya Hirata , Akio Ishiguro , Tetsu Go
发明人： Hiroyuki Kato , Isao Umeda , Kazuo Watanabe , Kazuya Hirata , Akio Ishiguro , Tetsu Go
IPC分类号： A61K9/14 , A61K31/44 , A61K9/127 , C21C1/00
CPC分类号： A61K9/146 , A61K9/5161 , A61K31/44
摘要： A method of producing water-insoluble anti-cancer drug in the form of particulates, the method including preparing a water-insoluble anti-cancer drug having at least one multiple bond in the structure, and irradiating said water-insoluble anti-cancer drug with a laser beam having a wavelength of a low absorption portion in the vicinity of the foot of an absorption curve on the long wavelength side within the absorption band until said water-insoluble anti-cancer drug is formed into particulates having an average particle diameter of 50 to 200 nm.
摘要翻译：一种以微粒形式生产不溶于水的抗癌药物的方法，该方法包括制备结构中具有至少一个多重键的水不溶性抗癌药物，并将所述水不溶性抗癌药物与在吸收带内的长波长侧的吸收曲线的脚附近具有低吸收部分的波长的激光束，直到所述水不溶性抗癌药物形成具有平均粒径为50微米的颗粒至200nm。

5. 发明授权

US07815426B2 Apparatus for forming ultrafine particles 失效
标题翻译：用于形成超细颗粒的装置
公开(公告)号：US07815426B2
公开(公告)日：2010-10-19
申请号：US11748842
申请日：2007-05-15
申请人： Hiroyuki Kato , Isao Umeda , Tsuyoshi Asahi , Hiroshi Masuhara , Teruki Sugiyama , Isamu Oh , Sen-ichi Ryo , Kazuya Hirata , Motohiko Nohmi
发明人： Hiroyuki Kato , Isao Umeda , Tsuyoshi Asahi , Hiroshi Masuhara , Teruki Sugiyama , Isamu Oh , Sen-ichi Ryo , Kazuya Hirata , Motohiko Nohmi
IPC分类号： A61K9/16 , B02C19/18
CPC分类号： B02C19/18 , B01J19/0093 , B01J2219/0086 , B01J2219/00862 , B01J2219/00873 , B01J2219/00934 , B01J2219/00984 , Y10S977/901
摘要： An apparatus for forming ultrafine particles, including: a light source generating a laser beam to be irradiated at an organic substance; at least one microflow channel capable of passing therethrough a suspension containing the organic substance; and a flow device for allowing the suspension containing the organic substance to continuously or intermittently pass through the microflow channel, the organic substance present in the microflow channel being irradiated with the laser beam at least once within a predetermined period, thereby forming ultrafine particles of the organic substance.
摘要翻译：一种用于形成超微粒子的装置，包括：产生要在有机物质上照射的激光束的光源; 至少一个能够通过其中含有有机物的悬浮液的微流道; 以及用于允许包含有机物质的悬浮液连续或间歇地通过微流道的流动装置，存在于微流道中的有机物质在预定时间内至少一次被激光束照射，由此形成超细颗粒有机物质。

6. 发明授权

US07597278B2 Method of producing medicinal nanoparticle suspension 失效
标题翻译：生产药用纳米颗粒悬浮液的方法
公开(公告)号：US07597278B2
公开(公告)日：2009-10-06
申请号：US11798621
申请日：2007-05-15
申请人： Tsuyoshi Asahi , Hiroshi Masuhara , Teruki Sugiyama , Isamu Oh , Sen-ichi Ryo , Hiroyuki Kato , Isao Umeda
发明人： Tsuyoshi Asahi , Hiroshi Masuhara , Teruki Sugiyama , Isamu Oh , Sen-ichi Ryo , Hiroyuki Kato , Isao Umeda
IPC分类号： B02C19/00
CPC分类号： A61K9/10 , A61K9/14 , A61K31/475 , B01J19/10 , B01J19/121 , B01J2219/089
摘要： A method of producing a medicinal nanoparticle suspension is provided, wherein a medicinal ingredient added in a suspending solution is ground to form nanoparticles of the medicinal ingredient by irradiating the suspending solution with a laser. The process is implemented after adding a poorly water-soluble or water-insoluble medicinal ingredient of a drug in a poor solvent to form the suspending solution.
摘要翻译：提供一种生产药用纳米颗粒悬浮液的方法，其中通过用激光照射悬浮溶液将加入悬浮液中的药物成分研磨成药物成分的纳米颗粒。在不良溶剂中加入难溶于水或不溶于水的药物成分的药物后，进行上述处理，形成悬浮液。

7. 发明申请

US20090118271A1 Preventive or Therapeutic Agents for Pancreatic Cancer, Ovarian Cancer, or Liver Cancer Comprising a Novel Water-Soluble Prodrug 审中-公开
标题翻译：包含新型水溶性前体药物的胰腺癌，卵巢癌或肝癌的预防或治疗剂
公开(公告)号：US20090118271A1
公开(公告)日：2009-05-07
申请号：US12083831
申请日：2006-10-19
申请人： Isao Umeda , Jun Ohwada , Sawako Ozawa , Mika Endo , Masako Ura
发明人： Isao Umeda , Jun Ohwada , Sawako Ozawa , Mika Endo , Masako Ura
IPC分类号： A61K31/5377 , C07D491/22 , A61K31/519 , A61P35/00 , A61K31/4375
CPC分类号： C07D491/22 , A61K31/519
摘要： Preventive or therapeutic agents for pancreatic cancer, ovarian cancer, or liver cancer of the present invention comprise a water-soluble prodrug represented by formula 1 described below, or a pharmaceutically acceptable salt, or a hydrate or solvate of the prodrug or pharmaceutically acceptable salt, (wherein, R1 represents a hydrogen atom, or a C1-C6 alkyl group; W represents a divalent group comprising a tertiary amino group or a divalent group comprising a sulfonyl group, and Y represents a residue of a compound represented by Y—OH comprising an alcoholic hydroxyl group, wherein said Y—OH is a camptothecin, a taxane, or an anticancer nucleotide).
摘要翻译：本发明的胰腺癌，卵巢癌或肝癌的预防或治疗剂包含由下述式1表示的水溶性前药或其前药或药学上可接受的盐的药学上可接受的盐或水合物或溶剂合物，（其中，R1表示氢原子或C1-C6烷基; W表示包含叔氨基或包含磺酰基的二价基团的二价基团，Y表示由Y-OH表示的化合物的残基，包括醇羟基，其中所述Y-OH是喜树碱，紫杉烷或抗癌核苷酸）。

8. 发明申请

US20070264350A1 WATER-INSOLUBLE MEDICINE 审中-公开
标题翻译：水不溶性药物
公开(公告)号：US20070264350A1
公开(公告)日：2007-11-15
申请号：US11748808
申请日：2007-05-15
申请人： Hiroyuki KATO , Isao Umeda , Kazuo Watanabe , Kazuya Hirata , Akio Ishiguro , Tetsu Go
发明人： Hiroyuki KATO , Isao Umeda , Kazuo Watanabe , Kazuya Hirata , Akio Ishiguro , Tetsu Go
IPC分类号： A61K9/14 , A61K31/44
CPC分类号： A61K9/146 , A61K9/5161 , A61K31/44
摘要： A water-insoluble medicine in the form of particulates, having an average particle diameter of 50 to 200 nm; and a particulate complex of the water-insoluble medicine and a polymer electrolyte, having an average particle diameter of 50 to 250 nm.
摘要翻译：平均粒径为50〜200nm的微粒状水不溶性药物，以及平均粒径为50〜250nm的水不溶性药物和高分子电解质的微粒状络合物。

9. 发明授权

US06812238B1 N-substituted carbamoyloxyalkyl-azolium derivatives 有权
标题翻译： N-取代氨基甲酰氧基烷基 - 唑鎓衍生物
公开(公告)号：US06812238B1
公开(公告)日：2004-11-02
申请号：US09702944
申请日：2000-10-31
申请人： Hiroshi Fukuda , Tadakatsu Hayase , Eisaku Mizuguchi , Nobuo Shimma , Jun Ohwada , Nobuhiro Oikawa , Masahiro Sakaitani , Masao Tsukazaki , Isao Umeda
发明人： Hiroshi Fukuda , Tadakatsu Hayase , Eisaku Mizuguchi , Nobuo Shimma , Jun Ohwada , Nobuhiro Oikawa , Masahiro Sakaitani , Masao Tsukazaki , Isao Umeda
IPC分类号： A61K314439
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08 , C07D417/06 , C07D417/14
摘要： N-substituted carbamoyloxyalkyl-azolium derivatives which have antifungal activity and are useful for the treatment of fungal diseases.
摘要翻译：具有抗真菌活性并可用于治疗真菌疾病的N-取代氨基甲酰氧基烷基 - 唑鎓衍生物。

10. 发明授权

US4966891A Fluorocytidine derivatives 失效
标题翻译：氟胞嘧啶衍生物
公开(公告)号：US4966891A
公开(公告)日：1990-10-30
申请号：US268437
申请日：1988-11-08
申请人： Morio Fujiu , Hideo Ishitsuka , Masanori Miwa , Isao Umeda , Kazuteru Yokose
发明人： Morio Fujiu , Hideo Ishitsuka , Masanori Miwa , Isao Umeda , Kazuteru Yokose
IPC分类号： A61K31/70 , A61K31/7042 , A61K31/7052 , A61K31/7064 , A61K31/7068 , A61P35/00 , C07H19/06 , C07H19/067
CPC分类号： C07H19/06
摘要： The novel 5'-deoxy-5-fluorocytidine derivatives of formula ##STR1## wherein R.sup.1, R.sup.2 and R.sup.3 are hydrogen or an easily hydrolyzable radical under physiological conditions, with the proviso that, at least one or R.sup.1, R.sup.2 and R.sup.3 is an easily hydrolyzable radical under physiological conditions,as well as hydrates of solvates of these compounds have antitumor properties. They can be prepared from compounds of formula I, wherein R.sup.1 is hydrogen or an amino-protecting radical and R.sup.2 and R.sup.3 are hydrogen or a hydroxy-protecting radical or taken together are a cyclic hydroxy-protecting radical.
摘要翻译：式（Ⅰ）的新的5'-脱氧-5-氟胞苷衍生物，其中R 1，R 2和R 3在生理条件下为氢或易水解的基团，条件是至少一个或R 1，R 2和R 3 在生理条件下是易水解的基团，以及这些化合物的溶剂合物的水合物具有抗肿瘤性质。它们可以由式I化合物制备，其中R 1是氢或氨基保护基，并且R 2和R 3是氢或羟基保护基或一起是环状羟基保护基。

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